TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatase and tensin homolog, putative

Species:

Leishmania major

UniProt:

Q4QA73_LEIMA

TriTrypDb:

LmjF.25.0230 , LMJLV39_250007600 , LMJSD75_250007500

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QA73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA73

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	2
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	2
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	2
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	2
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	2
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.355
CLV_NRD_NRD_1	227	229	PF00675	0.410
CLV_NRD_NRD_1	280	282	PF00675	0.570
CLV_NRD_NRD_1	45	47	PF00675	0.487
CLV_PCSK_FUR_1	267	271	PF00082	0.210
CLV_PCSK_KEX2_1	269	271	PF00082	0.391
CLV_PCSK_KEX2_1	280	282	PF00082	0.495
CLV_PCSK_KEX2_1	44	46	PF00082	0.468
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.391
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.483
CLV_PCSK_SKI1_1	294	298	PF00082	0.597
CLV_PCSK_SKI1_1	55	59	PF00082	0.594
DEG_Nend_UBRbox_3	1	3	PF02207	0.666
DOC_CYCLIN_RxL_1	289	298	PF00134	0.456
DOC_MAPK_gen_1	226	234	PF00069	0.328
DOC_MAPK_MEF2A_6	155	163	PF00069	0.333
DOC_USP7_MATH_1	207	211	PF00917	0.311
DOC_USP7_MATH_1	275	279	PF00917	0.322
DOC_WW_Pin1_4	273	278	PF00397	0.299
LIG_14-3-3_CanoR_1	155	160	PF00244	0.478
LIG_14-3-3_CanoR_1	228	233	PF00244	0.410
LIG_14-3-3_CanoR_1	45	51	PF00244	0.538
LIG_BRCT_BRCA1_1	7	11	PF00533	0.675
LIG_eIF4E_1	93	99	PF01652	0.383
LIG_FHA_1	113	119	PF00498	0.517
LIG_FHA_1	122	128	PF00498	0.296
LIG_FHA_1	156	162	PF00498	0.412
LIG_FHA_1	229	235	PF00498	0.410
LIG_FHA_1	69	75	PF00498	0.745
LIG_FHA_2	10	16	PF00498	0.617
LIG_FHA_2	31	37	PF00498	0.529
LIG_FHA_2	47	53	PF00498	0.535
LIG_FHA_2	70	76	PF00498	0.647
LIG_LIR_Gen_1	196	202	PF02991	0.349
LIG_LIR_Nem_3	184	190	PF02991	0.289
LIG_LIR_Nem_3	196	200	PF02991	0.258
LIG_NRBOX	292	298	PF00104	0.399
LIG_Pex14_2	282	286	PF04695	0.353
LIG_SH2_STAT5	106	109	PF00017	0.503
LIG_SH2_STAT5	233	236	PF00017	0.279
LIG_SH2_STAT5	250	253	PF00017	0.279
LIG_SH2_STAT5	93	96	PF00017	0.380
LIG_TRAF2_1	12	15	PF00917	0.581
LIG_TRAF2_1	73	76	PF00917	0.686
LIG_TYR_ITIM	195	200	PF00017	0.297
LIG_UBA3_1	296	301	PF00899	0.368
LIG_WRC_WIRS_1	251	256	PF05994	0.210
MOD_CDK_SPxxK_3	273	280	PF00069	0.334
MOD_CK2_1	190	196	PF00069	0.289
MOD_CK2_1	255	261	PF00069	0.282
MOD_CK2_1	28	34	PF00069	0.490
MOD_CK2_1	46	52	PF00069	0.530
MOD_CK2_1	69	75	PF00069	0.664
MOD_CK2_1	9	15	PF00069	0.607
MOD_GlcNHglycan	140	143	PF01048	0.463
MOD_GlcNHglycan	2	5	PF01048	0.732
MOD_GlcNHglycan	81	84	PF01048	0.606
MOD_GSK3_1	108	115	PF00069	0.501
MOD_GSK3_1	133	140	PF00069	0.442
MOD_GSK3_1	203	210	PF00069	0.250
MOD_GSK3_1	240	247	PF00069	0.391
MOD_GSK3_1	30	37	PF00069	0.486
MOD_GSK3_1	5	12	PF00069	0.639
MOD_GSK3_1	77	84	PF00069	0.629
MOD_GSK3_1	94	101	PF00069	0.336
MOD_N-GLC_1	155	160	PF02516	0.374
MOD_N-GLC_1	207	212	PF02516	0.255
MOD_NEK2_1	190	195	PF00069	0.369
MOD_NEK2_1	202	207	PF00069	0.350
MOD_NEK2_1	38	43	PF00069	0.418
MOD_NEK2_1	94	99	PF00069	0.428
MOD_NEK2_2	316	321	PF00069	0.505
MOD_PIKK_1	133	139	PF00454	0.456
MOD_PIKK_1	143	149	PF00454	0.429
MOD_PIKK_1	190	196	PF00454	0.210
MOD_PIKK_1	275	281	PF00454	0.322
MOD_PIKK_1	38	44	PF00454	0.609
MOD_PIKK_1	9	15	PF00454	0.688
MOD_PKA_1	228	234	PF00069	0.355
MOD_PKA_2	108	114	PF00069	0.529
MOD_Plk_1	14	20	PF00069	0.584
MOD_Plk_1	155	161	PF00069	0.369
MOD_Plk_1	207	213	PF00069	0.214
MOD_Plk_1	38	44	PF00069	0.491
MOD_Plk_2-3	34	40	PF00069	0.531
MOD_Plk_4	228	234	PF00069	0.398
MOD_Plk_4	46	52	PF00069	0.472
MOD_Plk_4	94	100	PF00069	0.388
MOD_ProDKin_1	273	279	PF00069	0.299
MOD_SUMO_rev_2	52	57	PF00179	0.642
TRG_DiLeu_BaEn_1	186	191	PF01217	0.355
TRG_DiLeu_BaEn_1	53	58	PF01217	0.616
TRG_DiLeu_BaEn_2	260	266	PF01217	0.321
TRG_DiLeu_BaEn_4	14	20	PF01217	0.565
TRG_ENDOCYTIC_2	197	200	PF00928	0.297
TRG_ER_diArg_1	280	282	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A1	Leptomonas seymouri	66%	100%
A0A0S4JDL0	Bodo saltans	46%	87%
A0A1X0P5C5	Trypanosomatidae	51%	100%
A0A3Q8IF49	Leishmania donovani	94%	100%
A0A3R7ME04	Trypanosoma rangeli	52%	100%
A4HDX0	Leishmania braziliensis	80%	100%
A4I165	Leishmania infantum	94%	100%
E9AX99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B7P3	Trypanosoma cruzi	53%	96%