Putative Qc-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QA87_LEIMA

TriTrypDb:

LmjF.25.0090 , LMJLV39_250006100 , LMJSD75_250006000

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA87

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.583
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.583
CLV_PCSK_SKI1_1	10	14	PF00082	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.714
DOC_USP7_MATH_1	12	16	PF00917	0.658
DOC_USP7_MATH_1	39	43	PF00917	0.624
DOC_USP7_MATH_1	82	86	PF00917	0.633
DOC_USP7_UBL2_3	66	70	PF12436	0.547
LIG_Actin_WH2_2	102	120	PF00022	0.323
LIG_LIR_Gen_1	19	29	PF02991	0.648
LIG_PCNA_PIPBox_1	47	56	PF02747	0.634
LIG_Pex14_2	107	111	PF04695	0.304
LIG_RPA_C_Fungi	71	83	PF08784	0.540
LIG_SH2_STAT5	110	113	PF00017	0.374
LIG_UBA3_1	64	70	PF00899	0.502
MOD_CK1_1	81	87	PF00069	0.468
MOD_GlcNHglycan	80	83	PF01048	0.499
MOD_GSK3_1	12	19	PF00069	0.601
MOD_GSK3_1	78	85	PF00069	0.476
MOD_N-GLC_1	32	37	PF02516	0.534
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	40	45	PF00069	0.411
MOD_NEK2_2	82	87	PF00069	0.524
MOD_Plk_1	32	38	PF00069	0.534
MOD_Plk_4	1	7	PF00069	0.536
MOD_Plk_4	32	38	PF00069	0.372
MOD_Plk_4	85	91	PF00069	0.490
TRG_DiLeu_BaEn_1	60	65	PF01217	0.537
TRG_ENDOCYTIC_2	113	116	PF00928	0.340
TRG_ENDOCYTIC_2	22	25	PF00928	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I772	Leptomonas seymouri	72%	98%
A0A1X0P4K2	Trypanosomatidae	43%	99%
A0A3S7WYP8	Leishmania donovani	92%	100%
A0A422NF19	Trypanosoma rangeli	44%	100%
A4HDV6	Leishmania braziliensis	80%	100%
A4I151	Leishmania infantum	92%	100%
D0A5D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AX85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%