RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QA67_LEIMA

TriTrypDb:

LmjF.25.0290 , LMJLV39_250008300 , LMJSD75_250008300

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QA67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.526
CLV_NRD_NRD_1	232	234	PF00675	0.653
CLV_NRD_NRD_1	364	366	PF00675	0.665
CLV_NRD_NRD_1	490	492	PF00675	0.639
CLV_PCSK_KEX2_1	232	234	PF00082	0.653
CLV_PCSK_KEX2_1	364	366	PF00082	0.665
CLV_PCSK_KEX2_1	490	492	PF00082	0.642
CLV_PCSK_SKI1_1	232	236	PF00082	0.483
CLV_PCSK_SKI1_1	365	369	PF00082	0.611
DEG_SPOP_SBC_1	57	61	PF00917	0.554
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.721
DOC_CYCLIN_yCln2_LP_2	528	534	PF00134	0.651
DOC_MAPK_gen_1	396	405	PF00069	0.508
DOC_MAPK_MEF2A_6	535	543	PF00069	0.566
DOC_PP1_RVXF_1	154	161	PF00149	0.484
DOC_PP2B_LxvP_1	152	155	PF13499	0.377
DOC_PP2B_LxvP_1	189	192	PF13499	0.622
DOC_PP2B_LxvP_1	253	256	PF13499	0.703
DOC_PP2B_LxvP_1	482	485	PF13499	0.725
DOC_PP2B_LxvP_1	528	531	PF13499	0.719
DOC_PP4_FxxP_1	130	133	PF00568	0.401
DOC_PP4_FxxP_1	82	85	PF00568	0.522
DOC_USP7_MATH_1	224	228	PF00917	0.689
DOC_USP7_MATH_1	267	271	PF00917	0.615
DOC_USP7_MATH_1	282	286	PF00917	0.662
DOC_USP7_MATH_1	334	338	PF00917	0.517
DOC_USP7_MATH_1	494	498	PF00917	0.819
DOC_USP7_MATH_1	501	505	PF00917	0.728
DOC_USP7_MATH_1	545	549	PF00917	0.731
DOC_USP7_MATH_1	9	13	PF00917	0.540
DOC_WW_Pin1_4	10	15	PF00397	0.576
DOC_WW_Pin1_4	107	112	PF00397	0.550
DOC_WW_Pin1_4	237	242	PF00397	0.674
DOC_WW_Pin1_4	273	278	PF00397	0.711
DOC_WW_Pin1_4	343	348	PF00397	0.491
DOC_WW_Pin1_4	426	431	PF00397	0.749
DOC_WW_Pin1_4	503	508	PF00397	0.724
DOC_WW_Pin1_4	517	522	PF00397	0.761
DOC_WW_Pin1_4	566	571	PF00397	0.746
LIG_14-3-3_CanoR_1	24	28	PF00244	0.458
LIG_14-3-3_CanoR_1	446	452	PF00244	0.745
LIG_14-3-3_CanoR_1	577	583	PF00244	0.670
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.510
LIG_deltaCOP1_diTrp_1	315	324	PF00928	0.523
LIG_EVH1_1	189	193	PF00568	0.626
LIG_EVH1_2	347	351	PF00568	0.476
LIG_FHA_1	367	373	PF00498	0.471
LIG_FHA_1	384	390	PF00498	0.289
LIG_FHA_1	407	413	PF00498	0.444
LIG_FHA_1	85	91	PF00498	0.421
LIG_FHA_1	93	99	PF00498	0.370
LIG_FHA_2	107	113	PF00498	0.482
LIG_FHA_2	303	309	PF00498	0.572
LIG_FHA_2	58	64	PF00498	0.561
LIG_Integrin_isoDGR_2	138	140	PF01839	0.344
LIG_LIR_Apic_2	128	133	PF02991	0.401
LIG_LIR_Apic_2	247	251	PF02991	0.704
LIG_LIR_Apic_2	29	34	PF02991	0.489
LIG_LIR_Apic_2	315	320	PF02991	0.515
LIG_LIR_Apic_2	423	428	PF02991	0.625
LIG_LIR_Gen_1	119	129	PF02991	0.482
LIG_LIR_Gen_1	178	189	PF02991	0.601
LIG_LIR_Gen_1	337	347	PF02991	0.409
LIG_LIR_Gen_1	95	105	PF02991	0.419
LIG_LIR_Nem_3	119	124	PF02991	0.482
LIG_LIR_Nem_3	178	184	PF02991	0.632
LIG_LIR_Nem_3	299	303	PF02991	0.378
LIG_LIR_Nem_3	337	342	PF02991	0.370
LIG_LIR_Nem_3	95	100	PF02991	0.472
LIG_MYND_1	187	191	PF01753	0.639
LIG_MYND_1	211	215	PF01753	0.627
LIG_MYND_1	70	74	PF01753	0.511
LIG_PROFILIN_1	207	213	PF00235	0.573
LIG_PROFILIN_1	454	460	PF00235	0.641
LIG_PTB_Apo_2	101	108	PF02174	0.412
LIG_PTB_Apo_2	318	325	PF02174	0.448
LIG_PTB_Apo_2	72	79	PF02174	0.503
LIG_PTB_Phospho_1	72	78	PF10480	0.503
LIG_REV1ctd_RIR_1	79	84	PF16727	0.493
LIG_SH2_CRK	181	185	PF00017	0.653
LIG_SH2_CRK	248	252	PF00017	0.709
LIG_SH2_CRK	31	35	PF00017	0.455
LIG_SH2_CRK	353	357	PF00017	0.382
LIG_SH2_GRB2like	19	22	PF00017	0.410
LIG_SH2_NCK_1	91	95	PF00017	0.499
LIG_SH2_PTP2	97	100	PF00017	0.456
LIG_SH2_SRC	19	22	PF00017	0.410
LIG_SH2_STAP1	353	357	PF00017	0.382
LIG_SH2_STAT3	161	164	PF00017	0.530
LIG_SH2_STAT5	101	104	PF00017	0.544
LIG_SH2_STAT5	117	120	PF00017	0.355
LIG_SH2_STAT5	167	170	PF00017	0.391
LIG_SH2_STAT5	19	22	PF00017	0.410
LIG_SH2_STAT5	303	306	PF00017	0.419
LIG_SH2_STAT5	317	320	PF00017	0.450
LIG_SH2_STAT5	38	41	PF00017	0.404
LIG_SH2_STAT5	425	428	PF00017	0.725
LIG_SH2_STAT5	97	100	PF00017	0.422
LIG_SH3_1	248	254	PF00018	0.704
LIG_SH3_1	453	459	PF00018	0.709
LIG_SH3_2	191	196	PF14604	0.628
LIG_SH3_3	184	190	PF00018	0.641
LIG_SH3_3	203	209	PF00018	0.721
LIG_SH3_3	216	222	PF00018	0.672
LIG_SH3_3	248	254	PF00018	0.704
LIG_SH3_3	424	430	PF00018	0.655
LIG_SH3_3	448	454	PF00018	0.663
LIG_SH3_3	470	476	PF00018	0.629
LIG_SH3_3	567	573	PF00018	0.773
LIG_SH3_3	64	70	PF00018	0.499
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.437
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.469
LIG_SUMO_SIM_par_1	409	417	PF11976	0.358
LIG_TYR_ITSM	93	100	PF00017	0.419
LIG_WRC_WIRS_1	118	123	PF05994	0.531
LIG_WW_2	211	214	PF00397	0.623
LIG_WW_3	51	55	PF00397	0.473
MOD_CK1_1	10	16	PF00069	0.537
MOD_CK1_1	270	276	PF00069	0.657
MOD_CK1_1	346	352	PF00069	0.537
MOD_CK1_1	382	388	PF00069	0.532
MOD_CK1_1	513	519	PF00069	0.677
MOD_CK1_1	520	526	PF00069	0.761
MOD_CK1_1	568	574	PF00069	0.734
MOD_CK1_1	578	584	PF00069	0.753
MOD_CK2_1	106	112	PF00069	0.482
MOD_CK2_1	168	174	PF00069	0.483
MOD_CK2_1	23	29	PF00069	0.469
MOD_CK2_1	327	333	PF00069	0.506
MOD_CK2_1	58	64	PF00069	0.549
MOD_GlcNHglycan	336	339	PF01048	0.414
MOD_GlcNHglycan	479	482	PF01048	0.722
MOD_GlcNHglycan	512	515	PF01048	0.660
MOD_GlcNHglycan	532	535	PF01048	0.717
MOD_GlcNHglycan	60	63	PF01048	0.537
MOD_GlcNHglycan	7	10	PF01048	0.617
MOD_GSK3_1	1	8	PF00069	0.648
MOD_GSK3_1	263	270	PF00069	0.677
MOD_GSK3_1	342	349	PF00069	0.560
MOD_GSK3_1	379	386	PF00069	0.366
MOD_GSK3_1	513	520	PF00069	0.773
MOD_GSK3_1	554	561	PF00069	0.771
MOD_GSK3_1	564	571	PF00069	0.710
MOD_GSK3_1	58	65	PF00069	0.560
MOD_GSK3_1	86	93	PF00069	0.520
MOD_N-GLC_1	107	112	PF02516	0.264
MOD_N-GLC_1	494	499	PF02516	0.821
MOD_N-GLC_1	501	506	PF02516	0.781
MOD_N-GLC_1	559	564	PF02516	0.754
MOD_NEK2_1	262	267	PF00069	0.731
MOD_NEK2_1	342	347	PF00069	0.489
MOD_NEK2_1	414	419	PF00069	0.569
MOD_NEK2_1	553	558	PF00069	0.745
MOD_NEK2_1	90	95	PF00069	0.501
MOD_NEK2_2	282	287	PF00069	0.645
MOD_PIKK_1	255	261	PF00454	0.714
MOD_PIKK_1	406	412	PF00454	0.462
MOD_PKA_2	224	230	PF00069	0.684
MOD_PKA_2	23	29	PF00069	0.469
MOD_PKA_2	334	340	PF00069	0.433
MOD_PKB_1	402	410	PF00069	0.466
MOD_Plk_2-3	23	29	PF00069	0.469
MOD_Plk_4	224	230	PF00069	0.684
MOD_Plk_4	23	29	PF00069	0.492
MOD_Plk_4	296	302	PF00069	0.427
MOD_Plk_4	346	352	PF00069	0.547
MOD_Plk_4	578	584	PF00069	0.576
MOD_Plk_4	86	92	PF00069	0.528
MOD_ProDKin_1	10	16	PF00069	0.564
MOD_ProDKin_1	107	113	PF00069	0.550
MOD_ProDKin_1	237	243	PF00069	0.676
MOD_ProDKin_1	273	279	PF00069	0.714
MOD_ProDKin_1	343	349	PF00069	0.486
MOD_ProDKin_1	426	432	PF00069	0.749
MOD_ProDKin_1	503	509	PF00069	0.727
MOD_ProDKin_1	517	523	PF00069	0.761
MOD_ProDKin_1	566	572	PF00069	0.743
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.489
TRG_ENDOCYTIC_2	167	170	PF00928	0.404
TRG_ENDOCYTIC_2	181	184	PF00928	0.602
TRG_ENDOCYTIC_2	353	356	PF00928	0.397
TRG_ENDOCYTIC_2	36	39	PF00928	0.403
TRG_ENDOCYTIC_2	78	81	PF00928	0.472
TRG_ENDOCYTIC_2	97	100	PF00928	0.456
TRG_ER_diArg_1	232	234	PF00400	0.653
TRG_ER_diArg_1	402	405	PF00400	0.470
TRG_ER_diArg_1	438	441	PF00400	0.687
TRG_NES_CRM1_1	112	126	PF08389	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM94	Leptomonas seymouri	53%	93%
A0A3R7MBU5	Trypanosoma rangeli	34%	100%
A0A3S7WYR7	Leishmania donovani	95%	100%
A4HDX6	Leishmania braziliensis	80%	98%
A4I171	Leishmania infantum	95%	100%
D0A5F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AXA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
V5B7N8	Trypanosoma cruzi	35%	100%