Protein geranylgeranyltransferase type II

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAE0_LEIMA

TriTrypDb:

LmjF.24.1905

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAE0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018342	protein prenylation	4	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0097354	prenylation	3	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004659	prenyltransferase activity	4	3
GO:0008318	protein prenyltransferase activity	3	3
GO:0016740	transferase activity	2	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.577
CLV_C14_Caspase3-7	499	503	PF00656	0.554
CLV_NRD_NRD_1	144	146	PF00675	0.557
CLV_NRD_NRD_1	216	218	PF00675	0.424
CLV_NRD_NRD_1	318	320	PF00675	0.300
CLV_NRD_NRD_1	449	451	PF00675	0.513
CLV_PCSK_KEX2_1	144	146	PF00082	0.557
CLV_PCSK_KEX2_1	215	217	PF00082	0.412
CLV_PCSK_KEX2_1	318	320	PF00082	0.301
CLV_PCSK_KEX2_1	380	382	PF00082	0.575
CLV_PCSK_KEX2_1	449	451	PF00082	0.534
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.402
CLV_PCSK_SKI1_1	104	108	PF00082	0.530
CLV_PCSK_SKI1_1	13	17	PF00082	0.419
CLV_PCSK_SKI1_1	151	155	PF00082	0.489
CLV_PCSK_SKI1_1	187	191	PF00082	0.579
CLV_PCSK_SKI1_1	429	433	PF00082	0.561
DEG_APCC_DBOX_1	186	194	PF00400	0.559
DEG_APCC_DBOX_1	318	326	PF00400	0.412
DEG_APCC_DBOX_1	32	40	PF00400	0.416
DEG_ODPH_VHL_1	432	443	PF01847	0.569
DOC_CDC14_PxL_1	51	59	PF14671	0.458
DOC_CKS1_1	95	100	PF01111	0.454
DOC_CYCLIN_RxL_1	315	324	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.684
DOC_MAPK_gen_1	335	343	PF00069	0.323
DOC_MAPK_MEF2A_6	241	250	PF00069	0.559
DOC_MAPK_MEF2A_6	33	40	PF00069	0.416
DOC_MAPK_MEF2A_6	338	345	PF00069	0.315
DOC_PP1_RVXF_1	11	17	PF00149	0.418
DOC_USP7_MATH_1	113	117	PF00917	0.547
DOC_USP7_MATH_1	21	25	PF00917	0.433
DOC_USP7_MATH_1	327	331	PF00917	0.597
DOC_USP7_MATH_1	526	530	PF00917	0.521
DOC_WW_Pin1_4	172	177	PF00397	0.713
DOC_WW_Pin1_4	179	184	PF00397	0.605
DOC_WW_Pin1_4	325	330	PF00397	0.541
DOC_WW_Pin1_4	471	476	PF00397	0.601
DOC_WW_Pin1_4	506	511	PF00397	0.636
DOC_WW_Pin1_4	94	99	PF00397	0.449
LIG_14-3-3_CanoR_1	187	197	PF00244	0.486
LIG_14-3-3_CanoR_1	321	326	PF00244	0.630
LIG_14-3-3_CanoR_1	478	483	PF00244	0.611
LIG_14-3-3_CanoR_1	490	496	PF00244	0.459
LIG_Actin_WH2_2	207	222	PF00022	0.485
LIG_Actin_WH2_2	37	54	PF00022	0.427
LIG_Actin_WH2_2	475	492	PF00022	0.600
LIG_APCC_ABBA_1	38	43	PF00400	0.418
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_CaM_IQ_9	441	456	PF13499	0.555
LIG_eIF4E_1	34	40	PF01652	0.415
LIG_eIF4E_1	495	501	PF01652	0.544
LIG_FHA_1	167	173	PF00498	0.665
LIG_FHA_1	362	368	PF00498	0.473
LIG_FHA_1	538	544	PF00498	0.318
LIG_FHA_2	442	448	PF00498	0.478
LIG_FXI_DFP_1	135	139	PF00024	0.493
LIG_GBD_Chelix_1	500	508	PF00786	0.561
LIG_LIR_Gen_1	133	142	PF02991	0.444
LIG_LIR_Gen_1	209	219	PF02991	0.510
LIG_LIR_Gen_1	242	250	PF02991	0.569
LIG_LIR_Gen_1	364	371	PF02991	0.406
LIG_LIR_Gen_1	524	535	PF02991	0.478
LIG_LIR_Gen_1	67	77	PF02991	0.571
LIG_LIR_Nem_3	133	138	PF02991	0.462
LIG_LIR_Nem_3	209	214	PF02991	0.513
LIG_LIR_Nem_3	242	246	PF02991	0.569
LIG_LIR_Nem_3	247	252	PF02991	0.576
LIG_LIR_Nem_3	29	34	PF02991	0.429
LIG_LIR_Nem_3	364	369	PF02991	0.411
LIG_LIR_Nem_3	493	498	PF02991	0.496
LIG_LIR_Nem_3	524	530	PF02991	0.471
LIG_LIR_Nem_3	67	73	PF02991	0.583
LIG_NRBOX	35	41	PF00104	0.415
LIG_NRBOX	366	372	PF00104	0.440
LIG_NRBOX	538	544	PF00104	0.505
LIG_PCNA_PIPBox_1	476	485	PF02747	0.642
LIG_PCNA_yPIPBox_3	473	483	PF02747	0.644
LIG_Pex14_1	491	495	PF04695	0.521
LIG_Pex14_2	154	158	PF04695	0.559
LIG_Pex14_2	16	20	PF04695	0.421
LIG_RPA_C_Fungi	140	152	PF08784	0.482
LIG_SH2_CRK	317	321	PF00017	0.442
LIG_SH2_CRK	34	38	PF00017	0.417
LIG_SH2_CRK	70	74	PF00017	0.570
LIG_SH2_NCK_1	70	74	PF00017	0.570
LIG_SH2_STAP1	70	74	PF00017	0.570
LIG_SH2_STAT3	535	538	PF00017	0.458
LIG_SH2_STAT5	366	369	PF00017	0.377
LIG_SH2_STAT5	70	73	PF00017	0.566
LIG_SH2_STAT5	91	94	PF00017	0.498
LIG_SH3_1	52	58	PF00018	0.463
LIG_SH3_3	52	58	PF00018	0.463
LIG_SH3_3	95	101	PF00018	0.473
LIG_SUMO_SIM_par_1	137	143	PF11976	0.537
LIG_UBA3_1	248	257	PF00899	0.438
LIG_WRC_WIRS_1	155	160	PF05994	0.562
MOD_CDK_SPxxK_3	471	478	PF00069	0.477
MOD_CK1_1	166	172	PF00069	0.675
MOD_CK1_1	175	181	PF00069	0.641
MOD_CK1_1	361	367	PF00069	0.447
MOD_CK1_1	481	487	PF00069	0.591
MOD_CK1_1	509	515	PF00069	0.622
MOD_CK1_1	519	525	PF00069	0.557
MOD_CK1_1	94	100	PF00069	0.447
MOD_CK2_1	255	261	PF00069	0.438
MOD_CK2_1	381	387	PF00069	0.573
MOD_CK2_1	441	447	PF00069	0.441
MOD_Cter_Amidation	378	381	PF01082	0.444
MOD_GlcNHglycan	130	133	PF01048	0.372
MOD_GlcNHglycan	231	234	PF01048	0.550
MOD_GlcNHglycan	360	364	PF01048	0.407
MOD_GlcNHglycan	404	407	PF01048	0.682
MOD_GlcNHglycan	483	486	PF01048	0.595
MOD_GlcNHglycan	511	514	PF01048	0.587
MOD_GlcNHglycan	520	524	PF01048	0.470
MOD_GSK3_1	175	182	PF00069	0.679
MOD_GSK3_1	19	26	PF00069	0.430
MOD_GSK3_1	321	328	PF00069	0.409
MOD_GSK3_1	358	365	PF00069	0.431
MOD_GSK3_1	518	525	PF00069	0.546
MOD_GSK3_1	526	533	PF00069	0.402
MOD_GSK3_1	56	63	PF00069	0.525
MOD_N-GLC_1	166	171	PF02516	0.460
MOD_N-GLC_1	411	416	PF02516	0.630
MOD_N-GLC_1	530	535	PF02516	0.542
MOD_N-GLC_1	544	549	PF02516	0.423
MOD_N-GLC_2	331	333	PF02516	0.407
MOD_NEK2_1	107	112	PF00069	0.607
MOD_NEK2_1	154	159	PF00069	0.476
MOD_NEK2_1	19	24	PF00069	0.390
MOD_NEK2_1	219	224	PF00069	0.436
MOD_NEK2_1	248	253	PF00069	0.368
MOD_NEK2_1	266	271	PF00069	0.438
MOD_NEK2_1	402	407	PF00069	0.705
MOD_NEK2_1	441	446	PF00069	0.516
MOD_NEK2_1	530	535	PF00069	0.521
MOD_NEK2_1	9	14	PF00069	0.419
MOD_NEK2_2	91	96	PF00069	0.366
MOD_PIKK_1	107	113	PF00454	0.577
MOD_PIKK_1	441	447	PF00454	0.477
MOD_PKA_1	449	455	PF00069	0.602
MOD_PKA_2	219	225	PF00069	0.495
MOD_PKA_2	449	455	PF00069	0.602
MOD_PKB_1	319	327	PF00069	0.512
MOD_Plk_1	381	387	PF00069	0.619
MOD_Plk_1	530	536	PF00069	0.544
MOD_Plk_4	193	199	PF00069	0.457
MOD_Plk_4	255	261	PF00069	0.388
MOD_Plk_4	26	32	PF00069	0.435
MOD_Plk_4	362	368	PF00069	0.407
MOD_Plk_4	538	544	PF00069	0.503
MOD_Plk_4	68	74	PF00069	0.561
MOD_ProDKin_1	172	178	PF00069	0.706
MOD_ProDKin_1	179	185	PF00069	0.591
MOD_ProDKin_1	325	331	PF00069	0.549
MOD_ProDKin_1	471	477	PF00069	0.608
MOD_ProDKin_1	506	512	PF00069	0.630
MOD_ProDKin_1	94	100	PF00069	0.447
MOD_SUMO_rev_2	221	230	PF00179	0.634
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.464
TRG_ENDOCYTIC_2	317	320	PF00928	0.461
TRG_ENDOCYTIC_2	34	37	PF00928	0.416
TRG_ENDOCYTIC_2	366	369	PF00928	0.396
TRG_ENDOCYTIC_2	495	498	PF00928	0.492
TRG_ENDOCYTIC_2	70	73	PF00928	0.566
TRG_ER_diArg_1	144	146	PF00400	0.553
TRG_ER_diArg_1	214	217	PF00400	0.414
TRG_ER_diArg_1	317	319	PF00400	0.356
TRG_ER_diArg_1	320	323	PF00400	0.356
TRG_ER_diArg_1	338	341	PF00400	0.253
TRG_ER_diArg_1	448	450	PF00400	0.494
TRG_NES_CRM1_1	234	247	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ1	Leptomonas seymouri	41%	100%
A0A3Q8IF02	Leishmania donovani	87%	100%
A0A422NWV9	Trypanosoma rangeli	31%	100%
A4HDQ2	Leishmania braziliensis	72%	100%
A4I0Z8	Leishmania infantum	87%	100%
C9ZWB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AX36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%