Cob_adeno_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP:cob(I)alamin adenosyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QAA6_LEIMA

TriTrypDb:

LmjF.24.2240 , LMJLV39_240030300 , LMJSD75_240029600

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QAA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008817	corrinoid adenosyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.768
CLV_C14_Caspase3-7	291	295	PF00656	0.517
CLV_NRD_NRD_1	196	198	PF00675	0.320
CLV_NRD_NRD_1	31	33	PF00675	0.532
CLV_NRD_NRD_1	324	326	PF00675	0.307
CLV_NRD_NRD_1	328	330	PF00675	0.312
CLV_NRD_NRD_1	372	374	PF00675	0.459
CLV_NRD_NRD_1	67	69	PF00675	0.500
CLV_PCSK_KEX2_1	195	197	PF00082	0.317
CLV_PCSK_KEX2_1	31	33	PF00082	0.541
CLV_PCSK_KEX2_1	324	326	PF00082	0.295
CLV_PCSK_KEX2_1	328	330	PF00082	0.288
CLV_PCSK_KEX2_1	67	69	PF00082	0.500
CLV_PCSK_PC7_1	320	326	PF00082	0.317
CLV_PCSK_SKI1_1	105	109	PF00082	0.407
CLV_PCSK_SKI1_1	171	175	PF00082	0.389
CLV_PCSK_SKI1_1	220	224	PF00082	0.325
CLV_PCSK_SKI1_1	268	272	PF00082	0.332
CLV_PCSK_SKI1_1	329	333	PF00082	0.374
CLV_PCSK_SKI1_1	346	350	PF00082	0.353
DEG_COP1_1	151	159	PF00400	0.659
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_CKS1_1	254	259	PF01111	0.517
DOC_MAPK_gen_1	324	333	PF00069	0.517
DOC_MAPK_MEF2A_6	296	304	PF00069	0.549
DOC_PP4_FxxP_1	303	306	PF00568	0.509
DOC_USP7_MATH_1	146	150	PF00917	0.805
DOC_USP7_MATH_1	235	239	PF00917	0.579
DOC_USP7_MATH_1	362	366	PF00917	0.546
DOC_WW_Pin1_4	253	258	PF00397	0.517
DOC_WW_Pin1_4	47	52	PF00397	0.764
DOC_WW_Pin1_4	6	11	PF00397	0.583
LIG_14-3-3_CanoR_1	11	17	PF00244	0.459
LIG_14-3-3_CanoR_1	328	334	PF00244	0.551
LIG_14-3-3_CanoR_1	346	351	PF00244	0.531
LIG_14-3-3_CanoR_1	354	361	PF00244	0.500
LIG_14-3-3_CanoR_1	41	48	PF00244	0.683
LIG_14-3-3_CanoR_1	92	98	PF00244	0.551
LIG_Actin_WH2_2	209	226	PF00022	0.556
LIG_BRCT_BRCA1_1	187	191	PF00533	0.517
LIG_BRCT_BRCA1_1	355	359	PF00533	0.556
LIG_FHA_1	269	275	PF00498	0.542
LIG_FHA_1	281	287	PF00498	0.517
LIG_FHA_1	340	346	PF00498	0.574
LIG_FHA_1	7	13	PF00498	0.549
LIG_FHA_2	146	152	PF00498	0.757
LIG_FHA_2	330	336	PF00498	0.573
LIG_FHA_2	338	344	PF00498	0.536
LIG_FHA_2	85	91	PF00498	0.553
LIG_KLC1_Yacidic_2	85	90	PF13176	0.607
LIG_LIR_Apic_2	275	280	PF02991	0.533
LIG_LIR_Gen_1	200	209	PF02991	0.496
LIG_LIR_Gen_1	85	95	PF02991	0.583
LIG_LIR_Gen_1	96	104	PF02991	0.522
LIG_LIR_Nem_3	200	206	PF02991	0.496
LIG_LIR_Nem_3	356	361	PF02991	0.500
LIG_LIR_Nem_3	85	91	PF02991	0.548
LIG_LIR_Nem_3	93	98	PF02991	0.500
LIG_MLH1_MIPbox_1	355	359	PF16413	0.556
LIG_PCNA_PIPBox_1	330	339	PF02747	0.556
LIG_PCNA_PIPBox_1	352	361	PF02747	0.551
LIG_SH2_GRB2like	351	354	PF00017	0.546
LIG_SH2_PTP2	88	91	PF00017	0.607
LIG_SH2_STAP1	341	345	PF00017	0.556
LIG_SH2_STAT5	179	182	PF00017	0.511
LIG_SH2_STAT5	341	344	PF00017	0.504
LIG_SH2_STAT5	88	91	PF00017	0.556
LIG_SH3_3	251	257	PF00018	0.556
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.424
LIG_SUMO_SIM_par_1	329	335	PF11976	0.501
LIG_SUMO_SIM_par_1	50	56	PF11976	0.634
LIG_UBA3_1	103	108	PF00899	0.607
MOD_CDK_SPK_2	6	11	PF00069	0.583
MOD_CDK_SPxxK_3	253	260	PF00069	0.556
MOD_CK1_1	142	148	PF00069	0.795
MOD_CK1_1	3	9	PF00069	0.505
MOD_CK2_1	222	228	PF00069	0.594
MOD_GlcNHglycan	141	144	PF01048	0.603
MOD_GlcNHglycan	148	151	PF01048	0.627
MOD_GlcNHglycan	187	190	PF01048	0.323
MOD_GlcNHglycan	22	25	PF01048	0.430
MOD_GlcNHglycan	224	227	PF01048	0.407
MOD_GlcNHglycan	312	315	PF01048	0.317
MOD_GSK3_1	138	145	PF00069	0.727
MOD_GSK3_1	146	153	PF00069	0.745
MOD_GSK3_1	173	180	PF00069	0.642
MOD_GSK3_1	185	192	PF00069	0.467
MOD_GSK3_1	249	256	PF00069	0.514
MOD_GSK3_1	47	54	PF00069	0.741
MOD_GSK3_1	6	13	PF00069	0.497
MOD_LATS_1	344	350	PF00433	0.556
MOD_N-GLC_2	112	114	PF02516	0.407
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	129	134	PF00069	0.746
MOD_NEK2_1	173	178	PF00069	0.716
MOD_NEK2_1	20	25	PF00069	0.501
MOD_NEK2_1	222	227	PF00069	0.558
MOD_NEK2_2	319	324	PF00069	0.556
MOD_PKA_2	10	16	PF00069	0.310
MOD_PKA_2	319	325	PF00069	0.556
MOD_PKA_2	353	359	PF00069	0.517
MOD_Plk_1	84	90	PF00069	0.556
MOD_Plk_4	12	18	PF00069	0.424
MOD_Plk_4	173	179	PF00069	0.641
MOD_Plk_4	235	241	PF00069	0.551
MOD_Plk_4	249	255	PF00069	0.527
MOD_Plk_4	346	352	PF00069	0.505
MOD_Plk_4	84	90	PF00069	0.553
MOD_ProDKin_1	253	259	PF00069	0.517
MOD_ProDKin_1	47	53	PF00069	0.763
MOD_ProDKin_1	6	12	PF00069	0.581
MOD_SUMO_rev_2	161	167	PF00179	0.761
MOD_SUMO_rev_2	66	76	PF00179	0.681
TRG_ENDOCYTIC_2	88	91	PF00928	0.551
TRG_ER_diArg_1	195	197	PF00400	0.551
TRG_ER_diArg_1	328	330	PF00400	0.556
TRG_ER_diArg_1	67	69	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC8	Leptomonas seymouri	52%	100%
A0A0S4KL87	Bodo saltans	43%	100%
A0A3Q8ID37	Leishmania donovani	92%	100%
A4HDT5	Leishmania braziliensis	81%	100%
A4I133	Leishmania infantum	92%	100%
E9AX70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%