LeishMANIAdb
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Coiled-coil domain-containing protein 153

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Coiled-coil domain-containing protein 153
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QA99_LEIMA
TriTrypDb:
LmjF.24.2310 , LMJLV39_240031000 , LMJSD75_240030300 *
Length:
163

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005930 axoneme 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QA99
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA99

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 50 52 PF00675 0.506
CLV_NRD_NRD_1 64 66 PF00675 0.459
CLV_PCSK_KEX2_1 134 136 PF00082 0.517
CLV_PCSK_KEX2_1 38 40 PF00082 0.404
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.517
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.404
CLV_PCSK_SKI1_1 35 39 PF00082 0.468
CLV_PCSK_SKI1_1 6 10 PF00082 0.535
CLV_PCSK_SKI1_1 92 96 PF00082 0.387
DEG_APCC_DBOX_1 38 46 PF00400 0.407
DEG_APCC_DBOX_1 91 99 PF00400 0.386
DOC_MAPK_gen_1 33 42 PF00069 0.472
DOC_MAPK_gen_1 51 58 PF00069 0.498
DOC_MAPK_gen_1 72 79 PF00069 0.505
DOC_MAPK_gen_1 85 95 PF00069 0.499
DOC_USP7_MATH_1 71 75 PF00917 0.425
DOC_USP7_UBL2_3 72 76 PF12436 0.487
LIG_Actin_WH2_2 23 40 PF00022 0.450
LIG_CaM_IQ_9 105 120 PF13499 0.444
LIG_LIR_Gen_1 136 145 PF02991 0.426
LIG_LIR_Gen_1 148 158 PF02991 0.459
LIG_LIR_Nem_3 136 140 PF02991 0.411
LIG_LIR_Nem_3 148 154 PF02991 0.456
LIG_SH2_STAT3 18 21 PF00017 0.537
LIG_SH2_STAT5 41 44 PF00017 0.509
LIG_SUMO_SIM_anti_2 25 32 PF11976 0.443
LIG_SUMO_SIM_anti_2 74 82 PF11976 0.448
LIG_SUMO_SIM_par_1 25 32 PF11976 0.499
LIG_TRAF2_1 94 97 PF00917 0.420
MOD_CK2_1 136 142 PF00069 0.482
MOD_CK2_1 153 159 PF00069 0.558
MOD_GlcNHglycan 58 61 PF01048 0.598
MOD_GSK3_1 125 132 PF00069 0.501
MOD_NEK2_1 108 113 PF00069 0.439
MOD_PIKK_1 97 103 PF00454 0.571
MOD_PKA_2 43 49 PF00069 0.315
MOD_Plk_2-3 136 142 PF00069 0.526
MOD_SUMO_rev_2 25 34 PF00179 0.399
TRG_DiLeu_BaEn_1 150 155 PF01217 0.521
TRG_NES_CRM1_1 32 43 PF08389 0.495
TRG_NLS_MonoExtC_3 111 117 PF00514 0.441
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.375

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCM4 Leptomonas seymouri 58% 100%
A0A1X0NW82 Trypanosomatidae 34% 95%
A0A3Q8ICA5 Leishmania donovani 93% 100%
A0A422N6N3 Trypanosoma rangeli 32% 94%
A4HDU2 Leishmania braziliensis 76% 100%
A4I139 Leishmania infantum 93% 100%
C9ZW69 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 99%
E9AX77 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS