Putative 60S ribosomal protein L26

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L26, putative

Species:

Leishmania major

UniProt:

Q4QAC5_LEIMA

TriTrypDb:

LmjF.35.1670 , LMJLV39_240028300 , LMJSD75_240027600

Length:

143

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L26

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 24

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	12
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0044391	ribosomal subunit	3	12
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4QAC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAC5

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	2
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044085	cellular component biogenesis	3	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.309
CLV_NRD_NRD_1	117	119	PF00675	0.309
CLV_NRD_NRD_1	13	15	PF00675	0.309
CLV_NRD_NRD_1	24	26	PF00675	0.181
CLV_NRD_NRD_1	47	49	PF00675	0.329
CLV_NRD_NRD_1	9	11	PF00675	0.309
CLV_PCSK_KEX2_1	13	15	PF00082	0.309
CLV_PCSK_KEX2_1	24	26	PF00082	0.181
CLV_PCSK_KEX2_1	56	58	PF00082	0.265
CLV_PCSK_KEX2_1	9	11	PF00082	0.309
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.264
CLV_PCSK_PC7_1	9	15	PF00082	0.309
CLV_PCSK_SKI1_1	113	117	PF00082	0.306
CLV_PCSK_SKI1_1	24	28	PF00082	0.309
DOC_MAPK_gen_1	48	55	PF00069	0.329
DOC_MAPK_gen_1	72	79	PF00069	0.464
DOC_PP1_RVXF_1	70	76	PF00149	0.464
DOC_PP4_FxxP_1	17	20	PF00568	0.309
DOC_USP7_MATH_1	87	91	PF00917	0.438
DOC_USP7_UBL2_3	127	131	PF12436	0.578
LIG_14-3-3_CanoR_1	25	31	PF00244	0.309
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_FHA_1	89	95	PF00498	0.311
LIG_SUMO_SIM_par_1	75	80	PF11976	0.473
MOD_CK1_1	122	128	PF00069	0.575
MOD_CK2_1	111	117	PF00069	0.479
MOD_CK2_1	96	102	PF00069	0.309
MOD_GlcNHglycan	132	135	PF01048	0.680
MOD_GlcNHglycan	28	31	PF01048	0.309
MOD_GSK3_1	26	33	PF00069	0.309
MOD_N-GLC_1	87	92	PF02516	0.329
MOD_NEK2_1	106	111	PF00069	0.433
MOD_PKA_1	56	62	PF00069	0.503
MOD_PKA_2	111	117	PF00069	0.366
MOD_PKA_2	120	126	PF00069	0.487
MOD_PKA_2	56	62	PF00069	0.545
MOD_Plk_4	111	117	PF00069	0.353
TRG_ER_diArg_1	23	25	PF00400	0.318
TRG_NLS_MonoExtC_3	9	14	PF00514	0.309
TRG_NLS_MonoExtN_4	9	14	PF00514	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J234	Bodo saltans	86%	100%
A0A1D8PCQ5	Candida albicans (strain SC5314 / ATCC MYA-2876)	57%	100%
A0A1X0NWK2	Trypanosomatidae	89%	100%
A0A3Q8II69	Leishmania donovani	100%	100%
A0A422NWT6	Trypanosoma rangeli	87%	100%
A0B9V9	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	45%	100%
A0RVY4	Cenarchaeum symbiosum (strain A)	36%	86%
A1RS05	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	37%	100%
A1RWS4	Thermofilum pendens (strain DSM 2475 / Hrk 5)	43%	100%
A2BMD0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	46%	96%
A2SPL3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	40%	100%
A3CT08	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	44%	100%
A3DNB8	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	41%	94%
A3MWZ8	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	40%	100%
A4FWB0	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	47%	100%
A4HDR7	Leishmania braziliensis	97%	100%
A4I114	Leishmania infantum	100%	100%
A4WLL3	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	39%	100%
A4YCX7	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	43%	100%
A6UQ55	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	46%	100%
A6UWU9	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	43%	100%
A6VGZ6	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	47%	100%
A7I5Q0	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	40%	100%
A8ACD3	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	43%	100%
A8MB21	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	43%	100%
A9A5I4	Nitrosopumilus maritimus (strain SCM1)	40%	85%
B1L777	Korarchaeum cryptofilum (strain OPF8)	47%	100%
C9ZW97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
C9ZZH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AX51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B645	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O05633	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	38%	100%
O26122	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O28365	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	47%	100%
O59429	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	50%	100%
P05743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P10972	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	38%	100%
P12749	Rattus norvegicus	62%	99%
P14034	Methanococcus vannielii	46%	100%
P47832	Gallus gallus	66%	100%
P51414	Arabidopsis thaliana	59%	98%
P53221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P54038	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	47%	100%
P60663	Nanoarchaeum equitans (strain Kin4-M)	35%	100%
P61254	Homo sapiens	63%	99%
P61255	Mus musculus	63%	99%
P61256	Macaca fascicularis	63%	99%
P61257	Bos taurus	63%	99%
P78946	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
Q0W1X7	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	41%	100%
Q12ZU0	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	45%	100%
Q18GG0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	37%	100%
Q19869	Caenorhabditis elegans	64%	100%
Q23F79	Tetrahymena thermophila (strain SB210)	54%	100%
Q2FT34	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	41%	100%
Q2I0I6	Ailuropoda melanoleuca	59%	99%
Q2NFW8	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	40%	100%
Q39411	Brassica campestris	55%	98%
Q3IMX7	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	36%	100%
Q46GA6	Methanosarcina barkeri (strain Fusaro / DSM 804)	44%	100%
Q54QM8	Dictyostelium discoideum	60%	100%
Q5JJF9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	47%	100%
Q6LXE2	Methanococcus maripaludis (strain S2 / LL)	47%	100%
Q8PV39	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	41%	100%
Q8TRT6	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	41%	100%
Q8TW19	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	45%	96%
Q8U010	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	49%	100%
Q8ZTD4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	39%	100%
Q95WA0	Littorina littorea	58%	99%
Q975J1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	42%	100%
Q9FJX2	Arabidopsis thaliana	63%	98%
Q9UNX3	Homo sapiens	64%	99%
Q9UX95	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	36%	100%
Q9V1U7	Pyrococcus abyssi (strain GE5 / Orsay)	47%	100%
Q9YF83	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	52%	100%