Pre-mRNA-splicing factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA-splicing factor of RES complex, putative

Species:

Leishmania major

UniProt:

Q4QA72_LEIMA

TriTrypDb:

LmjF.25.0240 , LMJLV39_250007700 , LMJSD75_250007600

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.300
CLV_NRD_NRD_1	9	11	PF00675	0.608
CLV_PCSK_KEX2_1	7	9	PF00082	0.579
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.579
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.511
DOC_PP2B_LxvP_1	126	129	PF13499	0.510
DOC_USP7_MATH_1	151	155	PF00917	0.589
DOC_WW_Pin1_4	24	29	PF00397	0.612
LIG_14-3-3_CanoR_1	137	144	PF00244	0.552
LIG_14-3-3_CanoR_1	160	164	PF00244	0.461
LIG_14-3-3_CanoR_1	24	28	PF00244	0.555
LIG_14-3-3_CanoR_1	58	67	PF00244	0.554
LIG_14-3-3_CanoR_1	81	87	PF00244	0.611
LIG_APCC_ABBAyCdc20_2	99	105	PF00400	0.567
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	34	38	PF00533	0.608
LIG_FHA_1	138	144	PF00498	0.546
LIG_FHA_1	164	170	PF00498	0.414
LIG_FHA_1	38	44	PF00498	0.630
LIG_FHA_1	81	87	PF00498	0.559
LIG_FHA_2	43	49	PF00498	0.618
LIG_FHA_2	67	73	PF00498	0.733
LIG_LIR_Gen_1	17	28	PF02991	0.677
LIG_LIR_Nem_3	113	117	PF02991	0.531
LIG_LIR_Nem_3	17	23	PF02991	0.645
LIG_MYND_3	43	47	PF01753	0.593
LIG_PTB_Apo_2	121	128	PF02174	0.474
LIG_SH2_GRB2like	163	166	PF00017	0.483
LIG_SH2_PTP2	20	23	PF00017	0.581
LIG_SH2_SRC	70	73	PF00017	0.588
LIG_SH2_STAT5	132	135	PF00017	0.471
LIG_SH2_STAT5	20	23	PF00017	0.629
LIG_SH2_STAT5	70	73	PF00017	0.588
LIG_UBA3_1	126	135	PF00899	0.530
MOD_CK2_1	153	159	PF00069	0.542
MOD_CK2_1	66	72	PF00069	0.699
MOD_GlcNHglycan	1	4	PF01048	0.650
MOD_GlcNHglycan	118	121	PF01048	0.534
MOD_GlcNHglycan	155	158	PF01048	0.556
MOD_GSK3_1	147	154	PF00069	0.552
MOD_GSK3_1	159	166	PF00069	0.481
MOD_GSK3_1	33	40	PF00069	0.562
MOD_NEK2_1	59	64	PF00069	0.547
MOD_OFUCOSY	134	139	PF10250	0.496
MOD_PIKK_1	142	148	PF00454	0.544
MOD_PKA_2	159	165	PF00069	0.461
MOD_PKA_2	23	29	PF00069	0.570
MOD_PKA_2	80	86	PF00069	0.553
MOD_PKB_1	8	16	PF00069	0.562
MOD_Plk_2-3	42	48	PF00069	0.665
MOD_Plk_4	66	72	PF00069	0.605
MOD_ProDKin_1	24	30	PF00069	0.609
MOD_SUMO_rev_2	154	162	PF00179	0.291
TRG_DiLeu_BaEn_1	113	118	PF01217	0.487
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.570
TRG_ENDOCYTIC_2	114	117	PF00928	0.546
TRG_ENDOCYTIC_2	20	23	PF00928	0.647
TRG_ER_diArg_1	179	182	PF00400	0.506
TRG_ER_diArg_1	8	10	PF00400	0.573
TRG_NES_CRM1_1	121	131	PF08389	0.476
TRG_NLS_MonoCore_2	6	11	PF00514	0.574
TRG_NLS_MonoExtC_3	6	12	PF00514	0.569
TRG_NLS_MonoExtN_4	5	11	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X4	Leptomonas seymouri	47%	96%
A0A3Q8ICC4	Leishmania donovani	85%	100%
A0A3R7K9Y6	Trypanosoma rangeli	33%	100%
A4HDX1	Leishmania braziliensis	67%	100%
A4I166	Leishmania infantum	86%	100%
E9AXA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%