Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA71_LEIMA

TriTrypDb:

LmjF.25.0250 , LMJLV39_250007800 , LMJSD75_250007700

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.639
CLV_C14_Caspase3-7	697	701	PF00656	0.588
CLV_NRD_NRD_1	49	51	PF00675	0.514
CLV_NRD_NRD_1	497	499	PF00675	0.615
CLV_NRD_NRD_1	650	652	PF00675	0.655
CLV_NRD_NRD_1	681	683	PF00675	0.544
CLV_NRD_NRD_1	718	720	PF00675	0.656
CLV_NRD_NRD_1	870	872	PF00675	0.819
CLV_NRD_NRD_1	97	99	PF00675	0.606
CLV_PCSK_KEX2_1	650	652	PF00082	0.655
CLV_PCSK_KEX2_1	681	683	PF00082	0.544
CLV_PCSK_KEX2_1	717	719	PF00082	0.620
CLV_PCSK_KEX2_1	869	871	PF00082	0.821
CLV_PCSK_KEX2_1	97	99	PF00082	0.606
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.655
CLV_PCSK_SKI1_1	19	23	PF00082	0.713
CLV_PCSK_SKI1_1	229	233	PF00082	0.683
CLV_PCSK_SKI1_1	310	314	PF00082	0.390
CLV_PCSK_SKI1_1	533	537	PF00082	0.652
CLV_PCSK_SKI1_1	696	700	PF00082	0.546
CLV_PCSK_SKI1_1	763	767	PF00082	0.588
CLV_Separin_Metazoa	760	764	PF03568	0.648
DEG_APCC_DBOX_1	586	594	PF00400	0.604
DEG_APCC_DBOX_1	695	703	PF00400	0.672
DEG_APCC_DBOX_1	708	716	PF00400	0.480
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DEG_SPOP_SBC_1	670	674	PF00917	0.662
DOC_CKS1_1	399	404	PF01111	0.753
DOC_CKS1_1	77	82	PF01111	0.639
DOC_CKS1_1	872	877	PF01111	0.748
DOC_CYCLIN_RxL_1	255	266	PF00134	0.503
DOC_CYCLIN_RxL_1	619	631	PF00134	0.665
DOC_MAPK_gen_1	584	592	PF00069	0.692
DOC_MAPK_gen_1	620	628	PF00069	0.574
DOC_MAPK_gen_1	704	712	PF00069	0.451
DOC_PP1_RVXF_1	497	504	PF00149	0.455
DOC_USP7_MATH_1	237	241	PF00917	0.517
DOC_USP7_MATH_1	339	343	PF00917	0.675
DOC_USP7_MATH_1	409	413	PF00917	0.749
DOC_USP7_MATH_1	417	421	PF00917	0.729
DOC_USP7_MATH_1	422	426	PF00917	0.717
DOC_USP7_MATH_1	450	454	PF00917	0.693
DOC_USP7_MATH_1	517	521	PF00917	0.592
DOC_USP7_MATH_1	524	528	PF00917	0.565
DOC_USP7_MATH_1	542	546	PF00917	0.620
DOC_USP7_MATH_1	550	554	PF00917	0.445
DOC_USP7_MATH_1	555	559	PF00917	0.585
DOC_USP7_MATH_1	560	564	PF00917	0.679
DOC_USP7_MATH_1	810	814	PF00917	0.807
DOC_USP7_MATH_1	826	830	PF00917	0.642
DOC_USP7_UBL2_3	643	647	PF12436	0.680
DOC_WW_Pin1_4	246	251	PF00397	0.528
DOC_WW_Pin1_4	277	282	PF00397	0.492
DOC_WW_Pin1_4	365	370	PF00397	0.655
DOC_WW_Pin1_4	388	393	PF00397	0.784
DOC_WW_Pin1_4	398	403	PF00397	0.762
DOC_WW_Pin1_4	659	664	PF00397	0.521
DOC_WW_Pin1_4	76	81	PF00397	0.623
DOC_WW_Pin1_4	780	785	PF00397	0.781
DOC_WW_Pin1_4	799	804	PF00397	0.696
DOC_WW_Pin1_4	834	839	PF00397	0.773
DOC_WW_Pin1_4	871	876	PF00397	0.744
LIG_14-3-3_CanoR_1	16	22	PF00244	0.663
LIG_14-3-3_CanoR_1	187	195	PF00244	0.595
LIG_14-3-3_CanoR_1	229	238	PF00244	0.534
LIG_14-3-3_CanoR_1	28	33	PF00244	0.531
LIG_14-3-3_CanoR_1	305	314	PF00244	0.480
LIG_14-3-3_CanoR_1	377	385	PF00244	0.732
LIG_14-3-3_CanoR_1	48	54	PF00244	0.583
LIG_14-3-3_CanoR_1	519	523	PF00244	0.560
LIG_14-3-3_CanoR_1	584	593	PF00244	0.651
LIG_14-3-3_CanoR_1	687	695	PF00244	0.653
LIG_14-3-3_CanoR_1	82	90	PF00244	0.553
LIG_14-3-3_CanoR_1	843	850	PF00244	0.794
LIG_14-3-3_CanoR_1	97	102	PF00244	0.387
LIG_14-3-3_CterR_2	873	877	PF00244	0.635
LIG_Actin_WH2_2	217	234	PF00022	0.378
LIG_Actin_WH2_2	480	497	PF00022	0.671
LIG_BIR_III_2	833	837	PF00653	0.738
LIG_BRCT_BRCA1_1	200	204	PF00533	0.537
LIG_BRCT_BRCA1_1	390	394	PF00533	0.763
LIG_FHA_1	255	261	PF00498	0.576
LIG_FHA_1	327	333	PF00498	0.808
LIG_FHA_1	408	414	PF00498	0.604
LIG_FHA_1	469	475	PF00498	0.611
LIG_FHA_1	599	605	PF00498	0.577
LIG_FHA_1	705	711	PF00498	0.686
LIG_FHA_2	129	135	PF00498	0.600
LIG_FHA_2	153	159	PF00498	0.623
LIG_FHA_2	163	169	PF00498	0.400
LIG_FHA_2	221	227	PF00498	0.490
LIG_FHA_2	290	296	PF00498	0.482
LIG_FHA_2	38	44	PF00498	0.578
LIG_FHA_2	438	444	PF00498	0.651
LIG_FHA_2	495	501	PF00498	0.602
LIG_FHA_2	674	680	PF00498	0.664
LIG_FHA_2	687	693	PF00498	0.661
LIG_FHA_2	98	104	PF00498	0.611
LIG_HCF-1_HBM_1	618	621	PF13415	0.599
LIG_LIR_Apic_2	443	448	PF02991	0.620
LIG_LIR_Gen_1	162	172	PF02991	0.514
LIG_LIR_Gen_1	189	200	PF02991	0.497
LIG_LIR_Gen_1	216	227	PF02991	0.476
LIG_LIR_Gen_1	36	45	PF02991	0.382
LIG_LIR_Gen_1	63	74	PF02991	0.476
LIG_LIR_Gen_1	849	858	PF02991	0.738
LIG_LIR_Nem_3	162	167	PF02991	0.515
LIG_LIR_Nem_3	169	175	PF02991	0.512
LIG_LIR_Nem_3	178	184	PF02991	0.504
LIG_LIR_Nem_3	189	195	PF02991	0.270
LIG_LIR_Nem_3	216	222	PF02991	0.455
LIG_LIR_Nem_3	23	29	PF02991	0.626
LIG_LIR_Nem_3	278	282	PF02991	0.487
LIG_LIR_Nem_3	36	42	PF02991	0.269
LIG_LIR_Nem_3	470	475	PF02991	0.576
LIG_LIR_Nem_3	52	58	PF02991	0.538
LIG_LIR_Nem_3	63	69	PF02991	0.418
LIG_LIR_Nem_3	849	853	PF02991	0.759
LIG_NRBOX	258	264	PF00104	0.455
LIG_Pex14_1	275	279	PF04695	0.446
LIG_Pex14_2	202	206	PF04695	0.448
LIG_Pex14_2	293	297	PF04695	0.507
LIG_RPA_C_Fungi	230	242	PF08784	0.609
LIG_RPA_C_Fungi	645	657	PF08784	0.578
LIG_SH2_CRK	445	449	PF00017	0.620
LIG_SH2_CRK	472	476	PF00017	0.577
LIG_SH2_CRK	66	70	PF00017	0.539
LIG_SH2_NCK_1	445	449	PF00017	0.620
LIG_SH2_STAP1	307	311	PF00017	0.488
LIG_SH2_STAP1	522	526	PF00017	0.675
LIG_SH2_STAP1	66	70	PF00017	0.504
LIG_SH2_STAP1	743	747	PF00017	0.572
LIG_SH2_STAT3	743	746	PF00017	0.571
LIG_SH2_STAT5	172	175	PF00017	0.493
LIG_SH2_STAT5	261	264	PF00017	0.559
LIG_SH2_STAT5	30	33	PF00017	0.518
LIG_SH3_1	869	875	PF00018	0.822
LIG_SH3_2	385	390	PF14604	0.614
LIG_SH3_3	114	120	PF00018	0.626
LIG_SH3_3	382	388	PF00018	0.664
LIG_SH3_3	396	402	PF00018	0.764
LIG_SH3_3	66	72	PF00018	0.594
LIG_SH3_3	74	80	PF00018	0.470
LIG_SH3_3	765	771	PF00018	0.689
LIG_SH3_3	792	798	PF00018	0.644
LIG_SH3_3	869	875	PF00018	0.822
LIG_SUMO_SIM_anti_2	280	286	PF11976	0.615
LIG_SUMO_SIM_anti_2	308	315	PF11976	0.622
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.505
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.616
LIG_SUMO_SIM_par_1	280	286	PF11976	0.615
LIG_SUMO_SIM_par_1	40	46	PF11976	0.607
LIG_SUMO_SIM_par_1	624	629	PF11976	0.670
LIG_SUMO_SIM_par_1	86	91	PF11976	0.480
LIG_TRAF2_1	292	295	PF00917	0.557
LIG_TRAF2_1	458	461	PF00917	0.766
LIG_TRAF2_1	563	566	PF00917	0.634
LIG_TRAF2_1	676	679	PF00917	0.619
LIG_TRFH_1	261	265	PF08558	0.454
LIG_UBA3_1	259	264	PF00899	0.554
LIG_UBA3_1	761	767	PF00899	0.613
LIG_WRC_WIRS_1	199	204	PF05994	0.434
LIG_WRC_WIRS_1	219	224	PF05994	0.230
LIG_WRC_WIRS_1	276	281	PF05994	0.478
LIG_WW_3	802	806	PF00397	0.772
MOD_CDK_SPxK_1	76	82	PF00069	0.633
MOD_CDK_SPxK_1	799	805	PF00069	0.771
MOD_CDK_SPxxK_3	780	787	PF00069	0.790
MOD_CK1_1	11	17	PF00069	0.646
MOD_CK1_1	128	134	PF00069	0.592
MOD_CK1_1	177	183	PF00069	0.617
MOD_CK1_1	20	26	PF00069	0.537
MOD_CK1_1	280	286	PF00069	0.615
MOD_CK1_1	368	374	PF00069	0.742
MOD_CK1_1	376	382	PF00069	0.669
MOD_CK1_1	426	432	PF00069	0.735
MOD_CK1_1	553	559	PF00069	0.564
MOD_CK1_1	673	679	PF00069	0.626
MOD_CK1_1	752	758	PF00069	0.592
MOD_CK1_1	825	831	PF00069	0.849
MOD_CK1_1	846	852	PF00069	0.760
MOD_CK2_1	152	158	PF00069	0.634
MOD_CK2_1	162	168	PF00069	0.406
MOD_CK2_1	220	226	PF00069	0.477
MOD_CK2_1	280	286	PF00069	0.489
MOD_CK2_1	289	295	PF00069	0.409
MOD_CK2_1	510	516	PF00069	0.549
MOD_CK2_1	560	566	PF00069	0.628
MOD_CK2_1	671	677	PF00069	0.752
MOD_CK2_1	686	692	PF00069	0.637
MOD_DYRK1A_RPxSP_1	871	875	PF00069	0.744
MOD_GlcNHglycan	12	16	PF01048	0.636
MOD_GlcNHglycan	127	130	PF01048	0.574
MOD_GlcNHglycan	239	242	PF01048	0.580
MOD_GlcNHglycan	341	344	PF01048	0.672
MOD_GlcNHglycan	413	416	PF01048	0.729
MOD_GlcNHglycan	419	422	PF01048	0.691
MOD_GlcNHglycan	460	465	PF01048	0.632
MOD_GlcNHglycan	544	547	PF01048	0.534
MOD_GlcNHglycan	552	555	PF01048	0.609
MOD_GlcNHglycan	557	560	PF01048	0.587
MOD_GlcNHglycan	822	827	PF01048	0.763
MOD_GlcNHglycan	845	848	PF01048	0.752
MOD_GlcNHglycan	93	96	PF01048	0.514
MOD_GSK3_1	121	128	PF00069	0.593
MOD_GSK3_1	246	253	PF00069	0.571
MOD_GSK3_1	28	35	PF00069	0.601
MOD_GSK3_1	353	360	PF00069	0.658
MOD_GSK3_1	373	380	PF00069	0.780
MOD_GSK3_1	407	414	PF00069	0.779
MOD_GSK3_1	422	429	PF00069	0.619
MOD_GSK3_1	456	463	PF00069	0.688
MOD_GSK3_1	56	63	PF00069	0.515
MOD_GSK3_1	669	676	PF00069	0.539
MOD_GSK3_1	735	742	PF00069	0.670
MOD_GSK3_1	776	783	PF00069	0.765
MOD_GSK3_1	822	829	PF00069	0.689
MOD_LATS_1	17	23	PF00433	0.586
MOD_N-GLC_1	134	139	PF02516	0.635
MOD_N-GLC_1	213	218	PF02516	0.444
MOD_N-GLC_1	314	319	PF02516	0.650
MOD_N-GLC_1	59	64	PF02516	0.358
MOD_NEK2_1	109	114	PF00069	0.553
MOD_NEK2_1	206	211	PF00069	0.469
MOD_NEK2_1	231	236	PF00069	0.590
MOD_NEK2_1	252	257	PF00069	0.455
MOD_NEK2_1	306	311	PF00069	0.480
MOD_NEK2_1	314	319	PF00069	0.626
MOD_NEK2_1	494	499	PF00069	0.445
MOD_NEK2_1	58	63	PF00069	0.587
MOD_NEK2_1	73	78	PF00069	0.390
MOD_NEK2_1	735	740	PF00069	0.634
MOD_PIKK_1	60	66	PF00454	0.507
MOD_PIKK_1	704	710	PF00454	0.603
MOD_PIKK_1	81	87	PF00454	0.620
MOD_PKA_1	97	103	PF00069	0.596
MOD_PKA_2	144	150	PF00069	0.533
MOD_PKA_2	186	192	PF00069	0.604
MOD_PKA_2	376	382	PF00069	0.830
MOD_PKA_2	407	413	PF00069	0.761
MOD_PKA_2	49	55	PF00069	0.585
MOD_PKA_2	494	500	PF00069	0.603
MOD_PKA_2	518	524	PF00069	0.562
MOD_PKA_2	686	692	PF00069	0.664
MOD_PKA_2	81	87	PF00069	0.578
MOD_PKA_2	97	103	PF00069	0.377
MOD_Plk_1	134	140	PF00069	0.565
MOD_Plk_1	177	183	PF00069	0.557
MOD_Plk_1	213	219	PF00069	0.444
MOD_Plk_1	35	41	PF00069	0.588
MOD_Plk_1	775	781	PF00069	0.765
MOD_Plk_1	810	816	PF00069	0.640
MOD_Plk_2-3	134	140	PF00069	0.635
MOD_Plk_2-3	152	158	PF00069	0.585
MOD_Plk_2-3	289	295	PF00069	0.508
MOD_Plk_2-3	510	516	PF00069	0.682
MOD_Plk_2-3	686	692	PF00069	0.651
MOD_Plk_4	152	158	PF00069	0.663
MOD_Plk_4	263	269	PF00069	0.480
MOD_Plk_4	28	34	PF00069	0.586
MOD_Plk_4	280	286	PF00069	0.615
MOD_Plk_4	73	79	PF00069	0.491
MOD_Plk_4	863	869	PF00069	0.577
MOD_Plk_4	97	103	PF00069	0.596
MOD_ProDKin_1	246	252	PF00069	0.523
MOD_ProDKin_1	277	283	PF00069	0.497
MOD_ProDKin_1	365	371	PF00069	0.785
MOD_ProDKin_1	388	394	PF00069	0.786
MOD_ProDKin_1	398	404	PF00069	0.762
MOD_ProDKin_1	659	665	PF00069	0.525
MOD_ProDKin_1	76	82	PF00069	0.633
MOD_ProDKin_1	780	786	PF00069	0.781
MOD_ProDKin_1	799	805	PF00069	0.700
MOD_ProDKin_1	834	840	PF00069	0.775
MOD_ProDKin_1	871	877	PF00069	0.747
TRG_DiLeu_BaEn_1	599	604	PF01217	0.669
TRG_DiLeu_BaEn_2	678	684	PF01217	0.651
TRG_DiLeu_BaEn_4	720	726	PF01217	0.506
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.585
TRG_ENDOCYTIC_2	172	175	PF00928	0.493
TRG_ENDOCYTIC_2	29	32	PF00928	0.557
TRG_ENDOCYTIC_2	472	475	PF00928	0.581
TRG_ENDOCYTIC_2	55	58	PF00928	0.596
TRG_ENDOCYTIC_2	66	69	PF00928	0.407
TRG_ER_diArg_1	361	364	PF00400	0.756
TRG_ER_diArg_1	621	624	PF00400	0.527
TRG_ER_diArg_1	681	683	PF00400	0.492
TRG_ER_diArg_1	693	696	PF00400	0.672
TRG_ER_diArg_1	709	712	PF00400	0.429
TRG_ER_diArg_1	842	845	PF00400	0.837
TRG_ER_diArg_1	868	871	PF00400	0.819
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	748	753	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4T9	Trypanosomatidae	30%	96%
A0A3Q8IN51	Leishmania donovani	89%	100%
A4HDX2	Leishmania braziliensis	71%	100%
A4I167	Leishmania infantum	89%	100%
E9AXA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%