Putative fatty-acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty-acid desaturase, putative

Species:

Leishmania major

UniProt:

Q4QAA5_LEIMA

TriTrypDb:

LmjF.24.2250 , LMJLV39_240030400 , LMJSD75_240029700

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0016020	membrane	2	16
GO:0031090	organelle membrane	3	3
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QAA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAA5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0005488	binding	1	7
GO:0005506	iron ion binding	6	3
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.482
CLV_NRD_NRD_1	334	336	PF00675	0.364
CLV_NRD_NRD_1	368	370	PF00675	0.341
CLV_NRD_NRD_1	37	39	PF00675	0.409
CLV_PCSK_KEX2_1	37	39	PF00082	0.418
CLV_PCSK_SKI1_1	192	196	PF00082	0.201
CLV_PCSK_SKI1_1	228	232	PF00082	0.300
CLV_PCSK_SKI1_1	29	33	PF00082	0.484
CLV_PCSK_SKI1_1	328	332	PF00082	0.324
CLV_PCSK_SKI1_1	369	373	PF00082	0.308
CLV_PCSK_SKI1_1	417	421	PF00082	0.269
CLV_PCSK_SKI1_1	442	446	PF00082	0.214
CLV_PCSK_SKI1_1	447	451	PF00082	0.340
DEG_Nend_UBRbox_4	1	3	PF02207	0.329
DOC_CKS1_1	315	320	PF01111	0.492
DOC_CYCLIN_RxL_1	325	334	PF00134	0.592
DOC_MAPK_MEF2A_6	344	352	PF00069	0.594
DOC_PP1_RVXF_1	226	232	PF00149	0.244
DOC_PP1_RVXF_1	301	308	PF00149	0.448
DOC_PP1_RVXF_1	394	401	PF00149	0.553
DOC_PP2B_LxvP_1	348	351	PF13499	0.566
DOC_PP2B_LxvP_1	57	60	PF13499	0.267
DOC_USP7_MATH_1	433	437	PF00917	0.375
DOC_USP7_UBL2_3	192	196	PF12436	0.481
DOC_USP7_UBL2_3	328	332	PF12436	0.508
DOC_WW_Pin1_4	314	319	PF00397	0.472
LIG_14-3-3_CanoR_1	100	107	PF00244	0.458
LIG_14-3-3_CanoR_1	257	265	PF00244	0.457
LIG_14-3-3_CanoR_1	303	308	PF00244	0.579
LIG_14-3-3_CanoR_1	369	374	PF00244	0.442
LIG_Actin_WH2_2	434	449	PF00022	0.497
LIG_BRCT_BRCA1_1	109	113	PF00533	0.497
LIG_deltaCOP1_diTrp_1	216	222	PF00928	0.254
LIG_deltaCOP1_diTrp_1	354	358	PF00928	0.524
LIG_FHA_1	234	240	PF00498	0.261
LIG_FHA_1	296	302	PF00498	0.434
LIG_FHA_1	422	428	PF00498	0.454
LIG_FHA_1	79	85	PF00498	0.270
LIG_FHA_2	143	149	PF00498	0.441
LIG_FHA_2	20	26	PF00498	0.394
LIG_FHA_2	268	274	PF00498	0.435
LIG_FHA_2	315	321	PF00498	0.501
LIG_FHA_2	341	347	PF00498	0.566
LIG_FHA_2	39	45	PF00498	0.540
LIG_LIR_Gen_1	110	120	PF02991	0.488
LIG_LIR_Gen_1	169	178	PF02991	0.463
LIG_LIR_Gen_1	180	189	PF02991	0.399
LIG_LIR_Gen_1	245	254	PF02991	0.405
LIG_LIR_Gen_1	273	283	PF02991	0.433
LIG_LIR_Gen_1	323	331	PF02991	0.549
LIG_LIR_Gen_1	355	366	PF02991	0.524
LIG_LIR_Gen_1	48	59	PF02991	0.418
LIG_LIR_Gen_1	95	102	PF02991	0.296
LIG_LIR_Nem_3	110	116	PF02991	0.501
LIG_LIR_Nem_3	12	18	PF02991	0.248
LIG_LIR_Nem_3	169	173	PF02991	0.463
LIG_LIR_Nem_3	180	186	PF02991	0.399
LIG_LIR_Nem_3	245	251	PF02991	0.438
LIG_LIR_Nem_3	273	278	PF02991	0.433
LIG_LIR_Nem_3	355	361	PF02991	0.508
LIG_LIR_Nem_3	48	54	PF02991	0.418
LIG_LIR_Nem_3	95	101	PF02991	0.316
LIG_PCNA_yPIPBox_3	369	382	PF02747	0.538
LIG_Pex14_1	115	119	PF04695	0.454
LIG_Pex14_1	217	221	PF04695	0.241
LIG_Pex14_2	278	282	PF04695	0.413
LIG_REV1ctd_RIR_1	192	200	PF16727	0.414
LIG_SH2_CRK	170	174	PF00017	0.465
LIG_SH2_CRK	183	187	PF00017	0.447
LIG_SH2_CRK	223	227	PF00017	0.228
LIG_SH2_CRK	98	102	PF00017	0.454
LIG_SH2_GRB2like	275	278	PF00017	0.441
LIG_SH2_PTP2	51	54	PF00017	0.360
LIG_SH2_SRC	42	45	PF00017	0.596
LIG_SH2_SRC	428	431	PF00017	0.405
LIG_SH2_SRC	437	440	PF00017	0.375
LIG_SH2_STAP1	223	227	PF00017	0.244
LIG_SH2_STAP1	47	51	PF00017	0.459
LIG_SH2_STAT3	150	153	PF00017	0.425
LIG_SH2_STAT3	185	188	PF00017	0.425
LIG_SH2_STAT5	107	110	PF00017	0.472
LIG_SH2_STAT5	142	145	PF00017	0.446
LIG_SH2_STAT5	185	188	PF00017	0.476
LIG_SH2_STAT5	221	224	PF00017	0.228
LIG_SH2_STAT5	391	394	PF00017	0.564
LIG_SH2_STAT5	437	440	PF00017	0.510
LIG_SH2_STAT5	51	54	PF00017	0.360
LIG_SH3_3	200	206	PF00018	0.300
LIG_SH3_3	312	318	PF00018	0.487
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.542
LIG_TRAF2_1	41	44	PF00917	0.565
LIG_TYR_ITIM	49	54	PF00017	0.497
LIG_TYR_ITIM	96	101	PF00017	0.266
LIG_UBA3_1	17	26	PF00899	0.161
LIG_UBA3_1	410	417	PF00899	0.454
LIG_WRC_WIRS_1	268	273	PF05994	0.414
MOD_CK1_1	103	109	PF00069	0.454
MOD_CK1_1	260	266	PF00069	0.414
MOD_CK1_1	384	390	PF00069	0.531
MOD_CK1_1	421	427	PF00069	0.470
MOD_CK2_1	19	25	PF00069	0.315
MOD_CK2_1	267	273	PF00069	0.405
MOD_CK2_1	38	44	PF00069	0.579
MOD_CK2_1	433	439	PF00069	0.443
MOD_CMANNOS	214	217	PF00535	0.426
MOD_Cter_Amidation	367	370	PF01082	0.346
MOD_GlcNHglycan	126	130	PF01048	0.227
MOD_GlcNHglycan	200	203	PF01048	0.228
MOD_GlcNHglycan	420	423	PF01048	0.234
MOD_GSK3_1	103	110	PF00069	0.472
MOD_GSK3_1	121	128	PF00069	0.340
MOD_GSK3_1	238	245	PF00069	0.309
MOD_GSK3_1	252	259	PF00069	0.419
MOD_GSK3_1	350	357	PF00069	0.513
MOD_GSK3_1	417	424	PF00069	0.463
MOD_N-GLC_1	252	257	PF02516	0.225
MOD_N-GLC_2	89	91	PF02516	0.360
MOD_NEK2_1	125	130	PF00069	0.448
MOD_NEK2_1	156	161	PF00069	0.441
MOD_NEK2_1	17	22	PF00069	0.205
MOD_NEK2_1	238	243	PF00069	0.303
MOD_NEK2_1	331	336	PF00069	0.600
MOD_NEK2_1	381	386	PF00069	0.568
MOD_NEK2_1	92	97	PF00069	0.358
MOD_PIKK_1	3	9	PF00454	0.444
MOD_PKA_1	369	375	PF00069	0.447
MOD_PKA_2	256	262	PF00069	0.430
MOD_Plk_1	168	174	PF00069	0.512
MOD_Plk_1	354	360	PF00069	0.522
MOD_Plk_2-3	354	360	PF00069	0.441
MOD_Plk_4	168	174	PF00069	0.503
MOD_Plk_4	204	210	PF00069	0.228
MOD_Plk_4	233	239	PF00069	0.244
MOD_Plk_4	260	266	PF00069	0.446
MOD_Plk_4	303	309	PF00069	0.569
MOD_Plk_4	369	375	PF00069	0.472
MOD_Plk_4	433	439	PF00069	0.438
MOD_Plk_4	75	81	PF00069	0.205
MOD_ProDKin_1	314	320	PF00069	0.474
TRG_ENDOCYTIC_2	170	173	PF00928	0.482
TRG_ENDOCYTIC_2	183	186	PF00928	0.400
TRG_ENDOCYTIC_2	223	226	PF00928	0.228
TRG_ENDOCYTIC_2	275	278	PF00928	0.427
TRG_ENDOCYTIC_2	51	54	PF00928	0.407
TRG_ENDOCYTIC_2	98	101	PF00928	0.441
TRG_NES_CRM1_1	320	333	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	83%	100%
A0A0S4KNP4	Bodo saltans	59%	100%
A0A1X0NW01	Trypanosomatidae	64%	100%
A0A3Q8I9W7	Leishmania donovani	44%	97%
A0A3Q8IBJ0	Leishmania donovani	97%	100%
A0A3R7MEL0	Trypanosoma rangeli	65%	100%
A4H6I1	Leishmania braziliensis	45%	98%
A4HDT6	Leishmania braziliensis	92%	100%
A4HVZ3	Leishmania infantum	44%	97%
A4I134	Leishmania infantum	97%	100%
B7SB91	Acheta domesticus	28%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G5ED44	Caenorhabditis elegans	31%	100%
G5EGH6	Caenorhabditis elegans	32%	100%
O02858	Sus scrofa	28%	100%
O44390	Trichoplusia ni	31%	100%
O65797	Arabidopsis thaliana	27%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	94%
P07308	Rattus norvegicus	28%	100%
P13516	Mus musculus	28%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	88%
Q12618	Ajellomyces capsulatus	39%	95%
Q4QFT4	Leishmania major	45%	97%
Q9LVZ3	Arabidopsis thaliana	27%	100%
Q9SID2	Arabidopsis thaliana	30%	100%