PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QAD0_LEIMA

TriTrypDb:

LmjF.24.2000 , LMJLV39_240027700 , LMJSD75_240027000

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAD0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	11
GO:0001098	basal transcription machinery binding	3	11
GO:0001099	basal RNA polymerase II transcription machinery binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008174	mRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0019899	enzyme binding	3	11
GO:0043175	RNA polymerase core enzyme binding	5	11
GO:0070063	RNA polymerase binding	4	11
GO:0099122	RNA polymerase II C-terminal domain binding	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.460
CLV_C14_Caspase3-7	5	9	PF00656	0.727
CLV_NRD_NRD_1	206	208	PF00675	0.531
CLV_NRD_NRD_1	238	240	PF00675	0.596
CLV_NRD_NRD_1	290	292	PF00675	0.246
CLV_NRD_NRD_1	33	35	PF00675	0.421
CLV_NRD_NRD_1	491	493	PF00675	0.523
CLV_NRD_NRD_1	54	56	PF00675	0.550
CLV_PCSK_FUR_1	204	208	PF00082	0.573
CLV_PCSK_KEX2_1	179	181	PF00082	0.467
CLV_PCSK_KEX2_1	2	4	PF00082	0.623
CLV_PCSK_KEX2_1	206	208	PF00082	0.531
CLV_PCSK_KEX2_1	238	240	PF00082	0.596
CLV_PCSK_KEX2_1	290	292	PF00082	0.246
CLV_PCSK_KEX2_1	33	35	PF00082	0.421
CLV_PCSK_KEX2_1	460	462	PF00082	0.436
CLV_PCSK_KEX2_1	491	493	PF00082	0.568
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.467
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.623
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.488
CLV_PCSK_SKI1_1	21	25	PF00082	0.374
CLV_PCSK_SKI1_1	276	280	PF00082	0.671
CLV_PCSK_SKI1_1	34	38	PF00082	0.406
CLV_PCSK_SKI1_1	402	406	PF00082	0.377
CLV_PCSK_SKI1_1	460	464	PF00082	0.440
CLV_PCSK_SKI1_1	575	579	PF00082	0.562
CLV_PCSK_SKI1_1	67	71	PF00082	0.391
DEG_APCC_DBOX_1	33	41	PF00400	0.505
DEG_COP1_1	579	587	PF00400	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DOC_CKS1_1	214	219	PF01111	0.610
DOC_CKS1_1	339	344	PF01111	0.363
DOC_MAPK_gen_1	287	297	PF00069	0.246
DOC_MAPK_JIP1_4	402	408	PF00069	0.390
DOC_MAPK_MEF2A_6	243	250	PF00069	0.418
DOC_MAPK_MEF2A_6	402	410	PF00069	0.395
DOC_PP1_RVXF_1	45	52	PF00149	0.568
DOC_PP2B_LxvP_1	408	411	PF13499	0.395
DOC_PP2B_LxvP_1	446	449	PF13499	0.382
DOC_PP4_FxxP_1	463	466	PF00568	0.536
DOC_USP7_MATH_1	122	126	PF00917	0.704
DOC_USP7_MATH_1	129	133	PF00917	0.767
DOC_USP7_MATH_1	227	231	PF00917	0.505
DOC_USP7_MATH_1	304	308	PF00917	0.337
DOC_USP7_MATH_1	351	355	PF00917	0.466
DOC_USP7_MATH_1	577	581	PF00917	0.570
DOC_WW_Pin1_4	193	198	PF00397	0.502
DOC_WW_Pin1_4	213	218	PF00397	0.317
DOC_WW_Pin1_4	330	335	PF00397	0.335
DOC_WW_Pin1_4	338	343	PF00397	0.335
DOC_WW_Pin1_4	474	479	PF00397	0.755
DOC_WW_Pin1_4	516	521	PF00397	0.616
DOC_WW_Pin1_4	568	573	PF00397	0.624
DOC_WW_Pin1_4	585	590	PF00397	0.738
DOC_WW_Pin1_4	89	94	PF00397	0.683
LIG_14-3-3_CanoR_1	290	296	PF00244	0.348
LIG_14-3-3_CanoR_1	348	358	PF00244	0.462
LIG_14-3-3_CanoR_1	390	399	PF00244	0.463
LIG_14-3-3_CanoR_1	501	507	PF00244	0.524
LIG_Clathr_ClatBox_1	405	409	PF01394	0.382
LIG_deltaCOP1_diTrp_1	529	538	PF00928	0.406
LIG_FHA_1	292	298	PF00498	0.335
LIG_FHA_1	303	309	PF00498	0.335
LIG_FHA_1	405	411	PF00498	0.388
LIG_FHA_1	558	564	PF00498	0.403
LIG_FHA_2	141	147	PF00498	0.471
LIG_FHA_2	556	562	PF00498	0.423
LIG_LIR_Apic_2	498	503	PF02991	0.473
LIG_LIR_Apic_2	579	585	PF02991	0.590
LIG_LIR_Gen_1	249	260	PF02991	0.486
LIG_LIR_Gen_1	418	428	PF02991	0.387
LIG_LIR_Gen_1	443	450	PF02991	0.359
LIG_LIR_Gen_1	529	539	PF02991	0.378
LIG_LIR_Nem_3	374	380	PF02991	0.355
LIG_LIR_Nem_3	418	424	PF02991	0.374
LIG_LIR_Nem_3	443	447	PF02991	0.352
LIG_LIR_Nem_3	529	534	PF02991	0.383
LIG_LIR_Nem_3	540	546	PF02991	0.386
LIG_LIR_Nem_3	579	584	PF02991	0.541
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.415
LIG_Pex14_2	366	370	PF04695	0.335
LIG_Pex14_2	534	538	PF04695	0.360
LIG_SH2_CRK	500	504	PF00017	0.492
LIG_SH2_CRK	582	586	PF00017	0.599
LIG_SH2_NCK_1	114	118	PF00017	0.384
LIG_SH2_NCK_1	582	586	PF00017	0.511
LIG_SH2_PTP2	444	447	PF00017	0.353
LIG_SH2_STAP1	144	148	PF00017	0.424
LIG_SH2_STAP1	392	396	PF00017	0.560
LIG_SH2_STAP1	412	416	PF00017	0.385
LIG_SH2_STAT3	144	147	PF00017	0.447
LIG_SH2_STAT5	376	379	PF00017	0.322
LIG_SH2_STAT5	444	447	PF00017	0.356
LIG_SH2_STAT5	545	548	PF00017	0.378
LIG_SH3_3	228	234	PF00018	0.451
LIG_SH3_3	245	251	PF00018	0.315
LIG_SH3_3	393	399	PF00018	0.553
LIG_SH3_3	73	79	PF00018	0.561
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.514
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.356
LIG_SUMO_SIM_par_1	402	407	PF11976	0.393
LIG_TYR_ITIM	442	447	PF00017	0.425
LIG_WRC_WIRS_1	578	583	PF05994	0.481
MOD_CDK_SPxxK_3	568	575	PF00069	0.608
MOD_CK1_1	153	159	PF00069	0.525
MOD_CK1_1	266	272	PF00069	0.534
MOD_CK1_1	349	355	PF00069	0.306
MOD_CK1_1	379	385	PF00069	0.335
MOD_CK1_1	430	436	PF00069	0.530
MOD_CK1_1	472	478	PF00069	0.740
MOD_CK1_1	89	95	PF00069	0.660
MOD_CK2_1	140	146	PF00069	0.608
MOD_CK2_1	502	508	PF00069	0.583
MOD_CK2_1	555	561	PF00069	0.419
MOD_GlcNHglycan	107	110	PF01048	0.468
MOD_GlcNHglycan	125	128	PF01048	0.581
MOD_GlcNHglycan	132	135	PF01048	0.781
MOD_GlcNHglycan	161	164	PF01048	0.563
MOD_GlcNHglycan	279	282	PF01048	0.653
MOD_GlcNHglycan	348	351	PF01048	0.246
MOD_GlcNHglycan	367	370	PF01048	0.335
MOD_GlcNHglycan	381	384	PF01048	0.335
MOD_GlcNHglycan	429	432	PF01048	0.580
MOD_GlcNHglycan	478	481	PF01048	0.644
MOD_GlcNHglycan	93	96	PF01048	0.697
MOD_GSK3_1	123	130	PF00069	0.689
MOD_GSK3_1	467	474	PF00069	0.679
MOD_GSK3_1	585	592	PF00069	0.702
MOD_N-GLC_1	156	161	PF02516	0.574
MOD_N-GLC_1	173	178	PF02516	0.293
MOD_NEK2_1	1	6	PF00069	0.727
MOD_NEK2_1	432	437	PF00069	0.626
MOD_NEK2_2	577	582	PF00069	0.568
MOD_PIKK_1	311	317	PF00454	0.246
MOD_PIKK_1	68	74	PF00454	0.437
MOD_PK_1	150	156	PF00069	0.490
MOD_PKA_1	2	8	PF00069	0.734
MOD_PKA_1	290	296	PF00069	0.246
MOD_PKA_2	2	8	PF00069	0.734
MOD_PKA_2	290	296	PF00069	0.346
MOD_Plk_1	150	156	PF00069	0.424
MOD_Plk_1	173	179	PF00069	0.550
MOD_Plk_1	227	233	PF00069	0.473
MOD_Plk_2-3	140	146	PF00069	0.614
MOD_Plk_4	291	297	PF00069	0.384
MOD_Plk_4	577	583	PF00069	0.461
MOD_ProDKin_1	193	199	PF00069	0.505
MOD_ProDKin_1	213	219	PF00069	0.307
MOD_ProDKin_1	330	336	PF00069	0.335
MOD_ProDKin_1	338	344	PF00069	0.335
MOD_ProDKin_1	474	480	PF00069	0.748
MOD_ProDKin_1	516	522	PF00069	0.617
MOD_ProDKin_1	568	574	PF00069	0.610
MOD_ProDKin_1	585	591	PF00069	0.739
MOD_ProDKin_1	89	95	PF00069	0.678
MOD_SUMO_rev_2	394	404	PF00179	0.450
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.512
TRG_ENDOCYTIC_2	262	265	PF00928	0.420
TRG_ENDOCYTIC_2	325	328	PF00928	0.335
TRG_ENDOCYTIC_2	444	447	PF00928	0.353
TRG_ENDOCYTIC_2	543	546	PF00928	0.371
TRG_ER_diArg_1	203	206	PF00400	0.552
TRG_ER_diArg_1	237	239	PF00400	0.548
TRG_ER_diArg_1	32	34	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II31	Leptomonas seymouri	63%	99%
A0A1X0NXA7	Trypanosomatidae	45%	100%
A0A3Q8IBG9	Leishmania donovani	94%	100%
A0A422NWV1	Trypanosoma rangeli	47%	100%
A4HDR2	Leishmania braziliensis	84%	100%
A4I108	Leishmania infantum	94%	100%
C9ZWA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AX46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BAG8	Trypanosoma cruzi	46%	100%