Poly(A)-binding protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-binding protein 3

Species:

Leishmania major

UniProt:

Q4QA88_LEIMA

TriTrypDb:

LmjF.25.0080 , LMJLV39_250005900 , LMJSD75_250005800

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QA88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	9
GO:0005515	protein binding	2	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0031369	translation initiation factor binding	3	2
GO:0031370	eukaryotic initiation factor 4G binding	4	2
GO:0070717	poly-purine tract binding	6	2
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.498
CLV_C14_Caspase3-7	60	64	PF00656	0.485
CLV_NRD_NRD_1	175	177	PF00675	0.425
CLV_NRD_NRD_1	379	381	PF00675	0.505
CLV_NRD_NRD_1	433	435	PF00675	0.584
CLV_NRD_NRD_1	93	95	PF00675	0.422
CLV_PCSK_KEX2_1	175	177	PF00082	0.482
CLV_PCSK_KEX2_1	379	381	PF00082	0.505
CLV_PCSK_KEX2_1	433	435	PF00082	0.584
CLV_PCSK_SKI1_1	129	133	PF00082	0.260
CLV_PCSK_SKI1_1	153	157	PF00082	0.250
CLV_PCSK_SKI1_1	193	197	PF00082	0.216
CLV_PCSK_SKI1_1	228	232	PF00082	0.313
CLV_PCSK_SKI1_1	258	262	PF00082	0.519
CLV_PCSK_SKI1_1	306	310	PF00082	0.292
CLV_PCSK_SKI1_1	83	87	PF00082	0.423
CLV_Separin_Metazoa	445	449	PF03568	0.651
DEG_ODPH_VHL_1	76	88	PF01847	0.395
DOC_CYCLIN_RxL_1	490	500	PF00134	0.476
DOC_MAPK_MEF2A_6	504	512	PF00069	0.425
DOC_PP1_RVXF_1	81	87	PF00149	0.364
DOC_PP4_MxPP_1	408	411	PF00568	0.657
DOC_PP4_MxPP_1	412	415	PF00568	0.656
DOC_PP4_MxPP_1	447	450	PF00568	0.678
DOC_USP7_MATH_1	131	135	PF00917	0.520
DOC_USP7_MATH_1	183	187	PF00917	0.478
DOC_USP7_MATH_1	345	349	PF00917	0.506
DOC_USP7_MATH_1	35	39	PF00917	0.450
DOC_USP7_MATH_1	496	500	PF00917	0.492
DOC_WW_Pin1_4	475	480	PF00397	0.450
LIG_14-3-3_CanoR_1	124	132	PF00244	0.481
LIG_14-3-3_CanoR_1	452	460	PF00244	0.622
LIG_14-3-3_CanoR_1	7	11	PF00244	0.335
LIG_Actin_WH2_2	293	308	PF00022	0.472
LIG_Clathr_ClatBox_1	231	235	PF01394	0.440
LIG_CtBP_PxDLS_1	418	422	PF00389	0.660
LIG_FHA_1	504	510	PF00498	0.425
LIG_FHA_2	198	204	PF00498	0.424
LIG_FHA_2	58	64	PF00498	0.492
LIG_LIR_Gen_1	227	234	PF02991	0.479
LIG_LIR_Gen_1	488	497	PF02991	0.425
LIG_LIR_Gen_1	515	526	PF02991	0.492
LIG_LIR_Nem_3	138	144	PF02991	0.425
LIG_LIR_Nem_3	186	190	PF02991	0.349
LIG_LIR_Nem_3	209	214	PF02991	0.482
LIG_LIR_Nem_3	227	232	PF02991	0.382
LIG_LIR_Nem_3	307	312	PF02991	0.459
LIG_LIR_Nem_3	488	494	PF02991	0.425
LIG_LIR_Nem_3	50	56	PF02991	0.425
LIG_LIR_Nem_3	515	521	PF02991	0.492
LIG_LIR_Nem_3	523	528	PF02991	0.492
LIG_NRBOX	485	491	PF00104	0.492
LIG_Pex14_2	225	229	PF04695	0.492
LIG_Pex14_2	396	400	PF04695	0.600
LIG_SH2_CRK	141	145	PF00017	0.448
LIG_SH2_CRK	491	495	PF00017	0.450
LIG_SH2_CRK	53	57	PF00017	0.425
LIG_SH2_CRK	73	77	PF00017	0.503
LIG_SH2_GRB2like	284	287	PF00017	0.546
LIG_SH2_GRB2like	55	58	PF00017	0.425
LIG_SH2_SRC	284	287	PF00017	0.546
LIG_SH2_STAP1	491	495	PF00017	0.492
LIG_SH2_STAT3	460	463	PF00017	0.757
LIG_SH2_STAT5	11	14	PF00017	0.411
LIG_SH2_STAT5	191	194	PF00017	0.425
LIG_SH2_STAT5	292	295	PF00017	0.425
LIG_SH2_STAT5	362	365	PF00017	0.384
LIG_SH2_STAT5	453	456	PF00017	0.619
LIG_SH2_STAT5	473	476	PF00017	0.354
LIG_SH2_STAT5	485	488	PF00017	0.492
LIG_SH2_STAT5	55	58	PF00017	0.428
LIG_SH2_STAT5	73	76	PF00017	0.487
LIG_SH3_3	166	172	PF00018	0.502
LIG_SH3_3	398	404	PF00018	0.552
LIG_SH3_3	408	414	PF00018	0.537
LIG_SH3_3	433	439	PF00018	0.505
LIG_SH3_3	443	449	PF00018	0.578
LIG_TRAF2_1	233	236	PF00917	0.476
LIG_TRAF2_1	513	516	PF00917	0.492
LIG_TRAF2_2	462	467	PF00917	0.587
LIG_TYR_ITIM	489	494	PF00017	0.492
LIG_TYR_ITIM	51	56	PF00017	0.425
LIG_TYR_ITIM	71	76	PF00017	0.433
MOD_CK1_1	250	256	PF00069	0.618
MOD_CK1_1	475	481	PF00069	0.486
MOD_CK2_1	195	201	PF00069	0.408
MOD_CK2_1	266	272	PF00069	0.562
MOD_CK2_1	361	367	PF00069	0.421
MOD_CK2_1	510	516	PF00069	0.492
MOD_GlcNHglycan	133	136	PF01048	0.240
MOD_GlcNHglycan	197	200	PF01048	0.187
MOD_GlcNHglycan	251	255	PF01048	0.522
MOD_GlcNHglycan	342	345	PF01048	0.370
MOD_GlcNHglycan	355	359	PF01048	0.545
MOD_GlcNHglycan	427	430	PF01048	0.613
MOD_GlcNHglycan	95	98	PF01048	0.507
MOD_GSK3_1	131	138	PF00069	0.523
MOD_GSK3_1	145	152	PF00069	0.441
MOD_GSK3_1	193	200	PF00069	0.386
MOD_GSK3_1	213	220	PF00069	0.410
MOD_LATS_1	222	228	PF00433	0.378
MOD_N-GLC_1	158	163	PF02516	0.225
MOD_N-GLC_1	193	198	PF02516	0.178
MOD_N-GLC_1	247	252	PF02516	0.292
MOD_N-GLC_1	324	329	PF02516	0.272
MOD_N-GLC_1	71	76	PF02516	0.225
MOD_NEK2_1	158	163	PF00069	0.476
MOD_NEK2_1	29	34	PF00069	0.466
MOD_NEK2_1	354	359	PF00069	0.576
MOD_NEK2_1	361	366	PF00069	0.346
MOD_NEK2_1	392	397	PF00069	0.475
MOD_NEK2_1	489	494	PF00069	0.492
MOD_NEK2_1	497	502	PF00069	0.492
MOD_NEK2_1	71	76	PF00069	0.472
MOD_NEK2_2	183	188	PF00069	0.446
MOD_NEK2_2	324	329	PF00069	0.440
MOD_NEK2_2	35	40	PF00069	0.436
MOD_OFUCOSY	122	128	PF10250	0.292
MOD_PIKK_1	44	50	PF00454	0.425
MOD_PIKK_1	451	457	PF00454	0.623
MOD_PKA_2	451	457	PF00069	0.695
MOD_PKA_2	6	12	PF00069	0.348
MOD_PKA_2	93	99	PF00069	0.500
MOD_Plk_2-3	298	304	PF00069	0.492
MOD_Plk_4	213	219	PF00069	0.450
MOD_Plk_4	279	285	PF00069	0.514
MOD_Plk_4	6	12	PF00069	0.343
MOD_ProDKin_1	475	481	PF00069	0.450
MOD_SUMO_rev_2	198	207	PF00179	0.506
MOD_SUMO_rev_2	271	280	PF00179	0.631
MOD_SUMO_rev_2	364	371	PF00179	0.467
TRG_DiLeu_BaEn_3	515	521	PF01217	0.440
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.564
TRG_ENDOCYTIC_2	141	144	PF00928	0.448
TRG_ENDOCYTIC_2	491	494	PF00928	0.450
TRG_ENDOCYTIC_2	53	56	PF00928	0.432
TRG_ENDOCYTIC_2	73	76	PF00928	0.482
TRG_ER_diArg_1	174	176	PF00400	0.468
TRG_ER_diArg_1	371	374	PF00400	0.492
TRG_ER_diArg_1	432	434	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y8	Leptomonas seymouri	39%	96%
A0A0N1I0F0	Leptomonas seymouri	77%	99%
A0A0S4IKZ4	Bodo saltans	34%	95%
A0A0S4JPT3	Bodo saltans	48%	96%
A0A1X0P4T3	Trypanosomatidae	35%	97%
A0A1X0P4V5	Trypanosomatidae	45%	95%
A0A1X0P525	Trypanosomatidae	35%	99%
A0A3Q8IF40	Leishmania donovani	95%	100%
A0A3Q8IGR8	Leishmania donovani	36%	97%
A0A3Q8IMW2	Leishmania donovani	34%	93%
A0A3R7NAH9	Trypanosoma rangeli	38%	100%
A0A422NK82	Trypanosoma rangeli	35%	99%
A1D4K4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	36%	72%
A2Q848	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	74%
A3LXL0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	36%	86%
A4HDV5	Leishmania braziliensis	83%	99%
A4HN85	Leishmania braziliensis	33%	94%
A4HNG6	Leishmania braziliensis	34%	98%
A4I150	Leishmania infantum	95%	100%
A4IBV3	Leishmania infantum	34%	93%
A4IC57	Leishmania infantum	36%	97%
A5DM21	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	36%	86%
A5DW14	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	36%	82%
C9ZYE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
E9AFP0	Leishmania major	36%	100%
E9AFX7	Leishmania major	33%	100%
E9AX84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B6U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	92%
E9B730	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
F1QB54	Danio rerio	42%	86%
F4HT49	Arabidopsis thaliana	37%	100%
O04319	Arabidopsis thaliana	34%	100%
O22173	Arabidopsis thaliana	37%	82%
O60176	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
O64380	Arabidopsis thaliana	33%	82%
P04147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	94%
P0CB38	Homo sapiens	39%	100%
P0CP46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	36%	81%
P0CP47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	36%	81%
P11940	Homo sapiens	36%	86%
P20965	Xenopus laevis	41%	86%
P21187	Drosophila melanogaster	43%	86%
P29341	Mus musculus	37%	86%
P31209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	83%
P42731	Arabidopsis thaliana	38%	86%
P60047	Gorilla gorilla gorilla	34%	100%
P60048	Hylobates lar	34%	100%
P60049	Pan troglodytes	34%	100%
P60050	Pongo pygmaeus	34%	100%
P61286	Bos taurus	36%	86%
Q05196	Arabidopsis thaliana	34%	80%
Q0CR95	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	33%	72%
Q0U1G2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	36%	73%
Q13310	Homo sapiens	41%	84%
Q1DXH0	Coccidioides immitis (strain RS)	34%	71%
Q1ZXC2	Dictyostelium discoideum	36%	67%
Q2GSX8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	36%	69%
Q4P8R9	Ustilago maydis (strain 521 / FGSC 9021)	35%	84%
Q4VXU2	Homo sapiens	36%	89%
Q4WK03	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	72%
Q54BM2	Dictyostelium discoideum	34%	96%
Q5AI15	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	86%
Q5B630	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	74%
Q5R8F7	Pongo abelii	36%	86%
Q6BI95	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	87%
Q6CDH3	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	86%
Q6CSV3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	92%
Q6DEY7	Xenopus tropicalis	35%	86%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	94%
Q6GR16	Xenopus laevis	40%	86%
Q6IP09	Xenopus laevis	36%	86%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	93%
Q7JGR2	Macaca mulatta	34%	100%
Q7S6N6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	71%
Q8SR30	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q96DU9	Homo sapiens	34%	100%
Q98SP8	Xenopus laevis	39%	86%
Q9EPH8	Rattus norvegicus	36%	86%
Q9FXA2	Arabidopsis thaliana	40%	81%
Q9H361	Homo sapiens	35%	86%
Q9ZQA8	Arabidopsis thaliana	33%	89%
V5BYR2	Trypanosoma cruzi	38%	96%
V5DUJ1	Trypanosoma cruzi	34%	99%