Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Heme Response-1 protein, putative

Species:

Leishmania major

UniProt:

Q4QAA7_LEIMA

TriTrypDb:

LmjF.24.2230 , LMJLV39_240030200 , LMJSD75_240029500

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QAA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.436
CLV_NRD_NRD_1	8	10	PF00675	0.432
CLV_PCSK_FUR_1	6	10	PF00082	0.448
CLV_PCSK_KEX2_1	7	9	PF00082	0.453
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.453
CLV_PCSK_SKI1_1	101	105	PF00082	0.575
CLV_PCSK_SKI1_1	55	59	PF00082	0.415
DEG_APCC_KENBOX_2	170	174	PF00400	0.628
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DOC_CKS1_1	59	64	PF01111	0.523
DOC_MAPK_gen_1	6	15	PF00069	0.573
DOC_MAPK_MEF2A_6	126	135	PF00069	0.389
DOC_MAPK_MEF2A_6	8	17	PF00069	0.532
DOC_WW_Pin1_4	58	63	PF00397	0.462
LIG_14-3-3_CanoR_1	6	12	PF00244	0.607
LIG_Actin_WH2_2	41	57	PF00022	0.446
LIG_EH1_1	44	52	PF00400	0.434
LIG_eIF4E_1	25	31	PF01652	0.389
LIG_EVH1_2	71	75	PF00568	0.624
LIG_FHA_1	130	136	PF00498	0.442
LIG_FHA_1	8	14	PF00498	0.583
LIG_FHA_1	80	86	PF00498	0.386
LIG_FHA_2	140	146	PF00498	0.650
LIG_GBD_Chelix_1	15	23	PF00786	0.402
LIG_GBD_Chelix_1	46	54	PF00786	0.434
LIG_LIR_Gen_1	74	83	PF02991	0.604
LIG_LIR_Nem_3	61	67	PF02991	0.605
LIG_LIR_Nem_3	74	78	PF02991	0.601
LIG_Pex14_1	14	18	PF04695	0.480
LIG_SH2_STAT5	114	117	PF00017	0.354
LIG_SH2_STAT5	129	132	PF00017	0.375
LIG_SH2_STAT5	18	21	PF00017	0.356
LIG_SH2_STAT5	25	28	PF00017	0.353
LIG_SH3_3	128	134	PF00018	0.426
LIG_TRAF2_1	142	145	PF00917	0.623
LIG_WRC_WIRS_1	80	85	PF05994	0.447
MOD_CDK_SPxxK_3	58	65	PF00069	0.499
MOD_CK2_1	139	145	PF00069	0.646
MOD_GlcNHglycan	160	164	PF01048	0.552
MOD_GlcNHglycan	26	29	PF01048	0.470
MOD_GSK3_1	125	132	PF00069	0.463
MOD_NEK2_2	79	84	PF00069	0.447
MOD_PKA_1	7	13	PF00069	0.596
MOD_PKA_2	7	13	PF00069	0.604
MOD_Plk_1	139	145	PF00069	0.651
MOD_Plk_4	79	85	PF00069	0.379
MOD_ProDKin_1	58	64	PF00069	0.462
TRG_DiLeu_BaEn_1	144	149	PF01217	0.648
TRG_ENDOCYTIC_2	18	21	PF00928	0.355
TRG_ENDOCYTIC_2	67	70	PF00928	0.577
TRG_ENDOCYTIC_2	80	83	PF00928	0.403
TRG_ER_diArg_1	6	9	PF00400	0.571
TRG_NLS_MonoExtN_4	6	11	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	31%	78%
A0A1X0NWM1	Trypanosomatidae	33%	100%
A0A3R7LPV2	Trypanosoma rangeli	30%	100%
A0A3S7WYQ2	Leishmania donovani	91%	100%
A4HDT4	Leishmania braziliensis	69%	100%
A4I132	Leishmania infantum	92%	100%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AX69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%