BolA-like protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

BolA-like protein 3

Gene product:

BolA-like protein, putative

Species:

Leishmania major

UniProt:

Q4QAC6_LEIMA

TriTrypDb:

LmjF.24.2040 , LMJLV39_240028100 , LMJSD75_240027400

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QAC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAC6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	2
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DOC_CDC14_PxL_1	2	10	PF14671	0.543
DOC_USP7_MATH_1	29	33	PF00917	0.484
DOC_WW_Pin1_4	49	54	PF00397	0.486
LIG_14-3-3_CanoR_1	65	71	PF00244	0.473
LIG_Actin_WH2_2	14	30	PF00022	0.488
LIG_BRCT_BRCA1_1	51	55	PF00533	0.484
LIG_FHA_2	11	17	PF00498	0.438
LIG_LIR_Nem_3	44	48	PF02991	0.484
LIG_SH2_NCK_1	12	16	PF00017	0.493
LIG_SH2_STAT5	12	15	PF00017	0.491
LIG_SUMO_SIM_par_1	34	39	PF11976	0.457
MOD_CK2_1	66	72	PF00069	0.513
MOD_GlcNHglycan	37	41	PF01048	0.386
MOD_NEK2_1	66	71	PF00069	0.482
MOD_NEK2_2	29	34	PF00069	0.457
MOD_NEK2_2	41	46	PF00069	0.468
MOD_Plk_1	73	79	PF00069	0.518
MOD_Plk_4	41	47	PF00069	0.477
MOD_Plk_4	56	62	PF00069	0.535
MOD_Plk_4	66	72	PF00069	0.484
MOD_ProDKin_1	49	55	PF00069	0.486
MOD_SUMO_for_1	19	22	PF00179	0.553
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.544
TRG_NES_CRM1_1	25	37	PF08389	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX7	Leptomonas seymouri	85%	100%
A0A0S4IUF9	Bodo saltans	52%	97%
A0A3Q8IC84	Leishmania donovani	95%	100%
A4HDR6	Leishmania braziliensis	88%	94%
A4I112	Leishmania infantum	95%	100%
C9ZW98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AX50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14280	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P39724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	75%
P53082	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	73%
Q3SZ84	Bos taurus	34%	80%
Q53S33	Homo sapiens	34%	82%
Q8CEI1	Mus musculus	33%	80%
Q9FIC3	Arabidopsis thaliana	43%	95%
Q9USK1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	76%