RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QA61_LEIMA

TriTrypDb:

LmjF.25.0340 , LMJLV39_250009000 , LMJSD75_250009000

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA61

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.586
CLV_C14_Caspase3-7	350	354	PF00656	0.780
CLV_NRD_NRD_1	259	261	PF00675	0.587
CLV_NRD_NRD_1	390	392	PF00675	0.697
CLV_NRD_NRD_1	467	469	PF00675	0.646
CLV_NRD_NRD_1	480	482	PF00675	0.578
CLV_NRD_NRD_1	61	63	PF00675	0.426
CLV_PCSK_KEX2_1	382	384	PF00082	0.711
CLV_PCSK_KEX2_1	439	441	PF00082	0.521
CLV_PCSK_KEX2_1	467	469	PF00082	0.646
CLV_PCSK_KEX2_1	480	482	PF00082	0.578
CLV_PCSK_KEX2_1	61	63	PF00082	0.426
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.792
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.521
CLV_PCSK_PC7_1	57	63	PF00082	0.425
CLV_PCSK_SKI1_1	19	23	PF00082	0.460
CLV_PCSK_SKI1_1	495	499	PF00082	0.712
CLV_PCSK_SKI1_1	61	65	PF00082	0.414
CLV_Separin_Metazoa	54	58	PF03568	0.430
DEG_APCC_DBOX_1	60	68	PF00400	0.431
DOC_CDC14_PxL_1	148	156	PF14671	0.634
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.446
DOC_MAPK_gen_1	224	232	PF00069	0.457
DOC_MAPK_gen_1	467	474	PF00069	0.604
DOC_MAPK_gen_1	61	67	PF00069	0.427
DOC_MAPK_MEF2A_6	135	143	PF00069	0.455
DOC_MAPK_MEF2A_6	224	232	PF00069	0.457
DOC_MAPK_MEF2A_6	597	606	PF00069	0.519
DOC_PP1_RVXF_1	227	233	PF00149	0.549
DOC_PP1_RVXF_1	426	433	PF00149	0.387
DOC_PP2B_LxvP_1	206	209	PF13499	0.446
DOC_PP2B_LxvP_1	3	6	PF13499	0.637
DOC_USP7_MATH_1	496	500	PF00917	0.704
DOC_USP7_MATH_1	587	591	PF00917	0.597
DOC_USP7_UBL2_3	146	150	PF12436	0.625
DOC_WW_Pin1_4	487	492	PF00397	0.674
DOC_WW_Pin1_4	610	615	PF00397	0.479
LIG_14-3-3_CanoR_1	105	114	PF00244	0.451
LIG_14-3-3_CanoR_1	19	27	PF00244	0.484
LIG_14-3-3_CanoR_1	260	264	PF00244	0.555
LIG_14-3-3_CanoR_1	312	317	PF00244	0.608
LIG_14-3-3_CanoR_1	40	48	PF00244	0.456
LIG_14-3-3_CanoR_1	407	416	PF00244	0.522
LIG_14-3-3_CanoR_1	467	474	PF00244	0.542
LIG_14-3-3_CanoR_1	480	487	PF00244	0.709
LIG_14-3-3_CanoR_1	57	65	PF00244	0.424
LIG_14-3-3_CanoR_1	581	589	PF00244	0.588
LIG_14-3-3_CanoR_1	78	84	PF00244	0.567
LIG_Actin_WH2_2	44	59	PF00022	0.480
LIG_BRCT_BRCA1_1	261	265	PF00533	0.633
LIG_BRCT_BRCA1_1	319	323	PF00533	0.620
LIG_BRCT_BRCA1_1	410	414	PF00533	0.510
LIG_Clathr_ClatBox_1	64	68	PF01394	0.439
LIG_deltaCOP1_diTrp_1	75	83	PF00928	0.458
LIG_FHA_1	113	119	PF00498	0.498
LIG_FHA_1	220	226	PF00498	0.436
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_1	404	410	PF00498	0.583
LIG_FHA_1	417	423	PF00498	0.193
LIG_FHA_1	536	542	PF00498	0.471
LIG_FHA_1	581	587	PF00498	0.508
LIG_FHA_1	79	85	PF00498	0.385
LIG_FHA_2	570	576	PF00498	0.435
LIG_FHA_2	603	609	PF00498	0.569
LIG_LIR_Gen_1	320	331	PF02991	0.694
LIG_LIR_Gen_1	50	60	PF02991	0.435
LIG_LIR_Gen_1	79	88	PF02991	0.440
LIG_LIR_Gen_1	98	107	PF02991	0.447
LIG_LIR_Nem_3	320	326	PF02991	0.685
LIG_LIR_Nem_3	50	55	PF02991	0.413
LIG_LIR_Nem_3	75	80	PF02991	0.465
LIG_LIR_Nem_3	98	102	PF02991	0.454
LIG_MYND_1	516	520	PF01753	0.795
LIG_MYND_3	157	161	PF01753	0.556
LIG_Pex14_2	292	296	PF04695	0.571
LIG_Pex14_2	414	418	PF04695	0.545
LIG_PTB_Apo_2	142	149	PF02174	0.517
LIG_SH2_GRB2like	237	240	PF00017	0.676
LIG_SH2_PTP2	52	55	PF00017	0.434
LIG_SH2_SRC	52	55	PF00017	0.434
LIG_SH2_STAP1	80	84	PF00017	0.433
LIG_SH2_STAT3	276	279	PF00017	0.423
LIG_SH2_STAT3	645	648	PF00017	0.506
LIG_SH2_STAT5	124	127	PF00017	0.457
LIG_SH2_STAT5	213	216	PF00017	0.495
LIG_SH2_STAT5	218	221	PF00017	0.441
LIG_SH2_STAT5	362	365	PF00017	0.777
LIG_SH2_STAT5	52	55	PF00017	0.434
LIG_SH2_STAT5	58	61	PF00017	0.417
LIG_SH2_STAT5	80	83	PF00017	0.437
LIG_SH2_STAT5	99	102	PF00017	0.447
LIG_SH3_1	382	388	PF00018	0.757
LIG_SH3_1	510	516	PF00018	0.785
LIG_SH3_3	111	117	PF00018	0.490
LIG_SH3_3	370	376	PF00018	0.693
LIG_SH3_3	382	388	PF00018	0.713
LIG_SH3_3	398	404	PF00018	0.517
LIG_SH3_3	510	516	PF00018	0.680
LIG_SH3_4	146	153	PF00018	0.624
LIG_SUMO_SIM_par_1	525	535	PF11976	0.736
LIG_TRAF2_1	607	610	PF00917	0.600
LIG_UBA3_1	139	146	PF00899	0.513
LIG_WRC_WIRS_1	364	369	PF05994	0.668
LIG_WRC_WIRS_1	415	420	PF05994	0.544
LIG_WRC_WIRS_1	80	85	PF05994	0.548
MOD_CK1_1	187	193	PF00069	0.410
MOD_CK1_1	247	253	PF00069	0.576
MOD_CK1_1	332	338	PF00069	0.682
MOD_CK1_1	339	345	PF00069	0.683
MOD_CK1_1	500	506	PF00069	0.708
MOD_CK1_1	7	13	PF00069	0.674
MOD_CK1_1	82	88	PF00069	0.441
MOD_CK2_1	177	183	PF00069	0.576
MOD_CK2_1	604	610	PF00069	0.579
MOD_GlcNHglycan	107	110	PF01048	0.473
MOD_GlcNHglycan	214	217	PF01048	0.477
MOD_GlcNHglycan	305	308	PF01048	0.579
MOD_GlcNHglycan	410	413	PF01048	0.553
MOD_GlcNHglycan	481	484	PF01048	0.795
MOD_GlcNHglycan	492	495	PF01048	0.808
MOD_GlcNHglycan	6	9	PF01048	0.601
MOD_GlcNHglycan	651	654	PF01048	0.571
MOD_GSK3_1	187	194	PF00069	0.558
MOD_GSK3_1	332	339	PF00069	0.629
MOD_GSK3_1	414	421	PF00069	0.529
MOD_GSK3_1	455	462	PF00069	0.465
MOD_GSK3_1	496	503	PF00069	0.787
MOD_GSK3_1	78	85	PF00069	0.399
MOD_N-GLC_1	339	344	PF02516	0.670
MOD_N-GLC_1	395	400	PF02516	0.795
MOD_NEK2_1	191	196	PF00069	0.572
MOD_NEK2_1	219	224	PF00069	0.453
MOD_NEK2_1	27	32	PF00069	0.599
MOD_NEK2_1	305	310	PF00069	0.586
MOD_NEK2_1	326	331	PF00069	0.788
MOD_NEK2_1	414	419	PF00069	0.394
MOD_NEK2_1	523	528	PF00069	0.647
MOD_NEK2_1	56	61	PF00069	0.422
MOD_NEK2_1	649	654	PF00069	0.550
MOD_PIKK_1	130	136	PF00454	0.570
MOD_PIKK_1	184	190	PF00454	0.415
MOD_PIKK_1	27	33	PF00454	0.492
MOD_PIKK_1	467	473	PF00454	0.683
MOD_PIKK_1	654	660	PF00454	0.724
MOD_PIKK_1	82	88	PF00454	0.366
MOD_PK_1	312	318	PF00069	0.689
MOD_PKA_1	467	473	PF00069	0.683
MOD_PKA_2	259	265	PF00069	0.536
MOD_PKA_2	39	45	PF00069	0.541
MOD_PKA_2	467	473	PF00069	0.546
MOD_PKA_2	479	485	PF00069	0.759
MOD_PKA_2	56	62	PF00069	0.425
MOD_PKA_2	580	586	PF00069	0.530
MOD_PKB_1	310	318	PF00069	0.554
MOD_Plk_1	14	20	PF00069	0.587
MOD_Plk_1	318	324	PF00069	0.754
MOD_Plk_1	339	345	PF00069	0.750
MOD_Plk_1	508	514	PF00069	0.675
MOD_Plk_1	602	608	PF00069	0.466
MOD_Plk_1	631	637	PF00069	0.431
MOD_Plk_2-3	177	183	PF00069	0.576
MOD_Plk_4	171	177	PF00069	0.505
MOD_Plk_4	300	306	PF00069	0.459
MOD_Plk_4	79	85	PF00069	0.427
MOD_Plk_4	95	101	PF00069	0.306
MOD_ProDKin_1	487	493	PF00069	0.673
MOD_ProDKin_1	610	616	PF00069	0.473
MOD_SUMO_for_1	65	68	PF00179	0.445
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.539
TRG_ENDOCYTIC_2	52	55	PF00928	0.434
TRG_ENDOCYTIC_2	80	83	PF00928	0.437
TRG_ENDOCYTIC_2	99	102	PF00928	0.447
TRG_ER_diArg_1	310	313	PF00400	0.517
TRG_ER_diArg_1	466	468	PF00400	0.529
TRG_ER_diArg_1	61	63	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D4	Leptomonas seymouri	49%	94%
E9AXB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%