DUF4780 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAB1_LEIMA

TriTrypDb:

LmjF.24.2190 , LMJLV39_240029800 , LMJSD75_240029100

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0016020	membrane	2	8
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QAB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.372
CLV_NRD_NRD_1	123	125	PF00675	0.593
CLV_NRD_NRD_1	177	179	PF00675	0.635
CLV_NRD_NRD_1	65	67	PF00675	0.464
CLV_PCSK_KEX2_1	123	125	PF00082	0.567
CLV_PCSK_KEX2_1	13	15	PF00082	0.476
CLV_PCSK_KEX2_1	177	179	PF00082	0.589
CLV_PCSK_KEX2_1	192	194	PF00082	0.450
CLV_PCSK_KEX2_1	50	52	PF00082	0.487
CLV_PCSK_KEX2_1	65	67	PF00082	0.450
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.549
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.531
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.421
CLV_PCSK_PC7_1	46	52	PF00082	0.424
CLV_PCSK_SKI1_1	115	119	PF00082	0.603
CLV_PCSK_SKI1_1	167	171	PF00082	0.654
DEG_SPOP_SBC_1	109	113	PF00917	0.375
DOC_CKS1_1	185	190	PF01111	0.340
DOC_MAPK_gen_1	175	185	PF00069	0.370
DOC_PP1_RVXF_1	178	185	PF00149	0.294
DOC_PP2B_LxvP_1	170	173	PF13499	0.337
DOC_USP7_MATH_1	159	163	PF00917	0.341
DOC_USP7_MATH_1	214	218	PF00917	0.405
DOC_USP7_MATH_1	24	28	PF00917	0.708
DOC_USP7_MATH_1	49	53	PF00917	0.617
DOC_WW_Pin1_4	184	189	PF00397	0.377
DOC_WW_Pin1_4	20	25	PF00397	0.672
DOC_WW_Pin1_4	222	227	PF00397	0.447
DOC_WW_Pin1_4	88	93	PF00397	0.553
DOC_WW_Pin1_4	94	99	PF00397	0.454
LIG_14-3-3_CanoR_1	101	109	PF00244	0.399
LIG_14-3-3_CanoR_1	193	199	PF00244	0.365
LIG_14-3-3_CanoR_1	218	222	PF00244	0.334
LIG_BIR_II_1	1	5	PF00653	0.802
LIG_BIR_III_2	95	99	PF00653	0.467
LIG_BRCT_BRCA1_1	140	144	PF00533	0.372
LIG_EH1_1	237	245	PF00400	0.355
LIG_FHA_1	111	117	PF00498	0.391
LIG_FHA_1	218	224	PF00498	0.408
LIG_FHA_1	70	76	PF00498	0.391
LIG_FHA_2	135	141	PF00498	0.369
LIG_FHA_2	184	190	PF00498	0.375
LIG_NRBOX	85	91	PF00104	0.286
LIG_PALB2_WD40_1	66	74	PF16756	0.394
LIG_PDZ_Class_1	242	247	PF00595	0.361
LIG_SH3_3	151	157	PF00018	0.302
LIG_SH3_3	182	188	PF00018	0.330
LIG_SUMO_SIM_par_1	219	225	PF11976	0.346
LIG_TRAF2_1	97	100	PF00917	0.358
LIG_ULM_U2AF65_1	65	70	PF00076	0.581
MOD_CDK_SPxxK_3	222	229	PF00069	0.332
MOD_CDK_SPxxK_3	94	101	PF00069	0.406
MOD_CK1_1	122	128	PF00069	0.338
MOD_CK1_1	208	214	PF00069	0.426
MOD_CK1_1	217	223	PF00069	0.305
MOD_CK1_1	225	231	PF00069	0.294
MOD_CK1_1	27	33	PF00069	0.708
MOD_CK2_1	183	189	PF00069	0.355
MOD_CK2_1	194	200	PF00069	0.310
MOD_CK2_1	29	35	PF00069	0.596
MOD_CK2_1	94	100	PF00069	0.544
MOD_Cter_Amidation	175	178	PF01082	0.545
MOD_GlcNHglycan	127	130	PF01048	0.546
MOD_GlcNHglycan	148	151	PF01048	0.572
MOD_GlcNHglycan	207	210	PF01048	0.672
MOD_GlcNHglycan	29	32	PF01048	0.461
MOD_GlcNHglycan	43	46	PF01048	0.555
MOD_GlcNHglycan	6	9	PF01048	0.560
MOD_GlcNHglycan	92	95	PF01048	0.684
MOD_GSK3_1	134	141	PF00069	0.444
MOD_GSK3_1	2	9	PF00069	0.812
MOD_GSK3_1	20	27	PF00069	0.569
MOD_GSK3_1	35	42	PF00069	0.686
MOD_GSK3_1	90	97	PF00069	0.433
MOD_N-GLC_2	179	181	PF02516	0.506
MOD_NEK2_1	232	237	PF00069	0.407
MOD_PIKK_1	143	149	PF00454	0.339
MOD_PIKK_1	39	45	PF00454	0.619
MOD_PKA_2	122	128	PF00069	0.416
MOD_PKA_2	217	223	PF00069	0.326
MOD_PKA_2	27	33	PF00069	0.721
MOD_Plk_4	208	214	PF00069	0.414
MOD_Plk_4	217	223	PF00069	0.318
MOD_ProDKin_1	184	190	PF00069	0.375
MOD_ProDKin_1	20	26	PF00069	0.669
MOD_ProDKin_1	222	228	PF00069	0.447
MOD_ProDKin_1	88	94	PF00069	0.555
MOD_SUMO_rev_2	30	38	PF00179	0.616
MOD_SUMO_rev_2	42	52	PF00179	0.697
MOD_SUMO_rev_2	54	61	PF00179	0.602
TRG_ER_diArg_1	14	17	PF00400	0.664
TRG_ER_diArg_1	177	180	PF00400	0.431
TRG_ER_diArg_1	64	66	PF00400	0.593
TRG_NLS_MonoExtC_3	11	16	PF00514	0.705
TRG_NLS_MonoExtN_4	12	17	PF00514	0.753
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II61	Leptomonas seymouri	52%	96%
A0A1X0NXC1	Trypanosomatidae	32%	100%
A0A3Q8IC37	Leishmania donovani	86%	100%
A0A422MRD3	Trypanosoma rangeli	36%	100%
A4HDT0	Leishmania braziliensis	73%	99%
A4I128	Leishmania infantum	85%	100%
C9ZW81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AX65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%