Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAE8_LEIMA

TriTrypDb:

LmjF.24.1830 , LMJLV39_240025900 , LMJSD75_240025200

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.691
CLV_NRD_NRD_1	166	168	PF00675	0.622
CLV_NRD_NRD_1	225	227	PF00675	0.614
CLV_PCSK_KEX2_1	145	147	PF00082	0.658
CLV_PCSK_KEX2_1	225	227	PF00082	0.637
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.690
CLV_PCSK_SKI1_1	145	149	PF00082	0.642
CLV_PCSK_SKI1_1	62	66	PF00082	0.708
DEG_APCC_KENBOX_2	200	204	PF00400	0.666
DEG_Nend_UBRbox_1	1	4	PF02207	0.736
DEG_SCF_FBW7_2	83	88	PF00400	0.628
DOC_MAPK_gen_1	120	129	PF00069	0.677
DOC_MAPK_gen_1	145	154	PF00069	0.678
DOC_MAPK_MEF2A_6	120	129	PF00069	0.684
DOC_PP2B_LxvP_1	83	86	PF13499	0.627
DOC_PP4_FxxP_1	89	92	PF00568	0.634
DOC_USP7_MATH_2	130	136	PF00917	0.659
DOC_WW_Pin1_4	1	6	PF00397	0.665
DOC_WW_Pin1_4	49	54	PF00397	0.763
DOC_WW_Pin1_4	81	86	PF00397	0.623
LIG_14-3-3_CanoR_1	112	118	PF00244	0.593
LIG_14-3-3_CanoR_1	7	15	PF00244	0.702
LIG_deltaCOP1_diTrp_1	88	95	PF00928	0.658
LIG_EVH1_2	85	89	PF00568	0.637
LIG_FHA_1	14	20	PF00498	0.687
LIG_FHA_1	65	71	PF00498	0.720
LIG_FHA_2	63	69	PF00498	0.647
LIG_LIR_Apic_2	88	92	PF02991	0.642
LIG_PTB_Apo_2	155	162	PF02174	0.704
LIG_PTB_Phospho_1	155	161	PF10480	0.704
LIG_SH2_GRB2like	151	154	PF00017	0.611
LIG_SH2_PTP2	151	154	PF00017	0.668
LIG_SH2_STAP1	123	127	PF00017	0.695
LIG_SH2_STAP1	46	50	PF00017	0.680
LIG_SH2_STAT3	175	178	PF00017	0.647
LIG_SH2_STAT3	46	49	PF00017	0.624
LIG_SH2_STAT5	151	154	PF00017	0.636
LIG_SH2_STAT5	161	164	PF00017	0.617
LIG_SH2_STAT5	189	192	PF00017	0.645
LIG_SH3_3	124	130	PF00018	0.770
LIG_TRAF2_1	116	119	PF00917	0.508
LIG_TRAF2_1	99	102	PF00917	0.650
MOD_CDK_SPxK_1	1	7	PF00069	0.658
MOD_CDK_SPxxK_3	49	56	PF00069	0.771
MOD_CK2_1	113	119	PF00069	0.596
MOD_CK2_1	62	68	PF00069	0.651
MOD_GlcNHglycan	22	25	PF01048	0.635
MOD_GlcNHglycan	8	11	PF01048	0.690
MOD_N-GLC_1	211	216	PF02516	0.611
MOD_NEK2_1	13	18	PF00069	0.595
MOD_NEK2_1	20	25	PF00069	0.466
MOD_NEK2_1	6	11	PF00069	0.628
MOD_PKA_2	178	184	PF00069	0.659
MOD_PKA_2	6	12	PF00069	0.661
MOD_Plk_1	118	124	PF00069	0.665
MOD_Plk_1	171	177	PF00069	0.664
MOD_Plk_4	14	20	PF00069	0.726
MOD_ProDKin_1	1	7	PF00069	0.665
MOD_ProDKin_1	49	55	PF00069	0.765
MOD_ProDKin_1	81	87	PF00069	0.624
MOD_SUMO_rev_2	116	121	PF00179	0.597
TRG_ENDOCYTIC_2	151	154	PF00928	0.611
TRG_ENDOCYTIC_2	27	30	PF00928	0.597
TRG_ER_diArg_1	164	167	PF00400	0.611
TRG_ER_diArg_1	225	227	PF00400	0.637
TRG_NLS_MonoExtN_4	142	149	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P367	Leptomonas seymouri	84%	85%
A0A0S4J5N9	Bodo saltans	60%	100%
A0A1X0NVV7	Trypanosomatidae	77%	100%
A0A3Q8ICY8	Leishmania donovani	99%	100%
A4HDP4	Leishmania braziliensis	98%	100%
C9ZWB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH90	Leishmania infantum	99%	100%
E9AX28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%