PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAB0_LEIMA

TriTrypDb:

LmjF.24.2200 , LMJLV39_240029900 , LMJSD75_240029200

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.689
CLV_NRD_NRD_1	209	211	PF00675	0.579
CLV_NRD_NRD_1	239	241	PF00675	0.685
CLV_PCSK_KEX2_1	209	211	PF00082	0.453
CLV_PCSK_KEX2_1	239	241	PF00082	0.475
CLV_PCSK_KEX2_1	86	88	PF00082	0.302
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.394
CLV_PCSK_SKI1_1	122	126	PF00082	0.626
CLV_PCSK_SKI1_1	219	223	PF00082	0.722
CLV_PCSK_SKI1_1	239	243	PF00082	0.463
CLV_PCSK_SKI1_1	83	87	PF00082	0.390
CLV_Separin_Metazoa	184	188	PF03568	0.352
DOC_AGCK_PIF_1	161	166	PF00069	0.576
DOC_CYCLIN_RxL_1	213	226	PF00134	0.678
DOC_CYCLIN_RxL_1	236	245	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	241	244	PF00134	0.430
DOC_PP1_SILK_1	63	68	PF00149	0.238
DOC_PP2B_LxvP_1	241	244	PF13499	0.707
DOC_PP4_FxxP_1	217	220	PF00568	0.493
DOC_PP4_MxPP_1	1	4	PF00568	0.491
DOC_USP7_MATH_1	231	235	PF00917	0.755
LIG_14-3-3_CanoR_1	187	196	PF00244	0.355
LIG_ActinCP_TwfCPI_2	217	227	PF01115	0.474
LIG_eIF4E_1	164	170	PF01652	0.337
LIG_FHA_1	121	127	PF00498	0.622
LIG_FHA_1	165	171	PF00498	0.283
LIG_FHA_1	61	67	PF00498	0.289
LIG_LIR_Gen_1	114	125	PF02991	0.539
LIG_LIR_Gen_1	165	172	PF02991	0.277
LIG_LIR_Gen_1	60	70	PF02991	0.309
LIG_LIR_Nem_3	114	120	PF02991	0.535
LIG_LIR_Nem_3	165	169	PF02991	0.277
LIG_LIR_Nem_3	60	65	PF02991	0.297
LIG_Pex14_1	18	22	PF04695	0.504
LIG_SH2_NCK_1	110	114	PF00017	0.430
LIG_SH2_SRC	110	113	PF00017	0.424
LIG_SH2_STAP1	166	170	PF00017	0.337
LIG_SH2_STAP1	181	185	PF00017	0.326
LIG_SH2_STAT3	26	29	PF00017	0.515
LIG_SH2_STAT5	164	167	PF00017	0.300
LIG_SH3_3	157	163	PF00018	0.516
LIG_SUMO_SIM_par_1	200	206	PF11976	0.582
LIG_TRAF2_1	137	140	PF00917	0.616
LIG_TRAF2_1	50	53	PF00917	0.394
LIG_WRC_WIRS_1	117	122	PF05994	0.590
LIG_WRC_WIRS_1	232	237	PF05994	0.440
MOD_CK1_1	60	66	PF00069	0.376
MOD_Cter_Amidation	207	210	PF01082	0.432
MOD_GlcNHglycan	140	143	PF01048	0.658
MOD_GlcNHglycan	222	225	PF01048	0.571
MOD_GlcNHglycan	229	232	PF01048	0.556
MOD_GlcNHglycan	5	8	PF01048	0.553
MOD_GSK3_1	116	123	PF00069	0.635
MOD_GSK3_1	227	234	PF00069	0.580
MOD_GSK3_1	57	64	PF00069	0.426
MOD_N-GLC_1	57	62	PF02516	0.337
MOD_NEK2_1	120	125	PF00069	0.619
MOD_NEK2_1	235	240	PF00069	0.712
MOD_NEK2_1	46	51	PF00069	0.282
MOD_NEK2_1	57	62	PF00069	0.261
MOD_PIKK_1	194	200	PF00454	0.394
MOD_PKB_1	136	144	PF00069	0.485
MOD_Plk_1	57	63	PF00069	0.328
MOD_Plk_4	120	126	PF00069	0.692
MOD_Plk_4	61	67	PF00069	0.299
MOD_SUMO_for_1	85	88	PF00179	0.394
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.514
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.432
TRG_ENDOCYTIC_2	110	113	PF00928	0.587
TRG_ENDOCYTIC_2	166	169	PF00928	0.299
TRG_ER_diArg_1	135	138	PF00400	0.616
TRG_ER_diArg_1	239	241	PF00400	0.432
TRG_NES_CRM1_1	114	127	PF08389	0.664
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ2	Leptomonas seymouri	76%	99%
A0A0N1I1J7	Leptomonas seymouri	26%	88%
A0A0S4KKY6	Bodo saltans	49%	100%
A0A1X0NXK5	Trypanosomatidae	62%	100%
A0A1X0P0D8	Trypanosomatidae	23%	78%
A0A3Q8IF22	Leishmania donovani	96%	100%
A0A3Q8IJ22	Leishmania donovani	23%	88%
A0A3R7KPI7	Trypanosoma rangeli	25%	88%
A4HDT1	Leishmania braziliensis	87%	100%
A4I129	Leishmania infantum	96%	100%
A4IDQ9	Leishmania infantum	23%	88%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ATR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	88%
E9AX66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0T2	Leishmania major	23%	88%
V5DLI8	Trypanosoma cruzi	24%	81%