Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA81_LEIMA

TriTrypDb:

LmjF.25.0150 , LMJLV39_250006800 , LMJSD75_250006700

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QA81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.444
CLV_C14_Caspase3-7	283	287	PF00656	0.451
CLV_C14_Caspase3-7	372	376	PF00656	0.482
CLV_C14_Caspase3-7	643	647	PF00656	0.326
CLV_NRD_NRD_1	100	102	PF00675	0.576
CLV_NRD_NRD_1	493	495	PF00675	0.373
CLV_NRD_NRD_1	518	520	PF00675	0.405
CLV_NRD_NRD_1	97	99	PF00675	0.544
CLV_PCSK_FUR_1	98	102	PF00082	0.609
CLV_PCSK_KEX2_1	493	495	PF00082	0.370
CLV_PCSK_KEX2_1	518	520	PF00082	0.394
CLV_PCSK_KEX2_1	99	101	PF00082	0.587
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.621
CLV_PCSK_SKI1_1	100	104	PF00082	0.621
CLV_PCSK_SKI1_1	186	190	PF00082	0.676
CLV_PCSK_SKI1_1	451	455	PF00082	0.405
CLV_PCSK_SKI1_1	503	507	PF00082	0.427
CLV_PCSK_SKI1_1	555	559	PF00082	0.393
CLV_Separin_Metazoa	200	204	PF03568	0.378
CLV_Separin_Metazoa	560	564	PF03568	0.256
DEG_APCC_DBOX_1	185	193	PF00400	0.410
DEG_APCC_DBOX_1	197	205	PF00400	0.294
DEG_APCC_DBOX_1	554	562	PF00400	0.510
DEG_Nend_UBRbox_2	1	3	PF02207	0.490
DOC_CYCLIN_RxL_1	500	509	PF00134	0.536
DOC_CYCLIN_RxL_1	97	106	PF00134	0.427
DOC_MAPK_gen_1	196	204	PF00069	0.475
DOC_MAPK_gen_1	331	338	PF00069	0.437
DOC_MAPK_gen_1	518	528	PF00069	0.582
DOC_MAPK_MEF2A_6	198	206	PF00069	0.479
DOC_MAPK_MEF2A_6	519	528	PF00069	0.582
DOC_MAPK_MEF2A_6	685	693	PF00069	0.497
DOC_MAPK_MEF2A_6	86	93	PF00069	0.330
DOC_MAPK_RevD_3	87	100	PF00069	0.336
DOC_PP2B_LxvP_1	239	242	PF13499	0.406
DOC_PP4_FxxP_1	390	393	PF00568	0.429
DOC_PP4_FxxP_1	609	612	PF00568	0.281
DOC_USP7_MATH_1	207	211	PF00917	0.297
DOC_USP7_MATH_1	415	419	PF00917	0.422
DOC_USP7_MATH_1	549	553	PF00917	0.285
DOC_USP7_MATH_1	567	571	PF00917	0.406
DOC_USP7_MATH_1	582	586	PF00917	0.430
DOC_USP7_MATH_1	637	641	PF00917	0.413
DOC_USP7_MATH_1	75	79	PF00917	0.306
DOC_USP7_MATH_2	386	392	PF00917	0.479
DOC_WW_Pin1_4	162	167	PF00397	0.586
DOC_WW_Pin1_4	263	268	PF00397	0.569
DOC_WW_Pin1_4	382	387	PF00397	0.516
DOC_WW_Pin1_4	389	394	PF00397	0.462
DOC_WW_Pin1_4	578	583	PF00397	0.423
DOC_WW_Pin1_4	632	637	PF00397	0.357
DOC_WW_Pin1_4	691	696	PF00397	0.390
DOC_WW_Pin1_4	70	75	PF00397	0.416
LIG_14-3-3_CanoR_1	101	111	PF00244	0.522
LIG_14-3-3_CanoR_1	122	128	PF00244	0.369
LIG_14-3-3_CanoR_1	247	257	PF00244	0.452
LIG_14-3-3_CanoR_1	408	417	PF00244	0.473
LIG_14-3-3_CanoR_1	441	450	PF00244	0.594
LIG_14-3-3_CanoR_1	519	525	PF00244	0.578
LIG_14-3-3_CanoR_1	566	575	PF00244	0.439
LIG_14-3-3_CanoR_1	631	639	PF00244	0.370
LIG_14-3-3_CanoR_1	667	672	PF00244	0.440
LIG_Actin_WH2_2	135	151	PF00022	0.386
LIG_Actin_WH2_2	425	443	PF00022	0.350
LIG_APCC_ABBA_1	89	94	PF00400	0.333
LIG_APCC_ABBAyCdc20_2	100	106	PF00400	0.310
LIG_BIR_III_2	150	154	PF00653	0.423
LIG_BIR_III_4	217	221	PF00653	0.311
LIG_BRCT_BRCA1_1	107	111	PF00533	0.400
LIG_BRCT_BRCA1_1	314	318	PF00533	0.498
LIG_Clathr_ClatBox_1	368	372	PF01394	0.491
LIG_deltaCOP1_diTrp_1	31	40	PF00928	0.321
LIG_EVH1_1	241	245	PF00568	0.451
LIG_FHA_1	129	135	PF00498	0.421
LIG_FHA_1	249	255	PF00498	0.510
LIG_FHA_1	292	298	PF00498	0.444
LIG_FHA_1	333	339	PF00498	0.422
LIG_FHA_1	521	527	PF00498	0.533
LIG_FHA_2	209	215	PF00498	0.446
LIG_FHA_2	281	287	PF00498	0.538
LIG_FHA_2	675	681	PF00498	0.474
LIG_FHA_2	692	698	PF00498	0.446
LIG_GBD_Chelix_1	524	532	PF00786	0.377
LIG_LIR_Apic_2	387	393	PF02991	0.439
LIG_LIR_Apic_2	606	612	PF02991	0.298
LIG_LIR_Gen_1	108	119	PF02991	0.390
LIG_LIR_Gen_1	31	40	PF02991	0.372
LIG_LIR_Gen_1	492	502	PF02991	0.515
LIG_LIR_Gen_1	78	88	PF02991	0.322
LIG_LIR_LC3C_4	611	615	PF02991	0.363
LIG_LIR_Nem_3	108	114	PF02991	0.408
LIG_LIR_Nem_3	31	35	PF02991	0.356
LIG_LIR_Nem_3	492	498	PF02991	0.519
LIG_LIR_Nem_3	78	83	PF02991	0.294
LIG_LIR_Nem_3	85	91	PF02991	0.288
LIG_LYPXL_yS_3	550	553	PF13949	0.400
LIG_MYND_3	22	26	PF01753	0.378
LIG_NRBOX	455	461	PF00104	0.583
LIG_NRBOX	557	563	PF00104	0.378
LIG_OCRL_FandH_1	452	464	PF00620	0.455
LIG_PDZ_Class_2	708	713	PF00595	0.315
LIG_Pex14_1	257	261	PF04695	0.441
LIG_PTAP_UEV_1	165	170	PF05743	0.441
LIG_PTAP_UEV_1	266	271	PF05743	0.417
LIG_Rb_LxCxE_1	467	478	PF01857	0.546
LIG_REV1ctd_RIR_1	116	126	PF16727	0.280
LIG_RPA_C_Fungi	439	451	PF08784	0.411
LIG_SH2_CRK	227	231	PF00017	0.527
LIG_SH2_PTP2	80	83	PF00017	0.369
LIG_SH2_PTP2	88	91	PF00017	0.393
LIG_SH2_STAP1	421	425	PF00017	0.580
LIG_SH2_STAP1	495	499	PF00017	0.457
LIG_SH2_STAT5	436	439	PF00017	0.324
LIG_SH2_STAT5	466	469	PF00017	0.461
LIG_SH2_STAT5	80	83	PF00017	0.317
LIG_SH2_STAT5	88	91	PF00017	0.321
LIG_SH2_STAT5	92	95	PF00017	0.333
LIG_SH3_2	242	247	PF14604	0.576
LIG_SH3_3	163	169	PF00018	0.698
LIG_SH3_3	239	245	PF00018	0.659
LIG_SH3_3	264	270	PF00018	0.633
LIG_SH3_3	64	70	PF00018	0.569
LIG_SH3_4	180	187	PF00018	0.527
LIG_Sin3_3	399	406	PF02671	0.538
LIG_SUMO_SIM_par_1	204	212	PF11976	0.402
LIG_SUMO_SIM_par_1	366	372	PF11976	0.614
LIG_SUMO_SIM_par_1	399	405	PF11976	0.516
LIG_SUMO_SIM_par_1	504	509	PF11976	0.355
LIG_SUMO_SIM_par_1	522	527	PF11976	0.379
LIG_SUMO_SIM_par_1	587	593	PF11976	0.334
LIG_SUMO_SIM_par_1	62	68	PF11976	0.528
LIG_SUMO_SIM_par_1	694	700	PF11976	0.516
LIG_TRAF2_1	385	388	PF00917	0.598
LIG_TRAF2_1	678	681	PF00917	0.441
MOD_CDK_SPxxK_3	389	396	PF00069	0.438
MOD_CK1_1	105	111	PF00069	0.579
MOD_CK1_1	312	318	PF00069	0.536
MOD_CK1_1	326	332	PF00069	0.559
MOD_CK1_1	424	430	PF00069	0.293
MOD_CK1_1	489	495	PF00069	0.575
MOD_CK1_1	603	609	PF00069	0.505
MOD_CK1_1	625	631	PF00069	0.420
MOD_CK1_1	63	69	PF00069	0.443
MOD_CK1_1	632	638	PF00069	0.455
MOD_CK1_1	676	682	PF00069	0.452
MOD_CK2_1	209	215	PF00069	0.523
MOD_CK2_1	278	284	PF00069	0.622
MOD_CK2_1	382	388	PF00069	0.633
MOD_CK2_1	674	680	PF00069	0.493
MOD_GlcNHglycan	2	5	PF01048	0.431
MOD_GlcNHglycan	311	314	PF01048	0.537
MOD_GlcNHglycan	325	328	PF01048	0.450
MOD_GlcNHglycan	35	38	PF01048	0.450
MOD_GlcNHglycan	377	380	PF01048	0.654
MOD_GlcNHglycan	423	426	PF01048	0.363
MOD_GlcNHglycan	444	447	PF01048	0.531
MOD_GlcNHglycan	46	49	PF01048	0.375
MOD_GlcNHglycan	460	463	PF01048	0.370
MOD_GlcNHglycan	508	511	PF01048	0.411
MOD_GlcNHglycan	606	609	PF01048	0.493
MOD_GlcNHglycan	639	642	PF01048	0.498
MOD_GSK3_1	152	159	PF00069	0.657
MOD_GSK3_1	170	177	PF00069	0.565
MOD_GSK3_1	226	233	PF00069	0.466
MOD_GSK3_1	246	253	PF00069	0.667
MOD_GSK3_1	347	354	PF00069	0.632
MOD_GSK3_1	415	422	PF00069	0.592
MOD_GSK3_1	42	49	PF00069	0.536
MOD_GSK3_1	578	585	PF00069	0.556
MOD_GSK3_1	59	66	PF00069	0.429
MOD_GSK3_1	600	607	PF00069	0.449
MOD_GSK3_1	625	632	PF00069	0.343
MOD_GSK3_1	670	677	PF00069	0.387
MOD_N-GLC_1	673	678	PF02516	0.364
MOD_NEK2_1	138	143	PF00069	0.449
MOD_NEK2_1	208	213	PF00069	0.516
MOD_NEK2_1	246	251	PF00069	0.672
MOD_NEK2_1	289	294	PF00069	0.595
MOD_NEK2_1	419	424	PF00069	0.506
MOD_NEK2_1	44	49	PF00069	0.608
MOD_NEK2_1	506	511	PF00069	0.384
MOD_NEK2_1	520	525	PF00069	0.473
MOD_NEK2_1	540	545	PF00069	0.224
MOD_NEK2_1	60	65	PF00069	0.449
MOD_NEK2_1	604	609	PF00069	0.395
MOD_NEK2_1	699	704	PF00069	0.407
MOD_NEK2_2	486	491	PF00069	0.385
MOD_NEK2_2	75	80	PF00069	0.362
MOD_PIKK_1	291	297	PF00454	0.593
MOD_PIKK_1	597	603	PF00454	0.429
MOD_PIKK_1	622	628	PF00454	0.440
MOD_PKA_2	156	162	PF00069	0.683
MOD_PKA_2	246	252	PF00069	0.625
MOD_PKA_2	332	338	PF00069	0.588
MOD_PKA_2	342	348	PF00069	0.737
MOD_PKA_2	52	58	PF00069	0.505
MOD_PKA_2	630	636	PF00069	0.446
MOD_Plk_1	363	369	PF00069	0.505
MOD_Plk_1	533	539	PF00069	0.384
MOD_Plk_1	645	651	PF00069	0.454
MOD_Plk_1	689	695	PF00069	0.497
MOD_Plk_4	138	144	PF00069	0.433
MOD_Plk_4	364	370	PF00069	0.646
MOD_Plk_4	424	430	PF00069	0.293
MOD_Plk_4	540	546	PF00069	0.309
MOD_Plk_4	582	588	PF00069	0.402
MOD_Plk_4	60	66	PF00069	0.450
MOD_Plk_4	625	631	PF00069	0.326
MOD_Plk_4	667	673	PF00069	0.543
MOD_Plk_4	75	81	PF00069	0.258
MOD_ProDKin_1	162	168	PF00069	0.760
MOD_ProDKin_1	263	269	PF00069	0.736
MOD_ProDKin_1	382	388	PF00069	0.660
MOD_ProDKin_1	389	395	PF00069	0.583
MOD_ProDKin_1	578	584	PF00069	0.519
MOD_ProDKin_1	632	638	PF00069	0.436
MOD_ProDKin_1	691	697	PF00069	0.476
MOD_ProDKin_1	70	76	PF00069	0.514
MOD_SUMO_rev_2	173	182	PF00179	0.701
TRG_DiLeu_BaEn_1	200	205	PF01217	0.496
TRG_DiLeu_BaEn_1	364	369	PF01217	0.607
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.610
TRG_ENDOCYTIC_2	227	230	PF00928	0.526
TRG_ENDOCYTIC_2	32	35	PF00928	0.383
TRG_ENDOCYTIC_2	495	498	PF00928	0.461
TRG_ENDOCYTIC_2	550	553	PF00928	0.347
TRG_ENDOCYTIC_2	80	83	PF00928	0.317
TRG_ENDOCYTIC_2	88	91	PF00928	0.321
TRG_ER_diArg_1	195	198	PF00400	0.470
TRG_ER_diArg_1	257	260	PF00400	0.610
TRG_ER_diArg_1	493	495	PF00400	0.524
TRG_ER_diArg_1	518	520	PF00400	0.567
TRG_ER_diArg_1	535	538	PF00400	0.275
TRG_ER_diArg_1	98	101	PF00400	0.476
TRG_NES_CRM1_1	611	623	PF08389	0.461
TRG_NLS_MonoExtN_4	98	103	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAE2	Leptomonas seymouri	39%	85%
A0A1X0P4U7	Trypanosomatidae	22%	98%
A0A3Q8ID38	Leishmania donovani	89%	100%
A0A422NF62	Trypanosoma rangeli	23%	99%
A4HDW2	Leishmania braziliensis	69%	100%
A4I157	Leishmania infantum	90%	100%
D0A5E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
E9AX91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%