Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAD1_LEIMA

TriTrypDb:

LmjF.24.1990 , LMJLV39_240027600 , LMJSD75_240026900

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.589
CLV_C14_Caspase3-7	256	260	PF00656	0.659
CLV_NRD_NRD_1	107	109	PF00675	0.400
CLV_NRD_NRD_1	120	122	PF00675	0.524
CLV_NRD_NRD_1	37	39	PF00675	0.555
CLV_NRD_NRD_1	79	81	PF00675	0.522
CLV_NRD_NRD_1	88	90	PF00675	0.542
CLV_NRD_NRD_1	96	98	PF00675	0.572
CLV_PCSK_KEX2_1	107	109	PF00082	0.400
CLV_PCSK_KEX2_1	37	39	PF00082	0.501
CLV_PCSK_KEX2_1	78	80	PF00082	0.538
CLV_PCSK_KEX2_1	88	90	PF00082	0.537
CLV_PCSK_KEX2_1	95	97	PF00082	0.571
CLV_PCSK_SKI1_1	170	174	PF00082	0.724
CLV_PCSK_SKI1_1	32	36	PF00082	0.420
CLV_PCSK_SKI1_1	79	83	PF00082	0.637
CLV_PCSK_SKI1_1	89	93	PF00082	0.519
CLV_PCSK_SKI1_1	97	101	PF00082	0.522
DOC_MAPK_MEF2A_6	302	309	PF00069	0.638
DOC_PP1_RVXF_1	5	11	PF00149	0.661
DOC_PP2B_LxvP_1	332	335	PF13499	0.575
DOC_USP7_MATH_1	138	142	PF00917	0.582
DOC_USP7_MATH_1	211	215	PF00917	0.656
DOC_USP7_MATH_1	230	234	PF00917	0.419
DOC_USP7_MATH_1	246	250	PF00917	0.725
LIG_14-3-3_CanoR_1	213	220	PF00244	0.678
LIG_14-3-3_CanoR_1	221	226	PF00244	0.534
LIG_14-3-3_CanoR_1	254	258	PF00244	0.659
LIG_14-3-3_CanoR_1	95	100	PF00244	0.641
LIG_BIR_III_4	247	251	PF00653	0.706
LIG_FHA_2	331	337	PF00498	0.534
LIG_FHA_2	98	104	PF00498	0.680
LIG_LIR_Nem_3	51	57	PF02991	0.591
LIG_Pex14_1	180	184	PF04695	0.731
LIG_SH2_CRK	3	7	PF00017	0.586
LIG_SH2_GRB2like	16	19	PF00017	0.628
LIG_SH2_NCK_1	57	61	PF00017	0.497
LIG_SH2_SRC	123	126	PF00017	0.634
LIG_SH2_STAP1	16	20	PF00017	0.593
LIG_SH2_STAT5	11	14	PF00017	0.574
LIG_SH2_STAT5	157	160	PF00017	0.559
LIG_SH2_STAT5	205	208	PF00017	0.578
LIG_SH3_1	165	171	PF00018	0.606
LIG_SH3_2	321	326	PF14604	0.713
LIG_SH3_3	165	171	PF00018	0.624
LIG_SH3_3	318	324	PF00018	0.657
LIG_TRAF2_1	42	45	PF00917	0.595
MOD_CK1_1	106	112	PF00069	0.604
MOD_CK1_1	183	189	PF00069	0.671
MOD_CK1_1	277	283	PF00069	0.625
MOD_CK1_1	297	303	PF00069	0.699
MOD_CK2_1	211	217	PF00069	0.598
MOD_CK2_1	330	336	PF00069	0.555
MOD_CK2_1	65	71	PF00069	0.511
MOD_CK2_1	97	103	PF00069	0.640
MOD_GlcNHglycan	129	132	PF01048	0.649
MOD_GlcNHglycan	140	143	PF01048	0.673
MOD_GlcNHglycan	213	216	PF01048	0.644
MOD_GlcNHglycan	247	251	PF01048	0.712
MOD_GSK3_1	277	284	PF00069	0.644
MOD_GSK3_1	294	301	PF00069	0.615
MOD_GSK3_1	322	329	PF00069	0.682
MOD_GSK3_1	91	98	PF00069	0.670
MOD_N-GLC_1	330	335	PF02516	0.637
MOD_NEK2_1	127	132	PF00069	0.678
MOD_NEK2_1	173	178	PF00069	0.670
MOD_NEK2_1	294	299	PF00069	0.716
MOD_NEK2_1	307	312	PF00069	0.631
MOD_NEK2_1	346	351	PF00069	0.681
MOD_PK_1	30	36	PF00069	0.587
MOD_PKA_1	95	101	PF00069	0.708
MOD_PKA_2	106	112	PF00069	0.554
MOD_PKA_2	253	259	PF00069	0.791
MOD_PKA_2	322	328	PF00069	0.710
MOD_PKA_2	95	101	PF00069	0.718
MOD_PKB_1	95	103	PF00069	0.639
MOD_Plk_1	230	236	PF00069	0.624
MOD_Plk_1	330	336	PF00069	0.536
MOD_Plk_2-3	330	336	PF00069	0.601
MOD_Plk_4	274	280	PF00069	0.628
MOD_Plk_4	346	352	PF00069	0.693
MOD_SUMO_for_1	81	84	PF00179	0.617
MOD_SUMO_rev_2	141	148	PF00179	0.568
TRG_DiLeu_BaEn_4	71	77	PF01217	0.587
TRG_ENDOCYTIC_2	16	19	PF00928	0.615
TRG_ER_diArg_1	107	110	PF00400	0.440
TRG_ER_diArg_1	78	80	PF00400	0.594
TRG_ER_diArg_1	88	90	PF00400	0.569
TRG_ER_diArg_1	95	97	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P5	Leptomonas seymouri	54%	100%
A0A1X0NWD2	Trypanosomatidae	28%	100%
A0A3Q8ID13	Leishmania donovani	91%	100%
A0A422NWQ4	Trypanosoma rangeli	33%	100%
A4HDR1	Leishmania braziliensis	76%	100%
A4I107	Leishmania infantum	94%	100%
C9ZWA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AX45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJJ9	Trypanosoma cruzi	33%	100%