Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD5_LEIMA

TriTrypDb:

LmjF.24.1950 , LMJLV39_240027200 , LMJSD75_240026500

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

Q4QAD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.653
CLV_C14_Caspase3-7	163	167	PF00656	0.460
CLV_C14_Caspase3-7	294	298	PF00656	0.624
CLV_C14_Caspase3-7	36	40	PF00656	0.573
CLV_C14_Caspase3-7	461	465	PF00656	0.499
CLV_C14_Caspase3-7	548	552	PF00656	0.576
CLV_MEL_PAP_1	499	505	PF00089	0.571
CLV_NRD_NRD_1	182	184	PF00675	0.415
CLV_NRD_NRD_1	185	187	PF00675	0.428
CLV_NRD_NRD_1	501	503	PF00675	0.611
CLV_NRD_NRD_1	585	587	PF00675	0.687
CLV_NRD_NRD_1	631	633	PF00675	0.580
CLV_NRD_NRD_1	695	697	PF00675	0.509
CLV_PCSK_FUR_1	183	187	PF00082	0.413
CLV_PCSK_KEX2_1	184	186	PF00082	0.430
CLV_PCSK_KEX2_1	501	503	PF00082	0.611
CLV_PCSK_KEX2_1	585	587	PF00082	0.577
CLV_PCSK_KEX2_1	631	633	PF00082	0.690
CLV_PCSK_KEX2_1	695	697	PF00082	0.509
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.444
CLV_PCSK_SKI1_1	177	181	PF00082	0.338
CLV_PCSK_SKI1_1	186	190	PF00082	0.348
CLV_PCSK_SKI1_1	354	358	PF00082	0.523
CLV_PCSK_SKI1_1	59	63	PF00082	0.547
CLV_PCSK_SKI1_1	695	699	PF00082	0.424
CLV_PCSK_SKI1_1	703	707	PF00082	0.371
CLV_PCSK_SKI1_1	780	784	PF00082	0.603
CLV_Separin_Metazoa	692	696	PF03568	0.520
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SCF_FBW7_2	479	486	PF00400	0.356
DEG_SPOP_SBC_1	608	612	PF00917	0.521
DEG_SPOP_SBC_1	639	643	PF00917	0.630
DOC_CDC14_PxL_1	62	70	PF14671	0.542
DOC_CDC14_PxL_1	90	98	PF14671	0.459
DOC_MAPK_gen_1	183	189	PF00069	0.434
DOC_MAPK_gen_1	452	460	PF00069	0.445
DOC_MAPK_MEF2A_6	25	34	PF00069	0.494
DOC_MAPK_MEF2A_6	354	363	PF00069	0.396
DOC_MAPK_MEF2A_6	452	460	PF00069	0.445
DOC_PP2B_LxvP_1	652	655	PF13499	0.593
DOC_PP4_FxxP_1	290	293	PF00568	0.611
DOC_USP7_MATH_1	311	315	PF00917	0.666
DOC_USP7_MATH_1	397	401	PF00917	0.669
DOC_USP7_MATH_1	606	610	PF00917	0.618
DOC_USP7_MATH_1	640	644	PF00917	0.720
DOC_USP7_MATH_1	655	659	PF00917	0.555
DOC_USP7_MATH_1	770	774	PF00917	0.526
DOC_USP7_MATH_2	674	680	PF00917	0.540
DOC_WW_Pin1_4	393	398	PF00397	0.619
DOC_WW_Pin1_4	45	50	PF00397	0.686
DOC_WW_Pin1_4	479	484	PF00397	0.517
DOC_WW_Pin1_4	670	675	PF00397	0.588
LIG_14-3-3_CanoR_1	2	10	PF00244	0.395
LIG_14-3-3_CanoR_1	501	509	PF00244	0.592
LIG_14-3-3_CanoR_1	545	555	PF00244	0.694
LIG_Actin_WH2_2	83	99	PF00022	0.378
LIG_APCC_ABBA_1	759	764	PF00400	0.453
LIG_BIR_III_2	213	217	PF00653	0.485
LIG_Clathr_ClatBox_1	209	213	PF01394	0.465
LIG_CtBP_PxDLS_1	738	742	PF00389	0.427
LIG_deltaCOP1_diTrp_1	753	762	PF00928	0.456
LIG_FHA_1	120	126	PF00498	0.509
LIG_FHA_1	2	8	PF00498	0.487
LIG_FHA_1	304	310	PF00498	0.494
LIG_FHA_1	365	371	PF00498	0.493
LIG_FHA_1	471	477	PF00498	0.577
LIG_FHA_1	520	526	PF00498	0.504
LIG_FHA_1	568	574	PF00498	0.488
LIG_FHA_2	138	144	PF00498	0.633
LIG_FHA_2	34	40	PF00498	0.551
LIG_FHA_2	431	437	PF00498	0.547
LIG_LIR_Gen_1	403	414	PF02991	0.369
LIG_LIR_Gen_1	455	465	PF02991	0.394
LIG_LIR_Gen_1	658	667	PF02991	0.663
LIG_LIR_Gen_1	752	762	PF02991	0.495
LIG_LIR_Nem_3	403	409	PF02991	0.606
LIG_LIR_Nem_3	455	460	PF02991	0.351
LIG_LIR_Nem_3	658	664	PF02991	0.565
LIG_LIR_Nem_3	743	747	PF02991	0.483
LIG_LIR_Nem_3	752	758	PF02991	0.501
LIG_LIR_Nem_3	764	768	PF02991	0.385
LIG_MYND_3	156	160	PF01753	0.504
LIG_MYND_3	203	207	PF01753	0.472
LIG_Pex14_1	594	598	PF04695	0.539
LIG_SH2_CRK	492	496	PF00017	0.412
LIG_SH2_CRK	661	665	PF00017	0.568
LIG_SH2_PTP2	406	409	PF00017	0.383
LIG_SH2_PTP2	457	460	PF00017	0.467
LIG_SH2_SRC	723	726	PF00017	0.566
LIG_SH2_STAT5	124	127	PF00017	0.519
LIG_SH2_STAT5	380	383	PF00017	0.552
LIG_SH2_STAT5	406	409	PF00017	0.383
LIG_SH2_STAT5	457	460	PF00017	0.455
LIG_SH2_STAT5	723	726	PF00017	0.452
LIG_SH2_STAT5	747	750	PF00017	0.515
LIG_SH2_STAT5	80	83	PF00017	0.390
LIG_SH3_3	46	52	PF00018	0.698
LIG_SH3_3	600	606	PF00018	0.661
LIG_SH3_3	730	736	PF00018	0.597
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.532
LIG_SUMO_SIM_par_1	160	166	PF11976	0.464
LIG_SUMO_SIM_par_1	207	213	PF11976	0.548
LIG_TYR_ITIM	490	495	PF00017	0.464
LIG_UBA3_1	178	184	PF00899	0.386
MOD_CK1_1	257	263	PF00069	0.627
MOD_CK1_1	300	306	PF00069	0.501
MOD_CK1_1	338	344	PF00069	0.629
MOD_CK1_1	400	406	PF00069	0.577
MOD_CK1_1	519	525	PF00069	0.504
MOD_CK1_1	554	560	PF00069	0.633
MOD_CK1_1	561	567	PF00069	0.602
MOD_CK1_1	609	615	PF00069	0.607
MOD_CK1_1	726	732	PF00069	0.598
MOD_CK2_1	143	149	PF00069	0.628
MOD_CK2_1	16	22	PF00069	0.564
MOD_CK2_1	322	328	PF00069	0.590
MOD_CK2_1	430	436	PF00069	0.543
MOD_CK2_1	639	645	PF00069	0.686
MOD_CK2_1	670	676	PF00069	0.587
MOD_GlcNHglycan	117	120	PF01048	0.471
MOD_GlcNHglycan	145	148	PF01048	0.626
MOD_GlcNHglycan	173	176	PF01048	0.404
MOD_GlcNHglycan	256	259	PF01048	0.681
MOD_GlcNHglycan	294	297	PF01048	0.554
MOD_GlcNHglycan	324	327	PF01048	0.607
MOD_GlcNHglycan	337	340	PF01048	0.522
MOD_GlcNHglycan	399	402	PF01048	0.572
MOD_GlcNHglycan	4	7	PF01048	0.401
MOD_GlcNHglycan	556	559	PF01048	0.684
MOD_GlcNHglycan	560	563	PF01048	0.672
MOD_GlcNHglycan	611	614	PF01048	0.677
MOD_GlcNHglycan	678	681	PF01048	0.544
MOD_GSK3_1	115	122	PF00069	0.527
MOD_GSK3_1	137	144	PF00069	0.623
MOD_GSK3_1	311	318	PF00069	0.625
MOD_GSK3_1	335	342	PF00069	0.723
MOD_GSK3_1	392	399	PF00069	0.742
MOD_GSK3_1	430	437	PF00069	0.553
MOD_GSK3_1	497	504	PF00069	0.540
MOD_GSK3_1	547	554	PF00069	0.616
MOD_GSK3_1	594	601	PF00069	0.600
MOD_GSK3_1	666	673	PF00069	0.683
MOD_GSK3_1	72	79	PF00069	0.487
MOD_GSK3_1	745	752	PF00069	0.620
MOD_N-GLC_1	374	379	PF02516	0.389
MOD_N-GLC_2	310	312	PF02516	0.546
MOD_N-GLC_2	67	69	PF02516	0.588
MOD_NEK2_1	1	6	PF00069	0.473
MOD_NEK2_1	141	146	PF00069	0.586
MOD_NEK2_1	317	322	PF00069	0.557
MOD_NEK2_1	435	440	PF00069	0.475
MOD_NEK2_1	503	508	PF00069	0.683
MOD_NEK2_1	566	571	PF00069	0.666
MOD_NEK2_1	74	79	PF00069	0.419
MOD_PIKK_1	297	303	PF00454	0.671
MOD_PIKK_1	436	442	PF00454	0.585
MOD_PIKK_1	564	570	PF00454	0.732
MOD_PIKK_1	74	80	PF00454	0.454
MOD_PKA_1	501	507	PF00069	0.660
MOD_PKA_2	1	7	PF00069	0.531
MOD_PKA_2	240	246	PF00069	0.489
MOD_PKA_2	501	507	PF00069	0.660
MOD_PKA_2	546	552	PF00069	0.710
MOD_PKA_2	558	564	PF00069	0.558
MOD_PKB_1	545	553	PF00069	0.540
MOD_Plk_1	374	380	PF00069	0.392
MOD_Plk_4	374	380	PF00069	0.607
MOD_Plk_4	666	672	PF00069	0.532
MOD_Plk_4	737	743	PF00069	0.613
MOD_Plk_4	76	82	PF00069	0.482
MOD_ProDKin_1	393	399	PF00069	0.614
MOD_ProDKin_1	45	51	PF00069	0.684
MOD_ProDKin_1	479	485	PF00069	0.512
MOD_ProDKin_1	670	676	PF00069	0.591
TRG_DiLeu_BaEn_1	778	783	PF01217	0.597
TRG_DiLeu_BaEn_4	130	136	PF01217	0.555
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.378
TRG_ENDOCYTIC_2	235	238	PF00928	0.456
TRG_ENDOCYTIC_2	406	409	PF00928	0.421
TRG_ENDOCYTIC_2	457	460	PF00928	0.494
TRG_ENDOCYTIC_2	491	494	PF00928	0.389
TRG_ENDOCYTIC_2	661	664	PF00928	0.566
TRG_ER_diArg_1	182	185	PF00400	0.394
TRG_ER_diArg_1	451	454	PF00400	0.478
TRG_ER_diArg_1	501	503	PF00400	0.611
TRG_ER_diArg_1	584	586	PF00400	0.575
TRG_ER_diArg_1	630	632	PF00400	0.575
TRG_ER_diArg_1	694	696	PF00400	0.476
TRG_ER_diArg_1	711	714	PF00400	0.385
TRG_ER_diArg_1	766	769	PF00400	0.504
TRG_NLS_MonoCore_2	182	187	PF00514	0.395
TRG_NLS_MonoExtN_4	183	188	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	696	701	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	780	785	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U0	Leptomonas seymouri	45%	100%
A0A3S7WYK4	Leishmania donovani	93%	100%
A0A422NX08	Trypanosoma rangeli	24%	100%
A4HDQ7	Leishmania braziliensis	79%	99%
A4I103	Leishmania infantum	93%	100%
C9ZWA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AX41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BAG5	Trypanosoma cruzi	24%	100%