J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4QAD9_LEIMA

TriTrypDb:

LmjF.24.1910 , LMJLV39_240026800 , LMJSD75_240026100

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0001405	PAM complex, Tim23 associated import motor	4	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2

Expansion

Sequence features

Q4QAD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0030150	protein import into mitochondrial matrix	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.544
CLV_PCSK_KEX2_1	89	91	PF00082	0.495
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.472
CLV_PCSK_SKI1_1	116	120	PF00082	0.315
CLV_PCSK_SKI1_1	40	44	PF00082	0.473
DOC_PP4_FxxP_1	55	58	PF00568	0.413
DOC_PP4_FxxP_1	79	82	PF00568	0.467
DOC_USP7_UBL2_3	46	50	PF12436	0.471
DOC_WW_Pin1_4	102	107	PF00397	0.342
DOC_WW_Pin1_4	35	40	PF00397	0.380
DOC_WW_Pin1_4	54	59	PF00397	0.404
LIG_14-3-3_CanoR_1	40	48	PF00244	0.500
LIG_14-3-3_CanoR_1	90	95	PF00244	0.369
LIG_BRCT_BRCA1_1	37	41	PF00533	0.440
LIG_BRCT_BRCA1_2	37	43	PF00533	0.440
LIG_eIF4E_1	62	68	PF01652	0.358
LIG_FHA_1	103	109	PF00498	0.480
LIG_FHA_2	58	64	PF00498	0.444
LIG_LIR_Apic_2	52	58	PF02991	0.461
LIG_LIR_Gen_1	63	70	PF02991	0.402
LIG_LIR_Nem_3	60	65	PF02991	0.433
LIG_Pex14_2	51	55	PF04695	0.433
LIG_SH2_CRK	65	69	PF00017	0.411
LIG_SH2_STAP1	17	21	PF00017	0.459
LIG_SH2_STAP1	62	66	PF00017	0.361
LIG_SH2_STAT5	107	110	PF00017	0.418
LIG_SH3_4	46	53	PF00018	0.418
MOD_CDK_SPK_2	35	40	PF00069	0.377
MOD_CK1_1	100	106	PF00069	0.442
MOD_CK1_1	30	36	PF00069	0.507
MOD_CK1_1	57	63	PF00069	0.410
MOD_CK2_1	57	63	PF00069	0.332
MOD_GlcNHglycan	101	105	PF01048	0.439
MOD_GlcNHglycan	29	32	PF01048	0.498
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_N-GLC_1	35	40	PF02516	0.583
MOD_NEK2_1	41	46	PF00069	0.651
MOD_PKA_2	27	33	PF00069	0.481
MOD_ProDKin_1	102	108	PF00069	0.337
MOD_ProDKin_1	35	41	PF00069	0.382
MOD_ProDKin_1	54	60	PF00069	0.400
TRG_DiLeu_BaEn_1	63	68	PF01217	0.292
TRG_ENDOCYTIC_2	48	51	PF00928	0.459
TRG_ENDOCYTIC_2	65	68	PF00928	0.422
TRG_ENDOCYTIC_2	91	94	PF00928	0.380
TRG_NLS_MonoExtC_3	87	92	PF00514	0.466
TRG_NLS_MonoExtN_4	88	93	PF00514	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II15	Leptomonas seymouri	64%	100%
A0A0S4IZD1	Bodo saltans	41%	100%
A0A1X0NXI1	Trypanosomatidae	48%	100%
A0A3Q8IC73	Leishmania donovani	94%	100%
A0A422NWS9	Trypanosoma rangeli	45%	100%
A4HDQ3	Leishmania braziliensis	80%	100%
A4I0Z9	Leishmania infantum	94%	100%
C9ZWB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AX37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q54QN1	Dictyostelium discoideum	37%	100%
Q5RCP4	Pongo abelii	31%	81%
Q6CNW2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	74%
Q6FPU1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	79%
Q78YY6	Mus musculus	31%	81%
Q8RV04	Arabidopsis thaliana	33%	100%
Q9Y5T4	Homo sapiens	31%	81%