Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA80_LEIMA

TriTrypDb:

LmjF.25.0160 , LMJLV39_250006900 , LMJSD75_250006800

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.478
CLV_NRD_NRD_1	132	134	PF00675	0.465
CLV_NRD_NRD_1	154	156	PF00675	0.493
CLV_NRD_NRD_1	179	181	PF00675	0.527
CLV_NRD_NRD_1	187	189	PF00675	0.548
CLV_NRD_NRD_1	39	41	PF00675	0.614
CLV_PCSK_FUR_1	37	41	PF00082	0.470
CLV_PCSK_KEX2_1	126	128	PF00082	0.371
CLV_PCSK_KEX2_1	154	156	PF00082	0.493
CLV_PCSK_KEX2_1	186	188	PF00082	0.517
CLV_PCSK_KEX2_1	39	41	PF00082	0.614
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.544
CLV_PCSK_SKI1_1	101	105	PF00082	0.622
CLV_PCSK_SKI1_1	133	137	PF00082	0.440
CLV_PCSK_SKI1_1	154	158	PF00082	0.625
CLV_PCSK_SKI1_1	82	86	PF00082	0.535
CLV_Separin_Metazoa	34	38	PF03568	0.459
DEG_SCF_FBW7_1	60	67	PF00400	0.489
DOC_CKS1_1	61	66	PF01111	0.595
DOC_MAPK_MEF2A_6	51	58	PF00069	0.484
DOC_USP7_MATH_1	114	118	PF00917	0.570
DOC_USP7_MATH_1	148	152	PF00917	0.531
DOC_USP7_MATH_1	41	45	PF00917	0.617
DOC_USP7_MATH_1	54	58	PF00917	0.638
DOC_USP7_MATH_1	68	72	PF00917	0.726
DOC_USP7_MATH_2	60	66	PF00917	0.562
DOC_WW_Pin1_4	108	113	PF00397	0.473
DOC_WW_Pin1_4	204	209	PF00397	0.568
DOC_WW_Pin1_4	60	65	PF00397	0.614
LIG_14-3-3_CanoR_1	40	46	PF00244	0.545
LIG_Actin_WH2_2	24	41	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BIR_III_3	1	5	PF00653	0.574
LIG_Clathr_ClatBox_1	9	13	PF01394	0.417
LIG_FHA_1	5	11	PF00498	0.480
LIG_FHA_1	65	71	PF00498	0.626
LIG_LIR_Gen_1	179	189	PF02991	0.546
LIG_LIR_Gen_1	83	93	PF02991	0.433
LIG_LIR_Nem_3	179	185	PF02991	0.517
LIG_LIR_Nem_3	83	88	PF02991	0.417
LIG_NRBOX	87	93	PF00104	0.419
LIG_RPA_C_Fungi	35	47	PF08784	0.442
LIG_RPA_C_Fungi	67	79	PF08784	0.434
LIG_SH2_SRC	189	192	PF00017	0.421
LIG_SH2_STAP1	189	193	PF00017	0.417
LIG_SH3_3	58	64	PF00018	0.585
LIG_SUMO_SIM_par_1	6	13	PF11976	0.486
MOD_CDK_SPK_2	108	113	PF00069	0.446
MOD_CK1_1	117	123	PF00069	0.360
MOD_CK2_1	68	74	PF00069	0.620
MOD_GlcNHglycan	170	173	PF01048	0.353
MOD_GlcNHglycan	64	67	PF01048	0.749
MOD_GlcNHglycan	73	78	PF01048	0.463
MOD_GSK3_1	4	11	PF00069	0.512
MOD_GSK3_1	60	67	PF00069	0.615
MOD_GSK3_1	68	75	PF00069	0.574
MOD_N-GLC_1	41	46	PF02516	0.618
MOD_PIKK_1	206	212	PF00454	0.526
MOD_PIKK_1	22	28	PF00454	0.481
MOD_Plk_1	117	123	PF00069	0.483
MOD_Plk_1	41	47	PF00069	0.630
MOD_Plk_4	4	10	PF00069	0.435
MOD_Plk_4	41	47	PF00069	0.512
MOD_ProDKin_1	108	114	PF00069	0.477
MOD_ProDKin_1	204	210	PF00069	0.572
MOD_ProDKin_1	60	66	PF00069	0.610
TRG_DiLeu_BaEn_4	130	136	PF01217	0.459
TRG_ENDOCYTIC_2	182	185	PF00928	0.440
TRG_ER_diArg_1	153	155	PF00400	0.500
TRG_ER_diArg_1	187	189	PF00400	0.613
TRG_ER_diArg_1	36	39	PF00400	0.538
TRG_ER_diArg_1	98	101	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM96	Leptomonas seymouri	48%	96%
A0A1X0P602	Trypanosomatidae	34%	69%
A0A3Q8ID59	Leishmania donovani	88%	100%
A0A422NF37	Trypanosoma rangeli	33%	69%
A4HDW3	Leishmania braziliensis	74%	100%
A4I158	Leishmania infantum	88%	100%
D0A5E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	68%
E9AX92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BXK9	Trypanosoma cruzi	34%	69%