Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA85_LEIMA

TriTrypDb:

LmjF.25.0110 , LMJLV39_250006300 , LMJSD75_250006200

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.570
CLV_NRD_NRD_1	189	191	PF00675	0.661
CLV_NRD_NRD_1	2	4	PF00675	0.607
CLV_NRD_NRD_1	305	307	PF00675	0.720
CLV_NRD_NRD_1	67	69	PF00675	0.452
CLV_PCSK_FUR_1	341	345	PF00082	0.410
CLV_PCSK_KEX2_1	189	191	PF00082	0.641
CLV_PCSK_KEX2_1	2	4	PF00082	0.648
CLV_PCSK_KEX2_1	305	307	PF00082	0.716
CLV_PCSK_KEX2_1	343	345	PF00082	0.420
CLV_PCSK_KEX2_1	414	416	PF00082	0.440
CLV_PCSK_KEX2_1	67	69	PF00082	0.452
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.420
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.440
CLV_PCSK_SKI1_1	116	120	PF00082	0.374
CLV_PCSK_SKI1_1	322	326	PF00082	0.414
CLV_PCSK_SKI1_1	34	38	PF00082	0.409
CLV_PCSK_SKI1_1	407	411	PF00082	0.561
DEG_APCC_DBOX_1	97	105	PF00400	0.430
DEG_COP1_1	288	297	PF00400	0.663
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_CKS1_1	227	232	PF01111	0.451
DOC_CKS1_1	334	339	PF01111	0.589
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.524
DOC_MAPK_gen_1	186	195	PF00069	0.624
DOC_MAPK_gen_1	414	422	PF00069	0.422
DOC_MAPK_gen_1	48	56	PF00069	0.448
DOC_MAPK_MEF2A_6	116	123	PF00069	0.545
DOC_MAPK_MEF2A_6	189	197	PF00069	0.528
DOC_MAPK_MEF2A_6	377	385	PF00069	0.484
DOC_MAPK_MEF2A_6	50	58	PF00069	0.367
DOC_PP4_FxxP_1	334	337	PF00568	0.471
DOC_PP4_FxxP_1	418	421	PF00568	0.437
DOC_USP7_MATH_1	180	184	PF00917	0.665
DOC_USP7_MATH_1	19	23	PF00917	0.496
DOC_USP7_MATH_1	304	308	PF00917	0.634
DOC_USP7_MATH_1	361	365	PF00917	0.621
DOC_USP7_MATH_1	468	472	PF00917	0.697
DOC_WW_Pin1_4	226	231	PF00397	0.478
DOC_WW_Pin1_4	333	338	PF00397	0.607
DOC_WW_Pin1_4	8	13	PF00397	0.437
LIG_14-3-3_CanoR_1	137	144	PF00244	0.422
LIG_14-3-3_CanoR_1	2	6	PF00244	0.516
LIG_14-3-3_CanoR_1	208	215	PF00244	0.602
LIG_14-3-3_CanoR_1	34	39	PF00244	0.434
LIG_14-3-3_CanoR_1	458	464	PF00244	0.546
LIG_14-3-3_CanoR_1	50	55	PF00244	0.299
LIG_APCC_ABBA_1	235	240	PF00400	0.441
LIG_BRCT_BRCA1_1	298	302	PF00533	0.520
LIG_BRCT_BRCA1_1	38	42	PF00533	0.420
LIG_Clathr_ClatBox_1	120	124	PF01394	0.465
LIG_deltaCOP1_diTrp_1	89	95	PF00928	0.390
LIG_DLG_GKlike_1	50	57	PF00625	0.433
LIG_FAT_LD_1	54	62	PF03623	0.497
LIG_FHA_1	159	165	PF00498	0.462
LIG_FHA_1	2	8	PF00498	0.591
LIG_FHA_1	223	229	PF00498	0.489
LIG_FHA_1	353	359	PF00498	0.474
LIG_FHA_1	404	410	PF00498	0.556
LIG_FHA_1	75	81	PF00498	0.542
LIG_FHA_2	310	316	PF00498	0.682
LIG_FHA_2	42	48	PF00498	0.548
LIG_FHA_2	50	56	PF00498	0.444
LIG_LIR_Gen_1	200	211	PF02991	0.577
LIG_LIR_Gen_1	39	47	PF02991	0.433
LIG_LIR_Gen_1	89	96	PF02991	0.440
LIG_LIR_Nem_3	200	206	PF02991	0.572
LIG_LIR_Nem_3	360	365	PF02991	0.462
LIG_LIR_Nem_3	39	45	PF02991	0.439
LIG_LIR_Nem_3	81	86	PF02991	0.461
LIG_LIR_Nem_3	89	93	PF02991	0.393
LIG_MYND_1	347	351	PF01753	0.573
LIG_NRBOX	100	106	PF00104	0.497
LIG_NRBOX	53	59	PF00104	0.433
LIG_PCNA_yPIPBox_3	263	277	PF02747	0.399
LIG_Pex14_2	418	422	PF04695	0.429
LIG_SH2_CRK	30	34	PF00017	0.461
LIG_SH2_STAP1	412	416	PF00017	0.440
LIG_SH2_STAT5	165	168	PF00017	0.416
LIG_SH2_STAT5	425	428	PF00017	0.352
LIG_SH2_STAT5	6	9	PF00017	0.532
LIG_SH2_STAT5	64	67	PF00017	0.527
LIG_SH3_1	236	242	PF00018	0.471
LIG_SH3_3	224	230	PF00018	0.457
LIG_SH3_3	236	242	PF00018	0.475
LIG_SH3_3	289	295	PF00018	0.528
LIG_SH3_3	348	354	PF00018	0.408
LIG_SH3_4	331	338	PF00018	0.461
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.490
LIG_SUMO_SIM_anti_2	99	106	PF11976	0.469
LIG_SUMO_SIM_par_1	119	124	PF11976	0.482
LIG_SUMO_SIM_par_1	354	360	PF11976	0.508
LIG_SUMO_SIM_par_1	381	386	PF11976	0.442
LIG_SUMO_SIM_par_1	99	106	PF11976	0.457
LIG_TRAF2_1	399	402	PF00917	0.594
LIG_UBA3_1	119	126	PF00899	0.415
MOD_CK1_1	307	313	PF00069	0.672
MOD_CK1_1	41	47	PF00069	0.502
MOD_CK1_1	74	80	PF00069	0.544
MOD_CK2_1	314	320	PF00069	0.674
MOD_CK2_1	324	330	PF00069	0.678
MOD_Cter_Amidation	65	68	PF01082	0.441
MOD_GlcNHglycan	105	108	PF01048	0.552
MOD_GlcNHglycan	182	185	PF01048	0.604
MOD_GlcNHglycan	209	212	PF01048	0.690
MOD_GlcNHglycan	299	302	PF01048	0.540
MOD_GlcNHglycan	326	329	PF01048	0.644
MOD_GlcNHglycan	359	362	PF01048	0.559
MOD_GlcNHglycan	370	373	PF01048	0.590
MOD_GlcNHglycan	429	432	PF01048	0.512
MOD_GlcNHglycan	61	64	PF01048	0.345
MOD_GSK3_1	132	139	PF00069	0.441
MOD_GSK3_1	222	229	PF00069	0.488
MOD_GSK3_1	305	312	PF00069	0.635
MOD_GSK3_1	34	41	PF00069	0.545
MOD_GSK3_1	357	364	PF00069	0.558
MOD_GSK3_1	459	466	PF00069	0.522
MOD_LATS_1	303	309	PF00433	0.722
MOD_N-GLC_2	392	394	PF02516	0.464
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	324	329	PF00069	0.647
MOD_NEK2_1	36	41	PF00069	0.427
MOD_PIKK_1	307	313	PF00454	0.734
MOD_PIKK_1	74	80	PF00454	0.544
MOD_PKA_1	305	311	PF00069	0.738
MOD_PKA_2	1	7	PF00069	0.518
MOD_PKA_2	132	138	PF00069	0.424
MOD_PKA_2	207	213	PF00069	0.654
MOD_PKA_2	304	310	PF00069	0.683
MOD_PKA_2	403	409	PF00069	0.595
MOD_PKA_2	443	449	PF00069	0.506
MOD_PKA_2	49	55	PF00069	0.447
MOD_Plk_1	201	207	PF00069	0.529
MOD_Plk_1	314	320	PF00069	0.466
MOD_Plk_1	383	389	PF00069	0.424
MOD_Plk_4	222	228	PF00069	0.562
MOD_Plk_4	314	320	PF00069	0.466
MOD_Plk_4	352	358	PF00069	0.379
MOD_Plk_4	443	449	PF00069	0.571
MOD_ProDKin_1	226	232	PF00069	0.479
MOD_ProDKin_1	333	339	PF00069	0.613
MOD_ProDKin_1	8	14	PF00069	0.436
MOD_SUMO_rev_2	163	170	PF00179	0.337
MOD_SUMO_rev_2	89	96	PF00179	0.375
TRG_DiLeu_BaEn_1	100	105	PF01217	0.464
TRG_DiLeu_BaEn_1	115	120	PF01217	0.312
TRG_DiLeu_BaEn_1	443	448	PF01217	0.544
TRG_DiLeu_BaEn_2	221	227	PF01217	0.543
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.559
TRG_ENDOCYTIC_2	425	428	PF00928	0.352
TRG_ER_diArg_1	1	3	PF00400	0.663
TRG_NES_CRM1_1	78	92	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X3	Leptomonas seymouri	70%	100%
A0A0S4IT89	Bodo saltans	42%	82%
A0A1X0P4R6	Trypanosomatidae	57%	100%
A0A3Q8IN33	Leishmania donovani	93%	100%
A0A3R7MKC3	Trypanosoma rangeli	56%	100%
A4HDV8	Leishmania braziliensis	86%	100%
A4I153	Leishmania infantum	93%	100%
D0A5D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A5D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AX87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BSX0	Trypanosoma cruzi	55%	100%