Putative n-terminal acetyltransferase complex ard1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-terminal acetyltransferase complex ard1 subunit homolog, putative

Species:

Leishmania major

UniProt:

Q4QA94_LEIMA

TriTrypDb:

LmjF.25.0020 , LMJLV39_250005200 , LMJSD75_250005100

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	2
GO:0031414	N-terminal protein acetyltransferase complex	4	2
GO:0031416	NatB complex	5	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902493	acetyltransferase complex	4	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QA94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA94

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	2
GO:0006474	N-terminal protein amino acid acetylation	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0017196	N-terminal peptidyl-methionine acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018206	peptidyl-methionine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0031365	N-terminal protein amino acid modification	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004596	peptide alpha-N-acetyltransferase activity	8	2
GO:0008080	N-acetyltransferase activity	6	2
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	2
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0034212	peptide N-acetyltransferase activity	7	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.278
CLV_NRD_NRD_1	153	155	PF00675	0.382
CLV_NRD_NRD_1	19	21	PF00675	0.429
CLV_NRD_NRD_1	202	204	PF00675	0.373
CLV_NRD_NRD_1	207	209	PF00675	0.416
CLV_NRD_NRD_1	39	41	PF00675	0.494
CLV_NRD_NRD_1	46	48	PF00675	0.335
CLV_PCSK_KEX2_1	124	126	PF00082	0.278
CLV_PCSK_KEX2_1	202	204	PF00082	0.496
CLV_PCSK_KEX2_1	207	209	PF00082	0.507
CLV_PCSK_KEX2_1	38	40	PF00082	0.556
CLV_PCSK_KEX2_1	46	48	PF00082	0.327
CLV_PCSK_PC7_1	198	204	PF00082	0.487
CLV_PCSK_SKI1_1	125	129	PF00082	0.402
CLV_PCSK_SKI1_1	173	177	PF00082	0.330
CLV_PCSK_SKI1_1	198	202	PF00082	0.482
CLV_PCSK_SKI1_1	217	221	PF00082	0.446
CLV_PCSK_SKI1_1	40	44	PF00082	0.571
CLV_PCSK_SKI1_1	46	50	PF00082	0.400
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.405
DOC_MAPK_gen_1	18	28	PF00069	0.527
DOC_MAPK_gen_1	205	215	PF00069	0.414
DOC_MAPK_RevD_3	6	21	PF00069	0.413
DOC_USP7_MATH_1	137	141	PF00917	0.405
DOC_USP7_MATH_1	187	191	PF00917	0.498
DOC_USP7_UBL2_3	185	189	PF12436	0.477
DOC_USP7_UBL2_3	205	209	PF12436	0.376
DOC_USP7_UBL2_3	21	25	PF12436	0.436
LIG_14-3-3_CanoR_1	13	19	PF00244	0.426
LIG_14-3-3_CanoR_1	207	213	PF00244	0.406
LIG_14-3-3_CanoR_1	38	43	PF00244	0.661
LIG_14-3-3_CanoR_1	46	51	PF00244	0.421
LIG_AP2alpha_1	148	152	PF02296	0.278
LIG_FHA_1	129	135	PF00498	0.294
LIG_FHA_1	89	95	PF00498	0.391
LIG_FHA_2	47	53	PF00498	0.395
LIG_LIR_Gen_1	12	19	PF02991	0.523
LIG_LIR_Gen_1	162	172	PF02991	0.317
LIG_LIR_Gen_1	53	64	PF02991	0.409
LIG_LIR_Gen_1	82	90	PF02991	0.361
LIG_LIR_Nem_3	12	17	PF02991	0.522
LIG_LIR_Nem_3	122	126	PF02991	0.278
LIG_LIR_Nem_3	162	167	PF02991	0.272
LIG_LIR_Nem_3	53	59	PF02991	0.436
LIG_LIR_Nem_3	70	76	PF02991	0.255
LIG_LIR_Nem_3	78	83	PF02991	0.355
LIG_PDZ_Class_3	222	227	PF00595	0.542
LIG_PDZ_Wminus1_1	225	227	PF00595	0.578
LIG_Pex14_2	10	14	PF04695	0.417
LIG_Pex14_2	148	152	PF04695	0.278
LIG_PTB_Apo_2	142	149	PF02174	0.267
LIG_SH2_CRK	164	168	PF00017	0.278
LIG_SH2_CRK	172	176	PF00017	0.317
LIG_SH2_CRK	83	87	PF00017	0.259
LIG_SH2_STAT5	147	150	PF00017	0.293
LIG_SH2_STAT5	169	172	PF00017	0.297
LIG_SH2_STAT5	76	79	PF00017	0.355
LIG_SH2_STAT5	98	101	PF00017	0.333
LIG_SH3_2	184	189	PF14604	0.577
LIG_SH3_3	181	187	PF00018	0.574
LIG_SH3_3	215	221	PF00018	0.388
LIG_SH3_3	3	9	PF00018	0.421
LIG_SUMO_SIM_par_1	130	135	PF11976	0.375
LIG_TYR_ITIM	170	175	PF00017	0.323
MOD_CK1_1	115	121	PF00069	0.278
MOD_CK1_1	12	18	PF00069	0.507
MOD_GlcNHglycan	114	117	PF01048	0.279
MOD_GSK3_1	115	122	PF00069	0.278
MOD_GSK3_1	46	53	PF00069	0.444
MOD_GSK3_1	64	71	PF00069	0.315
MOD_N-GLC_1	68	73	PF02516	0.485
MOD_NEK2_1	128	133	PF00069	0.302
MOD_NEK2_1	50	55	PF00069	0.430
MOD_NEK2_1	64	69	PF00069	0.278
MOD_NEK2_1	96	101	PF00069	0.351
MOD_NEK2_2	68	73	PF00069	0.438
MOD_PK_1	208	214	PF00069	0.468
MOD_PKA_1	207	213	PF00069	0.462
MOD_PKA_1	38	44	PF00069	0.392
MOD_PKA_1	46	52	PF00069	0.376
MOD_PKA_2	12	18	PF00069	0.422
MOD_PKA_2	153	159	PF00069	0.301
MOD_PKA_2	207	213	PF00069	0.463
MOD_PKA_2	38	44	PF00069	0.652
MOD_PKA_2	46	52	PF00069	0.459
MOD_PKB_1	38	46	PF00069	0.446
MOD_Plk_1	68	74	PF00069	0.480
MOD_Plk_4	1	7	PF00069	0.463
MOD_Plk_4	128	134	PF00069	0.360
MOD_Plk_4	208	214	PF00069	0.412
MOD_Plk_4	68	74	PF00069	0.402
MOD_SUMO_for_1	219	222	PF00179	0.420
TRG_ENDOCYTIC_2	164	167	PF00928	0.278
TRG_ENDOCYTIC_2	172	175	PF00928	0.310
TRG_ENDOCYTIC_2	45	48	PF00928	0.412
TRG_ENDOCYTIC_2	83	86	PF00928	0.326
TRG_ER_diArg_1	123	125	PF00400	0.278
TRG_ER_diArg_1	17	20	PF00400	0.530
TRG_ER_diArg_1	201	203	PF00400	0.432
TRG_ER_diArg_1	38	40	PF00400	0.563
TRG_ER_diArg_1	45	47	PF00400	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I212	Leptomonas seymouri	91%	100%
A0A0S4JB69	Bodo saltans	27%	80%
A0A0S4KNL4	Bodo saltans	64%	100%
A0A1X0NYV1	Trypanosomatidae	77%	100%
A0A3Q8ID89	Leishmania donovani	95%	100%
A0A3R7M1B7	Trypanosoma rangeli	29%	90%
A0A422N4M9	Trypanosoma rangeli	77%	100%
A4HDU9	Leishmania braziliensis	91%	100%
A4I144	Leishmania infantum	95%	100%
C9ZKU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A6U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	85%
E9AXY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%
O61219	Caenorhabditis elegans	31%	100%
O74457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
P36416	Dictyostelium discoideum	29%	100%
P41227	Homo sapiens	29%	97%
P61599	Homo sapiens	53%	100%
P61600	Mus musculus	53%	100%
Q05885	Leishmania donovani	98%	100%
Q06504	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q2KI14	Bos taurus	29%	97%
Q2PFM2	Macaca fascicularis	53%	100%
Q3UX61	Mus musculus	29%	100%
Q4V8K3	Rattus norvegicus	29%	92%
Q58ED9	Danio rerio	52%	100%
Q6P632	Xenopus tropicalis	51%	100%
Q7ZXR3	Xenopus laevis	52%	100%
Q8LGI8	Arabidopsis thaliana	54%	100%
Q8SSN5	Dictyostelium discoideum	51%	100%
Q9BSU3	Homo sapiens	28%	99%
Q9FKI4	Arabidopsis thaliana	33%	100%
Q9QY36	Mus musculus	29%	97%
Q9UTI3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5BDZ0	Trypanosoma cruzi	28%	88%