Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative

Species:

Leishmania major

UniProt:

Q4QAE1_LEIMA

TriTrypDb:

LmjF.24.1900 , LMJLV39_240026700 , LMJSD75_240026000

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	8
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

Q4QAE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0010992	ubiquitin recycling	3	2
GO:0019538	protein metabolic process	3	2
GO:0019725	cellular homeostasis	2	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0042592	homeostatic process	3	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	756	760	PF00656	0.534
CLV_NRD_NRD_1	376	378	PF00675	0.380
CLV_PCSK_KEX2_1	376	378	PF00082	0.464
CLV_PCSK_KEX2_1	506	508	PF00082	0.728
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.542
CLV_PCSK_SKI1_1	164	168	PF00082	0.280
CLV_PCSK_SKI1_1	284	288	PF00082	0.459
CLV_PCSK_SKI1_1	348	352	PF00082	0.576
CLV_PCSK_SKI1_1	448	452	PF00082	0.275
CLV_PCSK_SKI1_1	608	612	PF00082	0.334
CLV_PCSK_SKI1_1	693	697	PF00082	0.371
CLV_PCSK_SKI1_1	708	712	PF00082	0.268
CLV_PCSK_SKI1_1	716	720	PF00082	0.345
CLV_PCSK_SKI1_1	771	775	PF00082	0.334
DEG_APCC_DBOX_1	763	771	PF00400	0.534
DEG_Nend_UBRbox_4	1	3	PF02207	0.693
DEG_SPOP_SBC_1	350	354	PF00917	0.627
DOC_CDC14_PxL_1	496	504	PF14671	0.636
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	535	541	PF00134	0.563
DOC_MAPK_gen_1	388	398	PF00069	0.505
DOC_MAPK_MEF2A_6	391	398	PF00069	0.502
DOC_MAPK_MEF2A_6	608	615	PF00069	0.469
DOC_MAPK_RevD_3	362	377	PF00069	0.612
DOC_PP2B_LxvP_1	450	453	PF13499	0.505
DOC_USP7_MATH_1	14	18	PF00917	0.557
DOC_USP7_MATH_1	216	220	PF00917	0.524
DOC_USP7_MATH_1	339	343	PF00917	0.498
DOC_USP7_MATH_1	350	354	PF00917	0.507
DOC_USP7_MATH_1	356	360	PF00917	0.482
DOC_USP7_MATH_1	476	480	PF00917	0.542
DOC_USP7_MATH_1	508	512	PF00917	0.684
DOC_USP7_MATH_1	517	521	PF00917	0.672
DOC_USP7_MATH_1	725	729	PF00917	0.542
DOC_USP7_MATH_1	98	102	PF00917	0.585
DOC_USP7_MATH_2	529	535	PF00917	0.660
DOC_WW_Pin1_4	120	125	PF00397	0.563
DOC_WW_Pin1_4	22	27	PF00397	0.472
DOC_WW_Pin1_4	489	494	PF00397	0.513
DOC_WW_Pin1_4	515	520	PF00397	0.620
DOC_WW_Pin1_4	721	726	PF00397	0.534
DOC_WW_Pin1_4	757	762	PF00397	0.500
DOC_WW_Pin1_4	774	779	PF00397	0.500
DOC_WW_Pin1_4	794	799	PF00397	0.551
LIG_14-3-3_CanoR_1	13	22	PF00244	0.511
LIG_14-3-3_CanoR_1	600	610	PF00244	0.572
LIG_14-3-3_CanoR_1	654	660	PF00244	0.572
LIG_14-3-3_CanoR_1	708	715	PF00244	0.552
LIG_14-3-3_CanoR_1	716	721	PF00244	0.510
LIG_14-3-3_CanoR_1	768	774	PF00244	0.534
LIG_Actin_WH2_1	785	803	PF00022	0.651
LIG_Actin_WH2_2	786	803	PF00022	0.654
LIG_BRCT_BRCA1_1	218	222	PF00533	0.534
LIG_BRCT_BRCA1_1	365	369	PF00533	0.609
LIG_Clathr_ClatBox_1	752	756	PF01394	0.572
LIG_CtBP_PxDLS_1	493	497	PF00389	0.571
LIG_deltaCOP1_diTrp_1	143	151	PF00928	0.404
LIG_FHA_1	14	20	PF00498	0.421
LIG_FHA_1	176	182	PF00498	0.534
LIG_FHA_1	198	204	PF00498	0.359
LIG_FHA_1	228	234	PF00498	0.475
LIG_FHA_1	270	276	PF00498	0.534
LIG_FHA_1	285	291	PF00498	0.426
LIG_FHA_1	314	320	PF00498	0.513
LIG_FHA_1	342	348	PF00498	0.570
LIG_FHA_1	368	374	PF00498	0.501
LIG_FHA_1	38	44	PF00498	0.493
LIG_FHA_1	602	608	PF00498	0.577
LIG_FHA_1	61	67	PF00498	0.425
LIG_FHA_1	610	616	PF00498	0.537
LIG_FHA_1	690	696	PF00498	0.546
LIG_FHA_1	709	715	PF00498	0.534
LIG_FHA_1	717	723	PF00498	0.541
LIG_FHA_1	795	801	PF00498	0.588
LIG_FHA_2	127	133	PF00498	0.589
LIG_FHA_2	264	270	PF00498	0.572
LIG_FHA_2	46	52	PF00498	0.562
LIG_FHA_2	670	676	PF00498	0.469
LIG_LIR_Gen_1	436	445	PF02991	0.502
LIG_LIR_Gen_1	590	599	PF02991	0.534
LIG_LIR_Nem_3	436	440	PF02991	0.502
LIG_LIR_Nem_3	590	595	PF02991	0.512
LIG_LIR_Nem_3	63	68	PF02991	0.409
LIG_LIR_Nem_3	658	663	PF02991	0.572
LIG_NRBOX	769	775	PF00104	0.534
LIG_PCNA_PIPBox_1	480	489	PF02747	0.534
LIG_Pex14_1	320	324	PF04695	0.495
LIG_Rb_pABgroove_1	539	547	PF01858	0.458
LIG_SH2_CRK	437	441	PF00017	0.500
LIG_SH2_CRK	592	596	PF00017	0.500
LIG_SH2_STAP1	162	166	PF00017	0.513
LIG_SH2_STAP1	253	257	PF00017	0.500
LIG_SH2_STAP1	437	441	PF00017	0.500
LIG_SH2_STAT3	432	435	PF00017	0.572
LIG_SH2_STAT5	265	268	PF00017	0.577
LIG_SH2_STAT5	397	400	PF00017	0.534
LIG_SH2_STAT5	419	422	PF00017	0.457
LIG_SH2_STAT5	439	442	PF00017	0.336
LIG_SH2_STAT5	68	71	PF00017	0.489
LIG_SH3_3	23	29	PF00018	0.574
LIG_SH3_3	408	414	PF00018	0.457
LIG_SH3_3	523	529	PF00018	0.721
LIG_SH3_3	612	618	PF00018	0.572
LIG_SH3_3	634	640	PF00018	0.556
LIG_SH3_3	665	671	PF00018	0.498
LIG_SH3_3	775	781	PF00018	0.564
LIG_SH3_3	819	825	PF00018	0.606
LIG_SUMO_SIM_par_1	146	152	PF11976	0.445
LIG_SUMO_SIM_par_1	28	34	PF11976	0.313
LIG_SUMO_SIM_par_1	609	614	PF11976	0.466
LIG_SUMO_SIM_par_1	718	724	PF11976	0.571
LIG_TRAF2_1	479	482	PF00917	0.534
LIG_TRAF2_2	241	246	PF00917	0.410
LIG_UBA3_1	147	154	PF00899	0.364
LIG_WRC_WIRS_1	545	550	PF05994	0.365
MOD_CDK_SPxxK_3	757	764	PF00069	0.365
MOD_CDK_SPxxK_3	794	801	PF00069	0.554
MOD_CK1_1	126	132	PF00069	0.551
MOD_CK1_1	256	262	PF00069	0.239
MOD_CK1_1	310	316	PF00069	0.396
MOD_CK1_1	341	347	PF00069	0.605
MOD_CK1_1	49	55	PF00069	0.586
MOD_CK1_1	520	526	PF00069	0.704
MOD_CK1_1	579	585	PF00069	0.422
MOD_CK1_1	687	693	PF00069	0.474
MOD_CK1_1	697	703	PF00069	0.301
MOD_CK1_1	724	730	PF00069	0.414
MOD_CK1_1	769	775	PF00069	0.380
MOD_CK1_1	777	783	PF00069	0.279
MOD_CK2_1	126	132	PF00069	0.572
MOD_CK2_1	263	269	PF00069	0.323
MOD_CK2_1	456	462	PF00069	0.481
MOD_CK2_1	476	482	PF00069	0.136
MOD_CK2_1	642	648	PF00069	0.402
MOD_CK2_1	669	675	PF00069	0.374
MOD_CK2_1	98	104	PF00069	0.545
MOD_GlcNHglycan	111	114	PF01048	0.392
MOD_GlcNHglycan	140	143	PF01048	0.488
MOD_GlcNHglycan	154	157	PF01048	0.438
MOD_GlcNHglycan	182	185	PF01048	0.335
MOD_GlcNHglycan	204	207	PF01048	0.363
MOD_GlcNHglycan	223	226	PF01048	0.332
MOD_GlcNHglycan	258	261	PF01048	0.397
MOD_GlcNHglycan	309	312	PF01048	0.438
MOD_GlcNHglycan	353	356	PF01048	0.549
MOD_GlcNHglycan	358	361	PF01048	0.573
MOD_GlcNHglycan	48	51	PF01048	0.419
MOD_GlcNHglycan	510	513	PF01048	0.672
MOD_GlcNHglycan	519	522	PF01048	0.687
MOD_GlcNHglycan	580	584	PF01048	0.395
MOD_GlcNHglycan	644	647	PF01048	0.466
MOD_GlcNHglycan	698	702	PF01048	0.406
MOD_GlcNHglycan	748	751	PF01048	0.379
MOD_GlcNHglycan	99	103	PF01048	0.581
MOD_GSK3_1	173	180	PF00069	0.348
MOD_GSK3_1	182	189	PF00069	0.281
MOD_GSK3_1	217	224	PF00069	0.352
MOD_GSK3_1	247	254	PF00069	0.399
MOD_GSK3_1	255	262	PF00069	0.413
MOD_GSK3_1	265	272	PF00069	0.373
MOD_GSK3_1	296	303	PF00069	0.341
MOD_GSK3_1	33	40	PF00069	0.421
MOD_GSK3_1	335	342	PF00069	0.578
MOD_GSK3_1	363	370	PF00069	0.531
MOD_GSK3_1	41	48	PF00069	0.428
MOD_GSK3_1	456	463	PF00069	0.390
MOD_GSK3_1	502	509	PF00069	0.746
MOD_GSK3_1	552	559	PF00069	0.409
MOD_GSK3_1	572	579	PF00069	0.263
MOD_GSK3_1	623	630	PF00069	0.429
MOD_GSK3_1	683	690	PF00069	0.438
MOD_GSK3_1	693	700	PF00069	0.398
MOD_GSK3_1	721	728	PF00069	0.402
MOD_GSK3_1	769	776	PF00069	0.303
MOD_GSK3_1	79	86	PF00069	0.477
MOD_GSK3_1	792	799	PF00069	0.571
MOD_N-GLC_1	176	181	PF02516	0.466
MOD_N-GLC_1	576	581	PF02516	0.383
MOD_N-GLC_1	716	721	PF02516	0.466
MOD_N-GLC_1	757	762	PF02516	0.413
MOD_N-GLC_2	227	229	PF02516	0.413
MOD_NEK2_1	175	180	PF00069	0.394
MOD_NEK2_1	21	26	PF00069	0.545
MOD_NEK2_1	251	256	PF00069	0.375
MOD_NEK2_1	502	507	PF00069	0.750
MOD_NEK2_1	544	549	PF00069	0.537
MOD_NEK2_1	655	660	PF00069	0.466
MOD_NEK2_1	684	689	PF00069	0.425
MOD_NEK2_1	773	778	PF00069	0.311
MOD_NEK2_2	186	191	PF00069	0.341
MOD_NEK2_2	587	592	PF00069	0.383
MOD_PIKK_1	339	345	PF00454	0.542
MOD_PIKK_1	476	482	PF00454	0.341
MOD_PIKK_1	562	568	PF00454	0.464
MOD_PKA_1	376	382	PF00069	0.413
MOD_PKA_1	506	512	PF00069	0.734
MOD_PKA_2	376	382	PF00069	0.466
MOD_PKA_2	506	512	PF00069	0.734
MOD_PKA_2	763	769	PF00069	0.431
MOD_Plk_1	176	182	PF00069	0.367
MOD_Plk_1	186	192	PF00069	0.287
MOD_Plk_1	217	223	PF00069	0.361
MOD_Plk_1	227	233	PF00069	0.277
MOD_Plk_1	269	275	PF00069	0.331
MOD_Plk_1	313	319	PF00069	0.413
MOD_Plk_1	494	500	PF00069	0.566
MOD_Plk_1	562	568	PF00069	0.395
MOD_Plk_1	716	722	PF00069	0.413
MOD_Plk_1	98	104	PF00069	0.586
MOD_Plk_4	177	183	PF00069	0.370
MOD_Plk_4	247	253	PF00069	0.332
MOD_Plk_4	456	462	PF00069	0.413
MOD_Plk_4	531	537	PF00069	0.629
MOD_Plk_4	55	61	PF00069	0.461
MOD_Plk_4	556	562	PF00069	0.395
MOD_Plk_4	587	593	PF00069	0.416
MOD_Plk_4	627	633	PF00069	0.466
MOD_Plk_4	655	661	PF00069	0.442
MOD_ProDKin_1	120	126	PF00069	0.564
MOD_ProDKin_1	22	28	PF00069	0.475
MOD_ProDKin_1	489	495	PF00069	0.384
MOD_ProDKin_1	515	521	PF00069	0.621
MOD_ProDKin_1	721	727	PF00069	0.413
MOD_ProDKin_1	757	763	PF00069	0.365
MOD_ProDKin_1	774	780	PF00069	0.365
MOD_ProDKin_1	794	800	PF00069	0.549
MOD_SUMO_rev_2	278	286	PF00179	0.511
TRG_DiLeu_BaEn_1	531	536	PF01217	0.722
TRG_DiLeu_BaEn_3	481	487	PF01217	0.365
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.466
TRG_ENDOCYTIC_2	324	327	PF00928	0.522
TRG_ENDOCYTIC_2	437	440	PF00928	0.365
TRG_ENDOCYTIC_2	592	595	PF00928	0.365
TRG_ENDOCYTIC_2	68	71	PF00928	0.489
TRG_NES_CRM1_1	605	619	PF08389	0.322
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR3	Leptomonas seymouri	62%	100%
A0A0S4J046	Bodo saltans	37%	100%
A0A1X0NVW7	Trypanosomatidae	37%	92%
A0A3Q8IC13	Leishmania donovani	94%	100%
A4HDQ1	Leishmania braziliensis	86%	100%
A4I0Z7	Leishmania infantum	94%	100%
E9AX35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94289	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q6GM65	Xenopus laevis	27%	100%