Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAE5_LEIMA

TriTrypDb:

LmjF.24.1860 , LMJLV39_240026300 , LMJSD75_240025600

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.672
CLV_C14_Caspase3-7	51	55	PF00656	0.581
CLV_NRD_NRD_1	300	302	PF00675	0.709
CLV_NRD_NRD_1	317	319	PF00675	0.678
CLV_NRD_NRD_1	369	371	PF00675	0.632
CLV_PCSK_KEX2_1	20	22	PF00082	0.696
CLV_PCSK_KEX2_1	299	301	PF00082	0.735
CLV_PCSK_KEX2_1	317	319	PF00082	0.677
CLV_PCSK_KEX2_1	369	371	PF00082	0.632
CLV_PCSK_KEX2_1	530	532	PF00082	0.637
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.647
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.637
CLV_PCSK_SKI1_1	530	534	PF00082	0.609
DEG_APCC_DBOX_1	476	484	PF00400	0.531
DOC_CDC14_PxL_1	443	451	PF14671	0.579
DOC_CKS1_1	105	110	PF01111	0.730
DOC_CKS1_1	153	158	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.656
DOC_MAPK_DCC_7	53	62	PF00069	0.640
DOC_MAPK_gen_1	460	468	PF00069	0.525
DOC_MAPK_gen_1	53	62	PF00069	0.568
DOC_MAPK_MEF2A_6	56	64	PF00069	0.562
DOC_PP2B_LxvP_1	15	18	PF13499	0.679
DOC_PP2B_LxvP_1	87	90	PF13499	0.670
DOC_USP7_MATH_1	199	203	PF00917	0.592
DOC_USP7_MATH_1	234	238	PF00917	0.810
DOC_USP7_MATH_1	291	295	PF00917	0.764
DOC_USP7_MATH_1	371	375	PF00917	0.718
DOC_USP7_MATH_1	387	391	PF00917	0.667
DOC_USP7_MATH_1	392	396	PF00917	0.640
DOC_USP7_MATH_1	81	85	PF00917	0.692
DOC_USP7_MATH_2	166	172	PF00917	0.574
DOC_USP7_MATH_2	310	316	PF00917	0.685
DOC_WW_Pin1_4	104	109	PF00397	0.684
DOC_WW_Pin1_4	152	157	PF00397	0.780
DOC_WW_Pin1_4	19	24	PF00397	0.665
DOC_WW_Pin1_4	217	222	PF00397	0.730
DOC_WW_Pin1_4	306	311	PF00397	0.785
DOC_WW_Pin1_4	334	339	PF00397	0.671
DOC_WW_Pin1_4	346	351	PF00397	0.711
DOC_WW_Pin1_4	42	47	PF00397	0.705
DOC_WW_Pin1_4	513	518	PF00397	0.672
DOC_WW_Pin1_4	55	60	PF00397	0.777
LIG_14-3-3_CanoR_1	231	239	PF00244	0.713
LIG_14-3-3_CanoR_1	241	248	PF00244	0.617
LIG_14-3-3_CterR_2	531	535	PF00244	0.629
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	123	127	PF00533	0.634
LIG_CtBP_PxDLS_1	405	409	PF00389	0.618
LIG_EH1_1	505	513	PF00400	0.485
LIG_EVH1_1	15	19	PF00568	0.682
LIG_FHA_1	160	166	PF00498	0.668
LIG_FHA_1	381	387	PF00498	0.648
LIG_FHA_1	438	444	PF00498	0.668
LIG_FHA_1	514	520	PF00498	0.646
LIG_FHA_2	114	120	PF00498	0.709
LIG_FHA_2	179	185	PF00498	0.609
LIG_FHA_2	28	34	PF00498	0.761
LIG_FHA_2	49	55	PF00498	0.678
LIG_LIR_Apic_2	152	156	PF02991	0.556
LIG_LIR_Gen_1	505	512	PF02991	0.595
LIG_LIR_Nem_3	245	251	PF02991	0.671
LIG_LIR_Nem_3	34	40	PF02991	0.654
LIG_LIR_Nem_3	390	396	PF02991	0.649
LIG_LIR_Nem_3	459	465	PF02991	0.540
LIG_LIR_Nem_3	505	509	PF02991	0.590
LIG_SH2_CRK	153	157	PF00017	0.652
LIG_SH2_CRK	26	30	PF00017	0.665
LIG_SH2_CRK	37	41	PF00017	0.533
LIG_SH2_CRK	462	466	PF00017	0.475
LIG_SH2_CRK	95	99	PF00017	0.572
LIG_SH2_NCK_1	153	157	PF00017	0.652
LIG_SH2_NCK_1	26	30	PF00017	0.665
LIG_SH2_NCK_1	8	12	PF00017	0.621
LIG_SH2_STAT3	330	333	PF00017	0.637
LIG_SH2_STAT3	361	364	PF00017	0.723
LIG_SH2_STAT3	471	474	PF00017	0.402
LIG_SH2_STAT3	72	75	PF00017	0.593
LIG_SH2_STAT5	330	333	PF00017	0.637
LIG_SH3_1	13	19	PF00018	0.735
LIG_SH3_2	16	21	PF14604	0.687
LIG_SH3_3	102	108	PF00018	0.681
LIG_SH3_3	13	19	PF00018	0.779
LIG_SH3_3	211	217	PF00018	0.627
LIG_SH3_3	349	355	PF00018	0.569
LIG_SH3_3	441	447	PF00018	0.767
LIG_SH3_3	514	520	PF00018	0.671
LIG_SUMO_SIM_par_1	382	390	PF11976	0.645
LIG_WW_1	23	26	PF00397	0.666
LIG_WW_3	22	26	PF00397	0.698
MOD_CDC14_SPxK_1	337	340	PF00782	0.628
MOD_CDC14_SPxK_1	45	48	PF00782	0.669
MOD_CDK_SPxK_1	19	25	PF00069	0.654
MOD_CDK_SPxK_1	334	340	PF00069	0.631
MOD_CDK_SPxK_1	42	48	PF00069	0.666
MOD_CK1_1	112	118	PF00069	0.687
MOD_CK1_1	125	131	PF00069	0.578
MOD_CK1_1	171	177	PF00069	0.724
MOD_CK1_1	237	243	PF00069	0.725
MOD_CK1_1	27	33	PF00069	0.729
MOD_CK1_1	311	317	PF00069	0.759
MOD_CK1_1	379	385	PF00069	0.680
MOD_CK1_1	395	401	PF00069	0.528
MOD_CK1_1	420	426	PF00069	0.674
MOD_CK2_1	113	119	PF00069	0.715
MOD_CK2_1	178	184	PF00069	0.612
MOD_CK2_1	27	33	PF00069	0.749
MOD_CK2_1	306	312	PF00069	0.715
MOD_CK2_1	44	50	PF00069	0.594
MOD_CK2_1	485	491	PF00069	0.483
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.679
MOD_GlcNHglycan	132	135	PF01048	0.635
MOD_GlcNHglycan	227	230	PF01048	0.728
MOD_GlcNHglycan	251	254	PF01048	0.675
MOD_GlcNHglycan	293	296	PF01048	0.713
MOD_GlcNHglycan	321	324	PF01048	0.648
MOD_GlcNHglycan	427	431	PF01048	0.650
MOD_GlcNHglycan	487	490	PF01048	0.485
MOD_GlcNHglycan	495	498	PF01048	0.393
MOD_GSK3_1	100	107	PF00069	0.635
MOD_GSK3_1	109	116	PF00069	0.670
MOD_GSK3_1	121	128	PF00069	0.571
MOD_GSK3_1	130	137	PF00069	0.703
MOD_GSK3_1	167	174	PF00069	0.744
MOD_GSK3_1	199	206	PF00069	0.673
MOD_GSK3_1	225	232	PF00069	0.775
MOD_GSK3_1	25	32	PF00069	0.685
MOD_GSK3_1	291	298	PF00069	0.680
MOD_GSK3_1	302	309	PF00069	0.731
MOD_GSK3_1	355	362	PF00069	0.648
MOD_GSK3_1	376	383	PF00069	0.699
MOD_GSK3_1	38	45	PF00069	0.597
MOD_GSK3_1	392	399	PF00069	0.690
MOD_GSK3_1	433	440	PF00069	0.613
MOD_LATS_1	306	312	PF00433	0.691
MOD_N-GLC_1	159	164	PF02516	0.749
MOD_N-GLC_1	178	183	PF02516	0.585
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	159	164	PF00069	0.679
MOD_NEK2_1	178	183	PF00069	0.504
MOD_NEK2_1	205	210	PF00069	0.585
MOD_NEK2_1	406	411	PF00069	0.619
MOD_NEK2_1	483	488	PF00069	0.407
MOD_NEK2_1	511	516	PF00069	0.575
MOD_NEK2_2	392	397	PF00069	0.652
MOD_PIKK_1	109	115	PF00454	0.684
MOD_PIKK_1	359	365	PF00454	0.651
MOD_PIKK_1	377	383	PF00454	0.751
MOD_PIKK_1	65	71	PF00454	0.710
MOD_PKA_1	369	375	PF00069	0.635
MOD_PKA_2	100	106	PF00069	0.610
MOD_PKA_2	174	180	PF00069	0.668
MOD_PKA_2	230	236	PF00069	0.717
MOD_PKA_2	24	30	PF00069	0.666
MOD_PKA_2	240	246	PF00069	0.614
MOD_PKA_2	369	375	PF00069	0.683
MOD_PKA_2	396	402	PF00069	0.700
MOD_PKA_2	65	71	PF00069	0.646
MOD_Plk_1	159	165	PF00069	0.648
MOD_Plk_1	311	317	PF00069	0.687
MOD_Plk_1	406	412	PF00069	0.619
MOD_Plk_2-3	168	174	PF00069	0.673
MOD_Plk_2-3	524	530	PF00069	0.547
MOD_ProDKin_1	104	110	PF00069	0.684
MOD_ProDKin_1	152	158	PF00069	0.782
MOD_ProDKin_1	19	25	PF00069	0.670
MOD_ProDKin_1	217	223	PF00069	0.731
MOD_ProDKin_1	306	312	PF00069	0.787
MOD_ProDKin_1	334	340	PF00069	0.674
MOD_ProDKin_1	346	352	PF00069	0.709
MOD_ProDKin_1	42	48	PF00069	0.708
MOD_ProDKin_1	513	519	PF00069	0.672
MOD_ProDKin_1	55	61	PF00069	0.776
MOD_SUMO_rev_2	50	58	PF00179	0.578
MOD_SUMO_rev_2	82	87	PF00179	0.729
TRG_DiLeu_BaEn_1	438	443	PF01217	0.669
TRG_DiLeu_BaEn_1	507	512	PF01217	0.490
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.649
TRG_ENDOCYTIC_2	26	29	PF00928	0.666
TRG_ENDOCYTIC_2	37	40	PF00928	0.532
TRG_ENDOCYTIC_2	462	465	PF00928	0.569
TRG_ER_diArg_1	299	301	PF00400	0.716
TRG_ER_diArg_1	316	318	PF00400	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID03	Leishmania donovani	87%	100%
A4HDP7	Leishmania braziliensis	50%	98%
A4I0Z3	Leishmania infantum	87%	100%
E9AX31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%