MEDS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA89_LEIMA

TriTrypDb:

LmjF.25.0070 , LMJLV39_250005800 , LMJSD75_250005700

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.773
CLV_NRD_NRD_1	261	263	PF00675	0.402
CLV_PCSK_KEX2_1	2	4	PF00082	0.703
CLV_PCSK_KEX2_1	260	262	PF00082	0.425
CLV_PCSK_SKI1_1	108	112	PF00082	0.507
DEG_COP1_1	37	45	PF00400	0.590
DEG_Nend_UBRbox_1	1	4	PF02207	0.710
DOC_MAPK_FxFP_2	79	82	PF00069	0.478
DOC_MAPK_gen_1	124	132	PF00069	0.470
DOC_MAPK_gen_1	2	9	PF00069	0.634
DOC_MAPK_MEF2A_6	124	132	PF00069	0.445
DOC_PP1_RVXF_1	259	266	PF00149	0.390
DOC_PP2B_LxvP_1	159	162	PF13499	0.458
DOC_PP4_FxxP_1	111	114	PF00568	0.367
DOC_PP4_FxxP_1	79	82	PF00568	0.457
DOC_USP7_MATH_1	287	291	PF00917	0.704
DOC_WW_Pin1_4	103	108	PF00397	0.511
DOC_WW_Pin1_4	142	147	PF00397	0.531
DOC_WW_Pin1_4	237	242	PF00397	0.581
DOC_WW_Pin1_4	285	290	PF00397	0.719
DOC_WW_Pin1_4	48	53	PF00397	0.654
LIG_14-3-3_CanoR_1	207	212	PF00244	0.474
LIG_AP2alpha_2	70	72	PF02296	0.452
LIG_BRCT_BRCA1_1	225	229	PF00533	0.501
LIG_eIF4E_1	183	189	PF01652	0.470
LIG_eIF4E_1	99	105	PF01652	0.315
LIG_FHA_1	113	119	PF00498	0.591
LIG_FHA_1	195	201	PF00498	0.426
LIG_FHA_1	228	234	PF00498	0.508
LIG_FHA_1	242	248	PF00498	0.531
LIG_FHA_1	37	43	PF00498	0.591
LIG_FHA_2	201	207	PF00498	0.320
LIG_FHA_2	35	41	PF00498	0.627
LIG_KLC1_Yacidic_2	201	206	PF13176	0.327
LIG_LIR_Apic_2	109	114	PF02991	0.419
LIG_LIR_Gen_1	75	84	PF02991	0.434
LIG_LIR_Nem_3	226	232	PF02991	0.406
LIG_LIR_Nem_3	25	30	PF02991	0.667
LIG_LIR_Nem_3	68	72	PF02991	0.407
LIG_LIR_Nem_3	75	79	PF02991	0.353
LIG_LIR_Nem_3	80	84	PF02991	0.375
LIG_NRBOX	131	137	PF00104	0.379
LIG_Pex14_2	65	69	PF04695	0.472
LIG_SH2_SRC	199	202	PF00017	0.503
LIG_SH2_STAT5	183	186	PF00017	0.428
LIG_SH2_STAT5	199	202	PF00017	0.454
LIG_SH2_STAT5	204	207	PF00017	0.441
LIG_SH2_STAT5	76	79	PF00017	0.382
LIG_SH3_3	152	158	PF00018	0.483
LIG_SH3_3	173	179	PF00018	0.425
LIG_SUMO_SIM_par_1	43	48	PF11976	0.514
LIG_WRC_WIRS_1	66	71	PF05994	0.439
MOD_CDK_SPK_2	103	108	PF00069	0.494
MOD_CK1_1	106	112	PF00069	0.490
MOD_CK1_1	142	148	PF00069	0.526
MOD_CK1_1	290	296	PF00069	0.599
MOD_CK1_1	48	54	PF00069	0.486
MOD_CK2_1	237	243	PF00069	0.609
MOD_CK2_1	89	95	PF00069	0.332
MOD_GlcNHglycan	14	17	PF01048	0.637
MOD_GlcNHglycan	190	193	PF01048	0.497
MOD_GlcNHglycan	225	228	PF01048	0.419
MOD_GlcNHglycan	23	27	PF01048	0.681
MOD_GlcNHglycan	47	50	PF01048	0.496
MOD_GSK3_1	12	19	PF00069	0.639
MOD_GSK3_1	188	195	PF00069	0.515
MOD_GSK3_1	223	230	PF00069	0.399
MOD_GSK3_1	237	244	PF00069	0.500
MOD_GSK3_1	281	288	PF00069	0.603
MOD_GSK3_1	41	48	PF00069	0.506
MOD_GSK3_1	99	106	PF00069	0.522
MOD_LATS_1	117	123	PF00433	0.349
MOD_N-GLC_1	207	212	PF02516	0.379
MOD_NEK2_1	188	193	PF00069	0.431
MOD_NEK2_1	200	205	PF00069	0.383
MOD_NEK2_1	291	296	PF00069	0.629
MOD_NEK2_1	72	77	PF00069	0.381
MOD_PIKK_1	170	176	PF00454	0.467
MOD_PKA_2	12	18	PF00069	0.671
MOD_Plk_1	207	213	PF00069	0.491
MOD_Plk_1	22	28	PF00069	0.500
MOD_Plk_4	131	137	PF00069	0.476
MOD_Plk_4	194	200	PF00069	0.479
MOD_Plk_4	287	293	PF00069	0.606
MOD_Plk_4	3	9	PF00069	0.553
MOD_Plk_4	41	47	PF00069	0.581
MOD_Plk_4	80	86	PF00069	0.451
MOD_Plk_4	99	105	PF00069	0.407
MOD_ProDKin_1	103	109	PF00069	0.514
MOD_ProDKin_1	142	148	PF00069	0.529
MOD_ProDKin_1	237	243	PF00069	0.578
MOD_ProDKin_1	285	291	PF00069	0.720
MOD_ProDKin_1	48	54	PF00069	0.650
TRG_ENDOCYTIC_2	76	79	PF00928	0.327
TRG_ER_diArg_1	1	3	PF00400	0.750
TRG_ER_diArg_1	11	14	PF00400	0.632
TRG_ER_diArg_1	260	262	PF00400	0.456
TRG_ER_diArg_1	273	276	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM27	Leptomonas seymouri	49%	100%
A0A1X0NV12	Trypanosomatidae	31%	100%
A0A3Q8IC57	Leishmania donovani	89%	100%
A0A422N5J2	Trypanosoma rangeli	30%	100%
A4HDV4	Leishmania braziliensis	70%	100%
A4I149	Leishmania infantum	89%	100%
D0A975	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
E9AX83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5D7W7	Trypanosoma cruzi	33%	96%