Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD7_LEIMA

TriTrypDb:

LmjF.24.1930 , LMJLV39_240027000 , LMJSD75_240026300

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006020	inositol metabolic process	4	2
GO:0006066	alcohol metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	8
GO:0019751	polyol metabolic process	4	8
GO:0032957	inositol trisphosphate metabolic process	5	8
GO:0043647	inositol phosphate metabolic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	8
GO:0046835	carbohydrate phosphorylation	4	2
GO:0052746	obsolete inositol phosphorylation	5	2
GO:0071704	organic substance metabolic process	2	8
GO:1901615	organic hydroxy compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0000287	magnesium ion binding	5	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0047325	inositol tetrakisphosphate 1-kinase activity	6	8
GO:0051765	inositol tetrakisphosphate kinase activity	5	8
GO:0051766	inositol trisphosphate kinase activity	5	8
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	6	8
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	6	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.489
CLV_NRD_NRD_1	237	239	PF00675	0.500
CLV_NRD_NRD_1	294	296	PF00675	0.777
CLV_NRD_NRD_1	558	560	PF00675	0.619
CLV_NRD_NRD_1	605	607	PF00675	0.720
CLV_NRD_NRD_1	700	702	PF00675	0.719
CLV_NRD_NRD_1	96	98	PF00675	0.763
CLV_PCSK_FUR_1	235	239	PF00082	0.558
CLV_PCSK_FUR_1	94	98	PF00082	0.819
CLV_PCSK_KEX2_1	231	233	PF00082	0.486
CLV_PCSK_KEX2_1	237	239	PF00082	0.491
CLV_PCSK_KEX2_1	294	296	PF00082	0.777
CLV_PCSK_KEX2_1	699	701	PF00082	0.796
CLV_PCSK_KEX2_1	96	98	PF00082	0.760
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.534
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.796
CLV_PCSK_PC7_1	233	239	PF00082	0.550
CLV_PCSK_SKI1_1	143	147	PF00082	0.484
CLV_PCSK_SKI1_1	18	22	PF00082	0.468
CLV_PCSK_SKI1_1	209	213	PF00082	0.488
CLV_PCSK_SKI1_1	256	260	PF00082	0.392
CLV_PCSK_SKI1_1	362	366	PF00082	0.543
CLV_PCSK_SKI1_1	371	375	PF00082	0.412
CLV_PCSK_SKI1_1	430	434	PF00082	0.570
CLV_PCSK_SKI1_1	48	52	PF00082	0.400
DEG_APCC_DBOX_1	237	245	PF00400	0.608
DEG_APCC_DBOX_1	255	263	PF00400	0.317
DEG_APCC_DBOX_1	370	378	PF00400	0.448
DEG_COP1_1	352	360	PF00400	0.452
DEG_Nend_UBRbox_3	1	3	PF02207	0.739
DEG_SCF_FBW7_1	516	522	PF00400	0.500
DEG_SPOP_SBC_1	450	454	PF00917	0.605
DOC_CKS1_1	213	218	PF01111	0.585
DOC_CKS1_1	516	521	PF01111	0.494
DOC_CYCLIN_RxL_1	128	138	PF00134	0.500
DOC_MAPK_gen_1	141	148	PF00069	0.511
DOC_MAPK_gen_1	235	244	PF00069	0.491
DOC_MAPK_MEF2A_6	141	148	PF00069	0.511
DOC_MAPK_MEF2A_6	235	244	PF00069	0.479
DOC_MAPK_MEF2A_6	398	405	PF00069	0.499
DOC_MAPK_NFAT4_5	141	149	PF00069	0.520
DOC_PP2B_PxIxI_1	239	245	PF00149	0.480
DOC_PP4_FxxP_1	213	216	PF00568	0.530
DOC_PP4_FxxP_1	513	516	PF00568	0.499
DOC_USP7_MATH_1	10	14	PF00917	0.710
DOC_USP7_MATH_1	109	113	PF00917	0.742
DOC_USP7_MATH_1	194	198	PF00917	0.611
DOC_USP7_MATH_1	333	337	PF00917	0.541
DOC_USP7_MATH_1	353	357	PF00917	0.521
DOC_USP7_MATH_1	401	405	PF00917	0.494
DOC_USP7_MATH_1	424	428	PF00917	0.561
DOC_USP7_MATH_1	437	441	PF00917	0.610
DOC_USP7_MATH_1	450	454	PF00917	0.747
DOC_USP7_MATH_1	493	497	PF00917	0.735
DOC_USP7_MATH_1	499	503	PF00917	0.504
DOC_USP7_MATH_1	586	590	PF00917	0.714
DOC_USP7_MATH_1	601	605	PF00917	0.718
DOC_USP7_MATH_1	611	615	PF00917	0.683
DOC_USP7_MATH_1	672	676	PF00917	0.460
DOC_USP7_MATH_1	83	87	PF00917	0.648
DOC_WW_Pin1_4	172	177	PF00397	0.726
DOC_WW_Pin1_4	212	217	PF00397	0.519
DOC_WW_Pin1_4	300	305	PF00397	0.552
DOC_WW_Pin1_4	461	466	PF00397	0.711
DOC_WW_Pin1_4	475	480	PF00397	0.684
DOC_WW_Pin1_4	515	520	PF00397	0.496
DOC_WW_Pin1_4	615	620	PF00397	0.764
DOC_WW_Pin1_4	8	13	PF00397	0.711
LIG_14-3-3_CanoR_1	100	109	PF00244	0.741
LIG_14-3-3_CanoR_1	111	120	PF00244	0.536
LIG_14-3-3_CanoR_1	131	136	PF00244	0.211
LIG_14-3-3_CanoR_1	18	23	PF00244	0.490
LIG_14-3-3_CanoR_1	3	8	PF00244	0.765
LIG_14-3-3_CanoR_1	414	419	PF00244	0.609
LIG_14-3-3_CanoR_1	598	608	PF00244	0.696
LIG_14-3-3_CanoR_1	625	632	PF00244	0.507
LIG_14-3-3_CanoR_1	700	705	PF00244	0.785
LIG_BIR_III_2	458	462	PF00653	0.579
LIG_BRCT_BRCA1_1	620	624	PF00533	0.628
LIG_BRCT_BRCA1_1	626	630	PF00533	0.494
LIG_Clathr_ClatBox_1	241	245	PF01394	0.495
LIG_deltaCOP1_diTrp_1	508	513	PF00928	0.480
LIG_FHA_1	100	106	PF00498	0.826
LIG_FHA_1	17	23	PF00498	0.509
LIG_FHA_1	340	346	PF00498	0.494
LIG_FHA_1	400	406	PF00498	0.444
LIG_FHA_1	636	642	PF00498	0.444
LIG_FHA_2	309	315	PF00498	0.669
LIG_FHA_2	321	327	PF00498	0.525
LIG_FHA_2	415	421	PF00498	0.598
LIG_FHA_2	453	459	PF00498	0.566
LIG_FHA_2	484	490	PF00498	0.788
LIG_FHA_2	691	697	PF00498	0.504
LIG_LIR_Apic_2	212	216	PF02991	0.523
LIG_LIR_Apic_2	279	285	PF02991	0.498
LIG_LIR_Gen_1	309	318	PF02991	0.605
LIG_LIR_Gen_1	34	41	PF02991	0.488
LIG_LIR_Gen_1	508	516	PF02991	0.496
LIG_LIR_Gen_1	518	528	PF02991	0.510
LIG_LIR_Nem_3	34	38	PF02991	0.488
LIG_LIR_Nem_3	508	513	PF02991	0.453
LIG_LIR_Nem_3	518	524	PF02991	0.454
LIG_LIR_Nem_3	572	578	PF02991	0.597
LIG_NRBOX	258	264	PF00104	0.486
LIG_PTB_Apo_2	124	131	PF02174	0.488
LIG_SH2_CRK	380	384	PF00017	0.528
LIG_SH2_CRK	521	525	PF00017	0.531
LIG_SH2_CRK	657	661	PF00017	0.557
LIG_SH2_GRB2like	509	512	PF00017	0.343
LIG_SH2_NCK_1	521	525	PF00017	0.504
LIG_SH2_SRC	378	381	PF00017	0.464
LIG_SH2_STAT3	137	140	PF00017	0.509
LIG_SH2_STAT5	378	381	PF00017	0.436
LIG_SH2_STAT5	389	392	PF00017	0.369
LIG_SH2_STAT5	408	411	PF00017	0.466
LIG_SH2_STAT5	521	524	PF00017	0.491
LIG_SH2_STAT5	552	555	PF00017	0.534
LIG_SH2_STAT5	653	656	PF00017	0.459
LIG_SH3_3	240	246	PF00018	0.510
LIG_SH3_3	352	358	PF00018	0.479
LIG_SH3_3	473	479	PF00018	0.715
LIG_SH3_3	513	519	PF00018	0.509
LIG_SH3_3	544	550	PF00018	0.455
LIG_SH3_3	613	619	PF00018	0.695
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.492
LIG_SUMO_SIM_anti_2	402	407	PF11976	0.492
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.402
LIG_SUMO_SIM_anti_2	545	550	PF11976	0.403
LIG_SUMO_SIM_par_1	239	245	PF11976	0.458
LIG_SUMO_SIM_par_1	643	650	PF11976	0.434
LIG_SUMO_SIM_par_1	669	675	PF11976	0.490
LIG_TRAF2_1	312	315	PF00917	0.595
LIG_TRAF2_1	77	80	PF00917	0.707
LIG_TYR_ITIM	573	578	PF00017	0.600
LIG_UBA3_1	667	674	PF00899	0.494
LIG_WRC_WIRS_1	210	215	PF05994	0.504
LIG_WRC_WIRS_1	307	312	PF05994	0.535
MOD_CAAXbox	702	705	PF01239	0.794
MOD_CK1_1	112	118	PF00069	0.509
MOD_CK1_1	13	19	PF00069	0.545
MOD_CK1_1	300	306	PF00069	0.613
MOD_CK1_1	309	315	PF00069	0.512
MOD_CK1_1	356	362	PF00069	0.359
MOD_CK1_1	393	399	PF00069	0.567
MOD_CK1_1	438	444	PF00069	0.673
MOD_CK1_1	449	455	PF00069	0.761
MOD_CK1_1	487	493	PF00069	0.740
MOD_CK1_1	589	595	PF00069	0.746
MOD_CK1_1	6	12	PF00069	0.690
MOD_CK1_1	618	624	PF00069	0.549
MOD_CK1_1	90	96	PF00069	0.745
MOD_CK1_1	99	105	PF00069	0.795
MOD_CK2_1	111	117	PF00069	0.706
MOD_CK2_1	174	180	PF00069	0.794
MOD_CK2_1	308	314	PF00069	0.576
MOD_CK2_1	320	326	PF00069	0.646
MOD_CK2_1	475	481	PF00069	0.800
MOD_CK2_1	483	489	PF00069	0.680
MOD_CK2_1	690	696	PF00069	0.622
MOD_GlcNHglycan	158	161	PF01048	0.713
MOD_GlcNHglycan	196	199	PF01048	0.511
MOD_GlcNHglycan	299	302	PF01048	0.646
MOD_GlcNHglycan	3	6	PF01048	0.802
MOD_GlcNHglycan	448	451	PF01048	0.773
MOD_GlcNHglycan	489	492	PF01048	0.775
MOD_GlcNHglycan	530	534	PF01048	0.532
MOD_GlcNHglycan	55	58	PF01048	0.571
MOD_GlcNHglycan	588	591	PF01048	0.718
MOD_GlcNHglycan	613	616	PF01048	0.702
MOD_GlcNHglycan	633	636	PF01048	0.365
MOD_GlcNHglycan	65	69	PF01048	0.676
MOD_GlcNHglycan	8	11	PF01048	0.743
MOD_GlcNHglycan	83	86	PF01048	0.530
MOD_GSK3_1	109	116	PF00069	0.689
MOD_GSK3_1	293	300	PF00069	0.660
MOD_GSK3_1	410	417	PF00069	0.572
MOD_GSK3_1	431	438	PF00069	0.599
MOD_GSK3_1	446	453	PF00069	0.727
MOD_GSK3_1	463	470	PF00069	0.511
MOD_GSK3_1	483	490	PF00069	0.590
MOD_GSK3_1	515	522	PF00069	0.457
MOD_GSK3_1	565	572	PF00069	0.623
MOD_GSK3_1	6	13	PF00069	0.752
MOD_GSK3_1	611	618	PF00069	0.680
MOD_GSK3_1	631	638	PF00069	0.258
MOD_GSK3_1	83	90	PF00069	0.672
MOD_GSK3_1	92	99	PF00069	0.716
MOD_LATS_1	412	418	PF00433	0.663
MOD_N-GLC_1	1	6	PF02516	0.727
MOD_N-GLC_1	296	301	PF02516	0.634
MOD_N-GLC_1	320	325	PF02516	0.687
MOD_N-GLC_1	467	472	PF02516	0.694
MOD_NEK2_1	1	6	PF00069	0.766
MOD_NEK2_1	24	29	PF00069	0.527
MOD_NEK2_1	252	257	PF00069	0.449
MOD_NEK2_1	432	437	PF00069	0.602
MOD_NEK2_1	467	472	PF00069	0.698
MOD_NEK2_1	553	558	PF00069	0.627
MOD_NEK2_1	641	646	PF00069	0.451
MOD_NEK2_2	601	606	PF00069	0.753
MOD_NEK2_2	672	677	PF00069	0.481
MOD_PIKK_1	192	198	PF00454	0.685
MOD_PIKK_1	424	430	PF00454	0.485
MOD_PIKK_1	441	447	PF00454	0.641
MOD_PIKK_1	618	624	PF00454	0.483
MOD_PKA_1	231	237	PF00069	0.630
MOD_PKA_1	96	102	PF00069	0.758
MOD_PKA_2	112	118	PF00069	0.608
MOD_PKA_2	231	237	PF00069	0.630
MOD_PKA_2	293	299	PF00069	0.706
MOD_PKA_2	413	419	PF00069	0.596
MOD_PKA_2	624	630	PF00069	0.551
MOD_PKA_2	95	101	PF00069	0.762
MOD_PKB_1	111	119	PF00069	0.473
MOD_PKB_1	94	102	PF00069	0.817
MOD_Plk_1	184	190	PF00069	0.599
MOD_Plk_1	353	359	PF00069	0.587
MOD_Plk_1	493	499	PF00069	0.594
MOD_Plk_4	401	407	PF00069	0.495
MOD_Plk_4	493	499	PF00069	0.639
MOD_Plk_4	537	543	PF00069	0.471
MOD_Plk_4	636	642	PF00069	0.569
MOD_ProDKin_1	172	178	PF00069	0.725
MOD_ProDKin_1	212	218	PF00069	0.511
MOD_ProDKin_1	300	306	PF00069	0.553
MOD_ProDKin_1	461	467	PF00069	0.713
MOD_ProDKin_1	475	481	PF00069	0.686
MOD_ProDKin_1	515	521	PF00069	0.493
MOD_ProDKin_1	615	621	PF00069	0.753
MOD_ProDKin_1	8	14	PF00069	0.705
MOD_SUMO_rev_2	149	155	PF00179	0.635
TRG_DiLeu_BaEn_1	248	253	PF01217	0.460
TRG_DiLeu_BaEn_1	47	52	PF01217	0.401
TRG_DiLeu_BaEn_2	367	373	PF01217	0.443
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.516
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.420
TRG_ENDOCYTIC_2	521	524	PF00928	0.531
TRG_ENDOCYTIC_2	575	578	PF00928	0.605
TRG_ENDOCYTIC_2	657	660	PF00928	0.552
TRG_ER_diArg_1	141	144	PF00400	0.514
TRG_ER_diArg_1	232	235	PF00400	0.488
TRG_ER_diArg_1	94	97	PF00400	0.770
TRG_NES_CRM1_1	669	680	PF08389	0.604
TRG_NLS_MonoCore_2	697	702	PF00514	0.712
TRG_NLS_MonoExtC_3	230	235	PF00514	0.578
TRG_NLS_MonoExtN_4	698	703	PF00514	0.781
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV4	Leptomonas seymouri	48%	100%
A0A1X0NVY7	Trypanosomatidae	24%	100%
A0A3S5H7D6	Leishmania donovani	93%	98%
A4HDQ5	Leishmania braziliensis	69%	100%
A4I101	Leishmania infantum	93%	99%
E9AX39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%