ATPase_AAA_core domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QAA8_LEIMA

TriTrypDb:

LmjF.24.2220 , LMJLV39_240030100 , LMJSD75_240029400

Length:

397

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 9
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QAA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAA8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	369	371	PF00675	0.325
CLV_NRD_NRD_1	47	49	PF00675	0.646
CLV_PCSK_FUR_1	80	84	PF00082	0.539
CLV_PCSK_KEX2_1	369	371	PF00082	0.325
CLV_PCSK_KEX2_1	82	84	PF00082	0.535
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.580
CLV_PCSK_SKI1_1	242	246	PF00082	0.411
CLV_PCSK_SKI1_1	316	320	PF00082	0.394
CLV_PCSK_SKI1_1	51	55	PF00082	0.640
DEG_APCC_DBOX_1	102	110	PF00400	0.311
DOC_CYCLIN_RxL_1	238	246	PF00134	0.567
DOC_CYCLIN_RxL_1	313	322	PF00134	0.538
DOC_MAPK_DCC_7	168	176	PF00069	0.315
DOC_MAPK_gen_1	125	134	PF00069	0.380
DOC_MAPK_gen_1	369	375	PF00069	0.515
DOC_MAPK_MEF2A_6	127	136	PF00069	0.374
DOC_MAPK_MEF2A_6	168	176	PF00069	0.396
DOC_MAPK_MEF2A_6	268	277	PF00069	0.525
DOC_MAPK_MEF2A_6	6	14	PF00069	0.462
DOC_PP1_RVXF_1	323	330	PF00149	0.589
DOC_PP2B_LxvP_1	18	21	PF13499	0.439
DOC_PP4_FxxP_1	23	26	PF00568	0.391
DOC_USP7_MATH_1	143	147	PF00917	0.416
DOC_USP7_MATH_1	38	42	PF00917	0.330
DOC_WW_Pin1_4	202	207	PF00397	0.373
DOC_WW_Pin1_4	392	397	PF00397	0.599
DOC_WW_Pin1_4	67	72	PF00397	0.339
LIG_14-3-3_CanoR_1	210	215	PF00244	0.348
LIG_14-3-3_CanoR_1	240	245	PF00244	0.596
LIG_14-3-3_CanoR_1	369	374	PF00244	0.540
LIG_14-3-3_CanoR_1	90	95	PF00244	0.362
LIG_Actin_WH2_2	54	69	PF00022	0.348
LIG_APCC_ABBA_1	187	192	PF00400	0.384
LIG_APCC_ABBAyCdc20_2	370	376	PF00400	0.506
LIG_CtBP_PxDLS_1	215	219	PF00389	0.181
LIG_CtBP_PxDLS_1	274	278	PF00389	0.529
LIG_FHA_1	142	148	PF00498	0.380
LIG_FHA_1	149	155	PF00498	0.300
LIG_FHA_1	3	9	PF00498	0.505
LIG_FHA_1	313	319	PF00498	0.616
LIG_FHA_1	353	359	PF00498	0.677
LIG_FHA_1	370	376	PF00498	0.601
LIG_FHA_2	155	161	PF00498	0.364
LIG_FHA_2	192	198	PF00498	0.411
LIG_FHA_2	277	283	PF00498	0.514
LIG_GBD_Chelix_1	128	136	PF00786	0.450
LIG_Integrin_isoDGR_2	323	325	PF01839	0.312
LIG_IRF3_LxIS_1	270	276	PF10401	0.587
LIG_IRF3_LxIS_1	298	304	PF10401	0.492
LIG_LIR_Apic_2	25	31	PF02991	0.467
LIG_LIR_Gen_1	253	263	PF02991	0.562
LIG_LIR_Nem_3	253	258	PF02991	0.517
LIG_LIR_Nem_3	269	275	PF02991	0.485
LIG_LIR_Nem_3	70	76	PF02991	0.385
LIG_NRBOX	14	20	PF00104	0.387
LIG_NRBOX	334	340	PF00104	0.533
LIG_PTB_Apo_2	249	256	PF02174	0.553
LIG_PTB_Apo_2	342	349	PF02174	0.503
LIG_PTB_Phospho_1	342	348	PF10480	0.496
LIG_SH2_PTP2	28	31	PF00017	0.381
LIG_SH2_SRC	28	31	PF00017	0.361
LIG_SH2_SRC	84	87	PF00017	0.300
LIG_SH2_STAP1	259	263	PF00017	0.609
LIG_SH2_STAT5	28	31	PF00017	0.381
LIG_SH2_STAT5	346	349	PF00017	0.615
LIG_SH2_STAT5	76	79	PF00017	0.350
LIG_SH2_STAT5	84	87	PF00017	0.344
LIG_SH3_1	268	274	PF00018	0.562
LIG_SH3_1	62	68	PF00018	0.332
LIG_SH3_3	106	112	PF00018	0.268
LIG_SH3_3	200	206	PF00018	0.326
LIG_SH3_3	268	274	PF00018	0.541
LIG_SH3_3	62	68	PF00018	0.419
LIG_SUMO_SIM_par_1	149	155	PF11976	0.319
LIG_SUMO_SIM_par_1	224	232	PF11976	0.283
LIG_SUMO_SIM_par_1	273	279	PF11976	0.600
LIG_UBA3_1	131	139	PF00899	0.297
MOD_CDK_SPxxK_3	67	74	PF00069	0.332
MOD_CK1_1	155	161	PF00069	0.331
MOD_CK1_1	276	282	PF00069	0.541
MOD_CK2_1	160	166	PF00069	0.353
MOD_CK2_1	191	197	PF00069	0.395
MOD_CK2_1	210	216	PF00069	0.212
MOD_CK2_1	240	246	PF00069	0.567
MOD_CK2_1	94	100	PF00069	0.400
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.316
MOD_GlcNHglycan	154	157	PF01048	0.496
MOD_GlcNHglycan	293	296	PF01048	0.386
MOD_GlcNHglycan	305	308	PF01048	0.415
MOD_GlcNHglycan	319	322	PF01048	0.425
MOD_GlcNHglycan	349	352	PF01048	0.544
MOD_GlcNHglycan	62	65	PF01048	0.660
MOD_GSK3_1	143	150	PF00069	0.328
MOD_GSK3_1	210	217	PF00069	0.387
MOD_GSK3_1	236	243	PF00069	0.575
MOD_GSK3_1	262	269	PF00069	0.522
MOD_GSK3_1	377	384	PF00069	0.608
MOD_GSK3_1	385	392	PF00069	0.711
MOD_GSK3_1	90	97	PF00069	0.383
MOD_N-GLC_1	344	349	PF02516	0.498
MOD_NEK2_1	152	157	PF00069	0.298
MOD_NEK2_1	218	223	PF00069	0.447
MOD_NEK2_1	381	386	PF00069	0.624
MOD_NEK2_1	57	62	PF00069	0.369
MOD_OFUCOSY	140	145	PF10250	0.618
MOD_PK_1	90	96	PF00069	0.413
MOD_PKA_1	369	375	PF00069	0.515
MOD_PKA_2	209	215	PF00069	0.353
MOD_PKA_2	369	375	PF00069	0.552
MOD_PKB_1	238	246	PF00069	0.583
MOD_Plk_1	148	154	PF00069	0.319
MOD_Plk_1	191	197	PF00069	0.366
MOD_Plk_1	344	350	PF00069	0.605
MOD_Plk_1	49	55	PF00069	0.430
MOD_Plk_2-3	160	166	PF00069	0.370
MOD_Plk_2-3	192	198	PF00069	0.404
MOD_Plk_4	148	154	PF00069	0.311
MOD_Plk_4	240	246	PF00069	0.623
MOD_Plk_4	369	375	PF00069	0.572
MOD_Plk_4	94	100	PF00069	0.385
MOD_ProDKin_1	202	208	PF00069	0.370
MOD_ProDKin_1	67	73	PF00069	0.323
TRG_DiLeu_BaEn_2	245	251	PF01217	0.607
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.306
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.327
TRG_ENDOCYTIC_2	159	162	PF00928	0.388
TRG_ER_diArg_1	101	104	PF00400	0.349
TRG_ER_diArg_1	368	370	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R1	Leptomonas seymouri	59%	100%
A0A0N1PFB4	Leptomonas seymouri	35%	80%
A0A0S4KNW8	Bodo saltans	39%	100%
A0A1X0NMJ2	Trypanosomatidae	34%	90%
A0A1X0NW12	Trypanosomatidae	43%	100%
A0A3Q8ID18	Leishmania donovani	94%	100%
A0A3R7RCD3	Trypanosoma rangeli	35%	89%
A0A422N6P1	Trypanosoma rangeli	47%	100%
A4H5R3	Leishmania braziliensis	30%	71%
A4I131	Leishmania infantum	94%	100%
C9ZW77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A9G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9AX68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B582	Trypanosoma cruzi	49%	100%
V5B864	Trypanosoma cruzi	34%	89%