DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA97_LEIMA

TriTrypDb:

LmjF.24.2330 , LMJLV39_240031200 , LMJSD75_240030500

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.579
CLV_NRD_NRD_1	235	237	PF00675	0.542
CLV_NRD_NRD_1	238	240	PF00675	0.533
CLV_NRD_NRD_1	243	245	PF00675	0.552
CLV_NRD_NRD_1	254	256	PF00675	0.633
CLV_NRD_NRD_1	43	45	PF00675	0.588
CLV_NRD_NRD_1	66	68	PF00675	0.548
CLV_NRD_NRD_1	93	95	PF00675	0.499
CLV_PCSK_FUR_1	236	240	PF00082	0.541
CLV_PCSK_KEX2_1	232	234	PF00082	0.554
CLV_PCSK_KEX2_1	237	239	PF00082	0.531
CLV_PCSK_KEX2_1	243	245	PF00082	0.529
CLV_PCSK_KEX2_1	254	256	PF00082	0.592
CLV_PCSK_KEX2_1	66	68	PF00082	0.525
CLV_PCSK_KEX2_1	93	95	PF00082	0.504
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.554
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.531
CLV_PCSK_PC7_1	233	239	PF00082	0.555
CLV_PCSK_SKI1_1	11	15	PF00082	0.539
CLV_PCSK_SKI1_1	115	119	PF00082	0.616
CLV_PCSK_SKI1_1	122	126	PF00082	0.680
CLV_PCSK_SKI1_1	243	247	PF00082	0.555
CLV_PCSK_SKI1_1	31	35	PF00082	0.493
CLV_PCSK_SKI1_1	55	59	PF00082	0.544
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DOC_MAPK_gen_1	66	75	PF00069	0.605
DOC_USP7_MATH_1	37	41	PF00917	0.379
DOC_USP7_UBL2_3	68	72	PF12436	0.614
LIG_14-3-3_CanoR_1	11	17	PF00244	0.561
LIG_14-3-3_CanoR_1	138	144	PF00244	0.611
LIG_14-3-3_CanoR_1	152	162	PF00244	0.375
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.565
LIG_BRCT_BRCA1_1	120	124	PF00533	0.420
LIG_CaM_IQ_9	194	209	PF13499	0.619
LIG_deltaCOP1_diTrp_1	59	64	PF00928	0.578
LIG_FHA_1	52	58	PF00498	0.613
LIG_FHA_1	90	96	PF00498	0.443
LIG_FHA_2	15	21	PF00498	0.552
LIG_FHA_2	156	162	PF00498	0.510
LIG_LIR_Gen_1	121	132	PF02991	0.478
LIG_LIR_Gen_1	58	65	PF02991	0.578
LIG_LIR_Nem_3	121	127	PF02991	0.507
LIG_LIR_Nem_3	128	132	PF02991	0.468
LIG_LIR_Nem_3	58	64	PF02991	0.586
LIG_NRBOX	161	167	PF00104	0.593
LIG_SH2_STAT3	130	133	PF00017	0.549
LIG_SH2_STAT5	74	77	PF00017	0.515
LIG_UBA3_1	107	115	PF00899	0.502
LIG_WRC_WIRS_1	13	18	PF05994	0.576
MOD_CK2_1	139	145	PF00069	0.607
MOD_CK2_1	153	159	PF00069	0.374
MOD_CK2_1	218	224	PF00069	0.451
MOD_CK2_1	45	51	PF00069	0.647
MOD_GlcNHglycan	47	50	PF01048	0.438
MOD_GlcNHglycan	99	102	PF01048	0.480
MOD_GSK3_1	51	58	PF00069	0.699
MOD_GSK3_1	89	96	PF00069	0.591
MOD_LATS_1	53	59	PF00433	0.584
MOD_NEK2_1	118	123	PF00069	0.444
MOD_NEK2_1	89	94	PF00069	0.583
MOD_PIKK_1	218	224	PF00454	0.394
MOD_PKA_1	93	99	PF00069	0.542
MOD_PKA_2	93	99	PF00069	0.581
MOD_PKB_1	9	17	PF00069	0.582
MOD_SUMO_rev_2	142	151	PF00179	0.585
MOD_SUMO_rev_2	65	73	PF00179	0.489
MOD_SUMO_rev_2	91	101	PF00179	0.485
TRG_ENDOCYTIC_2	132	135	PF00928	0.551
TRG_ER_diArg_1	236	239	PF00400	0.599
TRG_ER_diArg_1	93	95	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B7	Leptomonas seymouri	37%	98%
A0A3Q8IN13	Leishmania donovani	87%	100%
A4HDU4	Leishmania braziliensis	70%	100%
A4I141	Leishmania infantum	88%	100%
E9AX79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BEB7	Trypanosoma cruzi	33%	86%