UBC core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme, putative

Species:

Leishmania major

UniProt:

Q4QAB6_LEIMA

TriTrypDb:

LmjF.24.2140 , LMJLV39_240029200 , LMJSD75_240028500

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAB6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.559
CLV_NRD_NRD_1	258	260	PF00675	0.449
CLV_NRD_NRD_1	26	28	PF00675	0.417
CLV_NRD_NRD_1	263	265	PF00675	0.391
CLV_PCSK_KEX2_1	197	199	PF00082	0.527
CLV_PCSK_KEX2_1	258	260	PF00082	0.449
CLV_PCSK_KEX2_1	26	28	PF00082	0.411
CLV_PCSK_KEX2_1	263	265	PF00082	0.391
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.508
CLV_PCSK_PC7_1	254	260	PF00082	0.566
CLV_PCSK_SKI1_1	197	201	PF00082	0.507
CLV_PCSK_SKI1_1	226	230	PF00082	0.336
CLV_PCSK_SKI1_1	264	268	PF00082	0.433
CLV_PCSK_SKI1_1	27	31	PF00082	0.478
CLV_PCSK_SKI1_1	317	321	PF00082	0.603
CLV_PCSK_SKI1_1	67	71	PF00082	0.481
DEG_APCC_DBOX_1	316	324	PF00400	0.529
DOC_CKS1_1	98	103	PF01111	0.587
DOC_CYCLIN_RxL_1	16	28	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.381
DOC_MAPK_DCC_7	132	142	PF00069	0.414
DOC_MAPK_gen_1	197	203	PF00069	0.440
DOC_MAPK_gen_1	26	32	PF00069	0.518
DOC_MAPK_MEF2A_6	214	222	PF00069	0.468
DOC_PP1_RVXF_1	224	230	PF00149	0.375
DOC_PP2B_LxvP_1	70	73	PF13499	0.392
DOC_PP4_FxxP_1	135	138	PF00568	0.300
DOC_USP7_MATH_1	145	149	PF00917	0.325
DOC_USP7_MATH_1	190	194	PF00917	0.681
DOC_USP7_MATH_1	38	42	PF00917	0.536
DOC_USP7_MATH_2	231	237	PF00917	0.448
DOC_WW_Pin1_4	110	115	PF00397	0.281
DOC_WW_Pin1_4	179	184	PF00397	0.684
DOC_WW_Pin1_4	188	193	PF00397	0.674
DOC_WW_Pin1_4	39	44	PF00397	0.628
DOC_WW_Pin1_4	4	9	PF00397	0.610
DOC_WW_Pin1_4	81	86	PF00397	0.706
DOC_WW_Pin1_4	97	102	PF00397	0.428
LIG_14-3-3_CanoR_1	214	218	PF00244	0.369
LIG_14-3-3_CanoR_1	239	244	PF00244	0.504
LIG_14-3-3_CanoR_1	263	273	PF00244	0.459
LIG_Actin_WH2_2	52	69	PF00022	0.568
LIG_APCC_ABBA_1	200	205	PF00400	0.370
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.508
LIG_FHA_1	141	147	PF00498	0.478
LIG_FHA_1	265	271	PF00498	0.457
LIG_FHA_1	302	308	PF00498	0.665
LIG_FHA_1	314	320	PF00498	0.457
LIG_FHA_1	61	67	PF00498	0.488
LIG_FHA_1	82	88	PF00498	0.563
LIG_FHA_2	189	195	PF00498	0.581
LIG_FHA_2	40	46	PF00498	0.684
LIG_LIR_Gen_1	204	215	PF02991	0.449
LIG_LIR_Nem_3	102	108	PF02991	0.324
LIG_LIR_Nem_3	17	23	PF02991	0.482
LIG_LIR_Nem_3	204	210	PF02991	0.384
LIG_Pex14_2	125	129	PF04695	0.386
LIG_Pex14_2	288	292	PF04695	0.600
LIG_SH2_NCK_1	207	211	PF00017	0.495
LIG_SH2_STAP1	315	319	PF00017	0.615
LIG_SH2_STAT5	126	129	PF00017	0.364
LIG_SH2_STAT5	18	21	PF00017	0.450
LIG_SH2_STAT5	24	27	PF00017	0.347
LIG_SH2_STAT5	279	282	PF00017	0.491
LIG_SH2_STAT5	315	318	PF00017	0.613
LIG_SH2_STAT5	76	79	PF00017	0.543
LIG_SH3_3	108	114	PF00018	0.359
LIG_SH3_3	124	130	PF00018	0.256
LIG_SH3_3	131	137	PF00018	0.325
LIG_SH3_3	196	202	PF00018	0.495
LIG_SH3_4	274	281	PF00018	0.594
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.600
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.383
LIG_SUMO_SIM_par_1	138	143	PF11976	0.337
LIG_SUMO_SIM_par_1	28	34	PF11976	0.518
LIG_TRAF2_1	202	205	PF00917	0.492
LIG_TRAF2_1	43	46	PF00917	0.651
LIG_WW_1	73	76	PF00397	0.532
MOD_CDC14_SPxK_1	182	185	PF00782	0.637
MOD_CDK_SPxK_1	179	185	PF00069	0.636
MOD_CDK_SPxxK_3	113	120	PF00069	0.325
MOD_CK1_1	113	119	PF00069	0.403
MOD_CK1_1	12	18	PF00069	0.562
MOD_CK1_1	171	177	PF00069	0.673
MOD_CK1_1	188	194	PF00069	0.609
MOD_CK1_1	237	243	PF00069	0.615
MOD_CK1_1	39	45	PF00069	0.691
MOD_CK1_1	4	10	PF00069	0.711
MOD_CK1_1	58	64	PF00069	0.388
MOD_CK2_1	188	194	PF00069	0.593
MOD_CK2_1	39	45	PF00069	0.716
MOD_GlcNHglycan	163	166	PF01048	0.652
MOD_GlcNHglycan	170	173	PF01048	0.684
MOD_GlcNHglycan	246	251	PF01048	0.547
MOD_GlcNHglycan	38	41	PF01048	0.607
MOD_GlcNHglycan	63	66	PF01048	0.532
MOD_GlcNHglycan	89	93	PF01048	0.593
MOD_GSK3_1	168	175	PF00069	0.697
MOD_GSK3_1	186	193	PF00069	0.662
MOD_GSK3_1	233	240	PF00069	0.491
MOD_GSK3_1	301	308	PF00069	0.736
MOD_GSK3_1	51	58	PF00069	0.756
MOD_GSK3_1	79	86	PF00069	0.659
MOD_LATS_1	110	116	PF00433	0.343
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	19	24	PF00069	0.381
MOD_NEK2_1	213	218	PF00069	0.377
MOD_NEK2_1	30	35	PF00069	0.421
MOD_NEK2_2	192	197	PF00069	0.543
MOD_PIKK_1	264	270	PF00454	0.441
MOD_PK_1	51	57	PF00069	0.655
MOD_PKA_2	213	219	PF00069	0.375
MOD_PKA_2	238	244	PF00069	0.497
MOD_PKA_2	262	268	PF00069	0.429
MOD_Plk_2-3	305	311	PF00069	0.751
MOD_Plk_4	213	219	PF00069	0.375
MOD_ProDKin_1	110	116	PF00069	0.281
MOD_ProDKin_1	179	185	PF00069	0.686
MOD_ProDKin_1	188	194	PF00069	0.672
MOD_ProDKin_1	39	45	PF00069	0.632
MOD_ProDKin_1	4	10	PF00069	0.609
MOD_ProDKin_1	81	87	PF00069	0.709
MOD_ProDKin_1	97	103	PF00069	0.424
TRG_AP2beta_CARGO_1	17	27	PF09066	0.506
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.460
TRG_ENDOCYTIC_2	126	129	PF00928	0.326
TRG_ENDOCYTIC_2	207	210	PF00928	0.380
TRG_ER_diArg_1	25	27	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S2	Leptomonas seymouri	50%	100%
A0A1X0NWL0	Trypanosomatidae	33%	100%
A0A3Q8ID23	Leishmania donovani	91%	100%
A0A3S5IS47	Trypanosoma rangeli	35%	100%
A4HDS5	Leishmania braziliensis	73%	100%
A4I123	Leishmania infantum	91%	100%
E9AX60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BEA3	Trypanosoma cruzi	33%	100%