Putative short chain dehydrogenase/reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase, putative

Species:

Leishmania major

UniProt:

Q4QAE9_LEIMA

TriTrypDb:

LmjF.24.1820 , LMJLV39_240025800 , LMJSD75_240025100

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 26
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	9
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QAE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.220
CLV_NRD_NRD_1	169	171	PF00675	0.605
CLV_NRD_NRD_1	27	29	PF00675	0.458
CLV_NRD_NRD_1	324	326	PF00675	0.431
CLV_NRD_NRD_1	388	390	PF00675	0.527
CLV_PCSK_KEX2_1	127	129	PF00082	0.220
CLV_PCSK_KEX2_1	169	171	PF00082	0.632
CLV_PCSK_KEX2_1	27	29	PF00082	0.470
CLV_PCSK_KEX2_1	388	390	PF00082	0.527
CLV_PCSK_KEX2_1	478	480	PF00082	0.515
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.586
CLV_PCSK_SKI1_1	175	179	PF00082	0.570
CLV_PCSK_SKI1_1	27	31	PF00082	0.484
CLV_PCSK_SKI1_1	354	358	PF00082	0.537
CLV_PCSK_SKI1_1	72	76	PF00082	0.565
DEG_APCC_DBOX_1	127	135	PF00400	0.454
DEG_APCC_DBOX_1	6	14	PF00400	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.706
DEG_SPOP_SBC_1	237	241	PF00917	0.204
DEG_SPOP_SBC_1	43	47	PF00917	0.756
DOC_CYCLIN_RxL_1	24	33	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.364
DOC_MAPK_DCC_7	397	406	PF00069	0.388
DOC_MAPK_gen_1	127	135	PF00069	0.495
DOC_MAPK_gen_1	299	308	PF00069	0.241
DOC_MAPK_gen_1	388	395	PF00069	0.323
DOC_MAPK_MEF2A_6	127	135	PF00069	0.491
DOC_MAPK_MEF2A_6	301	310	PF00069	0.318
DOC_MAPK_NFAT4_5	128	136	PF00069	0.361
DOC_PP1_RVXF_1	250	256	PF00149	0.241
DOC_PP2B_LxvP_1	129	132	PF13499	0.364
DOC_PP4_FxxP_1	310	313	PF00568	0.281
DOC_USP7_MATH_1	155	159	PF00917	0.486
DOC_USP7_MATH_1	209	213	PF00917	0.367
DOC_USP7_MATH_1	238	242	PF00917	0.319
DOC_USP7_MATH_1	36	40	PF00917	0.785
DOC_USP7_MATH_1	56	60	PF00917	0.699
DOC_USP7_MATH_1	73	77	PF00917	0.699
DOC_USP7_MATH_1	86	90	PF00917	0.669
DOC_USP7_MATH_1	98	102	PF00917	0.556
DOC_USP7_UBL2_3	496	500	PF12436	0.405
DOC_WW_Pin1_4	240	245	PF00397	0.324
DOC_WW_Pin1_4	421	426	PF00397	0.362
DOC_WW_Pin1_4	54	59	PF00397	0.640
DOC_WW_Pin1_4	62	67	PF00397	0.586
DOC_WW_Pin1_4	76	81	PF00397	0.628
LIG_14-3-3_CanoR_1	163	167	PF00244	0.308
LIG_14-3-3_CanoR_1	252	256	PF00244	0.244
LIG_14-3-3_CanoR_1	325	334	PF00244	0.372
LIG_14-3-3_CanoR_1	369	376	PF00244	0.287
LIG_14-3-3_CanoR_1	397	404	PF00244	0.408
LIG_14-3-3_CanoR_1	434	440	PF00244	0.321
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.289
LIG_BRCT_BRCA1_1	58	62	PF00533	0.592
LIG_CSL_BTD_1	129	132	PF09270	0.283
LIG_eIF4E_1	194	200	PF01652	0.270
LIG_eIF4E_1	466	472	PF01652	0.321
LIG_FHA_1	154	160	PF00498	0.413
LIG_FHA_1	179	185	PF00498	0.277
LIG_FHA_1	186	192	PF00498	0.272
LIG_FHA_1	232	238	PF00498	0.366
LIG_FHA_1	315	321	PF00498	0.258
LIG_FHA_1	63	69	PF00498	0.679
LIG_LIR_Apic_2	143	148	PF02991	0.376
LIG_LIR_Gen_1	178	184	PF02991	0.318
LIG_LIR_Gen_1	254	261	PF02991	0.261
LIG_LIR_Nem_3	178	183	PF02991	0.323
LIG_Pex14_2	310	314	PF04695	0.242
LIG_PTB_Apo_2	384	391	PF02174	0.386
LIG_PTB_Apo_2	459	466	PF02174	0.300
LIG_PTB_Phospho_1	384	390	PF10480	0.381
LIG_PTB_Phospho_1	459	465	PF10480	0.302
LIG_SH2_CRK	180	184	PF00017	0.323
LIG_SH2_GRB2like	145	148	PF00017	0.235
LIG_SH2_NCK_1	113	117	PF00017	0.629
LIG_SH2_NCK_1	154	158	PF00017	0.492
LIG_SH2_SRC	145	148	PF00017	0.235
LIG_SH2_STAP1	136	140	PF00017	0.374
LIG_SH2_STAP1	180	184	PF00017	0.323
LIG_SH2_STAP1	466	470	PF00017	0.258
LIG_SH2_STAT3	260	263	PF00017	0.329
LIG_SH2_STAT3	380	383	PF00017	0.233
LIG_SH2_STAT5	103	106	PF00017	0.616
LIG_SH2_STAT5	121	124	PF00017	0.496
LIG_SH2_STAT5	140	143	PF00017	0.336
LIG_SH2_STAT5	145	148	PF00017	0.318
LIG_SH2_STAT5	180	183	PF00017	0.277
LIG_SH2_STAT5	194	197	PF00017	0.216
LIG_SH2_STAT5	336	339	PF00017	0.274
LIG_SH2_STAT5	502	505	PF00017	0.416
LIG_SH3_3	225	231	PF00018	0.376
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.243
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.287
LIG_TYR_ITSM	176	183	PF00017	0.326
LIG_UBA3_1	320	326	PF00899	0.233
MOD_CK1_1	112	118	PF00069	0.618
MOD_CK1_1	14	20	PF00069	0.728
MOD_CK1_1	240	246	PF00069	0.347
MOD_CK1_1	39	45	PF00069	0.752
MOD_CK1_1	47	53	PF00069	0.695
MOD_CK1_1	474	480	PF00069	0.315
MOD_CK1_1	57	63	PF00069	0.625
MOD_CK1_1	64	70	PF00069	0.647
MOD_CK1_1	76	82	PF00069	0.623
MOD_CK2_1	209	215	PF00069	0.394
MOD_Cter_Amidation	167	170	PF01082	0.644
MOD_GlcNHglycan	105	108	PF01048	0.440
MOD_GlcNHglycan	114	117	PF01048	0.448
MOD_GlcNHglycan	13	16	PF01048	0.383
MOD_GlcNHglycan	142	145	PF01048	0.332
MOD_GlcNHglycan	188	191	PF01048	0.499
MOD_GlcNHglycan	211	214	PF01048	0.593
MOD_GlcNHglycan	240	243	PF01048	0.566
MOD_GlcNHglycan	32	35	PF01048	0.406
MOD_GlcNHglycan	371	374	PF01048	0.464
MOD_GlcNHglycan	38	41	PF01048	0.545
MOD_GlcNHglycan	473	476	PF01048	0.526
MOD_GlcNHglycan	49	52	PF01048	0.449
MOD_GlcNHglycan	80	83	PF01048	0.447
MOD_GlcNHglycan	99	103	PF01048	0.344
MOD_GSK3_1	178	185	PF00069	0.303
MOD_GSK3_1	209	216	PF00069	0.400
MOD_GSK3_1	233	240	PF00069	0.311
MOD_GSK3_1	30	37	PF00069	0.674
MOD_GSK3_1	320	327	PF00069	0.254
MOD_GSK3_1	39	46	PF00069	0.659
MOD_GSK3_1	50	57	PF00069	0.640
MOD_GSK3_1	58	65	PF00069	0.639
MOD_N-GLC_1	22	27	PF02516	0.392
MOD_N-GLC_1	34	39	PF02516	0.359
MOD_N-GLC_1	421	426	PF02516	0.645
MOD_N-GLC_2	453	455	PF02516	0.471
MOD_NEK2_1	123	128	PF00069	0.580
MOD_NEK2_1	153	158	PF00069	0.407
MOD_NEK2_1	22	27	PF00069	0.698
MOD_NEK2_1	29	34	PF00069	0.679
MOD_NEK2_1	324	329	PF00069	0.232
MOD_NEK2_1	364	369	PF00069	0.424
MOD_NEK2_1	413	418	PF00069	0.340
MOD_NEK2_1	427	432	PF00069	0.346
MOD_NEK2_1	494	499	PF00069	0.330
MOD_NEK2_2	86	91	PF00069	0.756
MOD_PIKK_1	445	451	PF00454	0.257
MOD_PKA_1	325	331	PF00069	0.320
MOD_PKA_2	162	168	PF00069	0.340
MOD_PKA_2	251	257	PF00069	0.244
MOD_PKA_2	324	330	PF00069	0.241
MOD_PKA_2	396	402	PF00069	0.416
MOD_PKA_2	456	462	PF00069	0.254
MOD_PKA_2	47	53	PF00069	0.714
MOD_Plk_1	98	104	PF00069	0.618
MOD_Plk_2-3	215	221	PF00069	0.255
MOD_Plk_4	155	161	PF00069	0.421
MOD_Plk_4	251	257	PF00069	0.270
MOD_Plk_4	427	433	PF00069	0.410
MOD_Plk_4	447	453	PF00069	0.253
MOD_ProDKin_1	240	246	PF00069	0.324
MOD_ProDKin_1	421	427	PF00069	0.359
MOD_ProDKin_1	54	60	PF00069	0.640
MOD_ProDKin_1	62	68	PF00069	0.585
MOD_ProDKin_1	76	82	PF00069	0.628
MOD_SUMO_rev_2	477	485	PF00179	0.307
MOD_SUMO_rev_2	89	98	PF00179	0.659
TRG_DiLeu_BaEn_1	353	358	PF01217	0.266
TRG_DiLeu_BaEn_2	216	222	PF01217	0.334
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.593
TRG_ENDOCYTIC_2	121	124	PF00928	0.519
TRG_ENDOCYTIC_2	139	142	PF00928	0.296
TRG_ENDOCYTIC_2	180	183	PF00928	0.291
TRG_ENDOCYTIC_2	194	197	PF00928	0.272
TRG_ENDOCYTIC_2	390	393	PF00928	0.338
TRG_ENDOCYTIC_2	501	504	PF00928	0.386
TRG_ER_diArg_1	127	129	PF00400	0.420
TRG_ER_diArg_1	27	29	PF00400	0.668
TRG_ER_diArg_1	388	390	PF00400	0.327
TRG_ER_diArg_1	6	9	PF00400	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S5	Leptomonas seymouri	29%	100%
A0A0N0P2S7	Leptomonas seymouri	80%	99%
A0A0N1HZ81	Leptomonas seymouri	32%	91%
A0A0S4IWT0	Bodo saltans	46%	100%
A0A0S4IZG2	Bodo saltans	30%	100%
A0A0S4J1I6	Bodo saltans	31%	100%
A0A1X0NVT8	Trypanosomatidae	64%	100%
A0A3Q8ID46	Leishmania donovani	92%	100%
A0A3Q8IM89	Leishmania donovani	29%	100%
A0A3R7K071	Trypanosoma rangeli	32%	100%
A0A3R7N7S2	Trypanosoma rangeli	26%	100%
A0A3S5H7D5	Leishmania donovani	34%	100%
A0A3S7WQY1	Leishmania donovani	27%	100%
A0A422N2B6	Trypanosoma rangeli	62%	100%
A4H5Z1	Leishmania braziliensis	24%	100%
A4HDP2	Leishmania braziliensis	33%	100%
A4HDP3	Leishmania braziliensis	87%	100%
A4HMN7	Leishmania braziliensis	28%	100%
A4HUB6	Leishmania infantum	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF39	Leishmania major	29%	100%
E9AH88	Leishmania infantum	34%	100%
E9AH89	Leishmania infantum	92%	100%
E9AHV6	Leishmania infantum	29%	100%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4QAF0	Leishmania major	34%	100%
Q4QHL1	Leishmania major	27%	100%
Q6UX07	Homo sapiens	27%	100%
Q803A8	Danio rerio	27%	100%
Q92247	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
V5BAF4	Trypanosoma cruzi	62%	100%
V5BJC7	Trypanosoma cruzi	25%	100%