Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania major

UniProt:

Q4QAE6_LEIMA

TriTrypDb:

LmjF.24.1850 , LMJLV39_240026100 , LMJSD75_240025400

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QAE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.500
CLV_NRD_NRD_1	221	223	PF00675	0.723
CLV_NRD_NRD_1	305	307	PF00675	0.639
CLV_NRD_NRD_1	319	321	PF00675	0.542
CLV_NRD_NRD_1	351	353	PF00675	0.615
CLV_NRD_NRD_1	391	393	PF00675	0.437
CLV_NRD_NRD_1	7	9	PF00675	0.450
CLV_PCSK_KEX2_1	220	222	PF00082	0.729
CLV_PCSK_KEX2_1	305	307	PF00082	0.639
CLV_PCSK_KEX2_1	351	353	PF00082	0.632
CLV_PCSK_KEX2_1	7	9	PF00082	0.506
CLV_PCSK_PC7_1	3	9	PF00082	0.487
CLV_PCSK_SKI1_1	178	182	PF00082	0.681
DEG_Nend_UBRbox_3	1	3	PF02207	0.700
DEG_SPOP_SBC_1	105	109	PF00917	0.448
DEG_SPOP_SBC_1	238	242	PF00917	0.507
DOC_CKS1_1	67	72	PF01111	0.527
DOC_MAPK_gen_1	305	314	PF00069	0.452
DOC_MAPK_MEF2A_6	20	27	PF00069	0.315
DOC_MAPK_MEF2A_6	305	314	PF00069	0.452
DOC_MAPK_MEF2A_6	367	375	PF00069	0.302
DOC_PP1_RVXF_1	385	392	PF00149	0.605
DOC_PP2B_LxvP_1	102	105	PF13499	0.478
DOC_PP4_FxxP_1	100	103	PF00568	0.456
DOC_USP7_MATH_1	106	110	PF00917	0.441
DOC_USP7_MATH_1	19	23	PF00917	0.364
DOC_USP7_MATH_1	236	240	PF00917	0.557
DOC_USP7_MATH_1	255	259	PF00917	0.505
DOC_USP7_MATH_1	304	308	PF00917	0.477
DOC_USP7_MATH_1	360	364	PF00917	0.464
DOC_USP7_MATH_1	91	95	PF00917	0.484
DOC_WW_Pin1_4	230	235	PF00397	0.580
DOC_WW_Pin1_4	66	71	PF00397	0.525
LIG_14-3-3_CanoR_1	20	24	PF00244	0.337
LIG_14-3-3_CanoR_1	250	260	PF00244	0.500
LIG_14-3-3_CanoR_1	351	357	PF00244	0.453
LIG_14-3-3_CanoR_1	361	365	PF00244	0.460
LIG_BIR_III_4	115	119	PF00653	0.455
LIG_BRCT_BRCA1_1	96	100	PF00533	0.425
LIG_EVH1_1	102	106	PF00568	0.432
LIG_FHA_1	214	220	PF00498	0.510
LIG_FHA_1	260	266	PF00498	0.464
LIG_FHA_1	340	346	PF00498	0.369
LIG_FHA_1	352	358	PF00498	0.447
LIG_FHA_1	383	389	PF00498	0.666
LIG_FHA_1	48	54	PF00498	0.437
LIG_FHA_1	62	68	PF00498	0.429
LIG_FHA_2	291	297	PF00498	0.473
LIG_GBD_Chelix_1	23	31	PF00786	0.388
LIG_LIR_Apic_2	97	103	PF02991	0.443
LIG_LIR_Gen_1	343	350	PF02991	0.428
LIG_LIR_Gen_1	376	386	PF02991	0.475
LIG_LIR_Nem_3	155	159	PF02991	0.443
LIG_LIR_Nem_3	187	193	PF02991	0.448
LIG_LIR_Nem_3	376	382	PF02991	0.428
LIG_NRBOX	26	32	PF00104	0.388
LIG_NRBOX	51	57	PF00104	0.449
LIG_Pex14_1	370	374	PF04695	0.340
LIG_Pex14_2	364	368	PF04695	0.420
LIG_REV1ctd_RIR_1	178	187	PF16727	0.467
LIG_REV1ctd_RIR_1	362	370	PF16727	0.421
LIG_RPA_C_Fungi	382	394	PF08784	0.551
LIG_SH2_CRK	379	383	PF00017	0.291
LIG_SH2_STAP1	346	350	PF00017	0.583
LIG_SH2_STAP1	379	383	PF00017	0.340
LIG_SH2_STAT3	193	196	PF00017	0.576
LIG_SH2_STAT5	297	300	PF00017	0.628
LIG_SH3_3	100	106	PF00018	0.515
LIG_SH3_3	228	234	PF00018	0.657
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.340
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.557
LIG_SUMO_SIM_par_1	44	51	PF11976	0.517
LIG_SUMO_SIM_par_1	63	69	PF11976	0.642
LIG_TRAF2_1	160	163	PF00917	0.546
LIG_TRAF2_1	282	285	PF00917	0.676
LIG_TRAF2_1	41	44	PF00917	0.530
LIG_TRFH_1	100	104	PF08558	0.573
MOD_CDK_SPK_2	230	235	PF00069	0.660
MOD_CK1_1	239	245	PF00069	0.642
MOD_CK1_1	395	401	PF00069	0.643
MOD_CK1_1	66	72	PF00069	0.535
MOD_CK1_1	94	100	PF00069	0.694
MOD_CK2_1	157	163	PF00069	0.539
MOD_CK2_1	237	243	PF00069	0.717
MOD_CK2_1	290	296	PF00069	0.601
MOD_GlcNHglycan	131	134	PF01048	0.648
MOD_GlcNHglycan	17	20	PF01048	0.491
MOD_GlcNHglycan	196	199	PF01048	0.557
MOD_GlcNHglycan	243	247	PF01048	0.736
MOD_GlcNHglycan	253	256	PF01048	0.673
MOD_GlcNHglycan	257	260	PF01048	0.618
MOD_GlcNHglycan	269	272	PF01048	0.511
MOD_GlcNHglycan	277	281	PF01048	0.513
MOD_GlcNHglycan	324	327	PF01048	0.597
MOD_GlcNHglycan	397	400	PF01048	0.539
MOD_GlcNHglycan	93	96	PF01048	0.588
MOD_GSK3_1	15	22	PF00069	0.387
MOD_GSK3_1	230	237	PF00069	0.720
MOD_GSK3_1	238	245	PF00069	0.620
MOD_GSK3_1	251	258	PF00069	0.624
MOD_GSK3_1	94	101	PF00069	0.600
MOD_NEK2_1	140	145	PF00069	0.704
MOD_NEK2_1	152	157	PF00069	0.593
MOD_NEK2_1	267	272	PF00069	0.622
MOD_NEK2_1	373	378	PF00069	0.424
MOD_NEK2_1	382	387	PF00069	0.380
MOD_NEK2_1	48	53	PF00069	0.656
MOD_NEK2_1	98	103	PF00069	0.678
MOD_NEK2_2	360	365	PF00069	0.574
MOD_PIKK_1	138	144	PF00454	0.703
MOD_PIKK_1	392	398	PF00454	0.560
MOD_PIKK_1	86	92	PF00454	0.620
MOD_PKA_1	204	210	PF00069	0.580
MOD_PKA_1	351	357	PF00069	0.513
MOD_PKA_1	392	398	PF00069	0.532
MOD_PKA_2	19	25	PF00069	0.319
MOD_PKA_2	304	310	PF00069	0.580
MOD_PKA_2	319	325	PF00069	0.641
MOD_PKA_2	350	356	PF00069	0.625
MOD_PKA_2	360	366	PF00069	0.536
MOD_Plk_1	290	296	PF00069	0.698
MOD_Plk_4	19	25	PF00069	0.340
MOD_Plk_4	360	366	PF00069	0.548
MOD_Plk_4	48	54	PF00069	0.514
MOD_Plk_4	94	100	PF00069	0.515
MOD_ProDKin_1	230	236	PF00069	0.738
MOD_ProDKin_1	66	72	PF00069	0.659
TRG_ENDOCYTIC_2	346	349	PF00928	0.704
TRG_ENDOCYTIC_2	379	382	PF00928	0.292
TRG_ER_diArg_1	110	113	PF00400	0.643
TRG_ER_diArg_1	219	222	PF00400	0.666
TRG_ER_diArg_1	350	352	PF00400	0.513
TRG_ER_diArg_1	7	10	PF00400	0.559
TRG_ER_diLys_1	408	412	PF00400	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P420	Leptomonas seymouri	39%	98%
A0A3S7WYI6	Leishmania donovani	89%	100%
A4HDP6	Leishmania braziliensis	63%	100%
E9AH92	Leishmania infantum	88%	100%
E9AX30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%