Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA62_LEIMA

TriTrypDb:

LmjF.25.0330 , LMJLV39_250008800 , LMJSD75_250008800

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QA62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA62

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	3
GO:0006518	peptide metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0019538	protein metabolic process	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	3
GO:0043043	peptide biosynthetic process	5	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043603	amide metabolic process	3	3
GO:0043604	amide biosynthetic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	3
GO:0005198	structural molecule activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	502	506	PF00656	0.494
CLV_NRD_NRD_1	342	344	PF00675	0.685
CLV_NRD_NRD_1	346	348	PF00675	0.662
CLV_NRD_NRD_1	364	366	PF00675	0.588
CLV_NRD_NRD_1	383	385	PF00675	0.434
CLV_NRD_NRD_1	423	425	PF00675	0.663
CLV_NRD_NRD_1	457	459	PF00675	0.705
CLV_NRD_NRD_1	562	564	PF00675	0.718
CLV_NRD_NRD_1	573	575	PF00675	0.472
CLV_PCSK_FUR_1	560	564	PF00082	0.685
CLV_PCSK_FUR_1	571	575	PF00082	0.492
CLV_PCSK_KEX2_1	248	250	PF00082	0.803
CLV_PCSK_KEX2_1	333	335	PF00082	0.717
CLV_PCSK_KEX2_1	342	344	PF00082	0.678
CLV_PCSK_KEX2_1	346	348	PF00082	0.636
CLV_PCSK_KEX2_1	383	385	PF00082	0.450
CLV_PCSK_KEX2_1	423	425	PF00082	0.663
CLV_PCSK_KEX2_1	457	459	PF00082	0.693
CLV_PCSK_KEX2_1	562	564	PF00082	0.730
CLV_PCSK_KEX2_1	573	575	PF00082	0.472
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.803
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.677
CLV_PCSK_PC7_1	338	344	PF00082	0.688
CLV_PCSK_PC7_1	419	425	PF00082	0.649
CLV_PCSK_SKI1_1	119	123	PF00082	0.578
CLV_PCSK_SKI1_1	129	133	PF00082	0.496
CLV_PCSK_SKI1_1	585	589	PF00082	0.482
DEG_COP1_1	78	86	PF00400	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SCF_FBW7_2	300	306	PF00400	0.686
DEG_SPOP_SBC_1	152	156	PF00917	0.614
DEG_SPOP_SBC_1	325	329	PF00917	0.615
DEG_SPOP_SBC_1	609	613	PF00917	0.598
DOC_CKS1_1	265	270	PF01111	0.658
DOC_CKS1_1	300	305	PF01111	0.683
DOC_CKS1_1	427	432	PF01111	0.694
DOC_CKS1_1	434	439	PF01111	0.618
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.660
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.472
DOC_MAPK_DCC_7	661	671	PF00069	0.480
DOC_MAPK_gen_1	127	134	PF00069	0.575
DOC_MAPK_gen_1	571	580	PF00069	0.490
DOC_MAPK_MEF2A_6	426	434	PF00069	0.549
DOC_MAPK_MEF2A_6	571	580	PF00069	0.490
DOC_PP1_RVXF_1	477	483	PF00149	0.512
DOC_PP2B_LxvP_1	525	528	PF13499	0.500
DOC_USP7_MATH_1	103	107	PF00917	0.578
DOC_USP7_MATH_1	110	114	PF00917	0.566
DOC_USP7_MATH_1	152	156	PF00917	0.614
DOC_USP7_MATH_1	22	26	PF00917	0.679
DOC_USP7_MATH_1	255	259	PF00917	0.673
DOC_USP7_MATH_1	285	289	PF00917	0.681
DOC_USP7_MATH_1	307	311	PF00917	0.589
DOC_USP7_MATH_1	316	320	PF00917	0.610
DOC_USP7_MATH_1	325	329	PF00917	0.709
DOC_USP7_MATH_1	336	340	PF00917	0.602
DOC_USP7_MATH_1	411	415	PF00917	0.581
DOC_USP7_MATH_1	531	535	PF00917	0.293
DOC_USP7_MATH_1	77	81	PF00917	0.674
DOC_USP7_MATH_1	86	90	PF00917	0.575
DOC_WW_Pin1_4	148	153	PF00397	0.565
DOC_WW_Pin1_4	18	23	PF00397	0.653
DOC_WW_Pin1_4	186	191	PF00397	0.619
DOC_WW_Pin1_4	213	218	PF00397	0.709
DOC_WW_Pin1_4	259	264	PF00397	0.726
DOC_WW_Pin1_4	279	284	PF00397	0.554
DOC_WW_Pin1_4	287	292	PF00397	0.663
DOC_WW_Pin1_4	29	34	PF00397	0.627
DOC_WW_Pin1_4	294	299	PF00397	0.610
DOC_WW_Pin1_4	326	331	PF00397	0.806
DOC_WW_Pin1_4	341	346	PF00397	0.642
DOC_WW_Pin1_4	348	353	PF00397	0.685
DOC_WW_Pin1_4	360	365	PF00397	0.554
DOC_WW_Pin1_4	426	431	PF00397	0.689
DOC_WW_Pin1_4	433	438	PF00397	0.619
DOC_WW_Pin1_4	441	446	PF00397	0.665
DOC_WW_Pin1_4	47	52	PF00397	0.488
DOC_WW_Pin1_4	547	552	PF00397	0.502
DOC_WW_Pin1_4	82	87	PF00397	0.533
LIG_14-3-3_CanoR_1	159	165	PF00244	0.666
LIG_14-3-3_CanoR_1	204	209	PF00244	0.729
LIG_14-3-3_CanoR_1	324	330	PF00244	0.710
LIG_14-3-3_CanoR_1	365	374	PF00244	0.668
LIG_14-3-3_CanoR_1	424	430	PF00244	0.680
LIG_14-3-3_CanoR_1	539	545	PF00244	0.470
LIG_FHA_1	410	416	PF00498	0.587
LIG_FHA_1	427	433	PF00498	0.694
LIG_FHA_1	448	454	PF00498	0.667
LIG_FHA_1	48	54	PF00498	0.631
LIG_FHA_1	502	508	PF00498	0.498
LIG_FHA_1	600	606	PF00498	0.459
LIG_IBAR_NPY_1	90	92	PF08397	0.681
LIG_KLC1_Yacidic_2	643	647	PF13176	0.446
LIG_LIR_Apic_2	618	624	PF02991	0.540
LIG_LIR_Apic_2	96	100	PF02991	0.682
LIG_LIR_Gen_1	538	546	PF02991	0.345
LIG_LIR_Nem_3	538	544	PF02991	0.354
LIG_LIR_Nem_3	584	590	PF02991	0.482
LIG_LIR_Nem_3	60	66	PF02991	0.541
LIG_LYPXL_yS_3	63	66	PF13949	0.509
LIG_PDZ_Class_2	680	685	PF00595	0.455
LIG_Pex14_2	544	548	PF04695	0.447
LIG_SH2_CRK	54	58	PF00017	0.683
LIG_SH2_CRK	621	625	PF00017	0.507
LIG_SH2_SRC	625	628	PF00017	0.497
LIG_SH2_SRC	645	648	PF00017	0.260
LIG_SH2_STAP1	45	49	PF00017	0.655
LIG_SH2_STAT5	229	232	PF00017	0.662
LIG_SH2_STAT5	45	48	PF00017	0.654
LIG_SH2_STAT5	541	544	PF00017	0.338
LIG_SH2_STAT5	599	602	PF00017	0.581
LIG_SH2_STAT5	645	648	PF00017	0.465
LIG_SH2_STAT5	67	70	PF00017	0.649
LIG_SH2_STAT5	72	75	PF00017	0.638
LIG_SH2_STAT5	92	95	PF00017	0.492
LIG_SH3_1	342	348	PF00018	0.719
LIG_SH3_1	361	367	PF00018	0.541
LIG_SH3_1	621	627	PF00018	0.505
LIG_SH3_2	100	105	PF14604	0.605
LIG_SH3_2	300	305	PF14604	0.683
LIG_SH3_2	468	473	PF14604	0.527
LIG_SH3_3	159	165	PF00018	0.635
LIG_SH3_3	208	214	PF00018	0.695
LIG_SH3_3	251	257	PF00018	0.674
LIG_SH3_3	288	294	PF00018	0.630
LIG_SH3_3	297	303	PF00018	0.670
LIG_SH3_3	342	348	PF00018	0.719
LIG_SH3_3	361	367	PF00018	0.541
LIG_SH3_3	435	441	PF00018	0.668
LIG_SH3_3	465	471	PF00018	0.605
LIG_SH3_3	621	627	PF00018	0.523
LIG_SH3_3	662	668	PF00018	0.488
LIG_SH3_3	80	86	PF00018	0.621
LIG_SH3_3	97	103	PF00018	0.563
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.626
LIG_SUMO_SIM_par_1	411	416	PF11976	0.526
LIG_SUMO_SIM_par_1	667	673	PF11976	0.434
LIG_SxIP_EBH_1	19	33	PF03271	0.704
LIG_WRC_WIRS_1	532	537	PF05994	0.315
LIG_WRC_WIRS_1	541	546	PF05994	0.303
LIG_WW_3	292	296	PF00397	0.590
MOD_CDC14_SPxK_1	292	295	PF00782	0.731
MOD_CDC14_SPxK_1	331	334	PF00782	0.743
MOD_CDC14_SPxK_1	34	37	PF00782	0.692
MOD_CDC14_SPxK_1	363	366	PF00782	0.664
MOD_CDK_SPK_2	328	333	PF00069	0.659
MOD_CDK_SPK_2	341	346	PF00069	0.581
MOD_CDK_SPK_2	360	365	PF00069	0.595
MOD_CDK_SPxK_1	289	295	PF00069	0.734
MOD_CDK_SPxK_1	299	305	PF00069	0.631
MOD_CDK_SPxK_1	31	37	PF00069	0.693
MOD_CDK_SPxK_1	328	334	PF00069	0.735
MOD_CDK_SPxK_1	341	347	PF00069	0.604
MOD_CDK_SPxK_1	360	366	PF00069	0.594
MOD_CDK_SPxxK_3	294	301	PF00069	0.631
MOD_CDK_SPxxK_3	326	333	PF00069	0.661
MOD_CDK_SPxxK_3	441	448	PF00069	0.635
MOD_CK1_1	151	157	PF00069	0.653
MOD_CK1_1	184	190	PF00069	0.685
MOD_CK1_1	215	221	PF00069	0.708
MOD_CK1_1	264	270	PF00069	0.639
MOD_CK1_1	279	285	PF00069	0.641
MOD_CK1_1	310	316	PF00069	0.649
MOD_CK1_1	328	334	PF00069	0.735
MOD_CK1_1	360	366	PF00069	0.721
MOD_CK1_1	403	409	PF00069	0.575
MOD_CK1_1	461	467	PF00069	0.686
MOD_CK1_1	55	61	PF00069	0.676
MOD_CK1_1	550	556	PF00069	0.542
MOD_CK1_1	75	81	PF00069	0.478
MOD_CK1_1	85	91	PF00069	0.574
MOD_CK1_1	9	15	PF00069	0.639
MOD_CK2_1	120	126	PF00069	0.542
MOD_CK2_1	309	315	PF00069	0.724
MOD_CK2_1	41	47	PF00069	0.693
MOD_Cter_Amidation	246	249	PF01082	0.577
MOD_GlcNHglycan	105	108	PF01048	0.695
MOD_GlcNHglycan	112	115	PF01048	0.548
MOD_GlcNHglycan	155	158	PF01048	0.673
MOD_GlcNHglycan	193	196	PF01048	0.609
MOD_GlcNHglycan	2	5	PF01048	0.575
MOD_GlcNHglycan	220	223	PF01048	0.727
MOD_GlcNHglycan	24	27	PF01048	0.583
MOD_GlcNHglycan	276	281	PF01048	0.611
MOD_GlcNHglycan	29	32	PF01048	0.634
MOD_GlcNHglycan	318	321	PF01048	0.792
MOD_GlcNHglycan	368	371	PF01048	0.678
MOD_GlcNHglycan	38	42	PF01048	0.564
MOD_GlcNHglycan	405	408	PF01048	0.610
MOD_GlcNHglycan	486	489	PF01048	0.475
MOD_GlcNHglycan	54	57	PF01048	0.517
MOD_GlcNHglycan	59	62	PF01048	0.611
MOD_GlcNHglycan	613	616	PF01048	0.635
MOD_GlcNHglycan	672	675	PF01048	0.463
MOD_GlcNHglycan	74	77	PF01048	0.467
MOD_GlcNHglycan	8	11	PF01048	0.639
MOD_GSK3_1	148	155	PF00069	0.626
MOD_GSK3_1	18	25	PF00069	0.676
MOD_GSK3_1	181	188	PF00069	0.680
MOD_GSK3_1	255	262	PF00069	0.720
MOD_GSK3_1	27	34	PF00069	0.611
MOD_GSK3_1	285	292	PF00069	0.729
MOD_GSK3_1	307	314	PF00069	0.767
MOD_GSK3_1	316	323	PF00069	0.627
MOD_GSK3_1	324	331	PF00069	0.582
MOD_GSK3_1	348	355	PF00069	0.743
MOD_GSK3_1	37	44	PF00069	0.532
MOD_GSK3_1	531	538	PF00069	0.314
MOD_GSK3_1	55	62	PF00069	0.503
MOD_GSK3_1	581	588	PF00069	0.463
MOD_GSK3_1	71	78	PF00069	0.554
MOD_GSK3_1	82	89	PF00069	0.556
MOD_NEK2_1	160	165	PF00069	0.613
MOD_NEK2_1	409	414	PF00069	0.642
MOD_NEK2_1	432	437	PF00069	0.672
MOD_NEK2_1	535	540	PF00069	0.535
MOD_NEK2_1	57	62	PF00069	0.670
MOD_NEK2_1	598	603	PF00069	0.494
MOD_PIKK_1	285	291	PF00454	0.657
MOD_PKA_2	158	164	PF00069	0.663
MOD_PKA_2	400	406	PF00069	0.534
MOD_PKA_2	425	431	PF00069	0.684
MOD_PKA_2	447	453	PF00069	0.651
MOD_PKA_2	555	561	PF00069	0.650
MOD_Plk_1	176	182	PF00069	0.670
MOD_Plk_1	37	43	PF00069	0.660
MOD_Plk_4	62	68	PF00069	0.530
MOD_ProDKin_1	148	154	PF00069	0.572
MOD_ProDKin_1	18	24	PF00069	0.652
MOD_ProDKin_1	186	192	PF00069	0.614
MOD_ProDKin_1	213	219	PF00069	0.707
MOD_ProDKin_1	259	265	PF00069	0.728
MOD_ProDKin_1	279	285	PF00069	0.550
MOD_ProDKin_1	287	293	PF00069	0.662
MOD_ProDKin_1	29	35	PF00069	0.624
MOD_ProDKin_1	294	300	PF00069	0.609
MOD_ProDKin_1	326	332	PF00069	0.806
MOD_ProDKin_1	341	347	PF00069	0.643
MOD_ProDKin_1	348	354	PF00069	0.686
MOD_ProDKin_1	360	366	PF00069	0.551
MOD_ProDKin_1	426	432	PF00069	0.692
MOD_ProDKin_1	433	439	PF00069	0.619
MOD_ProDKin_1	441	447	PF00069	0.667
MOD_ProDKin_1	47	53	PF00069	0.489
MOD_ProDKin_1	547	553	PF00069	0.516
MOD_ProDKin_1	82	88	PF00069	0.535
TRG_DiLeu_BaEn_2	592	598	PF01217	0.476
TRG_ENDOCYTIC_2	54	57	PF00928	0.684
TRG_ENDOCYTIC_2	541	544	PF00928	0.338
TRG_ENDOCYTIC_2	63	66	PF00928	0.561
TRG_ER_diArg_1	143	146	PF00400	0.572
TRG_ER_diArg_1	345	347	PF00400	0.618
TRG_ER_diArg_1	383	385	PF00400	0.450
TRG_ER_diArg_1	423	426	PF00400	0.667
TRG_ER_diArg_1	456	458	PF00400	0.694
TRG_ER_diArg_1	479	482	PF00400	0.477
TRG_ER_diArg_1	560	563	PF00400	0.732
TRG_ER_diArg_1	571	574	PF00400	0.502
TRG_NES_CRM1_1	197	209	PF08389	0.634
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYR3	Leishmania donovani	89%	100%
A4HDY0	Leishmania braziliensis	69%	98%
A4I176	Leishmania infantum	89%	100%
E9AXB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%