Cleavage and polyadenylation specificity factor subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cleavage and polyadenylation specificity factor, putative

Species:

Leishmania major

UniProt:

Q4QA79_LEIMA

TriTrypDb:

LmjF.25.0170 , LMJLV39_250007000 , LMJSD75_250006900

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	11
GO:0005849	mRNA cleavage factor complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

Q4QA79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA79

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006378	mRNA polyadenylation	7	11
GO:0006379	mRNA cleavage	7	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008334	histone mRNA metabolic process	7	2
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043631	RNA polyadenylation	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	11
GO:0090501	RNA phosphodiester bond hydrolysis	6	11
GO:0098787	mRNA cleavage involved in mRNA processing	8	2
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	2
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.562
CLV_NRD_NRD_1	392	394	PF00675	0.487
CLV_NRD_NRD_1	416	418	PF00675	0.528
CLV_NRD_NRD_1	588	590	PF00675	0.430
CLV_NRD_NRD_1	685	687	PF00675	0.355
CLV_NRD_NRD_1	722	724	PF00675	0.392
CLV_NRD_NRD_1	764	766	PF00675	0.457
CLV_NRD_NRD_1	795	797	PF00675	0.313
CLV_NRD_NRD_1	817	819	PF00675	0.335
CLV_PCSK_KEX2_1	307	309	PF00082	0.562
CLV_PCSK_KEX2_1	392	394	PF00082	0.464
CLV_PCSK_KEX2_1	415	417	PF00082	0.530
CLV_PCSK_KEX2_1	528	530	PF00082	0.707
CLV_PCSK_KEX2_1	548	550	PF00082	0.426
CLV_PCSK_KEX2_1	588	590	PF00082	0.494
CLV_PCSK_KEX2_1	685	687	PF00082	0.331
CLV_PCSK_KEX2_1	721	723	PF00082	0.335
CLV_PCSK_KEX2_1	764	766	PF00082	0.473
CLV_PCSK_KEX2_1	817	819	PF00082	0.424
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.562
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.700
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.426
CLV_PCSK_SKI1_1	230	234	PF00082	0.435
CLV_PCSK_SKI1_1	276	280	PF00082	0.460
CLV_PCSK_SKI1_1	307	311	PF00082	0.499
CLV_PCSK_SKI1_1	34	38	PF00082	0.273
CLV_PCSK_SKI1_1	491	495	PF00082	0.763
CLV_PCSK_SKI1_1	591	595	PF00082	0.476
CLV_PCSK_SKI1_1	607	611	PF00082	0.222
CLV_PCSK_SKI1_1	631	635	PF00082	0.413
CLV_PCSK_SKI1_1	641	645	PF00082	0.392
DEG_APCC_DBOX_1	590	598	PF00400	0.485
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DEG_SCF_FBW7_2	9	16	PF00400	0.393
DOC_ANK_TNKS_1	795	802	PF00023	0.424
DOC_CKS1_1	10	15	PF01111	0.382
DOC_CKS1_1	808	813	PF01111	0.424
DOC_CYCLIN_RxL_1	224	235	PF00134	0.547
DOC_CYCLIN_RxL_1	505	517	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	500	506	PF00134	0.653
DOC_MAPK_gen_1	489	498	PF00069	0.667
DOC_MAPK_gen_1	578	586	PF00069	0.548
DOC_MAPK_gen_1	588	594	PF00069	0.459
DOC_MAPK_gen_1	782	789	PF00069	0.424
DOC_MAPK_HePTP_8	252	264	PF00069	0.448
DOC_MAPK_MEF2A_6	241	250	PF00069	0.381
DOC_MAPK_MEF2A_6	255	264	PF00069	0.325
DOC_MAPK_MEF2A_6	491	500	PF00069	0.727
DOC_MAPK_MEF2A_6	578	586	PF00069	0.525
DOC_MAPK_MEF2A_6	782	789	PF00069	0.331
DOC_MAPK_RevD_3	784	797	PF00069	0.424
DOC_PP1_RVXF_1	32	38	PF00149	0.539
DOC_PP1_RVXF_1	507	514	PF00149	0.595
DOC_PP2B_LxvP_1	498	501	PF13499	0.607
DOC_PP2B_PxIxI_1	327	333	PF00149	0.435
DOC_PP4_FxxP_1	182	185	PF00568	0.473
DOC_PP4_FxxP_1	198	201	PF00568	0.391
DOC_USP7_MATH_1	736	740	PF00917	0.369
DOC_USP7_UBL2_3	146	150	PF12436	0.539
DOC_USP7_UBL2_3	230	234	PF12436	0.542
DOC_USP7_UBL2_3	607	611	PF12436	0.496
DOC_WW_Pin1_4	16	21	PF00397	0.519
DOC_WW_Pin1_4	64	69	PF00397	0.473
DOC_WW_Pin1_4	807	812	PF00397	0.323
DOC_WW_Pin1_4	81	86	PF00397	0.473
DOC_WW_Pin1_4	9	14	PF00397	0.446
LIG_14-3-3_CanoR_1	3	11	PF00244	0.383
LIG_14-3-3_CanoR_1	308	314	PF00244	0.536
LIG_14-3-3_CanoR_1	553	560	PF00244	0.637
LIG_14-3-3_CanoR_1	591	601	PF00244	0.397
LIG_14-3-3_CanoR_1	721	729	PF00244	0.457
LIG_14-3-3_CanoR_1	817	821	PF00244	0.355
LIG_Actin_WH2_2	225	243	PF00022	0.412
LIG_Actin_WH2_2	669	687	PF00022	0.457
LIG_Actin_WH2_2	754	769	PF00022	0.341
LIG_Actin_WH2_2	801	819	PF00022	0.331
LIG_APCC_ABBA_1	786	791	PF00400	0.424
LIG_BIR_III_2	557	561	PF00653	0.730
LIG_BRCT_BRCA1_1	113	117	PF00533	0.511
LIG_BRCT_BRCA1_1	210	214	PF00533	0.475
LIG_BRCT_BRCA1_1	336	340	PF00533	0.485
LIG_BRCT_BRCA1_1	646	650	PF00533	0.559
LIG_BRCT_BRCA1_1	7	11	PF00533	0.412
LIG_BRCT_BRCA1_1	752	756	PF00533	0.424
LIG_Clathr_ClatBox_1	27	31	PF01394	0.473
LIG_Clathr_ClatBox_1	786	790	PF01394	0.386
LIG_CtBP_PxDLS_1	658	662	PF00389	0.527
LIG_deltaCOP1_diTrp_1	38	45	PF00928	0.473
LIG_eIF4E_1	176	182	PF01652	0.473
LIG_FHA_1	114	120	PF00498	0.470
LIG_FHA_1	124	130	PF00498	0.473
LIG_FHA_1	201	207	PF00498	0.367
LIG_FHA_1	293	299	PF00498	0.406
LIG_FHA_1	45	51	PF00498	0.516
LIG_FHA_1	493	499	PF00498	0.622
LIG_FHA_1	517	523	PF00498	0.599
LIG_FHA_1	531	537	PF00498	0.665
LIG_FHA_1	693	699	PF00498	0.405
LIG_FHA_1	800	806	PF00498	0.424
LIG_FHA_1	808	814	PF00498	0.424
LIG_FHA_1	93	99	PF00498	0.495
LIG_FHA_2	116	122	PF00498	0.562
LIG_FHA_2	221	227	PF00498	0.565
LIG_FHA_2	291	297	PF00498	0.414
LIG_FHA_2	742	748	PF00498	0.368
LIG_GBD_Chelix_1	676	684	PF00786	0.424
LIG_KLC1_Yacidic_2	402	407	PF13176	0.611
LIG_LIR_Apic_2	106	112	PF02991	0.562
LIG_LIR_Apic_2	179	185	PF02991	0.473
LIG_LIR_Apic_2	531	537	PF02991	0.567
LIG_LIR_Gen_1	130	139	PF02991	0.459
LIG_LIR_Gen_1	300	309	PF02991	0.563
LIG_LIR_Gen_1	402	412	PF02991	0.515
LIG_LIR_Gen_1	423	432	PF02991	0.702
LIG_LIR_Gen_1	774	785	PF02991	0.424
LIG_LIR_Nem_3	130	136	PF02991	0.459
LIG_LIR_Nem_3	231	236	PF02991	0.408
LIG_LIR_Nem_3	273	278	PF02991	0.401
LIG_LIR_Nem_3	300	304	PF02991	0.543
LIG_LIR_Nem_3	402	408	PF02991	0.514
LIG_LIR_Nem_3	423	428	PF02991	0.693
LIG_LIR_Nem_3	512	516	PF02991	0.640
LIG_LIR_Nem_3	774	780	PF02991	0.424
LIG_LIR_Nem_3	8	14	PF02991	0.407
LIG_LIR_Nem_3	819	824	PF02991	0.333
LIG_Pex14_1	172	176	PF04695	0.459
LIG_Pex14_1	41	45	PF04695	0.473
LIG_Pex14_2	37	41	PF04695	0.539
LIG_Pex14_2	45	49	PF04695	0.539
LIG_Rb_pABgroove_1	31	39	PF01858	0.539
LIG_RPA_C_Fungi	350	362	PF08784	0.534
LIG_SH2_CRK	109	113	PF00017	0.424
LIG_SH2_CRK	24	28	PF00017	0.432
LIG_SH2_CRK	275	279	PF00017	0.371
LIG_SH2_CRK	534	538	PF00017	0.572
LIG_SH2_NCK_1	729	733	PF00017	0.379
LIG_SH2_PTP2	405	408	PF00017	0.572
LIG_SH2_SRC	109	112	PF00017	0.424
LIG_SH2_STAP1	170	174	PF00017	0.457
LIG_SH2_STAP1	225	229	PF00017	0.422
LIG_SH2_STAP1	24	28	PF00017	0.438
LIG_SH2_STAP1	666	670	PF00017	0.494
LIG_SH2_STAP1	824	828	PF00017	0.598
LIG_SH2_STAT3	225	228	PF00017	0.432
LIG_SH2_STAT3	668	671	PF00017	0.483
LIG_SH2_STAT5	183	186	PF00017	0.312
LIG_SH2_STAT5	26	29	PF00017	0.385
LIG_SH2_STAT5	301	304	PF00017	0.554
LIG_SH2_STAT5	349	352	PF00017	0.434
LIG_SH2_STAT5	405	408	PF00017	0.572
LIG_SH3_1	52	58	PF00018	0.379
LIG_SH3_3	17	23	PF00018	0.451
LIG_SH3_3	243	249	PF00018	0.350
LIG_SH3_3	364	370	PF00018	0.438
LIG_SH3_3	496	502	PF00018	0.724
LIG_SH3_3	52	58	PF00018	0.379
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.468
LIG_SUMO_SIM_par_1	26	31	PF11976	0.312
LIG_SUMO_SIM_par_1	359	366	PF11976	0.471
LIG_SUMO_SIM_par_1	657	663	PF11976	0.535
LIG_SUMO_SIM_par_1	784	791	PF11976	0.385
LIG_SUMO_SIM_par_1	800	807	PF11976	0.385
LIG_TRAF2_1	318	321	PF00917	0.408
LIG_TRAF2_1	397	400	PF00917	0.587
LIG_TRAF2_1	539	542	PF00917	0.660
LIG_TRAF2_1	770	773	PF00917	0.467
LIG_TRFH_1	193	197	PF08558	0.401
LIG_WRC_WIRS_1	104	109	PF05994	0.457
LIG_WRC_WIRS_1	133	138	PF05994	0.385
LIG_WW_2	367	370	PF00397	0.559
MOD_CK1_1	135	141	PF00069	0.457
MOD_CK1_1	312	318	PF00069	0.503
MOD_CK1_1	394	400	PF00069	0.607
MOD_CK1_1	5	11	PF00069	0.360
MOD_CK1_1	520	526	PF00069	0.619
MOD_CK1_1	577	583	PF00069	0.536
MOD_CK1_1	595	601	PF00069	0.475
MOD_CK1_1	651	657	PF00069	0.581
MOD_CK1_1	692	698	PF00069	0.375
MOD_CK1_1	730	736	PF00069	0.333
MOD_CK1_1	807	813	PF00069	0.341
MOD_CK1_1	81	87	PF00069	0.450
MOD_CK2_1	135	141	PF00069	0.424
MOD_CK2_1	220	226	PF00069	0.582
MOD_CK2_1	290	296	PF00069	0.420
MOD_CK2_1	315	321	PF00069	0.386
MOD_CK2_1	394	400	PF00069	0.584
MOD_CK2_1	536	542	PF00069	0.628
MOD_CK2_1	691	697	PF00069	0.405
MOD_CK2_1	741	747	PF00069	0.368
MOD_CK2_1	767	773	PF00069	0.467
MOD_GlcNHglycan	317	320	PF01048	0.470
MOD_GlcNHglycan	342	345	PF01048	0.382
MOD_GlcNHglycan	396	399	PF01048	0.602
MOD_GlcNHglycan	4	7	PF01048	0.382
MOD_GlcNHglycan	422	425	PF01048	0.618
MOD_GlcNHglycan	522	525	PF01048	0.556
MOD_GlcNHglycan	596	600	PF01048	0.406
MOD_GlcNHglycan	625	628	PF01048	0.499
MOD_GlcNHglycan	654	657	PF01048	0.460
MOD_GlcNHglycan	704	708	PF01048	0.456
MOD_GlcNHglycan	752	755	PF01048	0.424
MOD_GlcNHglycan	773	776	PF01048	0.382
MOD_GSK3_1	111	118	PF00069	0.258
MOD_GSK3_1	128	135	PF00069	0.126
MOD_GSK3_1	185	192	PF00069	0.301
MOD_GSK3_1	5	12	PF00069	0.360
MOD_GSK3_1	505	512	PF00069	0.686
MOD_GSK3_1	516	523	PF00069	0.657
MOD_GSK3_1	605	612	PF00069	0.417
MOD_GSK3_1	64	71	PF00069	0.385
MOD_GSK3_1	644	651	PF00069	0.571
MOD_GSK3_1	660	667	PF00069	0.453
MOD_GSK3_1	672	679	PF00069	0.331
MOD_GSK3_1	687	694	PF00069	0.288
MOD_GSK3_1	732	739	PF00069	0.411
MOD_GSK3_1	767	774	PF00069	0.424
MOD_GSK3_1	799	806	PF00069	0.323
MOD_GSK3_1	99	106	PF00069	0.457
MOD_LATS_1	507	513	PF00433	0.725
MOD_N-GLC_1	219	224	PF02516	0.652
MOD_NEK2_1	2	7	PF00069	0.428
MOD_NEK2_1	208	213	PF00069	0.406
MOD_NEK2_1	214	219	PF00069	0.479
MOD_NEK2_1	236	241	PF00069	0.432
MOD_NEK2_1	309	314	PF00069	0.409
MOD_NEK2_1	388	393	PF00069	0.451
MOD_NEK2_1	45	50	PF00069	0.385
MOD_NEK2_1	516	521	PF00069	0.580
MOD_NEK2_1	650	655	PF00069	0.576
MOD_NEK2_1	672	677	PF00069	0.350
MOD_NEK2_1	766	771	PF00069	0.355
MOD_NEK2_1	78	83	PF00069	0.467
MOD_NEK2_1	816	821	PF00069	0.374
MOD_NEK2_2	145	150	PF00069	0.334
MOD_NEK2_2	170	175	PF00069	0.363
MOD_NEK2_2	185	190	PF00069	0.269
MOD_PIKK_1	736	742	PF00454	0.419
MOD_PIKK_1	822	828	PF00454	0.494
MOD_PKA_1	721	727	PF00069	0.424
MOD_PKA_2	2	8	PF00069	0.414
MOD_PKA_2	220	226	PF00069	0.582
MOD_PKA_2	391	397	PF00069	0.525
MOD_PKA_2	623	629	PF00069	0.429
MOD_PKA_2	687	693	PF00069	0.385
MOD_PKA_2	721	727	PF00069	0.424
MOD_PKA_2	766	772	PF00069	0.366
MOD_PKA_2	816	822	PF00069	0.355
MOD_PKB_1	765	773	PF00069	0.424
MOD_Plk_1	185	191	PF00069	0.312
MOD_Plk_1	45	51	PF00069	0.361
MOD_Plk_1	530	536	PF00069	0.570
MOD_Plk_1	672	678	PF00069	0.424
MOD_Plk_2-3	334	340	PF00069	0.389
MOD_Plk_4	128	134	PF00069	0.470
MOD_Plk_4	228	234	PF00069	0.480
MOD_Plk_4	309	315	PF00069	0.510
MOD_Plk_4	45	51	PF00069	0.355
MOD_Plk_4	605	611	PF00069	0.463
MOD_Plk_4	752	758	PF00069	0.385
MOD_Plk_4	84	90	PF00069	0.424
MOD_Plk_4	99	105	PF00069	0.424
MOD_ProDKin_1	16	22	PF00069	0.511
MOD_ProDKin_1	64	70	PF00069	0.331
MOD_ProDKin_1	807	813	PF00069	0.323
MOD_ProDKin_1	81	87	PF00069	0.331
MOD_ProDKin_1	9	15	PF00069	0.445
MOD_SUMO_for_1	437	440	PF00179	0.718
MOD_SUMO_rev_2	300	309	PF00179	0.577
TRG_DiLeu_BaEn_4	541	547	PF01217	0.684
TRG_DiLeu_BaLyEn_6	782	787	PF01217	0.424
TRG_ENDOCYTIC_2	133	136	PF00928	0.331
TRG_ENDOCYTIC_2	24	27	PF00928	0.439
TRG_ENDOCYTIC_2	275	278	PF00928	0.375
TRG_ENDOCYTIC_2	301	304	PF00928	0.554
TRG_ENDOCYTIC_2	405	408	PF00928	0.518
TRG_ENDOCYTIC_2	777	780	PF00928	0.424
TRG_ER_diArg_1	392	395	PF00400	0.497
TRG_ER_diArg_1	415	417	PF00400	0.589
TRG_ER_diArg_1	588	591	PF00400	0.496
TRG_ER_diArg_1	684	686	PF00400	0.355
TRG_ER_diArg_1	721	723	PF00400	0.358
TRG_ER_diArg_1	763	765	PF00400	0.451
TRG_ER_diArg_1	816	818	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP3	Leptomonas seymouri	76%	100%
A0A0S4JJR9	Bodo saltans	30%	88%
A0A1X0P5N3	Trypanosomatidae	50%	100%
A0A3Q8IBL1	Leishmania donovani	95%	100%
A0A422NF58	Trypanosoma rangeli	50%	100%
A4HDW4	Leishmania braziliensis	90%	100%
A4I159	Leishmania infantum	95%	100%
A8XUS3	Caenorhabditis briggsae	23%	98%
D0A5E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AX93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q652P4	Oryza sativa subsp. japonica	23%	100%