Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QA77_LEIMA

TriTrypDb:

LmjF.25.0190 , LMJLV39_250007200 , LMJSD75_250007100

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA77

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.424
CLV_C14_Caspase3-7	197	201	PF00656	0.447
CLV_NRD_NRD_1	187	189	PF00675	0.331
CLV_NRD_NRD_1	61	63	PF00675	0.359
CLV_PCSK_KEX2_1	61	63	PF00082	0.424
CLV_PCSK_SKI1_1	202	206	PF00082	0.402
DEG_APCC_DBOX_1	106	114	PF00400	0.379
DEG_APCC_KENBOX_2	188	192	PF00400	0.340
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DOC_PP1_RVXF_1	23	29	PF00149	0.331
DOC_USP7_MATH_1	114	118	PF00917	0.379
DOC_USP7_MATH_1	127	131	PF00917	0.214
DOC_USP7_MATH_1	4	8	PF00917	0.331
DOC_USP7_UBL2_3	134	138	PF12436	0.340
DOC_WW_Pin1_4	41	46	PF00397	0.406
LIG_14-3-3_CanoR_1	14	20	PF00244	0.456
LIG_BRCT_BRCA1_1	221	225	PF00533	0.406
LIG_CSL_BTD_1	1	4	PF09270	0.385
LIG_EH1_1	224	232	PF00400	0.433
LIG_FHA_1	16	22	PF00498	0.379
LIG_FHA_1	226	232	PF00498	0.461
LIG_FHA_1	69	75	PF00498	0.421
LIG_FHA_1	84	90	PF00498	0.255
LIG_FHA_1	94	100	PF00498	0.255
LIG_FHA_2	127	133	PF00498	0.370
LIG_LIR_Gen_1	27	34	PF02991	0.251
LIG_LIR_Nem_3	27	31	PF02991	0.251
LIG_SH2_STAT5	15	18	PF00017	0.302
LIG_SH3_3	39	45	PF00018	0.314
LIG_TRAF2_1	153	156	PF00917	0.385
LIG_TRAF2_1	211	214	PF00917	0.418
MOD_CK1_1	145	151	PF00069	0.395
MOD_CK1_1	203	209	PF00069	0.446
MOD_CK2_1	218	224	PF00069	0.438
MOD_Cter_Amidation	186	189	PF01082	0.331
MOD_GlcNHglycan	147	150	PF01048	0.356
MOD_GlcNHglycan	34	37	PF01048	0.438
MOD_GSK3_1	141	148	PF00069	0.410
MOD_GSK3_1	15	22	PF00069	0.410
MOD_GSK3_1	190	197	PF00069	0.372
MOD_N-GLC_1	200	205	PF02516	0.461
MOD_N-GLC_2	92	94	PF02516	0.312
MOD_NEK2_1	194	199	PF00069	0.404
MOD_NEK2_1	225	230	PF00069	0.463
MOD_NEK2_1	83	88	PF00069	0.302
MOD_Plk_1	141	147	PF00069	0.468
MOD_Plk_1	200	206	PF00069	0.376
MOD_Plk_4	114	120	PF00069	0.364
MOD_Plk_4	200	206	PF00069	0.289
MOD_ProDKin_1	41	47	PF00069	0.406
MOD_SUMO_for_1	24	27	PF00179	0.285
MOD_SUMO_rev_2	130	136	PF00179	0.328
MOD_SUMO_rev_2	17	26	PF00179	0.426
MOD_SUMO_rev_2	197	204	PF00179	0.223
TRG_DiLeu_BaEn_4	72	78	PF01217	0.340
TRG_ER_diArg_1	61	63	PF00400	0.459
TRG_NES_CRM1_1	10	23	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E1	Leptomonas seymouri	64%	99%
A0A0N1I1H5	Leptomonas seymouri	29%	76%
A0A0S4J7R4	Bodo saltans	24%	75%
A0A0S4JHD6	Bodo saltans	45%	99%
A0A1X0NIK0	Trypanosomatidae	26%	73%
A0A1X0P4J5	Trypanosomatidae	46%	99%
A0A3Q8IGE5	Leishmania donovani	92%	100%
A0A3R7LDV5	Trypanosoma rangeli	28%	75%
A0A3S7WY30	Leishmania donovani	28%	76%
A4HD98	Leishmania braziliensis	27%	76%
A4HDW6	Leishmania braziliensis	78%	100%
A4I161	Leishmania infantum	93%	100%
D0A5E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
D0A712	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	75%
E9AH53	Leishmania infantum	28%	76%
E9AWN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	76%
E9AX95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O01391	Aplysia californica	36%	100%
O04482	Arabidopsis thaliana	28%	71%
P09936	Homo sapiens	34%	100%
P15374	Homo sapiens	35%	100%
P23356	Bos taurus	31%	92%
P35122	Drosophila melanogaster	34%	100%
P35127	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P50103	Monodelphis domestica	36%	100%
P58321	Mus musculus	34%	100%
Q00981	Rattus norvegicus	34%	100%
Q06AB3	Sus scrofa	35%	100%
Q06AT3	Sus scrofa	25%	71%
Q09444	Caenorhabditis elegans	24%	73%
Q10171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q2TBG8	Bos taurus	36%	100%
Q4QAT9	Leishmania major	29%	76%
Q54N38	Dictyostelium discoideum	25%	68%
Q54T48	Dictyostelium discoideum	31%	91%
Q60HC8	Macaca fascicularis	35%	100%
Q6SEG5	Sus scrofa	34%	100%
Q8GWE1	Arabidopsis thaliana	37%	100%
Q8IKM8	Plasmodium falciparum (isolate 3D7)	31%	100%
Q91Y78	Rattus norvegicus	35%	100%
Q9FFF2	Arabidopsis thaliana	26%	70%
Q9GM50	Equus caballus	34%	100%
Q9JKB1	Mus musculus	36%	100%
Q9R0P9	Mus musculus	34%	100%
Q9UUB6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	78%
Q9WUP7	Mus musculus	26%	71%
Q9XSJ0	Bos taurus	26%	71%
Q9Y5K5	Homo sapiens	25%	71%
V5BN93	Trypanosoma cruzi	45%	99%
V5DSM1	Trypanosoma cruzi	25%	75%