DUF2431 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF2431), putative

Species:

Leishmania major

UniProt:

Q4QA93_LEIMA

TriTrypDb:

LmjF.25.0030 , LMJLV39_250005300 , LMJSD75_250005200

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA93

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	6
GO:0001510	RNA methylation	4	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0031167	rRNA methylation	5	6
GO:0032259	methylation	2	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043414	macromolecule methylation	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0070475	rRNA base methylation	6	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008170	N-methyltransferase activity	5	6
GO:0008173	RNA methyltransferase activity	4	6
GO:0008649	rRNA methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016436	rRNA (uridine) methyltransferase activity	6	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0070042	rRNA (uridine-N3-)-methyltransferase activity	6	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140102	catalytic activity, acting on a rRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.535
CLV_NRD_NRD_1	100	102	PF00675	0.402
CLV_NRD_NRD_1	214	216	PF00675	0.531
CLV_NRD_NRD_1	377	379	PF00675	0.482
CLV_NRD_NRD_1	432	434	PF00675	0.745
CLV_NRD_NRD_1	491	493	PF00675	0.649
CLV_NRD_NRD_1	51	53	PF00675	0.531
CLV_NRD_NRD_1	556	558	PF00675	0.661
CLV_NRD_NRD_1	64	66	PF00675	0.315
CLV_NRD_NRD_1	83	85	PF00675	0.319
CLV_PCSK_KEX2_1	214	216	PF00082	0.531
CLV_PCSK_KEX2_1	377	379	PF00082	0.447
CLV_PCSK_KEX2_1	42	44	PF00082	0.511
CLV_PCSK_KEX2_1	432	434	PF00082	0.745
CLV_PCSK_KEX2_1	491	493	PF00082	0.649
CLV_PCSK_KEX2_1	51	53	PF00082	0.394
CLV_PCSK_KEX2_1	556	558	PF00082	0.661
CLV_PCSK_KEX2_1	63	65	PF00082	0.336
CLV_PCSK_KEX2_1	99	101	PF00082	0.402
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.511
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.402
CLV_PCSK_PC7_1	373	379	PF00082	0.411
CLV_PCSK_SKI1_1	276	280	PF00082	0.563
CLV_PCSK_SKI1_1	404	408	PF00082	0.630
CLV_PCSK_SKI1_1	416	420	PF00082	0.478
CLV_PCSK_SKI1_1	51	55	PF00082	0.494
CLV_PCSK_SKI1_1	551	555	PF00082	0.641
CLV_PCSK_SKI1_1	556	560	PF00082	0.386
DEG_SIAH_1	14	22	PF03145	0.442
DOC_MAPK_gen_1	377	385	PF00069	0.480
DOC_MAPK_gen_1	63	71	PF00069	0.511
DOC_MAPK_gen_1	84	92	PF00069	0.439
DOC_MAPK_MEF2A_6	63	71	PF00069	0.439
DOC_PP4_FxxP_1	132	135	PF00568	0.494
DOC_PP4_FxxP_1	232	235	PF00568	0.518
DOC_PP4_FxxP_1	345	348	PF00568	0.551
DOC_USP7_MATH_1	190	194	PF00917	0.472
DOC_USP7_MATH_1	2	6	PF00917	0.743
DOC_USP7_MATH_1	202	206	PF00917	0.339
DOC_USP7_MATH_1	283	287	PF00917	0.520
DOC_USP7_MATH_1	80	84	PF00917	0.439
DOC_USP7_UBL2_3	409	413	PF12436	0.562
DOC_WW_Pin1_4	469	474	PF00397	0.622
DOC_WW_Pin1_4	529	534	PF00397	0.617
DOC_WW_Pin1_4	576	581	PF00397	0.632
LIG_14-3-3_CanoR_1	276	282	PF00244	0.360
LIG_14-3-3_CanoR_1	377	385	PF00244	0.574
LIG_14-3-3_CanoR_1	51	59	PF00244	0.472
LIG_APCC_ABBA_1	393	398	PF00400	0.635
LIG_BRCT_BRCA1_1	149	153	PF00533	0.494
LIG_BRCT_BRCA1_1	204	208	PF00533	0.494
LIG_eIF4E_1	143	149	PF01652	0.494
LIG_FHA_1	290	296	PF00498	0.709
LIG_FHA_1	8	14	PF00498	0.701
LIG_FHA_2	249	255	PF00498	0.412
LIG_FHA_2	268	274	PF00498	0.417
LIG_FHA_2	405	411	PF00498	0.657
LIG_FHA_2	454	460	PF00498	0.569
LIG_FHA_2	52	58	PF00498	0.522
LIG_FHA_2	572	578	PF00498	0.573
LIG_FHA_2	72	78	PF00498	0.209
LIG_LIR_Gen_1	124	135	PF02991	0.328
LIG_LIR_Gen_1	193	203	PF02991	0.457
LIG_LIR_Gen_1	22	29	PF02991	0.478
LIG_LIR_Gen_1	268	277	PF02991	0.485
LIG_LIR_Gen_1	35	44	PF02991	0.494
LIG_LIR_Gen_1	362	371	PF02991	0.548
LIG_LIR_Gen_1	477	486	PF02991	0.681
LIG_LIR_Gen_1	507	518	PF02991	0.477
LIG_LIR_Nem_3	124	130	PF02991	0.384
LIG_LIR_Nem_3	140	146	PF02991	0.347
LIG_LIR_Nem_3	193	198	PF02991	0.472
LIG_LIR_Nem_3	205	211	PF02991	0.339
LIG_LIR_Nem_3	22	28	PF02991	0.481
LIG_LIR_Nem_3	268	272	PF02991	0.483
LIG_LIR_Nem_3	273	277	PF02991	0.546
LIG_LIR_Nem_3	280	284	PF02991	0.526
LIG_LIR_Nem_3	35	41	PF02991	0.524
LIG_LIR_Nem_3	353	359	PF02991	0.560
LIG_LIR_Nem_3	362	368	PF02991	0.440
LIG_LIR_Nem_3	477	482	PF02991	0.690
LIG_LIR_Nem_3	507	513	PF02991	0.494
LIG_MLH1_MIPbox_1	149	153	PF16413	0.494
LIG_MYND_1	325	329	PF01753	0.539
LIG_MYND_1	391	395	PF01753	0.650
LIG_NRBOX	23	29	PF00104	0.322
LIG_NRBOX	401	407	PF00104	0.443
LIG_PCNA_PIPBox_1	145	154	PF02747	0.457
LIG_PCNA_yPIPBox_3	236	244	PF02747	0.514
LIG_Pex14_1	365	369	PF04695	0.542
LIG_Pex14_2	92	96	PF04695	0.439
LIG_REV1ctd_RIR_1	150	158	PF16727	0.494
LIG_SH2_CRK	143	147	PF00017	0.402
LIG_SH2_CRK	38	42	PF00017	0.494
LIG_SH2_CRK	479	483	PF00017	0.683
LIG_SH2_GRB2like	211	214	PF00017	0.494
LIG_SH2_NCK_1	269	273	PF00017	0.544
LIG_SH2_PTP2	195	198	PF00017	0.439
LIG_SH2_SRC	359	362	PF00017	0.484
LIG_SH2_SRC	524	527	PF00017	0.596
LIG_SH2_STAP1	284	288	PF00017	0.630
LIG_SH2_STAP1	524	528	PF00017	0.603
LIG_SH2_STAT3	284	287	PF00017	0.646
LIG_SH2_STAT3	369	372	PF00017	0.546
LIG_SH2_STAT5	195	198	PF00017	0.494
LIG_SH2_STAT5	211	214	PF00017	0.258
LIG_SH2_STAT5	231	234	PF00017	0.211
LIG_SH2_STAT5	269	272	PF00017	0.537
LIG_SH2_STAT5	281	284	PF00017	0.415
LIG_SH2_STAT5	359	362	PF00017	0.540
LIG_SH2_STAT5	417	420	PF00017	0.654
LIG_SH2_STAT5	510	513	PF00017	0.472
LIG_SH2_STAT5	530	533	PF00017	0.649
LIG_SH2_STAT5	95	98	PF00017	0.501
LIG_SH3_3	355	361	PF00018	0.500
LIG_SH3_3	388	394	PF00018	0.668
LIG_SH3_3	470	476	PF00018	0.634
LIG_SH3_3	543	549	PF00018	0.635
LIG_SUMO_SIM_par_1	25	31	PF11976	0.494
LIG_TRAF2_1	523	526	PF00917	0.590
LIG_TRAF2_1	574	577	PF00917	0.576
LIG_TYR_ITIM	228	233	PF00017	0.507
LIG_TYR_ITSM	475	482	PF00017	0.698
LIG_UBA3_1	401	409	PF00899	0.443
LIG_WW_2	391	394	PF00397	0.665
MOD_CK1_1	114	120	PF00069	0.494
MOD_CK1_1	298	304	PF00069	0.696
MOD_CK1_1	316	322	PF00069	0.404
MOD_CK1_1	346	352	PF00069	0.645
MOD_CK2_1	152	158	PF00069	0.439
MOD_CK2_1	2	8	PF00069	0.723
MOD_CK2_1	248	254	PF00069	0.470
MOD_CK2_1	267	273	PF00069	0.395
MOD_CK2_1	404	410	PF00069	0.627
MOD_CK2_1	441	447	PF00069	0.423
MOD_CK2_1	51	57	PF00069	0.375
MOD_CK2_1	571	577	PF00069	0.648
MOD_CK2_1	75	81	PF00069	0.465
MOD_GlcNHglycan	116	119	PF01048	0.489
MOD_GlcNHglycan	154	157	PF01048	0.527
MOD_GlcNHglycan	192	195	PF01048	0.472
MOD_GlcNHglycan	204	207	PF01048	0.339
MOD_GlcNHglycan	245	249	PF01048	0.469
MOD_GlcNHglycan	294	298	PF01048	0.673
MOD_GlcNHglycan	306	309	PF01048	0.571
MOD_GlcNHglycan	315	318	PF01048	0.516
MOD_GlcNHglycan	46	49	PF01048	0.494
MOD_GlcNHglycan	519	522	PF01048	0.469
MOD_GlcNHglycan	571	574	PF01048	0.687
MOD_GSK3_1	110	117	PF00069	0.494
MOD_GSK3_1	158	165	PF00069	0.413
MOD_GSK3_1	244	251	PF00069	0.397
MOD_GSK3_1	289	296	PF00069	0.598
MOD_GSK3_1	309	316	PF00069	0.494
MOD_GSK3_1	346	353	PF00069	0.642
MOD_GSK3_1	405	412	PF00069	0.606
MOD_GSK3_1	571	578	PF00069	0.603
MOD_GSK3_1	71	78	PF00069	0.503
MOD_LATS_1	160	166	PF00433	0.328
MOD_N-GLC_1	110	115	PF02516	0.494
MOD_N-GLC_1	313	318	PF02516	0.653
MOD_N-GLC_1	32	37	PF02516	0.494
MOD_N-GLC_2	509	511	PF02516	0.371
MOD_NEK2_1	152	157	PF00069	0.494
MOD_NEK2_1	282	287	PF00069	0.576
MOD_NEK2_1	397	402	PF00069	0.557
MOD_NEK2_1	44	49	PF00069	0.377
MOD_NEK2_2	441	446	PF00069	0.424
MOD_PIKK_1	283	289	PF00454	0.608
MOD_PIKK_1	434	440	PF00454	0.544
MOD_PIKK_1	51	57	PF00454	0.439
MOD_PKA_1	377	383	PF00069	0.462
MOD_PKA_1	42	48	PF00069	0.494
MOD_PKA_1	51	57	PF00069	0.362
MOD_PKA_2	256	262	PF00069	0.489
MOD_PKA_2	377	383	PF00069	0.598
MOD_PKA_2	42	48	PF00069	0.494
MOD_PKA_2	51	57	PF00069	0.362
MOD_PKA_2	562	568	PF00069	0.612
MOD_Plk_1	110	116	PF00069	0.494
MOD_Plk_1	248	254	PF00069	0.400
MOD_Plk_1	309	315	PF00069	0.570
MOD_Plk_1	32	38	PF00069	0.494
MOD_Plk_1	397	403	PF00069	0.561
MOD_Plk_4	248	254	PF00069	0.400
MOD_Plk_4	277	283	PF00069	0.370
MOD_Plk_4	327	333	PF00069	0.546
MOD_Plk_4	361	367	PF00069	0.552
MOD_Plk_4	397	403	PF00069	0.596
MOD_Plk_4	474	480	PF00069	0.707
MOD_ProDKin_1	469	475	PF00069	0.624
MOD_ProDKin_1	529	535	PF00069	0.628
MOD_ProDKin_1	576	582	PF00069	0.636
TRG_DiLeu_BaEn_2	87	93	PF01217	0.439
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.544
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.448
TRG_ENDOCYTIC_2	107	110	PF00928	0.328
TRG_ENDOCYTIC_2	143	146	PF00928	0.439
TRG_ENDOCYTIC_2	195	198	PF00928	0.494
TRG_ENDOCYTIC_2	230	233	PF00928	0.503
TRG_ENDOCYTIC_2	269	272	PF00928	0.537
TRG_ENDOCYTIC_2	38	41	PF00928	0.531
TRG_ENDOCYTIC_2	479	482	PF00928	0.683
TRG_ENDOCYTIC_2	510	513	PF00928	0.472
TRG_ER_diArg_1	100	103	PF00400	0.489
TRG_ER_diArg_1	491	493	PF00400	0.686
TRG_ER_diArg_1	50	52	PF00400	0.494
TRG_ER_diArg_1	63	65	PF00400	0.302
TRG_NLS_Bipartite_1	84	103	PF00514	0.402
TRG_NLS_MonoExtC_3	98	103	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID26	Leishmania donovani	88%	100%
A4HDV0	Leishmania braziliensis	67%	100%
A4I145	Leishmania infantum	88%	100%
E9AXY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%