Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD4_LEIMA

TriTrypDb:

LmjF.24.1960 , LMJLV39_240027300 , LMJSD75_240026600

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	649	653	PF00656	0.681
CLV_MEL_PAP_1	852	858	PF00089	0.706
CLV_NRD_NRD_1	108	110	PF00675	0.473
CLV_NRD_NRD_1	261	263	PF00675	0.718
CLV_NRD_NRD_1	325	327	PF00675	0.783
CLV_NRD_NRD_1	35	37	PF00675	0.539
CLV_NRD_NRD_1	397	399	PF00675	0.569
CLV_NRD_NRD_1	443	445	PF00675	0.500
CLV_NRD_NRD_1	462	464	PF00675	0.487
CLV_NRD_NRD_1	69	71	PF00675	0.674
CLV_NRD_NRD_1	818	820	PF00675	0.654
CLV_NRD_NRD_1	854	856	PF00675	0.632
CLV_PCSK_KEX2_1	108	110	PF00082	0.473
CLV_PCSK_KEX2_1	261	263	PF00082	0.761
CLV_PCSK_KEX2_1	325	327	PF00082	0.783
CLV_PCSK_KEX2_1	34	36	PF00082	0.566
CLV_PCSK_KEX2_1	396	398	PF00082	0.571
CLV_PCSK_KEX2_1	443	445	PF00082	0.500
CLV_PCSK_KEX2_1	461	463	PF00082	0.489
CLV_PCSK_KEX2_1	69	71	PF00082	0.524
CLV_PCSK_KEX2_1	818	820	PF00082	0.654
CLV_PCSK_KEX2_1	854	856	PF00082	0.632
CLV_PCSK_PC7_1	257	263	PF00082	0.773
CLV_PCSK_PC7_1	393	399	PF00082	0.572
CLV_PCSK_SKI1_1	334	338	PF00082	0.770
CLV_PCSK_SKI1_1	372	376	PF00082	0.716
CLV_PCSK_SKI1_1	536	540	PF00082	0.692
CLV_PCSK_SKI1_1	738	742	PF00082	0.588
CLV_PCSK_SKI1_1	772	776	PF00082	0.644
DEG_APCC_DBOX_1	371	379	PF00400	0.714
DEG_SPOP_SBC_1	798	802	PF00917	0.716
DOC_CKS1_1	739	744	PF01111	0.645
DOC_CYCLIN_RxL_1	769	777	PF00134	0.665
DOC_MAPK_DCC_7	372	380	PF00069	0.709
DOC_MAPK_MEF2A_6	44	51	PF00069	0.629
DOC_MAPK_NFAT4_5	44	52	PF00069	0.569
DOC_PP4_FxxP_1	733	736	PF00568	0.705
DOC_PP4_FxxP_1	739	742	PF00568	0.698
DOC_USP7_MATH_1	124	128	PF00917	0.601
DOC_USP7_MATH_1	193	197	PF00917	0.777
DOC_USP7_MATH_1	23	27	PF00917	0.654
DOC_USP7_MATH_1	239	243	PF00917	0.688
DOC_USP7_MATH_1	311	315	PF00917	0.676
DOC_USP7_MATH_1	328	332	PF00917	0.649
DOC_USP7_MATH_1	343	347	PF00917	0.541
DOC_USP7_MATH_1	431	435	PF00917	0.567
DOC_USP7_MATH_1	610	614	PF00917	0.824
DOC_USP7_MATH_1	714	718	PF00917	0.625
DOC_USP7_MATH_1	734	738	PF00917	0.599
DOC_USP7_MATH_1	799	803	PF00917	0.643
DOC_USP7_MATH_2	219	225	PF00917	0.623
DOC_USP7_MATH_2	664	670	PF00917	0.757
DOC_WW_Pin1_4	318	323	PF00397	0.840
DOC_WW_Pin1_4	326	331	PF00397	0.697
DOC_WW_Pin1_4	373	378	PF00397	0.571
DOC_WW_Pin1_4	564	569	PF00397	0.813
DOC_WW_Pin1_4	576	581	PF00397	0.682
DOC_WW_Pin1_4	644	649	PF00397	0.751
DOC_WW_Pin1_4	738	743	PF00397	0.685
DOC_WW_Pin1_4	794	799	PF00397	0.813
DOC_WW_Pin1_4	810	815	PF00397	0.540
LIG_14-3-3_CanoR_1	342	352	PF00244	0.627
LIG_14-3-3_CanoR_1	489	497	PF00244	0.529
LIG_14-3-3_CanoR_1	504	512	PF00244	0.572
LIG_14-3-3_CanoR_1	614	620	PF00244	0.708
LIG_14-3-3_CanoR_1	784	790	PF00244	0.596
LIG_14-3-3_CanoR_1	805	815	PF00244	0.739
LIG_14-3-3_CanoR_1	818	822	PF00244	0.828
LIG_Actin_WH2_2	358	374	PF00022	0.718
LIG_BIR_III_2	597	601	PF00653	0.608
LIG_BIR_III_4	348	352	PF00653	0.773
LIG_BRCT_BRCA1_1	204	208	PF00533	0.815
LIG_BRCT_BRCA1_1	837	841	PF00533	0.740
LIG_CaM_IQ_9	142	158	PF13499	0.511
LIG_Dynein_DLC8_1	59	65	PF01221	0.444
LIG_FHA_1	254	260	PF00498	0.857
LIG_FHA_1	354	360	PF00498	0.681
LIG_FHA_1	374	380	PF00498	0.458
LIG_FHA_1	703	709	PF00498	0.586
LIG_FHA_1	743	749	PF00498	0.687
LIG_FHA_1	840	846	PF00498	0.594
LIG_FHA_2	201	207	PF00498	0.720
LIG_FHA_2	27	33	PF00498	0.570
LIG_FHA_2	319	325	PF00498	0.729
LIG_FHA_2	343	349	PF00498	0.813
LIG_FHA_2	362	368	PF00498	0.434
LIG_FHA_2	61	67	PF00498	0.447
LIG_FHA_2	647	653	PF00498	0.748
LIG_FHA_2	702	708	PF00498	0.689
LIG_LIR_Apic_2	737	742	PF02991	0.727
LIG_LIR_Apic_2	745	750	PF02991	0.793
LIG_LIR_Gen_1	205	213	PF02991	0.822
LIG_LIR_Gen_1	474	483	PF02991	0.635
LIG_LIR_Gen_1	525	535	PF02991	0.695
LIG_LIR_Gen_1	785	794	PF02991	0.637
LIG_LIR_Gen_1	836	845	PF02991	0.719
LIG_LIR_Gen_1	95	105	PF02991	0.645
LIG_LIR_Nem_3	205	211	PF02991	0.821
LIG_LIR_Nem_3	474	479	PF02991	0.635
LIG_LIR_Nem_3	525	531	PF02991	0.699
LIG_LIR_Nem_3	785	789	PF02991	0.719
LIG_LIR_Nem_3	95	100	PF02991	0.642
LIG_MYND_1	581	585	PF01753	0.734
LIG_NRBOX	176	182	PF00104	0.575
LIG_PDZ_Class_2	861	866	PF00595	0.681
LIG_PTB_Apo_2	180	187	PF02174	0.715
LIG_PTB_Phospho_1	180	186	PF10480	0.715
LIG_Rb_LxCxE_1	465	484	PF01857	0.626
LIG_SH2_CRK	528	532	PF00017	0.687
LIG_SH2_CRK	535	539	PF00017	0.575
LIG_SH2_NCK_1	410	414	PF00017	0.465
LIG_SH2_PTP2	747	750	PF00017	0.607
LIG_SH2_SRC	410	413	PF00017	0.466
LIG_SH2_SRC	747	750	PF00017	0.607
LIG_SH2_STAP1	837	841	PF00017	0.740
LIG_SH2_STAT3	186	189	PF00017	0.731
LIG_SH2_STAT5	747	750	PF00017	0.607
LIG_SH2_STAT5	821	824	PF00017	0.823
LIG_SH3_1	793	799	PF00018	0.733
LIG_SH3_3	233	239	PF00018	0.673
LIG_SH3_3	317	323	PF00018	0.704
LIG_SH3_3	324	330	PF00018	0.697
LIG_SH3_3	565	571	PF00018	0.827
LIG_SH3_3	578	584	PF00018	0.612
LIG_SH3_3	793	799	PF00018	0.801
LIG_SH3_3	808	814	PF00018	0.565
LIG_SH3_CIN85_PxpxPR_1	719	724	PF14604	0.744
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.520
LIG_SUMO_SIM_par_1	704	709	PF11976	0.609
LIG_SUMO_SIM_par_1	78	83	PF11976	0.650
LIG_TRAF2_1	425	428	PF00917	0.606
LIG_TYR_ITIM	526	531	PF00017	0.698
LIG_UBA3_1	378	383	PF00899	0.698
LIG_WW_2	581	584	PF00397	0.732
MOD_CDK_SPxxK_3	318	325	PF00069	0.762
MOD_CDK_SPxxK_3	644	651	PF00069	0.630
MOD_CK1_1	224	230	PF00069	0.589
MOD_CK1_1	242	248	PF00069	0.680
MOD_CK1_1	26	32	PF00069	0.650
MOD_CK1_1	265	271	PF00069	0.620
MOD_CK1_1	295	301	PF00069	0.624
MOD_CK1_1	329	335	PF00069	0.707
MOD_CK1_1	357	363	PF00069	0.753
MOD_CK1_1	370	376	PF00069	0.631
MOD_CK1_1	426	432	PF00069	0.486
MOD_CK1_1	491	497	PF00069	0.610
MOD_CK1_1	547	553	PF00069	0.761
MOD_CK1_1	613	619	PF00069	0.764
MOD_CK1_1	669	675	PF00069	0.764
MOD_CK1_1	697	703	PF00069	0.744
MOD_CK1_1	752	758	PF00069	0.727
MOD_CK1_1	785	791	PF00069	0.782
MOD_CK1_1	797	803	PF00069	0.611
MOD_CK1_1	820	826	PF00069	0.807
MOD_CK1_1	839	845	PF00069	0.415
MOD_CK2_1	133	139	PF00069	0.670
MOD_CK2_1	200	206	PF00069	0.717
MOD_CK2_1	26	32	PF00069	0.567
MOD_CK2_1	261	267	PF00069	0.725
MOD_CK2_1	318	324	PF00069	0.677
MOD_CK2_1	341	347	PF00069	0.589
MOD_CK2_1	426	432	PF00069	0.629
MOD_CK2_1	60	66	PF00069	0.445
MOD_CK2_1	701	707	PF00069	0.685
MOD_DYRK1A_RPxSP_1	326	330	PF00069	0.774
MOD_GlcNHglycan	102	106	PF01048	0.478
MOD_GlcNHglycan	158	161	PF01048	0.709
MOD_GlcNHglycan	166	169	PF01048	0.651
MOD_GlcNHglycan	245	248	PF01048	0.650
MOD_GlcNHglycan	267	270	PF01048	0.784
MOD_GlcNHglycan	278	281	PF01048	0.558
MOD_GlcNHglycan	298	301	PF01048	0.502
MOD_GlcNHglycan	311	314	PF01048	0.645
MOD_GlcNHglycan	359	362	PF01048	0.648
MOD_GlcNHglycan	423	426	PF01048	0.610
MOD_GlcNHglycan	507	510	PF01048	0.530
MOD_GlcNHglycan	549	552	PF01048	0.672
MOD_GlcNHglycan	586	589	PF01048	0.783
MOD_GlcNHglycan	592	595	PF01048	0.817
MOD_GlcNHglycan	668	671	PF01048	0.851
MOD_GlcNHglycan	716	719	PF01048	0.652
MOD_GlcNHglycan	751	754	PF01048	0.789
MOD_GlcNHglycan	765	768	PF01048	0.565
MOD_GlcNHglycan	856	859	PF01048	0.698
MOD_GSK3_1	224	231	PF00069	0.755
MOD_GSK3_1	239	246	PF00069	0.657
MOD_GSK3_1	261	268	PF00069	0.674
MOD_GSK3_1	292	299	PF00069	0.599
MOD_GSK3_1	326	333	PF00069	0.684
MOD_GSK3_1	337	344	PF00069	0.694
MOD_GSK3_1	353	360	PF00069	0.532
MOD_GSK3_1	462	469	PF00069	0.487
MOD_GSK3_1	610	617	PF00069	0.814
MOD_GSK3_1	621	628	PF00069	0.649
MOD_GSK3_1	658	665	PF00069	0.663
MOD_GSK3_1	694	701	PF00069	0.741
MOD_GSK3_1	734	741	PF00069	0.712
MOD_GSK3_1	749	756	PF00069	0.674
MOD_GSK3_1	794	801	PF00069	0.725
MOD_GSK3_1	806	813	PF00069	0.627
MOD_GSK3_1	835	842	PF00069	0.718
MOD_N-GLC_1	265	270	PF02516	0.685
MOD_NEK2_1	253	258	PF00069	0.857
MOD_NEK2_1	337	342	PF00069	0.840
MOD_NEK2_1	466	471	PF00069	0.561
MOD_NEK2_1	620	625	PF00069	0.774
MOD_NEK2_1	694	699	PF00069	0.594
MOD_NEK2_1	763	768	PF00069	0.675
MOD_NEK2_1	774	779	PF00069	0.779
MOD_NEK2_1	817	822	PF00069	0.750
MOD_NEK2_1	860	865	PF00069	0.672
MOD_PIKK_1	222	228	PF00454	0.766
MOD_PIKK_1	292	298	PF00454	0.792
MOD_PIKK_1	354	360	PF00454	0.661
MOD_PIKK_1	423	429	PF00454	0.690
MOD_PIKK_1	60	66	PF00454	0.490
MOD_PIKK_1	689	695	PF00454	0.690
MOD_PK_1	651	657	PF00069	0.637
MOD_PKA_1	261	267	PF00069	0.645
MOD_PKA_1	462	468	PF00069	0.569
MOD_PKA_1	854	860	PF00069	0.710
MOD_PKA_2	164	170	PF00069	0.744
MOD_PKA_2	209	215	PF00069	0.645
MOD_PKA_2	23	29	PF00069	0.654
MOD_PKA_2	261	267	PF00069	0.748
MOD_PKA_2	341	347	PF00069	0.630
MOD_PKA_2	462	468	PF00069	0.569
MOD_PKA_2	488	494	PF00069	0.603
MOD_PKA_2	547	553	PF00069	0.555
MOD_PKA_2	60	66	PF00069	0.451
MOD_PKA_2	613	619	PF00069	0.630
MOD_PKA_2	817	823	PF00069	0.747
MOD_PKA_2	854	860	PF00069	0.617
MOD_Plk_1	367	373	PF00069	0.689
MOD_Plk_1	542	548	PF00069	0.661
MOD_Plk_1	835	841	PF00069	0.748
MOD_Plk_1	860	866	PF00069	0.654
MOD_Plk_2-3	454	460	PF00069	0.453
MOD_Plk_4	384	390	PF00069	0.557
MOD_Plk_4	615	621	PF00069	0.825
MOD_Plk_4	75	81	PF00069	0.578
MOD_Plk_4	785	791	PF00069	0.613
MOD_Plk_4	836	842	PF00069	0.581
MOD_ProDKin_1	318	324	PF00069	0.842
MOD_ProDKin_1	326	332	PF00069	0.668
MOD_ProDKin_1	373	379	PF00069	0.569
MOD_ProDKin_1	564	570	PF00069	0.812
MOD_ProDKin_1	576	582	PF00069	0.680
MOD_ProDKin_1	644	650	PF00069	0.754
MOD_ProDKin_1	738	744	PF00069	0.688
MOD_ProDKin_1	794	800	PF00069	0.815
MOD_ProDKin_1	810	816	PF00069	0.541
MOD_SUMO_for_1	5	8	PF00179	0.656
MOD_SUMO_rev_2	71	78	PF00179	0.581
TRG_DiLeu_BaEn_1	474	479	PF01217	0.635
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.708
TRG_ENDOCYTIC_2	410	413	PF00928	0.652
TRG_ENDOCYTIC_2	528	531	PF00928	0.694
TRG_ENDOCYTIC_2	535	538	PF00928	0.578
TRG_ENDOCYTIC_2	837	840	PF00928	0.744
TRG_ER_diArg_1	107	109	PF00400	0.556
TRG_ER_diArg_1	163	166	PF00400	0.765
TRG_ER_diArg_1	325	327	PF00400	0.783
TRG_ER_diArg_1	33	36	PF00400	0.668
TRG_ER_diArg_1	396	398	PF00400	0.673
TRG_ER_diArg_1	443	445	PF00400	0.660
TRG_ER_diArg_1	460	463	PF00400	0.369
TRG_ER_diArg_1	817	819	PF00400	0.660
TRG_ER_diArg_1	854	856	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	760	765	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYM1	Leishmania donovani	84%	100%
A4HDQ8	Leishmania braziliensis	66%	100%
A4I104	Leishmania infantum	84%	90%
E9AX42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%