Cyclin 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin 10

Gene product:

cyclin 10

Species:

Leishmania major

UniProt:

Q4QAE2_LEIMA

TriTrypDb:

LmjF.24.1890 , LMJLV39_240026600 , LMJSD75_240025900

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE2

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	7
GO:0001932	regulation of protein phosphorylation	7	7
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031399	regulation of protein modification process	6	7
GO:0042325	regulation of phosphorylation	7	7
GO:0043549	regulation of kinase activity	5	7
GO:0045859	regulation of protein kinase activity	6	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051338	regulation of transferase activity	4	7
GO:0051726	regulation of cell cycle	4	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071900	regulation of protein serine/threonine kinase activity	7	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0019899	enzyme binding	3	7
GO:0019900	kinase binding	4	7
GO:0019901	protein kinase binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	365	367	PF00675	0.710
CLV_NRD_NRD_1	610	612	PF00675	0.714
CLV_PCSK_FUR_1	363	367	PF00082	0.706
CLV_PCSK_KEX2_1	160	162	PF00082	0.684
CLV_PCSK_KEX2_1	213	215	PF00082	0.411
CLV_PCSK_KEX2_1	365	367	PF00082	0.710
CLV_PCSK_KEX2_1	610	612	PF00082	0.714
CLV_PCSK_KEX2_1	91	93	PF00082	0.581
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.684
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.411
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.623
CLV_PCSK_PC7_1	606	612	PF00082	0.705
CLV_PCSK_SKI1_1	214	218	PF00082	0.411
CLV_PCSK_SKI1_1	252	256	PF00082	0.438
CLV_PCSK_SKI1_1	351	355	PF00082	0.710
CLV_PCSK_SKI1_1	393	397	PF00082	0.709
CLV_PCSK_SKI1_1	477	481	PF00082	0.703
CLV_PCSK_SKI1_1	585	589	PF00082	0.808
CLV_PCSK_SKI1_1	610	614	PF00082	0.717
CLV_Separin_Metazoa	130	134	PF03568	0.622
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DEG_SCF_FBW7_1	335	341	PF00400	0.749
DEG_SCF_FBW7_1	78	84	PF00400	0.744
DEG_SPOP_SBC_1	543	547	PF00917	0.600
DOC_CKS1_1	335	340	PF01111	0.748
DOC_CKS1_1	78	83	PF01111	0.638
DOC_CYCLIN_yClb1_LxF_4	286	292	PF00134	0.411
DOC_CYCLIN_yClb1_LxF_4	298	303	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.513
DOC_MAPK_gen_1	631	641	PF00069	0.716
DOC_MAPK_MEF2A_6	201	208	PF00069	0.411
DOC_PP1_RVXF_1	298	304	PF00149	0.595
DOC_PP2B_LxvP_1	521	524	PF13499	0.811
DOC_PP2B_LxvP_1	648	651	PF13499	0.798
DOC_PP2B_PxIxI_1	203	209	PF00149	0.411
DOC_PP4_FxxP_1	113	116	PF00568	0.398
DOC_SPAK_OSR1_1	112	116	PF12202	0.475
DOC_USP7_MATH_1	140	144	PF00917	0.758
DOC_USP7_MATH_1	146	150	PF00917	0.708
DOC_USP7_MATH_1	177	181	PF00917	0.362
DOC_USP7_MATH_1	21	25	PF00917	0.611
DOC_USP7_MATH_1	34	38	PF00917	0.592
DOC_USP7_MATH_1	380	384	PF00917	0.731
DOC_USP7_MATH_1	387	391	PF00917	0.677
DOC_USP7_MATH_1	398	402	PF00917	0.589
DOC_USP7_MATH_1	426	430	PF00917	0.774
DOC_USP7_MATH_1	52	56	PF00917	0.555
DOC_USP7_MATH_1	528	532	PF00917	0.748
DOC_USP7_MATH_1	544	548	PF00917	0.583
DOC_USP7_MATH_1	579	583	PF00917	0.674
DOC_USP7_MATH_1	6	10	PF00917	0.591
DOC_USP7_MATH_1	65	69	PF00917	0.656
DOC_USP7_MATH_1	81	85	PF00917	0.492
DOC_USP7_MATH_2	338	344	PF00917	0.834
DOC_USP7_UBL2_3	213	217	PF12436	0.411
DOC_WW_Pin1_4	12	17	PF00397	0.733
DOC_WW_Pin1_4	141	146	PF00397	0.677
DOC_WW_Pin1_4	187	192	PF00397	0.513
DOC_WW_Pin1_4	219	224	PF00397	0.411
DOC_WW_Pin1_4	334	339	PF00397	0.742
DOC_WW_Pin1_4	383	388	PF00397	0.704
DOC_WW_Pin1_4	437	442	PF00397	0.719
DOC_WW_Pin1_4	453	458	PF00397	0.723
DOC_WW_Pin1_4	494	499	PF00397	0.793
DOC_WW_Pin1_4	53	58	PF00397	0.731
DOC_WW_Pin1_4	564	569	PF00397	0.703
DOC_WW_Pin1_4	604	609	PF00397	0.695
DOC_WW_Pin1_4	77	82	PF00397	0.591
LIG_14-3-3_CanoR_1	404	409	PF00244	0.815
LIG_14-3-3_CanoR_1	477	486	PF00244	0.772
LIG_14-3-3_CanoR_1	517	522	PF00244	0.753
LIG_14-3-3_CanoR_1	578	587	PF00244	0.703
LIG_14-3-3_CanoR_1	634	639	PF00244	0.720
LIG_BIR_III_4	533	537	PF00653	0.788
LIG_Clathr_ClatBox_1	505	509	PF01394	0.761
LIG_EH1_1	290	298	PF00400	0.563
LIG_eIF4E_1	248	254	PF01652	0.499
LIG_EVH1_1	63	67	PF00568	0.608
LIG_EVH1_1	648	652	PF00568	0.797
LIG_FAT_LD_1	289	297	PF03623	0.557
LIG_FHA_1	198	204	PF00498	0.411
LIG_FHA_1	265	271	PF00498	0.411
LIG_FHA_1	408	414	PF00498	0.826
LIG_FHA_1	480	486	PF00498	0.807
LIG_FHA_1	501	507	PF00498	0.756
LIG_FHA_1	552	558	PF00498	0.712
LIG_FHA_1	58	64	PF00498	0.756
LIG_FHA_1	78	84	PF00498	0.414
LIG_FHA_2	100	106	PF00498	0.554
LIG_FHA_2	170	176	PF00498	0.303
LIG_FHA_2	280	286	PF00498	0.411
LIG_FHA_2	305	311	PF00498	0.587
LIG_FHA_2	331	337	PF00498	0.815
LIG_FHA_2	495	501	PF00498	0.760
LIG_FHA_2	528	534	PF00498	0.566
LIG_FHA_2	67	73	PF00498	0.643
LIG_Integrin_RGD_1	511	513	PF01839	0.730
LIG_LIR_Apic_2	110	116	PF02991	0.477
LIG_LIR_Apic_2	219	223	PF02991	0.411
LIG_LIR_Apic_2	309	314	PF02991	0.511
LIG_LIR_Gen_1	274	281	PF02991	0.411
LIG_LIR_Gen_1	290	297	PF02991	0.456
LIG_LIR_Nem_3	110	114	PF02991	0.484
LIG_LIR_Nem_3	274	278	PF02991	0.411
LIG_LIR_Nem_3	290	294	PF02991	0.459
LIG_LIR_Nem_3	306	311	PF02991	0.352
LIG_MYND_1	61	65	PF01753	0.736
LIG_NRBOX	232	238	PF00104	0.411
LIG_Pex14_2	113	117	PF04695	0.559
LIG_PTB_Apo_2	269	276	PF02174	0.411
LIG_PTB_Apo_2	296	303	PF02174	0.478
LIG_PTB_Phospho_1	296	302	PF10480	0.480
LIG_SH2_CRK	111	115	PF00017	0.476
LIG_SH2_CRK	218	222	PF00017	0.454
LIG_SH2_CRK	311	315	PF00017	0.512
LIG_SH2_NCK_1	576	580	PF00017	0.569
LIG_SH2_PTP2	220	223	PF00017	0.411
LIG_SH2_STAP1	173	177	PF00017	0.280
LIG_SH2_STAP1	375	379	PF00017	0.698
LIG_SH2_STAT5	211	214	PF00017	0.411
LIG_SH2_STAT5	218	221	PF00017	0.411
LIG_SH2_STAT5	232	235	PF00017	0.411
LIG_SH2_STAT5	302	305	PF00017	0.486
LIG_SH2_STAT5	311	314	PF00017	0.421
LIG_SH3_3	139	145	PF00018	0.760
LIG_SH3_3	346	352	PF00018	0.718
LIG_SH3_3	391	397	PF00018	0.713
LIG_SH3_3	428	434	PF00018	0.760
LIG_SH3_3	438	444	PF00018	0.694
LIG_SH3_3	58	64	PF00018	0.612
LIG_SH3_3	646	652	PF00018	0.710
LIG_SH3_3	75	81	PF00018	0.469
LIG_SUMO_SIM_anti_2	500	506	PF11976	0.598
LIG_TRAF2_1	102	105	PF00917	0.550
LIG_TRFH_1	77	81	PF08558	0.605
LIG_TYR_ITIM	216	221	PF00017	0.411
LIG_WW_2	64	67	PF00397	0.626
MOD_CDC14_SPxK_1	386	389	PF00782	0.705
MOD_CDK_SPxK_1	383	389	PF00069	0.704
MOD_CDK_SPxK_1	604	610	PF00069	0.698
MOD_CDK_SPxxK_3	604	611	PF00069	0.702
MOD_CK1_1	11	17	PF00069	0.805
MOD_CK1_1	144	150	PF00069	0.715
MOD_CK1_1	163	169	PF00069	0.368
MOD_CK1_1	180	186	PF00069	0.288
MOD_CK1_1	304	310	PF00069	0.488
MOD_CK1_1	364	370	PF00069	0.726
MOD_CK1_1	378	384	PF00069	0.791
MOD_CK1_1	399	405	PF00069	0.784
MOD_CK1_1	407	413	PF00069	0.703
MOD_CK1_1	425	431	PF00069	0.811
MOD_CK1_1	545	551	PF00069	0.704
MOD_CK1_1	55	61	PF00069	0.624
MOD_CK1_1	580	586	PF00069	0.656
MOD_CK1_1	604	610	PF00069	0.692
MOD_CK1_1	614	620	PF00069	0.686
MOD_CK1_1	629	635	PF00069	0.598
MOD_CK1_1	90	96	PF00069	0.605
MOD_CK2_1	196	202	PF00069	0.411
MOD_CK2_1	304	310	PF00069	0.590
MOD_CK2_1	330	336	PF00069	0.809
MOD_CK2_1	368	374	PF00069	0.703
MOD_CK2_1	66	72	PF00069	0.641
MOD_CK2_1	99	105	PF00069	0.565
MOD_GlcNHglycan	148	151	PF01048	0.726
MOD_GlcNHglycan	165	168	PF01048	0.434
MOD_GlcNHglycan	17	20	PF01048	0.742
MOD_GlcNHglycan	180	183	PF01048	0.399
MOD_GlcNHglycan	23	26	PF01048	0.684
MOD_GlcNHglycan	342	345	PF01048	0.804
MOD_GlcNHglycan	36	39	PF01048	0.491
MOD_GlcNHglycan	382	385	PF01048	0.700
MOD_GlcNHglycan	389	392	PF01048	0.711
MOD_GlcNHglycan	398	401	PF01048	0.717
MOD_GlcNHglycan	42	45	PF01048	0.564
MOD_GlcNHglycan	424	427	PF01048	0.776
MOD_GlcNHglycan	428	431	PF01048	0.774
MOD_GlcNHglycan	465	468	PF01048	0.731
MOD_GlcNHglycan	470	473	PF01048	0.716
MOD_GlcNHglycan	521	524	PF01048	0.775
MOD_GlcNHglycan	57	60	PF01048	0.542
MOD_GlcNHglycan	579	582	PF01048	0.624
MOD_GlcNHglycan	589	592	PF01048	0.754
MOD_GlcNHglycan	628	631	PF01048	0.767
MOD_GlcNHglycan	633	637	PF01048	0.791
MOD_GlcNHglycan	92	95	PF01048	0.655
MOD_GSK3_1	140	147	PF00069	0.662
MOD_GSK3_1	159	166	PF00069	0.781
MOD_GSK3_1	169	176	PF00069	0.319
MOD_GSK3_1	17	24	PF00069	0.578
MOD_GSK3_1	255	262	PF00069	0.411
MOD_GSK3_1	320	327	PF00069	0.608
MOD_GSK3_1	330	337	PF00069	0.661
MOD_GSK3_1	357	364	PF00069	0.649
MOD_GSK3_1	36	43	PF00069	0.560
MOD_GSK3_1	383	390	PF00069	0.819
MOD_GSK3_1	398	405	PF00069	0.718
MOD_GSK3_1	418	425	PF00069	0.506
MOD_GSK3_1	477	484	PF00069	0.740
MOD_GSK3_1	494	501	PF00069	0.593
MOD_GSK3_1	515	522	PF00069	0.818
MOD_GSK3_1	528	535	PF00069	0.693
MOD_GSK3_1	53	60	PF00069	0.551
MOD_GSK3_1	577	584	PF00069	0.706
MOD_GSK3_1	595	602	PF00069	0.707
MOD_GSK3_1	7	14	PF00069	0.734
MOD_GSK3_1	77	84	PF00069	0.730
MOD_N-GLC_1	357	362	PF02516	0.687
MOD_N-GLC_1	40	45	PF02516	0.604
MOD_N-GLC_1	97	102	PF02516	0.585
MOD_N-GLC_2	569	571	PF02516	0.734
MOD_NEK2_1	253	258	PF00069	0.411
MOD_NEK2_1	435	440	PF00069	0.727
MOD_NEK2_1	542	547	PF00069	0.687
MOD_NEK2_1	599	604	PF00069	0.778
MOD_NEK2_2	204	209	PF00069	0.411
MOD_NEK2_2	8	13	PF00069	0.723
MOD_PIKK_1	368	374	PF00454	0.703
MOD_PIKK_1	378	384	PF00454	0.699
MOD_PK_1	365	371	PF00069	0.704
MOD_PK_1	404	410	PF00069	0.816
MOD_PK_1	515	521	PF00069	0.717
MOD_PK_1	634	640	PF00069	0.558
MOD_PKA_1	160	166	PF00069	0.280
MOD_PKA_1	365	371	PF00069	0.705
MOD_PKA_2	160	166	PF00069	0.459
MOD_PKA_2	304	310	PF00069	0.590
MOD_PKA_2	364	370	PF00069	0.704
MOD_PKA_2	536	542	PF00069	0.801
MOD_PKA_2	577	583	PF00069	0.638
MOD_PKA_2	87	93	PF00069	0.581
MOD_PKB_1	363	371	PF00069	0.704
MOD_PKB_1	515	523	PF00069	0.816
MOD_Plk_1	122	128	PF00069	0.460
MOD_Plk_1	273	279	PF00069	0.411
MOD_Plk_1	373	379	PF00069	0.700
MOD_Plk_2-3	99	105	PF00069	0.565
MOD_Plk_4	216	222	PF00069	0.411
MOD_Plk_4	365	371	PF00069	0.683
MOD_Plk_4	481	487	PF00069	0.730
MOD_Plk_4	500	506	PF00069	0.514
MOD_Plk_4	595	601	PF00069	0.805
MOD_Plk_4	634	640	PF00069	0.713
MOD_Plk_4	81	87	PF00069	0.570
MOD_ProDKin_1	12	18	PF00069	0.733
MOD_ProDKin_1	141	147	PF00069	0.681
MOD_ProDKin_1	187	193	PF00069	0.513
MOD_ProDKin_1	219	225	PF00069	0.411
MOD_ProDKin_1	334	340	PF00069	0.746
MOD_ProDKin_1	383	389	PF00069	0.704
MOD_ProDKin_1	437	443	PF00069	0.720
MOD_ProDKin_1	453	459	PF00069	0.724
MOD_ProDKin_1	494	500	PF00069	0.797
MOD_ProDKin_1	53	59	PF00069	0.727
MOD_ProDKin_1	564	570	PF00069	0.704
MOD_ProDKin_1	604	610	PF00069	0.698
MOD_ProDKin_1	77	83	PF00069	0.600
TRG_DiLeu_BaEn_1	110	115	PF01217	0.580
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.411
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.764
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.703
TRG_ENDOCYTIC_2	111	114	PF00928	0.483
TRG_ENDOCYTIC_2	218	221	PF00928	0.454
TRG_ENDOCYTIC_2	248	251	PF00928	0.445
TRG_ER_diArg_1	363	366	PF00400	0.706
TRG_NES_CRM1_1	284	295	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K2	Leptomonas seymouri	51%	94%
A0A3Q8IG93	Leishmania donovani	95%	100%
A4HDQ0	Leishmania braziliensis	77%	93%
A4I0Z6	Leishmania infantum	94%	100%
E9AX34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%