HSF_DOMAIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA91_LEIMA

TriTrypDb:

LmjF.25.0050 , LMJLV39_250005500 , LMJSD75_250005400

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.345
CLV_NRD_NRD_1	162	164	PF00675	0.517
CLV_NRD_NRD_1	57	59	PF00675	0.442
CLV_PCSK_KEX2_1	160	162	PF00082	0.532
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.594
CLV_PCSK_SKI1_1	116	120	PF00082	0.559
CLV_PCSK_SKI1_1	143	147	PF00082	0.707
CLV_PCSK_SKI1_1	162	166	PF00082	0.597
DEG_APCC_DBOX_1	161	169	PF00400	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.493
DEG_SCF_FBW7_1	118	123	PF00400	0.590
DOC_PP1_RVXF_1	14	20	PF00149	0.461
DOC_USP7_MATH_1	120	124	PF00917	0.664
DOC_USP7_MATH_1	132	136	PF00917	0.766
DOC_USP7_MATH_1	164	168	PF00917	0.562
DOC_WW_Pin1_4	116	121	PF00397	0.594
LIG_14-3-3_CanoR_1	113	119	PF00244	0.500
LIG_14-3-3_CanoR_1	163	169	PF00244	0.589
LIG_FHA_1	35	41	PF00498	0.460
LIG_FHA_1	51	57	PF00498	0.389
LIG_FHA_1	74	80	PF00498	0.480
LIG_FHA_1	82	88	PF00498	0.521
LIG_LIR_Gen_1	21	30	PF02991	0.505
LIG_LIR_Gen_1	37	46	PF02991	0.426
LIG_LIR_Gen_1	5	14	PF02991	0.457
LIG_LIR_Nem_3	21	25	PF02991	0.396
LIG_LIR_Nem_3	37	41	PF02991	0.403
LIG_LIR_Nem_3	5	10	PF02991	0.453
LIG_LIR_Nem_3	61	65	PF02991	0.457
LIG_NRBOX	110	116	PF00104	0.421
LIG_OCRL_FandH_1	6	18	PF00620	0.457
LIG_SH2_STAP1	38	42	PF00017	0.419
LIG_SH3_3	146	152	PF00018	0.569
LIG_WW_3	136	140	PF00397	0.546
MOD_CK1_1	5	11	PF00069	0.551
MOD_CK2_1	21	27	PF00069	0.498
MOD_DYRK1A_RPxSP_1	116	120	PF00069	0.617
MOD_GlcNHglycan	101	104	PF01048	0.483
MOD_GlcNHglycan	90	93	PF01048	0.508
MOD_GSK3_1	116	123	PF00069	0.602
MOD_GSK3_1	164	171	PF00069	0.672
MOD_N-GLC_1	5	10	PF02516	0.428
MOD_NEK2_1	107	112	PF00069	0.433
MOD_NEK2_1	114	119	PF00069	0.457
MOD_NEK2_2	73	78	PF00069	0.513
MOD_Plk_1	5	11	PF00069	0.475
MOD_Plk_2-3	21	27	PF00069	0.474
MOD_Plk_4	107	113	PF00069	0.501
MOD_Plk_4	36	42	PF00069	0.435
MOD_ProDKin_1	116	122	PF00069	0.606
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.487
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.435
TRG_ENDOCYTIC_2	38	41	PF00928	0.376
TRG_ENDOCYTIC_2	46	49	PF00928	0.382
TRG_ER_diArg_1	161	163	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW6	Leptomonas seymouri	56%	98%
A0A0S4IX66	Bodo saltans	26%	99%
A0A3Q8ID49	Leishmania donovani	95%	100%
A4HDV2	Leishmania braziliensis	78%	100%
A4I147	Leishmania infantum	94%	100%
C9ZU45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AX81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5D433	Trypanosoma cruzi	44%	98%