STOP axonemal protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STOP axonemal protein, putative

Species:

Leishmania major

UniProt:

Q4QAD2_LEIMA

TriTrypDb:

LmjF.24.1980 , LMJLV39_240027500 , LMJSD75_240026800

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QAD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.538
CLV_NRD_NRD_1	129	131	PF00675	0.630
CLV_NRD_NRD_1	57	59	PF00675	0.579
CLV_PCSK_FUR_1	127	131	PF00082	0.666
CLV_PCSK_KEX2_1	129	131	PF00082	0.631
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.663
CLV_PCSK_SKI1_1	167	171	PF00082	0.654
CLV_Separin_Metazoa	151	155	PF03568	0.624
DOC_MAPK_MEF2A_6	248	256	PF00069	0.661
DOC_MAPK_MEF2A_6	27	35	PF00069	0.549
DOC_PP2B_LxvP_1	33	36	PF13499	0.550
DOC_USP7_MATH_1	92	96	PF00917	0.545
LIG_14-3-3_CanoR_1	61	65	PF00244	0.648
LIG_BRCT_BRCA1_1	177	181	PF00533	0.633
LIG_EVH1_1	162	166	PF00568	0.612
LIG_EVH1_2	165	169	PF00568	0.551
LIG_FHA_2	40	46	PF00498	0.501
LIG_FHA_2	75	81	PF00498	0.557
LIG_LIR_Apic_2	222	228	PF02991	0.493
LIG_LIR_Apic_2	255	260	PF02991	0.567
LIG_LIR_Nem_3	178	184	PF02991	0.633
LIG_Pex14_1	121	125	PF04695	0.617
LIG_SH2_CRK	225	229	PF00017	0.518
LIG_SH2_CRK	257	261	PF00017	0.568
LIG_SH2_NCK_1	257	261	PF00017	0.568
LIG_SH2_STAP1	187	191	PF00017	0.463
LIG_SH2_STAT5	142	145	PF00017	0.564
LIG_SH2_STAT5	187	190	PF00017	0.475
LIG_SH2_STAT5	47	50	PF00017	0.533
LIG_SH3_3	133	139	PF00018	0.640
LIG_SH3_3	160	166	PF00018	0.532
LIG_SH3_3	206	212	PF00018	0.664
LIG_SH3_3	239	245	PF00018	0.564
LIG_SUMO_SIM_par_1	207	213	PF11976	0.536
LIG_TRAF2_1	148	151	PF00917	0.556
LIG_TRAF2_1	77	80	PF00917	0.547
MOD_CK1_1	6	12	PF00069	0.581
MOD_CK2_1	64	70	PF00069	0.640
MOD_CK2_1	74	80	PF00069	0.438
MOD_GlcNHglycan	200	203	PF01048	0.653
MOD_GlcNHglycan	221	224	PF01048	0.559
MOD_GlcNHglycan	260	263	PF01048	0.561
MOD_GSK3_1	138	145	PF00069	0.576
MOD_GSK3_1	171	178	PF00069	0.634
MOD_GSK3_1	60	67	PF00069	0.645
MOD_N-GLC_1	125	130	PF02516	0.571
MOD_N-GLC_1	185	190	PF02516	0.544
MOD_NEK2_1	108	113	PF00069	0.503
MOD_NEK2_1	175	180	PF00069	0.636
MOD_NEK2_1	198	203	PF00069	0.663
MOD_NEK2_1	217	222	PF00069	0.495
MOD_NEK2_1	74	79	PF00069	0.507
MOD_NEK2_2	60	65	PF00069	0.697
MOD_PKA_2	60	66	PF00069	0.613
MOD_Plk_1	171	177	PF00069	0.550
MOD_Plk_1	39	45	PF00069	0.499
MOD_Plk_4	138	144	PF00069	0.568
MOD_Plk_4	252	258	PF00069	0.593
MOD_Plk_4	60	66	PF00069	0.649
TRG_DiLeu_BaEn_1	80	85	PF01217	0.656
TRG_NLS_MonoExtN_4	56	62	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS5	Leptomonas seymouri	82%	99%
A0A0S4J038	Bodo saltans	38%	100%
A0A0S4J0F3	Bodo saltans	27%	100%
A0A0S4JWV5	Bodo saltans	32%	98%
A0A1X0NVY6	Trypanosomatidae	61%	100%
A0A3R7MY93	Trypanosoma rangeli	61%	100%
A0A3S7WYJ9	Leishmania donovani	97%	100%
A4HDR0	Leishmania braziliensis	92%	100%
A4I106	Leishmania infantum	97%	100%
C9ZWA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AX44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BF29	Trypanosoma cruzi	60%	89%