Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA68_LEIMA

TriTrypDb:

LmjF.25.0280 , LMJLV39_250008100 , LMJSD75_250008000

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.670
CLV_C14_Caspase3-7	551	555	PF00656	0.666
CLV_NRD_NRD_1	163	165	PF00675	0.663
CLV_NRD_NRD_1	17	19	PF00675	0.793
CLV_NRD_NRD_1	275	277	PF00675	0.869
CLV_NRD_NRD_1	285	287	PF00675	0.672
CLV_NRD_NRD_1	318	320	PF00675	0.599
CLV_NRD_NRD_1	339	341	PF00675	0.578
CLV_NRD_NRD_1	464	466	PF00675	0.629
CLV_NRD_NRD_1	533	535	PF00675	0.729
CLV_NRD_NRD_1	544	546	PF00675	0.632
CLV_NRD_NRD_1	562	564	PF00675	0.468
CLV_NRD_NRD_1	609	611	PF00675	0.623
CLV_NRD_NRD_1	85	87	PF00675	0.535
CLV_PCSK_KEX2_1	16	18	PF00082	0.779
CLV_PCSK_KEX2_1	162	164	PF00082	0.661
CLV_PCSK_KEX2_1	275	277	PF00082	0.869
CLV_PCSK_KEX2_1	285	287	PF00082	0.672
CLV_PCSK_KEX2_1	318	320	PF00082	0.596
CLV_PCSK_KEX2_1	341	343	PF00082	0.681
CLV_PCSK_KEX2_1	464	466	PF00082	0.629
CLV_PCSK_KEX2_1	491	493	PF00082	0.754
CLV_PCSK_KEX2_1	533	535	PF00082	0.729
CLV_PCSK_KEX2_1	544	546	PF00082	0.632
CLV_PCSK_KEX2_1	562	564	PF00082	0.468
CLV_PCSK_KEX2_1	609	611	PF00082	0.615
CLV_PCSK_KEX2_1	85	87	PF00082	0.527
CLV_PCSK_KEX2_1	92	94	PF00082	0.442
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.681
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.598
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.572
CLV_PCSK_PC7_1	281	287	PF00082	0.843
CLV_PCSK_PC7_1	88	94	PF00082	0.570
CLV_PCSK_SKI1_1	286	290	PF00082	0.828
CLV_PCSK_SKI1_1	365	369	PF00082	0.709
CLV_PCSK_SKI1_1	39	43	PF00082	0.560
CLV_PCSK_SKI1_1	391	395	PF00082	0.728
CLV_PCSK_SKI1_1	407	411	PF00082	0.442
DEG_APCC_DBOX_1	147	155	PF00400	0.547
DEG_APCC_DBOX_1	406	414	PF00400	0.628
DEG_APCC_DBOX_1	87	95	PF00400	0.649
DEG_SPOP_SBC_1	616	620	PF00917	0.668
DOC_CKS1_1	568	573	PF01111	0.727
DOC_CKS1_1	684	689	PF01111	0.691
DOC_CYCLIN_RxL_1	404	411	PF00134	0.573
DOC_MAPK_gen_1	285	292	PF00069	0.823
DOC_MAPK_gen_1	352	361	PF00069	0.615
DOC_MAPK_gen_1	609	615	PF00069	0.628
DOC_MAPK_MEF2A_6	203	212	PF00069	0.539
DOC_MAPK_MEF2A_6	285	292	PF00069	0.823
DOC_PP2B_LxvP_1	288	291	PF13499	0.705
DOC_PP4_FxxP_1	34	37	PF00568	0.579
DOC_USP7_MATH_1	251	255	PF00917	0.723
DOC_USP7_MATH_1	266	270	PF00917	0.670
DOC_USP7_MATH_1	280	284	PF00917	0.728
DOC_USP7_MATH_1	305	309	PF00917	0.746
DOC_USP7_MATH_1	314	318	PF00917	0.669
DOC_USP7_MATH_1	320	324	PF00917	0.567
DOC_USP7_MATH_1	416	420	PF00917	0.643
DOC_USP7_MATH_1	443	447	PF00917	0.813
DOC_USP7_MATH_1	627	631	PF00917	0.847
DOC_USP7_MATH_1	637	641	PF00917	0.655
DOC_WW_Pin1_4	17	22	PF00397	0.677
DOC_WW_Pin1_4	247	252	PF00397	0.677
DOC_WW_Pin1_4	257	262	PF00397	0.754
DOC_WW_Pin1_4	269	274	PF00397	0.658
DOC_WW_Pin1_4	276	281	PF00397	0.713
DOC_WW_Pin1_4	301	306	PF00397	0.772
DOC_WW_Pin1_4	453	458	PF00397	0.629
DOC_WW_Pin1_4	567	572	PF00397	0.785
DOC_WW_Pin1_4	596	601	PF00397	0.622
DOC_WW_Pin1_4	683	688	PF00397	0.810
DOC_WW_Pin1_4	9	14	PF00397	0.772
LIG_14-3-3_CanoR_1	275	282	PF00244	0.859
LIG_14-3-3_CanoR_1	285	291	PF00244	0.663
LIG_14-3-3_CanoR_1	365	375	PF00244	0.630
LIG_14-3-3_CanoR_1	436	441	PF00244	0.625
LIG_14-3-3_CanoR_1	548	557	PF00244	0.745
LIG_14-3-3_CanoR_1	609	615	PF00244	0.628
LIG_14-3-3_CanoR_1	86	92	PF00244	0.652
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	255	259	PF00533	0.820
LIG_CaM_IQ_9	78	94	PF13499	0.585
LIG_Clathr_ClatBox_1	383	387	PF01394	0.706
LIG_FHA_1	115	121	PF00498	0.651
LIG_FHA_1	142	148	PF00498	0.534
LIG_FHA_1	287	293	PF00498	0.816
LIG_FHA_1	591	597	PF00498	0.818
LIG_FHA_1	602	608	PF00498	0.706
LIG_FHA_1	82	88	PF00498	0.661
LIG_FHA_2	126	132	PF00498	0.615
LIG_FHA_2	421	427	PF00498	0.628
LIG_FHA_2	511	517	PF00498	0.673
LIG_FHA_2	549	555	PF00498	0.744
LIG_FHA_2	609	615	PF00498	0.702
LIG_FHA_2	684	690	PF00498	0.816
LIG_GBD_Chelix_1	405	413	PF00786	0.708
LIG_Integrin_isoDGR_2	389	391	PF01839	0.601
LIG_LIR_Apic_2	31	37	PF02991	0.580
LIG_LIR_Gen_1	216	224	PF02991	0.650
LIG_LIR_Gen_1	686	691	PF02991	0.596
LIG_LIR_Nem_3	216	220	PF02991	0.506
LIG_LIR_Nem_3	686	691	PF02991	0.810
LIG_PCNA_yPIPBox_3	365	379	PF02747	0.704
LIG_PCNA_yPIPBox_3	515	524	PF02747	0.746
LIG_PDZ_Class_3	686	691	PF00595	0.596
LIG_Pex14_2	424	428	PF04695	0.510
LIG_Rb_LxCxE_1	472	489	PF01857	0.653
LIG_SH2_CRK	302	306	PF00017	0.736
LIG_SH2_NCK_1	302	306	PF00017	0.775
LIG_SH2_STAT3	74	77	PF00017	0.673
LIG_SH2_STAT5	74	77	PF00017	0.518
LIG_SH2_STAT5	98	101	PF00017	0.470
LIG_SH3_2	598	603	PF14604	0.721
LIG_SH3_3	451	457	PF00018	0.635
LIG_SH3_3	592	598	PF00018	0.783
LIG_SH3_3	681	687	PF00018	0.656
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.708
LIG_SUMO_SIM_par_1	382	387	PF11976	0.708
LIG_TRAF2_1	268	271	PF00917	0.651
LIG_TRAF2_1	513	516	PF00917	0.749
LIG_WRC_WIRS_1	421	426	PF05994	0.509
LIG_WW_3	13	17	PF00397	0.658
MOD_CDC14_SPxK_1	304	307	PF00782	0.617
MOD_CDK_SPK_2	247	252	PF00069	0.580
MOD_CDK_SPK_2	276	281	PF00069	0.863
MOD_CDK_SPxK_1	269	275	PF00069	0.767
MOD_CDK_SPxK_1	301	307	PF00069	0.620
MOD_CDK_SPxxK_3	269	276	PF00069	0.771
MOD_CDK_SPxxK_3	453	460	PF00069	0.631
MOD_CDK_SPxxK_3	596	603	PF00069	0.590
MOD_CDK_SPxxK_3	9	16	PF00069	0.773
MOD_CK1_1	20	26	PF00069	0.579
MOD_CK1_1	260	266	PF00069	0.765
MOD_CK1_1	269	275	PF00069	0.682
MOD_CK1_1	456	462	PF00069	0.616
MOD_CK1_1	6	12	PF00069	0.774
MOD_CK1_1	618	624	PF00069	0.656
MOD_CK1_1	63	69	PF00069	0.619
MOD_CK1_1	676	682	PF00069	0.839
MOD_CK2_1	265	271	PF00069	0.654
MOD_CK2_1	305	311	PF00069	0.808
MOD_CK2_1	345	351	PF00069	0.570
MOD_CK2_1	420	426	PF00069	0.628
MOD_CK2_1	510	516	PF00069	0.676
MOD_GlcNHglycan	1	4	PF01048	0.716
MOD_GlcNHglycan	199	202	PF01048	0.597
MOD_GlcNHglycan	255	258	PF01048	0.814
MOD_GlcNHglycan	264	267	PF01048	0.652
MOD_GlcNHglycan	307	310	PF01048	0.816
MOD_GlcNHglycan	322	325	PF01048	0.614
MOD_GlcNHglycan	336	340	PF01048	0.572
MOD_GlcNHglycan	418	421	PF01048	0.734
MOD_GlcNHglycan	484	487	PF01048	0.701
MOD_GlcNHglycan	586	590	PF01048	0.750
MOD_GlcNHglycan	624	627	PF01048	0.765
MOD_GlcNHglycan	71	74	PF01048	0.592
MOD_GlcNHglycan	8	11	PF01048	0.685
MOD_GSK3_1	126	133	PF00069	0.551
MOD_GSK3_1	169	176	PF00069	0.589
MOD_GSK3_1	247	254	PF00069	0.705
MOD_GSK3_1	262	269	PF00069	0.659
MOD_GSK3_1	276	283	PF00069	0.695
MOD_GSK3_1	291	298	PF00069	0.645
MOD_GSK3_1	301	308	PF00069	0.612
MOD_GSK3_1	416	423	PF00069	0.673
MOD_GSK3_1	443	450	PF00069	0.749
MOD_GSK3_1	455	462	PF00069	0.675
MOD_GSK3_1	5	12	PF00069	0.751
MOD_GSK3_1	615	622	PF00069	0.819
MOD_GSK3_1	77	84	PF00069	0.612
MOD_N-GLC_1	3	8	PF02516	0.644
MOD_N-GLC_1	590	595	PF02516	0.626
MOD_N-GLC_1	69	74	PF02516	0.700
MOD_NEK2_1	87	92	PF00069	0.650
MOD_PIKK_1	141	147	PF00454	0.455
MOD_PIKK_1	152	158	PF00454	0.474
MOD_PIKK_1	280	286	PF00454	0.849
MOD_PIKK_1	510	516	PF00454	0.682
MOD_PKA_2	251	257	PF00069	0.585
MOD_PKA_2	274	280	PF00069	0.863
MOD_PKA_2	284	290	PF00069	0.670
MOD_PKA_2	320	326	PF00069	0.623
MOD_PKA_2	435	441	PF00069	0.593
MOD_PKA_2	547	553	PF00069	0.754
MOD_PKA_2	584	590	PF00069	0.745
MOD_PKA_2	608	614	PF00069	0.703
MOD_PKA_2	616	622	PF00069	0.735
MOD_PKA_2	63	69	PF00069	0.791
MOD_PKA_2	87	93	PF00069	0.651
MOD_Plk_1	130	136	PF00069	0.560
MOD_Plk_1	3	9	PF00069	0.631
MOD_Plk_1	430	436	PF00069	0.679
MOD_Plk_1	564	570	PF00069	0.770
MOD_Plk_1	57	63	PF00069	0.718
MOD_Plk_1	590	596	PF00069	0.626
MOD_Plk_4	20	26	PF00069	0.823
MOD_Plk_4	538	544	PF00069	0.690
MOD_Plk_4	57	63	PF00069	0.624
MOD_ProDKin_1	17	23	PF00069	0.673
MOD_ProDKin_1	247	253	PF00069	0.677
MOD_ProDKin_1	257	263	PF00069	0.756
MOD_ProDKin_1	269	275	PF00069	0.661
MOD_ProDKin_1	276	282	PF00069	0.707
MOD_ProDKin_1	301	307	PF00069	0.775
MOD_ProDKin_1	453	459	PF00069	0.629
MOD_ProDKin_1	567	573	PF00069	0.791
MOD_ProDKin_1	596	602	PF00069	0.625
MOD_ProDKin_1	683	689	PF00069	0.808
MOD_ProDKin_1	9	15	PF00069	0.773
TRG_DiLeu_BaEn_1	122	127	PF01217	0.662
TRG_DiLeu_BaEn_1	374	379	PF01217	0.696
TRG_DiLeu_BaEn_1	475	480	PF01217	0.548
TRG_DiLeu_BaEn_2	204	210	PF01217	0.424
TRG_ENDOCYTIC_2	688	691	PF00928	0.599
TRG_ER_diArg_1	15	18	PF00400	0.776
TRG_ER_diArg_1	161	164	PF00400	0.662
TRG_ER_diArg_1	318	321	PF00400	0.592
TRG_ER_diArg_1	340	343	PF00400	0.501
TRG_ER_diArg_1	464	466	PF00400	0.629
TRG_ER_diArg_1	543	545	PF00400	0.777
TRG_ER_diArg_1	561	563	PF00400	0.472
TRG_ER_diArg_1	608	610	PF00400	0.683
TRG_ER_diArg_1	639	642	PF00400	0.592
TRG_ER_diArg_1	85	88	PF00400	0.488
TRG_NES_CRM1_1	374	387	PF08389	0.701
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID47	Leishmania donovani	83%	100%
A4HDX5	Leishmania braziliensis	60%	100%
A4I170	Leishmania infantum	83%	99%
E9AXA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%