Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD8_LEIMA

TriTrypDb:

LmjF.24.1920 , LMJLV39_240026900 , LMJSD75_240026200

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.584
CLV_NRD_NRD_1	280	282	PF00675	0.542
CLV_NRD_NRD_1	452	454	PF00675	0.502
CLV_NRD_NRD_1	509	511	PF00675	0.533
CLV_PCSK_KEX2_1	280	282	PF00082	0.546
CLV_PCSK_KEX2_1	452	454	PF00082	0.518
CLV_PCSK_KEX2_1	509	511	PF00082	0.537
CLV_PCSK_PC7_1	276	282	PF00082	0.591
CLV_PCSK_PC7_1	505	511	PF00082	0.583
CLV_PCSK_SKI1_1	21	25	PF00082	0.793
CLV_PCSK_SKI1_1	250	254	PF00082	0.601
CLV_PCSK_SKI1_1	333	337	PF00082	0.603
CLV_PCSK_SKI1_1	456	460	PF00082	0.596
CLV_Separin_Metazoa	471	475	PF03568	0.583
DEG_SPOP_SBC_1	82	86	PF00917	0.792
DOC_CKS1_1	398	403	PF01111	0.694
DOC_CKS1_1	6	11	PF01111	0.775
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.518
DOC_MAPK_MEF2A_6	333	340	PF00069	0.459
DOC_MAPK_NFAT4_5	333	341	PF00069	0.514
DOC_PP1_RVXF_1	440	446	PF00149	0.600
DOC_PP4_FxxP_1	341	344	PF00568	0.535
DOC_USP7_MATH_1	308	312	PF00917	0.670
DOC_USP7_MATH_1	314	318	PF00917	0.629
DOC_USP7_MATH_1	364	368	PF00917	0.693
DOC_USP7_MATH_1	83	87	PF00917	0.705
DOC_USP7_UBL2_3	161	165	PF12436	0.713
DOC_WW_Pin1_4	14	19	PF00397	0.704
DOC_WW_Pin1_4	30	35	PF00397	0.596
DOC_WW_Pin1_4	397	402	PF00397	0.716
DOC_WW_Pin1_4	44	49	PF00397	0.728
DOC_WW_Pin1_4	5	10	PF00397	0.761
DOC_WW_Pin1_4	93	98	PF00397	0.701
LIG_14-3-3_CanoR_1	13	17	PF00244	0.738
LIG_14-3-3_CanoR_1	239	247	PF00244	0.575
LIG_14-3-3_CanoR_1	509	515	PF00244	0.589
LIG_Actin_WH2_2	133	150	PF00022	0.630
LIG_Actin_WH2_2	202	218	PF00022	0.458
LIG_APCC_ABBA_1	338	343	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_Clathr_ClatBox_1	322	326	PF01394	0.663
LIG_Clathr_ClatBox_1	346	350	PF01394	0.574
LIG_FHA_1	139	145	PF00498	0.598
LIG_FHA_1	249	255	PF00498	0.594
LIG_FHA_1	264	270	PF00498	0.349
LIG_FHA_1	36	42	PF00498	0.738
LIG_FHA_1	398	404	PF00498	0.688
LIG_FHA_1	45	51	PF00498	0.701
LIG_FHA_1	57	63	PF00498	0.690
LIG_FHA_2	107	113	PF00498	0.626
LIG_FHA_2	403	409	PF00498	0.608
LIG_MYND_1	48	52	PF01753	0.616
LIG_PCNA_yPIPBox_3	327	341	PF02747	0.581
LIG_SH2_SRC	469	472	PF00017	0.558
LIG_SH2_SRC	495	498	PF00017	0.608
LIG_SH2_STAP1	469	473	PF00017	0.552
LIG_SH2_STAT5	125	128	PF00017	0.538
LIG_SH2_STAT5	478	481	PF00017	0.565
LIG_SH3_3	3	9	PF00018	0.743
LIG_SH3_3	370	376	PF00018	0.724
LIG_SH3_3	395	401	PF00018	0.659
LIG_SH3_3	45	51	PF00018	0.655
LIG_SH3_3	68	74	PF00018	0.706
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.549
LIG_SUMO_SIM_par_1	268	273	PF11976	0.563
LIG_SUMO_SIM_par_1	35	42	PF11976	0.761
LIG_TRAF2_1	176	179	PF00917	0.650
LIG_TRAF2_1	34	37	PF00917	0.755
LIG_TRAF2_1	368	371	PF00917	0.743
LIG_UBA3_1	479	484	PF00899	0.558
MOD_CDK_SPK_2	14	19	PF00069	0.746
MOD_CDK_SPxxK_3	14	21	PF00069	0.779
MOD_CK1_1	238	244	PF00069	0.534
MOD_CK1_1	29	35	PF00069	0.661
MOD_CK1_1	508	514	PF00069	0.588
MOD_CK2_1	30	36	PF00069	0.753
MOD_GlcNHglycan	10	13	PF01048	0.760
MOD_GlcNHglycan	153	156	PF01048	0.661
MOD_GlcNHglycan	169	172	PF01048	0.696
MOD_GlcNHglycan	20	24	PF01048	0.718
MOD_GlcNHglycan	3	6	PF01048	0.688
MOD_GlcNHglycan	305	308	PF01048	0.646
MOD_GlcNHglycan	358	361	PF01048	0.614
MOD_GlcNHglycan	366	369	PF01048	0.655
MOD_GlcNHglycan	85	88	PF01048	0.754
MOD_GSK3_1	1	8	PF00069	0.701
MOD_GSK3_1	121	128	PF00069	0.557
MOD_GSK3_1	151	158	PF00069	0.633
MOD_GSK3_1	19	26	PF00069	0.701
MOD_GSK3_1	246	253	PF00069	0.524
MOD_GSK3_1	308	315	PF00069	0.660
MOD_GSK3_1	417	424	PF00069	0.471
MOD_GSK3_1	42	49	PF00069	0.790
MOD_GSK3_1	501	508	PF00069	0.589
MOD_GSK3_1	56	63	PF00069	0.720
MOD_N-GLC_1	56	61	PF02516	0.777
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	140	145	PF00069	0.541
MOD_NEK2_1	186	191	PF00069	0.647
MOD_NEK2_1	356	361	PF00069	0.628
MOD_PIKK_1	125	131	PF00454	0.591
MOD_PIKK_1	197	203	PF00454	0.459
MOD_PIKK_1	260	266	PF00454	0.568
MOD_PIKK_1	309	315	PF00454	0.728
MOD_PIKK_1	417	423	PF00454	0.555
MOD_PIKK_1	508	514	PF00454	0.651
MOD_PIKK_1	75	81	PF00454	0.713
MOD_PKA_2	12	18	PF00069	0.689
MOD_PKA_2	238	244	PF00069	0.561
MOD_PKA_2	508	514	PF00069	0.566
MOD_Plk_1	19	25	PF00069	0.727
MOD_Plk_1	35	41	PF00069	0.598
MOD_Plk_1	417	423	PF00069	0.574
MOD_Plk_2-3	60	66	PF00069	0.714
MOD_Plk_4	294	300	PF00069	0.591
MOD_Plk_4	351	357	PF00069	0.576
MOD_ProDKin_1	14	20	PF00069	0.703
MOD_ProDKin_1	30	36	PF00069	0.598
MOD_ProDKin_1	397	403	PF00069	0.712
MOD_ProDKin_1	44	50	PF00069	0.726
MOD_ProDKin_1	5	11	PF00069	0.762
MOD_ProDKin_1	93	99	PF00069	0.701
MOD_SUMO_for_1	176	179	PF00179	0.584
MOD_SUMO_for_1	483	486	PF00179	0.552
TRG_DiLeu_BaEn_2	440	446	PF01217	0.600
TRG_DiLeu_BaEn_4	242	248	PF01217	0.556
TRG_DiLeu_BaEn_4	417	423	PF01217	0.553
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.563
TRG_ENDOCYTIC_2	469	472	PF00928	0.558
TRG_ER_diArg_1	116	119	PF00400	0.581
TRG_ER_diArg_1	280	282	PF00400	0.521
TRG_ER_diArg_1	422	425	PF00400	0.571
TRG_ER_diArg_1	432	435	PF00400	0.527
TRG_ER_diArg_1	451	453	PF00400	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P7	Leptomonas seymouri	56%	95%
A0A0S4J1F8	Bodo saltans	26%	95%
A0A1X0NW49	Trypanosomatidae	32%	100%
A0A3Q8IMW3	Leishmania donovani	96%	100%
A0A422NWS4	Trypanosoma rangeli	33%	100%
A4HDQ4	Leishmania braziliensis	87%	99%
A4I100	Leishmania infantum	96%	100%
C9ZWA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AX38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%