Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP76

Species:

Leishmania major

UniProt:

Q4QAD3_LEIMA

TriTrypDb:

LmjF.24.1970 , LMJLV39_240027400 , LMJSD75_240026700

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0044612	nuclear pore linkers	3	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QAD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD3

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0046907	intracellular transport	3	2
GO:0050657	nucleic acid transport	6	2
GO:0050658	RNA transport	4	2
GO:0051028	mRNA transport	5	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051236	establishment of RNA localization	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	569	573	PF00656	0.504
CLV_C14_Caspase3-7	589	593	PF00656	0.365
CLV_NRD_NRD_1	116	118	PF00675	0.434
CLV_NRD_NRD_1	180	182	PF00675	0.526
CLV_NRD_NRD_1	190	192	PF00675	0.584
CLV_NRD_NRD_1	385	387	PF00675	0.522
CLV_NRD_NRD_1	44	46	PF00675	0.448
CLV_NRD_NRD_1	525	527	PF00675	0.463
CLV_NRD_NRD_1	673	675	PF00675	0.608
CLV_NRD_NRD_1	684	686	PF00675	0.460
CLV_NRD_NRD_1	694	696	PF00675	0.415
CLV_NRD_NRD_1	728	730	PF00675	0.553
CLV_NRD_NRD_1	741	743	PF00675	0.496
CLV_PCSK_FUR_1	692	696	PF00082	0.429
CLV_PCSK_KEX2_1	116	118	PF00082	0.456
CLV_PCSK_KEX2_1	180	182	PF00082	0.500
CLV_PCSK_KEX2_1	190	192	PF00082	0.557
CLV_PCSK_KEX2_1	385	387	PF00082	0.480
CLV_PCSK_KEX2_1	524	526	PF00082	0.461
CLV_PCSK_KEX2_1	673	675	PF00082	0.552
CLV_PCSK_KEX2_1	684	686	PF00082	0.404
CLV_PCSK_KEX2_1	692	694	PF00082	0.305
CLV_PCSK_KEX2_1	728	730	PF00082	0.535
CLV_PCSK_PC7_1	521	527	PF00082	0.388
CLV_PCSK_SKI1_1	108	112	PF00082	0.395
CLV_PCSK_SKI1_1	181	185	PF00082	0.422
CLV_PCSK_SKI1_1	19	23	PF00082	0.478
CLV_PCSK_SKI1_1	217	221	PF00082	0.607
CLV_PCSK_SKI1_1	610	614	PF00082	0.370
CLV_Separin_Metazoa	382	386	PF03568	0.490
DEG_APCC_DBOX_1	180	188	PF00400	0.389
DEG_APCC_DBOX_1	652	660	PF00400	0.413
DEG_COP1_1	580	588	PF00400	0.418
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DEG_ODPH_VHL_1	483	496	PF01847	0.466
DOC_MAPK_gen_1	116	124	PF00069	0.455
DOC_MAPK_gen_1	542	551	PF00069	0.613
DOC_MAPK_MEF2A_6	117	126	PF00069	0.452
DOC_MAPK_MEF2A_6	460	469	PF00069	0.525
DOC_MAPK_MEF2A_6	597	605	PF00069	0.419
DOC_PP1_RVXF_1	106	112	PF00149	0.400
DOC_PP2B_LxvP_1	134	137	PF13499	0.476
DOC_PP2B_LxvP_1	564	567	PF13499	0.389
DOC_PP2B_LxvP_1	583	586	PF13499	0.342
DOC_USP7_MATH_1	201	205	PF00917	0.763
DOC_USP7_MATH_1	297	301	PF00917	0.680
DOC_USP7_MATH_1	336	340	PF00917	0.463
DOC_USP7_MATH_1	443	447	PF00917	0.463
DOC_USP7_MATH_1	479	483	PF00917	0.609
DOC_USP7_MATH_1	486	490	PF00917	0.523
DOC_USP7_MATH_1	51	55	PF00917	0.485
DOC_USP7_MATH_1	586	590	PF00917	0.605
DOC_USP7_MATH_1	60	64	PF00917	0.700
DOC_USP7_MATH_1	662	666	PF00917	0.506
DOC_USP7_MATH_1	84	88	PF00917	0.685
DOC_USP7_MATH_1	89	93	PF00917	0.713
DOC_WW_Pin1_4	100	105	PF00397	0.464
DOC_WW_Pin1_4	199	204	PF00397	0.561
DOC_WW_Pin1_4	211	216	PF00397	0.455
DOC_WW_Pin1_4	278	283	PF00397	0.720
DOC_WW_Pin1_4	30	35	PF00397	0.497
DOC_WW_Pin1_4	461	466	PF00397	0.646
DOC_WW_Pin1_4	557	562	PF00397	0.433
DOC_WW_Pin1_4	90	95	PF00397	0.569
LIG_14-3-3_CanoR_1	480	484	PF00244	0.526
LIG_14-3-3_CanoR_1	742	748	PF00244	0.434
LIG_Actin_WH2_2	169	187	PF00022	0.463
LIG_Actin_WH2_2	596	612	PF00022	0.461
LIG_Actin_WH2_2	641	659	PF00022	0.399
LIG_BIR_III_2	555	559	PF00653	0.462
LIG_BRCT_BRCA1_1	28	32	PF00533	0.483
LIG_FHA_1	16	22	PF00498	0.424
LIG_FHA_1	239	245	PF00498	0.761
LIG_FHA_1	252	258	PF00498	0.717
LIG_FHA_1	321	327	PF00498	0.610
LIG_FHA_1	335	341	PF00498	0.412
LIG_FHA_1	426	432	PF00498	0.408
LIG_FHA_1	45	51	PF00498	0.583
LIG_FHA_1	468	474	PF00498	0.460
LIG_FHA_1	489	495	PF00498	0.475
LIG_FHA_1	511	517	PF00498	0.516
LIG_FHA_1	578	584	PF00498	0.353
LIG_FHA_1	629	635	PF00498	0.599
LIG_FHA_1	666	672	PF00498	0.395
LIG_FHA_1	74	80	PF00498	0.708
LIG_FHA_2	161	167	PF00498	0.525
LIG_FHA_2	218	224	PF00498	0.598
LIG_FHA_2	251	257	PF00498	0.588
LIG_FHA_2	376	382	PF00498	0.578
LIG_GBD_Chelix_1	601	609	PF00786	0.451
LIG_IRF3_LxIS_1	153	159	PF10401	0.345
LIG_LIR_Apic_2	330	335	PF02991	0.388
LIG_LIR_Gen_1	13	21	PF02991	0.446
LIG_LIR_Gen_1	142	153	PF02991	0.393
LIG_LIR_Gen_1	397	405	PF02991	0.478
LIG_LIR_Nem_3	13	17	PF02991	0.415
LIG_LIR_Nem_3	142	148	PF02991	0.368
LIG_LIR_Nem_3	168	174	PF02991	0.443
LIG_LIR_Nem_3	397	402	PF02991	0.462
LIG_LIR_Nem_3	716	720	PF02991	0.428
LIG_Pex14_2	28	32	PF04695	0.483
LIG_Pex14_2	515	519	PF04695	0.383
LIG_PTB_Apo_2	8	15	PF02174	0.377
LIG_SH2_CRK	179	183	PF00017	0.394
LIG_SH2_CRK	332	336	PF00017	0.435
LIG_SH2_CRK	399	403	PF00017	0.517
LIG_SH2_NCK_1	284	288	PF00017	0.504
LIG_SH2_NCK_1	332	336	PF00017	0.428
LIG_SH2_SRC	65	68	PF00017	0.573
LIG_SH2_STAP1	353	357	PF00017	0.444
LIG_SH2_STAP1	65	69	PF00017	0.601
LIG_SH2_STAT5	120	123	PF00017	0.338
LIG_SH2_STAT5	171	174	PF00017	0.646
LIG_SH3_3	171	177	PF00018	0.539
LIG_SH3_3	200	206	PF00018	0.657
LIG_SH3_3	310	316	PF00018	0.784
LIG_SH3_3	36	42	PF00018	0.568
LIG_SH3_3	442	448	PF00018	0.451
LIG_SH3_3	459	465	PF00018	0.621
LIG_SH3_3	482	488	PF00018	0.562
LIG_SH3_3	555	561	PF00018	0.399
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.413
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.548
LIG_SUMO_SIM_anti_2	580	587	PF11976	0.409
LIG_SUMO_SIM_anti_2	599	604	PF11976	0.357
LIG_SUMO_SIM_par_1	120	125	PF11976	0.340
LIG_SUMO_SIM_par_1	317	324	PF11976	0.548
LIG_SUMO_SIM_par_1	341	349	PF11976	0.418
LIG_SUMO_SIM_par_1	392	397	PF11976	0.454
LIG_SUMO_SIM_par_1	580	587	PF11976	0.365
LIG_SUMO_SIM_par_1	599	604	PF11976	0.492
LIG_TRAF2_1	378	381	PF00917	0.582
LIG_TRFH_1	332	336	PF08558	0.428
MOD_CDC14_SPxK_1	214	217	PF00782	0.576
MOD_CDK_SPxK_1	211	217	PF00069	0.576
MOD_CK1_1	204	210	PF00069	0.628
MOD_CK1_1	30	36	PF00069	0.423
MOD_CK1_1	403	409	PF00069	0.475
MOD_CK1_1	44	50	PF00069	0.332
MOD_CK1_1	665	671	PF00069	0.461
MOD_CK2_1	250	256	PF00069	0.723
MOD_CK2_1	297	303	PF00069	0.674
MOD_CK2_1	30	36	PF00069	0.584
MOD_CK2_1	375	381	PF00069	0.641
MOD_CMANNOS	529	532	PF00535	0.376
MOD_GlcNHglycan	158	161	PF01048	0.397
MOD_GlcNHglycan	266	269	PF01048	0.590
MOD_GlcNHglycan	299	302	PF01048	0.786
MOD_GlcNHglycan	348	351	PF01048	0.431
MOD_GlcNHglycan	402	405	PF01048	0.493
MOD_GlcNHglycan	473	476	PF01048	0.551
MOD_GlcNHglycan	506	509	PF01048	0.463
MOD_GlcNHglycan	610	613	PF01048	0.447
MOD_GlcNHglycan	624	627	PF01048	0.612
MOD_GlcNHglycan	663	667	PF01048	0.463
MOD_GlcNHglycan	67	70	PF01048	0.641
MOD_GlcNHglycan	678	681	PF01048	0.538
MOD_GlcNHglycan	86	89	PF01048	0.688
MOD_GlcNHglycan	98	101	PF01048	0.518
MOD_GSK3_1	15	22	PF00069	0.389
MOD_GSK3_1	156	163	PF00069	0.483
MOD_GSK3_1	201	208	PF00069	0.762
MOD_GSK3_1	26	33	PF00069	0.377
MOD_GSK3_1	364	371	PF00069	0.622
MOD_GSK3_1	400	407	PF00069	0.470
MOD_GSK3_1	461	468	PF00069	0.483
MOD_GSK3_1	486	493	PF00069	0.458
MOD_GSK3_1	567	574	PF00069	0.494
MOD_GSK3_1	96	103	PF00069	0.392
MOD_N-GLC_1	10	15	PF02516	0.309
MOD_N-GLC_1	465	470	PF02516	0.470
MOD_N-GLC_2	501	503	PF02516	0.411
MOD_NEK2_1	26	31	PF00069	0.369
MOD_NEK2_1	344	349	PF00069	0.474
MOD_NEK2_1	432	437	PF00069	0.336
MOD_NEK2_1	471	476	PF00069	0.469
MOD_NEK2_1	496	501	PF00069	0.466
MOD_NEK2_1	601	606	PF00069	0.406
MOD_NEK2_1	96	101	PF00069	0.434
MOD_NEK2_2	160	165	PF00069	0.383
MOD_PIKK_1	321	327	PF00454	0.585
MOD_PIKK_1	496	502	PF00454	0.471
MOD_PK_1	571	577	PF00069	0.447
MOD_PKA_1	742	748	PF00069	0.369
MOD_PKA_2	44	50	PF00069	0.562
MOD_PKA_2	479	485	PF00069	0.625
MOD_PKA_2	570	576	PF00069	0.370
MOD_PKA_2	596	602	PF00069	0.386
MOD_PKB_1	740	748	PF00069	0.375
MOD_Plk_1	10	16	PF00069	0.303
MOD_Plk_1	122	128	PF00069	0.523
MOD_Plk_1	160	166	PF00069	0.527
MOD_Plk_1	167	173	PF00069	0.601
MOD_Plk_1	465	471	PF00069	0.376
MOD_Plk_1	571	577	PF00069	0.417
MOD_Plk_1	586	592	PF00069	0.375
MOD_Plk_2-3	587	593	PF00069	0.484
MOD_Plk_4	10	16	PF00069	0.316
MOD_Plk_4	160	166	PF00069	0.371
MOD_Plk_4	167	173	PF00069	0.488
MOD_Plk_4	596	602	PF00069	0.397
MOD_Plk_4	743	749	PF00069	0.535
MOD_ProDKin_1	100	106	PF00069	0.460
MOD_ProDKin_1	199	205	PF00069	0.566
MOD_ProDKin_1	211	217	PF00069	0.456
MOD_ProDKin_1	278	284	PF00069	0.720
MOD_ProDKin_1	30	36	PF00069	0.498
MOD_ProDKin_1	461	467	PF00069	0.633
MOD_ProDKin_1	557	563	PF00069	0.437
MOD_ProDKin_1	90	96	PF00069	0.558
MOD_SUMO_rev_2	78	84	PF00179	0.611
TRG_DiLeu_BaEn_1	397	402	PF01217	0.484
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.522
TRG_ENDOCYTIC_2	171	174	PF00928	0.637
TRG_ENDOCYTIC_2	179	182	PF00928	0.457
TRG_ENDOCYTIC_2	399	402	PF00928	0.463
TRG_ER_diArg_1	115	117	PF00400	0.452
TRG_ER_diArg_1	179	181	PF00400	0.565
TRG_ER_diArg_1	190	192	PF00400	0.556
TRG_ER_diArg_1	376	379	PF00400	0.545
TRG_ER_diArg_1	384	386	PF00400	0.450
TRG_ER_diArg_1	453	456	PF00400	0.610
TRG_ER_diArg_1	524	526	PF00400	0.461
TRG_ER_diArg_1	672	674	PF00400	0.617
TRG_ER_diArg_1	692	695	PF00400	0.293
TRG_NLS_MonoExtN_4	42	49	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIR5	Leptomonas seymouri	47%	93%
A0A1X0NVW3	Trypanosomatidae	27%	97%
A0A3Q8ICZ9	Leishmania donovani	93%	100%
A0A3R7NQB0	Trypanosoma rangeli	30%	100%
A4HDQ9	Leishmania braziliensis	71%	97%
A4I105	Leishmania infantum	93%	100%
C9ZWA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AX43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%