Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD6_LEIMA

TriTrypDb:

LmjF.24.1940 , LMJLV39_240027100 , LMJSD75_240026400

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.733
CLV_C14_Caspase3-7	87	91	PF00656	0.732
CLV_NRD_NRD_1	102	104	PF00675	0.458
CLV_NRD_NRD_1	218	220	PF00675	0.331
CLV_PCSK_KEX2_1	218	220	PF00082	0.331
CLV_PCSK_KEX2_1	362	364	PF00082	0.710
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.699
CLV_PCSK_SKI1_1	177	181	PF00082	0.446
CLV_PCSK_SKI1_1	195	199	PF00082	0.413
DEG_APCC_DBOX_1	217	225	PF00400	0.560
DEG_APCC_DBOX_1	291	299	PF00400	0.471
DEG_SPOP_SBC_1	53	57	PF00917	0.759
DOC_CKS1_1	30	35	PF01111	0.693
DOC_MAPK_gen_1	218	226	PF00069	0.536
DOC_MAPK_HePTP_8	216	228	PF00069	0.555
DOC_MAPK_HePTP_8	258	270	PF00069	0.432
DOC_MAPK_MEF2A_6	219	228	PF00069	0.561
DOC_MAPK_MEF2A_6	261	270	PF00069	0.565
DOC_PP2B_LxvP_1	38	41	PF13499	0.699
DOC_USP7_MATH_1	123	127	PF00917	0.807
DOC_USP7_MATH_1	253	257	PF00917	0.314
DOC_USP7_MATH_1	307	311	PF00917	0.406
DOC_USP7_MATH_1	41	45	PF00917	0.770
DOC_USP7_MATH_1	5	9	PF00917	0.647
DOC_USP7_MATH_1	53	57	PF00917	0.775
DOC_USP7_MATH_1	67	71	PF00917	0.724
DOC_USP7_MATH_1	89	93	PF00917	0.649
DOC_WW_Pin1_4	106	111	PF00397	0.710
DOC_WW_Pin1_4	11	16	PF00397	0.758
DOC_WW_Pin1_4	129	134	PF00397	0.703
DOC_WW_Pin1_4	29	34	PF00397	0.678
DOC_WW_Pin1_4	351	356	PF00397	0.316
LIG_14-3-3_CanoR_1	103	112	PF00244	0.688
LIG_14-3-3_CanoR_1	292	298	PF00244	0.318
LIG_14-3-3_CanoR_1	68	74	PF00244	0.767
LIG_14-3-3_CterR_2	363	366	PF00244	0.504
LIG_Actin_RPEL_3	239	258	PF02755	0.531
LIG_BIR_III_2	152	156	PF00653	0.653
LIG_BRCT_BRCA1_1	255	259	PF00533	0.314
LIG_CSL_BTD_1	2	5	PF09270	0.642
LIG_FHA_1	125	131	PF00498	0.674
LIG_FHA_1	21	27	PF00498	0.772
LIG_FHA_1	242	248	PF00498	0.372
LIG_FHA_1	258	264	PF00498	0.351
LIG_FHA_2	147	153	PF00498	0.776
LIG_FHA_2	156	162	PF00498	0.555
LIG_FHA_2	184	190	PF00498	0.573
LIG_FHA_2	196	202	PF00498	0.566
LIG_FHA_2	20	26	PF00498	0.776
LIG_LIR_Gen_1	256	266	PF02991	0.314
LIG_LIR_Nem_3	256	262	PF02991	0.314
LIG_LIR_Nem_3	339	345	PF02991	0.373
LIG_LIR_Nem_3	96	102	PF02991	0.741
LIG_NRP_CendR_1	363	366	PF00754	0.727
LIG_PCNA_yPIPBox_3	171	179	PF02747	0.507
LIG_Pex14_1	344	348	PF04695	0.332
LIG_Pex14_2	304	308	PF04695	0.402
LIG_SH2_GRB2like	248	251	PF00017	0.410
LIG_SH2_NCK_1	353	357	PF00017	0.427
LIG_SH2_STAP1	61	65	PF00017	0.647
LIG_SH2_STAT5	238	241	PF00017	0.400
LIG_SH2_STAT5	345	348	PF00017	0.391
LIG_SH2_STAT5	61	64	PF00017	0.647
LIG_SH3_3	157	163	PF00018	0.593
LIG_SH3_3	306	312	PF00018	0.488
MOD_CDC14_SPxK_1	132	135	PF00782	0.712
MOD_CDK_SPxK_1	129	135	PF00069	0.715
MOD_CDK_SPxxK_3	106	113	PF00069	0.612
MOD_CDK_SPxxK_3	29	36	PF00069	0.630
MOD_CK1_1	29	35	PF00069	0.670
MOD_CK1_1	296	302	PF00069	0.420
MOD_CK1_1	354	360	PF00069	0.695
MOD_CK1_1	52	58	PF00069	0.730
MOD_CK2_1	115	121	PF00069	0.762
MOD_CK2_1	183	189	PF00069	0.450
MOD_CK2_1	195	201	PF00069	0.383
MOD_Cter_Amidation	216	219	PF01082	0.403
MOD_GlcNHglycan	116	120	PF01048	0.723
MOD_GlcNHglycan	121	124	PF01048	0.718
MOD_GlcNHglycan	298	301	PF01048	0.432
MOD_GlcNHglycan	356	359	PF01048	0.648
MOD_GlcNHglycan	41	44	PF01048	0.684
MOD_GlcNHglycan	51	54	PF01048	0.741
MOD_GlcNHglycan	63	66	PF01048	0.751
MOD_GlcNHglycan	69	72	PF01048	0.689
MOD_GSK3_1	111	118	PF00069	0.661
MOD_GSK3_1	119	126	PF00069	0.590
MOD_GSK3_1	181	188	PF00069	0.534
MOD_GSK3_1	253	260	PF00069	0.342
MOD_GSK3_1	357	364	PF00069	0.674
MOD_GSK3_1	41	48	PF00069	0.787
MOD_GSK3_1	49	56	PF00069	0.725
MOD_GSK3_1	89	96	PF00069	0.686
MOD_NEK2_1	124	129	PF00069	0.718
MOD_NEK2_1	232	237	PF00069	0.344
MOD_NEK2_1	286	291	PF00069	0.416
MOD_NEK2_1	336	341	PF00069	0.488
MOD_NEK2_2	233	238	PF00069	0.476
MOD_NEK2_2	98	103	PF00069	0.568
MOD_PIKK_1	20	26	PF00454	0.693
MOD_PIKK_1	307	313	PF00454	0.459
MOD_PKA_2	134	140	PF00069	0.668
MOD_PKA_2	286	292	PF00069	0.436
MOD_PKA_2	5	11	PF00069	0.701
MOD_PKA_2	67	73	PF00069	0.730
MOD_Plk_1	195	201	PF00069	0.451
MOD_Plk_1	336	342	PF00069	0.496
MOD_Plk_4	125	131	PF00069	0.594
MOD_Plk_4	233	239	PF00069	0.432
MOD_Plk_4	253	259	PF00069	0.162
MOD_Plk_4	26	32	PF00069	0.623
MOD_Plk_4	293	299	PF00069	0.350
MOD_Plk_4	55	61	PF00069	0.625
MOD_Plk_4	94	100	PF00069	0.612
MOD_ProDKin_1	106	112	PF00069	0.653
MOD_ProDKin_1	11	17	PF00069	0.715
MOD_ProDKin_1	129	135	PF00069	0.639
MOD_ProDKin_1	29	35	PF00069	0.608
MOD_ProDKin_1	351	357	PF00069	0.390
TRG_DiLeu_BaEn_1	189	194	PF01217	0.443
TRG_DiLeu_BaEn_1	273	278	PF01217	0.572
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.361
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.369
TRG_ER_diArg_1	266	269	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV70	Leptomonas seymouri	46%	100%
A0A3Q8ID58	Leishmania donovani	87%	100%
A4HDQ6	Leishmania braziliensis	75%	100%
A4I102	Leishmania infantum	87%	100%
C9ZW90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AX40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DB44	Trypanosoma cruzi	43%	100%