Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QAA0_LEIMA

TriTrypDb:

LmjF.24.2300 , LMJLV39_240030900 , LMJSD75_240030200

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QAA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QAA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	138	142	PF00082	0.736
CLV_PCSK_SKI1_1	169	173	PF00082	0.715
CLV_PCSK_SKI1_1	232	236	PF00082	0.546
DEG_APCC_DBOX_1	137	145	PF00400	0.730
DEG_APCC_DBOX_1	168	176	PF00400	0.711
DEG_Nend_UBRbox_2	1	3	PF02207	0.808
DOC_MIT_MIM_1	97	105	PF04212	0.631
DOC_USP7_MATH_1	136	140	PF00917	0.550
DOC_USP7_MATH_1	143	147	PF00917	0.561
DOC_USP7_MATH_1	20	24	PF00917	0.622
DOC_USP7_MATH_1	49	53	PF00917	0.712
DOC_USP7_MATH_1	85	89	PF00917	0.555
DOC_USP7_UBL2_3	107	111	PF12436	0.714
LIG_14-3-3_CanoR_1	101	106	PF00244	0.621
LIG_14-3-3_CanoR_1	138	148	PF00244	0.607
LIG_14-3-3_CanoR_1	200	206	PF00244	0.499
LIG_14-3-3_CterR_2	232	236	PF00244	0.546
LIG_Actin_WH2_2	141	157	PF00022	0.706
LIG_Actin_WH2_2	185	202	PF00022	0.449
LIG_Actin_WH2_2	56	74	PF00022	0.701
LIG_Clathr_ClatBox_1	123	127	PF01394	0.651
LIG_DLG_GKlike_1	101	109	PF00625	0.624
LIG_FHA_1	200	206	PF00498	0.483
LIG_FHA_2	117	123	PF00498	0.692
LIG_FHA_2	192	198	PF00498	0.604
LIG_IRF3_LxIS_1	144	151	PF10401	0.476
LIG_LIR_Gen_1	146	154	PF02991	0.701
LIG_LIR_Gen_1	2	11	PF02991	0.793
LIG_LIR_Gen_1	58	68	PF02991	0.603
LIG_LIR_Nem_3	146	150	PF02991	0.707
LIG_LIR_Nem_3	2	7	PF02991	0.719
LIG_LIR_Nem_3	58	63	PF02991	0.610
LIG_NRBOX	108	114	PF00104	0.626
LIG_SH2_GRB2like	33	36	PF00017	0.744
LIG_SH2_NCK_1	33	37	PF00017	0.662
LIG_SH2_NCK_1	4	8	PF00017	0.713
LIG_SH2_NCK_1	48	52	PF00017	0.462
LIG_SH2_SRC	33	36	PF00017	0.744
LIG_SH2_STAP1	33	37	PF00017	0.701
LIG_SH2_STAP1	4	8	PF00017	0.791
LIG_SH2_STAT5	39	42	PF00017	0.744
LIG_SUMO_SIM_par_1	121	127	PF11976	0.656
LIG_SUMO_SIM_par_1	54	61	PF11976	0.602
LIG_TRAF2_1	119	122	PF00917	0.657
LIG_TRAF2_1	194	197	PF00917	0.537
LIG_UBA3_1	153	160	PF00899	0.461
LIG_WRC_WIRS_1	144	149	PF05994	0.718
MOD_CK1_1	131	137	PF00069	0.739
MOD_CK1_1	139	145	PF00069	0.591
MOD_CK1_1	146	152	PF00069	0.453
MOD_CK1_1	213	219	PF00069	0.680
MOD_CK1_1	23	29	PF00069	0.766
MOD_CK1_1	88	94	PF00069	0.703
MOD_CK2_1	116	122	PF00069	0.646
MOD_CK2_1	191	197	PF00069	0.635
MOD_CK2_1	3	9	PF00069	0.636
MOD_GlcNHglycan	133	136	PF01048	0.569
MOD_GlcNHglycan	150	153	PF01048	0.407
MOD_GlcNHglycan	212	215	PF01048	0.721
MOD_GlcNHglycan	22	25	PF01048	0.759
MOD_GlcNHglycan	27	30	PF01048	0.706
MOD_GlcNHglycan	94	97	PF01048	0.627
MOD_GSK3_1	139	146	PF00069	0.617
MOD_GSK3_1	20	27	PF00069	0.775
MOD_GSK3_1	209	216	PF00069	0.682
MOD_GSK3_1	228	235	PF00069	0.593
MOD_GSK3_1	47	54	PF00069	0.661
MOD_GSK3_1	85	92	PF00069	0.751
MOD_GSK3_1	97	104	PF00069	0.538
MOD_N-GLC_1	128	133	PF02516	0.765
MOD_NEK2_1	13	18	PF00069	0.797
MOD_NEK2_1	148	153	PF00069	0.682
MOD_NEK2_1	209	214	PF00069	0.723
MOD_PIKK_1	13	19	PF00454	0.565
MOD_PK_1	3	9	PF00069	0.713
MOD_PKA_2	199	205	PF00069	0.500
MOD_PKA_2	20	26	PF00069	0.691
MOD_Plk_1	105	111	PF00069	0.704
MOD_Plk_1	128	134	PF00069	0.759
MOD_Plk_1	66	72	PF00069	0.647
MOD_Plk_2-3	122	128	PF00069	0.657
MOD_Plk_4	143	149	PF00069	0.713
MOD_Plk_4	66	72	PF00069	0.724
MOD_SUMO_rev_2	193	199	PF00179	0.550
TRG_DiLeu_BaEn_4	121	127	PF01217	0.656
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.513
TRG_ENDOCYTIC_2	4	7	PF00928	0.797
TRG_ER_diArg_1	80	83	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYM3	Leishmania donovani	86%	100%
A4HDU1	Leishmania braziliensis	62%	100%
A4I138	Leishmania infantum	86%	100%
E9AX76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%