MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA74_LEIMA

TriTrypDb:

LmjF.25.0220 , LMJLV39_250007500 , LMJSD75_250007400

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.510
CLV_C14_Caspase3-7	507	511	PF00656	0.411
CLV_NRD_NRD_1	237	239	PF00675	0.500
CLV_NRD_NRD_1	253	255	PF00675	0.505
CLV_PCSK_FUR_1	237	241	PF00082	0.503
CLV_PCSK_KEX2_1	237	239	PF00082	0.500
CLV_PCSK_KEX2_1	262	264	PF00082	0.535
CLV_PCSK_KEX2_1	313	315	PF00082	0.497
CLV_PCSK_KEX2_1	447	449	PF00082	0.494
CLV_PCSK_KEX2_1	475	477	PF00082	0.419
CLV_PCSK_KEX2_1	629	631	PF00082	0.559
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.502
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.563
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.497
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.494
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.461
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.559
CLV_PCSK_PC7_1	258	264	PF00082	0.432
CLV_PCSK_SKI1_1	258	262	PF00082	0.666
CLV_PCSK_SKI1_1	343	347	PF00082	0.380
CLV_PCSK_SKI1_1	360	364	PF00082	0.445
CLV_PCSK_SKI1_1	447	451	PF00082	0.500
CLV_PCSK_SKI1_1	55	59	PF00082	0.343
CLV_PCSK_SKI1_1	64	68	PF00082	0.382
CLV_PCSK_SKI1_1	77	81	PF00082	0.465
DEG_APCC_DBOX_1	237	245	PF00400	0.509
DEG_APCC_DBOX_1	257	265	PF00400	0.381
DEG_APCC_DBOX_1	54	62	PF00400	0.468
DEG_APCC_DBOX_1	76	84	PF00400	0.348
DOC_CYCLIN_RxL_1	444	454	PF00134	0.424
DOC_MAPK_gen_1	144	153	PF00069	0.666
DOC_MAPK_gen_1	313	321	PF00069	0.456
DOC_MAPK_gen_1	634	643	PF00069	0.596
DOC_MAPK_MEF2A_6	104	111	PF00069	0.376
DOC_MAPK_MEF2A_6	314	323	PF00069	0.450
DOC_MAPK_MEF2A_6	564	572	PF00069	0.542
DOC_PP4_FxxP_1	559	562	PF00568	0.511
DOC_PP4_FxxP_1	609	612	PF00568	0.548
DOC_PP4_FxxP_1	707	710	PF00568	0.571
DOC_USP7_MATH_1	127	131	PF00917	0.640
DOC_USP7_MATH_1	400	404	PF00917	0.393
DOC_USP7_MATH_1	516	520	PF00917	0.441
DOC_USP7_MATH_1	694	698	PF00917	0.542
DOC_USP7_UBL2_3	134	138	PF12436	0.626
DOC_WW_Pin1_4	364	369	PF00397	0.561
LIG_14-3-3_CanoR_1	146	153	PF00244	0.706
LIG_14-3-3_CanoR_1	343	348	PF00244	0.492
LIG_14-3-3_CanoR_1	418	427	PF00244	0.374
LIG_14-3-3_CanoR_1	448	453	PF00244	0.455
LIG_14-3-3_CanoR_1	550	558	PF00244	0.437
LIG_14-3-3_CanoR_1	569	573	PF00244	0.578
LIG_14-3-3_CanoR_1	634	639	PF00244	0.595
LIG_Actin_RPEL_3	526	545	PF02755	0.467
LIG_AP_GAE_1	596	602	PF02883	0.582
LIG_APCC_ABBA_1	524	529	PF00400	0.467
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_BIR_III_4	432	436	PF00653	0.564
LIG_BRCT_BRCA1_1	107	111	PF00533	0.506
LIG_BRCT_BRCA1_1	366	370	PF00533	0.543
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.392
LIG_FHA_1	164	170	PF00498	0.577
LIG_FHA_1	367	373	PF00498	0.415
LIG_FHA_1	420	426	PF00498	0.367
LIG_FHA_1	550	556	PF00498	0.486
LIG_FHA_1	626	632	PF00498	0.537
LIG_FHA_2	512	518	PF00498	0.466
LIG_FHA_2	652	658	PF00498	0.538
LIG_FHA_2	90	96	PF00498	0.545
LIG_LIR_Apic_2	608	612	PF02991	0.576
LIG_LIR_Apic_2	706	710	PF02991	0.508
LIG_LIR_Gen_1	295	303	PF02991	0.535
LIG_LIR_Gen_1	361	370	PF02991	0.404
LIG_LIR_Gen_1	93	103	PF02991	0.376
LIG_LIR_Nem_3	290	296	PF02991	0.553
LIG_LIR_Nem_3	355	359	PF02991	0.423
LIG_LIR_Nem_3	361	365	PF02991	0.428
LIG_LIR_Nem_3	367	373	PF02991	0.463
LIG_LIR_Nem_3	391	397	PF02991	0.500
LIG_LIR_Nem_3	482	488	PF02991	0.427
LIG_LIR_Nem_3	575	579	PF02991	0.469
LIG_LIR_Nem_3	656	662	PF02991	0.636
LIG_LIR_Nem_3	93	99	PF02991	0.388
LIG_Pex14_2	620	624	PF04695	0.561
LIG_SH2_NCK_1	87	91	PF00017	0.305
LIG_SH2_SRC	198	201	PF00017	0.528
LIG_SH2_SRC	233	236	PF00017	0.604
LIG_SH2_SRC	87	90	PF00017	0.295
LIG_SH3_3	197	203	PF00018	0.538
LIG_SH3_3	288	294	PF00018	0.551
LIG_SH3_3	552	558	PF00018	0.444
LIG_SH3_3	559	565	PF00018	0.480
LIG_Sin3_3	509	516	PF02671	0.326
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.374
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.400
LIG_SUMO_SIM_anti_2	98	106	PF11976	0.354
LIG_SUMO_SIM_par_1	448	454	PF11976	0.435
LIG_SUMO_SIM_par_1	611	618	PF11976	0.538
LIG_TRAF2_1	248	251	PF00917	0.545
LIG_WW_3	561	565	PF00397	0.519
MOD_CDK_SPxxK_3	364	371	PF00069	0.475
MOD_CK1_1	105	111	PF00069	0.507
MOD_CK1_1	14	20	PF00069	0.608
MOD_CK1_1	193	199	PF00069	0.700
MOD_CK1_1	277	283	PF00069	0.682
MOD_CK1_1	618	624	PF00069	0.675
MOD_CK2_1	245	251	PF00069	0.652
MOD_CK2_1	281	287	PF00069	0.761
MOD_CK2_1	448	454	PF00069	0.461
MOD_CK2_1	590	596	PF00069	0.568
MOD_CK2_1	597	603	PF00069	0.569
MOD_CK2_1	651	657	PF00069	0.560
MOD_CK2_1	89	95	PF00069	0.562
MOD_GlcNHglycan	129	132	PF01048	0.698
MOD_GlcNHglycan	269	272	PF01048	0.714
MOD_GlcNHglycan	276	279	PF01048	0.722
MOD_GlcNHglycan	284	287	PF01048	0.589
MOD_GlcNHglycan	3	6	PF01048	0.576
MOD_GlcNHglycan	49	52	PF01048	0.558
MOD_GlcNHglycan	669	672	PF01048	0.698
MOD_GlcNHglycan	696	699	PF01048	0.725
MOD_GSK3_1	107	114	PF00069	0.452
MOD_GSK3_1	11	18	PF00069	0.521
MOD_GSK3_1	145	152	PF00069	0.692
MOD_GSK3_1	158	165	PF00069	0.556
MOD_GSK3_1	190	197	PF00069	0.756
MOD_GSK3_1	272	279	PF00069	0.709
MOD_GSK3_1	43	50	PF00069	0.494
MOD_GSK3_1	649	656	PF00069	0.614
MOD_GSK3_1	663	670	PF00069	0.570
MOD_GSK3_1	98	105	PF00069	0.470
MOD_N-GLC_1	681	686	PF02516	0.626
MOD_NEK2_1	1	6	PF00069	0.400
MOD_NEK2_1	102	107	PF00069	0.383
MOD_NEK2_1	111	116	PF00069	0.437
MOD_NEK2_1	158	163	PF00069	0.597
MOD_NEK2_1	190	195	PF00069	0.593
MOD_NEK2_1	43	48	PF00069	0.409
MOD_NEK2_1	479	484	PF00069	0.462
MOD_NEK2_1	662	667	PF00069	0.706
MOD_PIKK_1	185	191	PF00454	0.569
MOD_PIKK_1	649	655	PF00454	0.556
MOD_PKA_2	127	133	PF00069	0.526
MOD_PKA_2	145	151	PF00069	0.677
MOD_PKA_2	158	164	PF00069	0.522
MOD_PKA_2	381	387	PF00069	0.587
MOD_PKA_2	549	555	PF00069	0.421
MOD_PKA_2	568	574	PF00069	0.561
MOD_PKA_2	625	631	PF00069	0.535
MOD_PKB_1	263	271	PF00069	0.657
MOD_PKB_1	476	484	PF00069	0.575
MOD_Plk_1	390	396	PF00069	0.584
MOD_Plk_1	43	49	PF00069	0.523
MOD_Plk_1	516	522	PF00069	0.433
MOD_Plk_2-3	590	596	PF00069	0.573
MOD_Plk_2-3	597	603	PF00069	0.562
MOD_Plk_4	111	117	PF00069	0.428
MOD_Plk_4	277	283	PF00069	0.501
MOD_Plk_4	615	621	PF00069	0.594
MOD_Plk_4	67	73	PF00069	0.475
MOD_Plk_4	98	104	PF00069	0.419
MOD_ProDKin_1	364	370	PF00069	0.553
MOD_SUMO_rev_2	172	180	PF00179	0.700
MOD_SUMO_rev_2	625	631	PF00179	0.535
TRG_DiLeu_BaEn_1	336	341	PF01217	0.411
TRG_DiLeu_BaEn_2	574	580	PF01217	0.482
TRG_DiLeu_BaEn_2	94	100	PF01217	0.495
TRG_ENDOCYTIC_2	293	296	PF00928	0.582
TRG_ENDOCYTIC_2	576	579	PF00928	0.477
TRG_ENDOCYTIC_2	659	662	PF00928	0.639
TRG_ER_diArg_1	237	240	PF00400	0.503
TRG_ER_diArg_1	406	409	PF00400	0.419
TRG_ER_diArg_1	708	711	PF00400	0.714
TRG_NES_CRM1_1	113	126	PF08389	0.601
TRG_NLS_MonoExtC_3	237	242	PF00514	0.504
TRG_NLS_MonoExtC_3	261	267	PF00514	0.569
TRG_NLS_MonoExtN_4	237	242	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I765	Leptomonas seymouri	81%	100%
A0A0S4JHQ3	Bodo saltans	41%	82%
A0A1X0P4I5	Trypanosomatidae	59%	100%
A0A3S7WYX6	Leishmania donovani	95%	100%
A0A422NF47	Trypanosoma rangeli	59%	100%
A4HDW9	Leishmania braziliensis	88%	100%
A4I164	Leishmania infantum	95%	100%
D0A5F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AX98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DPB1	Trypanosoma cruzi	58%	100%