DUF1308 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1308), putative

Species:

Leishmania major

UniProt:

Q4QA60_LEIMA

TriTrypDb:

LmjF.25.0350 , LMJLV39_250009100 , LMJSD75_250009100

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.661
CLV_C14_Caspase3-7	766	770	PF00656	0.665
CLV_MEL_PAP_1	38	44	PF00089	0.482
CLV_NRD_NRD_1	106	108	PF00675	0.482
CLV_NRD_NRD_1	297	299	PF00675	0.509
CLV_NRD_NRD_1	305	307	PF00675	0.504
CLV_NRD_NRD_1	4	6	PF00675	0.497
CLV_NRD_NRD_1	460	462	PF00675	0.538
CLV_NRD_NRD_1	50	52	PF00675	0.495
CLV_NRD_NRD_1	502	504	PF00675	0.709
CLV_NRD_NRD_1	570	572	PF00675	0.510
CLV_NRD_NRD_1	82	84	PF00675	0.518
CLV_NRD_NRD_1	862	864	PF00675	0.590
CLV_NRD_NRD_1	866	868	PF00675	0.614
CLV_PCSK_FUR_1	2	6	PF00082	0.503
CLV_PCSK_FUR_1	451	455	PF00082	0.560
CLV_PCSK_KEX2_1	106	108	PF00082	0.482
CLV_PCSK_KEX2_1	305	307	PF00082	0.537
CLV_PCSK_KEX2_1	4	6	PF00082	0.497
CLV_PCSK_KEX2_1	453	455	PF00082	0.579
CLV_PCSK_KEX2_1	460	462	PF00082	0.502
CLV_PCSK_KEX2_1	50	52	PF00082	0.495
CLV_PCSK_KEX2_1	501	503	PF00082	0.709
CLV_PCSK_KEX2_1	82	84	PF00082	0.518
CLV_PCSK_KEX2_1	862	864	PF00082	0.588
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.649
CLV_PCSK_SKI1_1	245	249	PF00082	0.430
CLV_PCSK_SKI1_1	362	366	PF00082	0.700
CLV_PCSK_SKI1_1	414	418	PF00082	0.672
CLV_PCSK_SKI1_1	515	519	PF00082	0.662
CLV_PCSK_SKI1_1	597	601	PF00082	0.568
CLV_PCSK_SKI1_1	605	609	PF00082	0.460
CLV_PCSK_SKI1_1	725	729	PF00082	0.464
CLV_PCSK_SKI1_1	811	815	PF00082	0.411
CLV_PCSK_SKI1_1	850	854	PF00082	0.411
CLV_Separin_Metazoa	36	40	PF03568	0.473
CLV_Separin_Metazoa	92	96	PF03568	0.502
DEG_APCC_DBOX_1	596	604	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DEG_SPOP_SBC_1	210	214	PF00917	0.586
DEG_SPOP_SBC_1	321	325	PF00917	0.674
DEG_SPOP_SBC_1	407	411	PF00917	0.592
DEG_SPOP_SBC_1	418	422	PF00917	0.468
DEG_SPOP_SBC_1	54	58	PF00917	0.479
DOC_ANK_TNKS_1	304	311	PF00023	0.483
DOC_CYCLIN_RxL_1	419	431	PF00134	0.560
DOC_CYCLIN_RxL_1	739	748	PF00134	0.453
DOC_CYCLIN_yClb3_PxF_3	788	794	PF00134	0.636
DOC_MAPK_gen_1	360	369	PF00069	0.693
DOC_MAPK_gen_1	460	467	PF00069	0.535
DOC_MAPK_gen_1	739	749	PF00069	0.451
DOC_MAPK_MEF2A_6	362	371	PF00069	0.714
DOC_MAPK_MEF2A_6	398	407	PF00069	0.560
DOC_MAPK_MEF2A_6	460	469	PF00069	0.534
DOC_MAPK_RevD_3	35	51	PF00069	0.479
DOC_MIT_MIM_1	232	241	PF04212	0.522
DOC_PP1_RVXF_1	243	249	PF00149	0.426
DOC_PP1_RVXF_1	809	815	PF00149	0.389
DOC_PP2B_LxvP_1	329	332	PF13499	0.637
DOC_PP2B_LxvP_1	470	473	PF13499	0.521
DOC_PP2B_LxvP_1	636	639	PF13499	0.587
DOC_USP7_MATH_1	131	135	PF00917	0.668
DOC_USP7_MATH_1	172	176	PF00917	0.776
DOC_USP7_MATH_1	247	251	PF00917	0.594
DOC_USP7_MATH_1	275	279	PF00917	0.565
DOC_USP7_MATH_1	382	386	PF00917	0.681
DOC_USP7_MATH_1	513	517	PF00917	0.649
DOC_USP7_MATH_1	54	58	PF00917	0.479
DOC_USP7_MATH_1	587	591	PF00917	0.513
DOC_USP7_MATH_1	619	623	PF00917	0.663
DOC_USP7_MATH_1	676	680	PF00917	0.716
DOC_USP7_MATH_1	700	704	PF00917	0.610
DOC_USP7_MATH_1	848	852	PF00917	0.411
DOC_USP7_UBL2_3	288	292	PF12436	0.627
DOC_WW_Pin1_4	168	173	PF00397	0.738
DOC_WW_Pin1_4	213	218	PF00397	0.533
DOC_WW_Pin1_4	250	255	PF00397	0.589
DOC_WW_Pin1_4	322	327	PF00397	0.684
DOC_WW_Pin1_4	436	441	PF00397	0.494
DOC_WW_Pin1_4	524	529	PF00397	0.523
DOC_WW_Pin1_4	76	81	PF00397	0.503
LIG_14-3-3_CanoR_1	279	287	PF00244	0.572
LIG_14-3-3_CanoR_1	320	326	PF00244	0.502
LIG_14-3-3_CanoR_1	388	397	PF00244	0.624
LIG_14-3-3_CanoR_1	41	49	PF00244	0.482
LIG_14-3-3_CanoR_1	515	521	PF00244	0.640
LIG_14-3-3_CanoR_1	589	594	PF00244	0.478
LIG_14-3-3_CanoR_1	745	750	PF00244	0.455
LIG_14-3-3_CanoR_1	850	858	PF00244	0.411
LIG_14-3-3_CanoR_1	9	19	PF00244	0.483
LIG_14-3-3_CanoR_1	95	100	PF00244	0.497
LIG_BIR_III_2	618	622	PF00653	0.684
LIG_BIR_III_4	176	180	PF00653	0.758
LIG_CSL_BTD_1	519	522	PF09270	0.584
LIG_CSL_BTD_1	786	789	PF09270	0.707
LIG_EVH1_1	787	791	PF00568	0.571
LIG_EVH1_2	332	336	PF00568	0.615
LIG_EVH1_2	790	794	PF00568	0.535
LIG_FHA_1	108	114	PF00498	0.459
LIG_FHA_1	168	174	PF00498	0.738
LIG_FHA_1	299	305	PF00498	0.506
LIG_FHA_1	440	446	PF00498	0.493
LIG_FHA_1	494	500	PF00498	0.621
LIG_FHA_1	516	522	PF00498	0.703
LIG_FHA_1	533	539	PF00498	0.342
LIG_FHA_1	594	600	PF00498	0.356
LIG_FHA_1	62	68	PF00498	0.485
LIG_FHA_1	679	685	PF00498	0.636
LIG_FHA_1	686	692	PF00498	0.483
LIG_FHA_1	750	756	PF00498	0.511
LIG_FHA_1	94	100	PF00498	0.497
LIG_FHA_2	322	328	PF00498	0.661
LIG_FHA_2	354	360	PF00498	0.512
LIG_FHA_2	638	644	PF00498	0.538
LIG_FHA_2	718	724	PF00498	0.454
LIG_FHA_2	793	799	PF00498	0.503
LIG_FHA_2	82	88	PF00498	0.513
LIG_FHA_2	824	830	PF00498	0.389
LIG_GBD_Chelix_1	230	238	PF00786	0.491
LIG_LIR_Apic_2	518	523	PF02991	0.599
LIG_LIR_Apic_2	641	647	PF02991	0.501
LIG_LIR_Apic_2	784	790	PF02991	0.664
LIG_LIR_Gen_1	124	132	PF02991	0.708
LIG_LIR_Gen_1	412	423	PF02991	0.555
LIG_LIR_Gen_1	439	449	PF02991	0.495
LIG_LIR_Gen_1	718	728	PF02991	0.456
LIG_LIR_Gen_1	796	806	PF02991	0.418
LIG_LIR_LC3C_4	327	331	PF02991	0.600
LIG_LIR_Nem_3	284	290	PF02991	0.517
LIG_LIR_Nem_3	349	354	PF02991	0.537
LIG_LIR_Nem_3	365	371	PF02991	0.573
LIG_LIR_Nem_3	412	418	PF02991	0.549
LIG_LIR_Nem_3	718	724	PF02991	0.454
LIG_LIR_Nem_3	796	802	PF02991	0.419
LIG_MYND_1	522	526	PF01753	0.574
LIG_NRBOX	223	229	PF00104	0.598
LIG_NRBOX	237	243	PF00104	0.373
LIG_Rb_LxCxE_1	352	372	PF01857	0.601
LIG_SH2_CRK	287	291	PF00017	0.504
LIG_SH2_CRK	351	355	PF00017	0.621
LIG_SH2_PTP2	368	371	PF00017	0.663
LIG_SH2_SRC	368	371	PF00017	0.738
LIG_SH2_SRC	380	383	PF00017	0.599
LIG_SH2_SRC	547	550	PF00017	0.644
LIG_SH2_STAP1	595	599	PF00017	0.603
LIG_SH2_STAT3	194	197	PF00017	0.745
LIG_SH2_STAT3	858	861	PF00017	0.530
LIG_SH2_STAT5	368	371	PF00017	0.663
LIG_SH2_STAT5	595	598	PF00017	0.520
LIG_SH2_STAT5	799	802	PF00017	0.411
LIG_SH3_1	863	869	PF00018	0.596
LIG_SH3_3	327	333	PF00018	0.588
LIG_SH3_3	364	370	PF00018	0.560
LIG_SH3_3	469	475	PF00018	0.495
LIG_SH3_3	520	526	PF00018	0.613
LIG_SH3_3	580	586	PF00018	0.513
LIG_SH3_3	622	628	PF00018	0.632
LIG_SH3_3	783	789	PF00018	0.718
LIG_SH3_3	863	869	PF00018	0.596
LIG_SUMO_SIM_anti_2	404	412	PF11976	0.571
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.488
LIG_SUMO_SIM_par_1	112	117	PF11976	0.467
LIG_SUMO_SIM_par_1	442	450	PF11976	0.603
LIG_SUMO_SIM_par_1	534	543	PF11976	0.425
LIG_SUMO_SIM_par_1	579	585	PF11976	0.391
LIG_SUMO_SIM_par_1	61	66	PF11976	0.481
LIG_SUMO_SIM_par_1	634	641	PF11976	0.379
LIG_SUMO_SIM_par_1	685	692	PF11976	0.470
LIG_SUMO_SIM_par_1	745	753	PF11976	0.470
LIG_SxIP_EBH_1	515	527	PF03271	0.473
LIG_TRAF2_1	720	723	PF00917	0.457
LIG_TYR_ITIM	797	802	PF00017	0.411
LIG_UBA3_1	444	453	PF00899	0.613
LIG_WRC_WIRS_1	118	123	PF05994	0.464
MOD_CDK_SPxK_1	76	82	PF00069	0.506
MOD_CDK_SPxxK_3	76	83	PF00069	0.508
MOD_CK1_1	117	123	PF00069	0.463
MOD_CK1_1	13	19	PF00069	0.481
MOD_CK1_1	151	157	PF00069	0.730
MOD_CK1_1	171	177	PF00069	0.671
MOD_CK1_1	250	256	PF00069	0.673
MOD_CK1_1	265	271	PF00069	0.684
MOD_CK1_1	322	328	PF00069	0.622
MOD_CK1_1	516	522	PF00069	0.598
MOD_CK1_1	56	62	PF00069	0.476
MOD_CK1_1	70	76	PF00069	0.474
MOD_CK2_1	233	239	PF00069	0.595
MOD_CK2_1	256	262	PF00069	0.744
MOD_CK2_1	353	359	PF00069	0.541
MOD_CK2_1	406	412	PF00069	0.515
MOD_CK2_1	542	548	PF00069	0.501
MOD_CK2_1	656	662	PF00069	0.678
MOD_CK2_1	717	723	PF00069	0.457
MOD_CK2_1	792	798	PF00069	0.616
MOD_CK2_1	823	829	PF00069	0.389
MOD_CK2_1	848	854	PF00069	0.411
MOD_GlcNHglycan	134	137	PF01048	0.690
MOD_GlcNHglycan	154	157	PF01048	0.741
MOD_GlcNHglycan	165	168	PF01048	0.786
MOD_GlcNHglycan	271	274	PF01048	0.814
MOD_GlcNHglycan	284	287	PF01048	0.635
MOD_GlcNHglycan	311	314	PF01048	0.620
MOD_GlcNHglycan	371	374	PF01048	0.639
MOD_GlcNHglycan	382	385	PF01048	0.670
MOD_GlcNHglycan	491	494	PF01048	0.480
MOD_GlcNHglycan	515	518	PF01048	0.706
MOD_GlcNHglycan	658	661	PF01048	0.683
MOD_GlcNHglycan	678	681	PF01048	0.439
MOD_GlcNHglycan	692	696	PF01048	0.351
MOD_GlcNHglycan	702	705	PF01048	0.564
MOD_GlcNHglycan	760	763	PF01048	0.601
MOD_GlcNHglycan	802	805	PF01048	0.510
MOD_GSK3_1	10	17	PF00069	0.480
MOD_GSK3_1	147	154	PF00069	0.716
MOD_GSK3_1	155	162	PF00069	0.765
MOD_GSK3_1	163	170	PF00069	0.788
MOD_GSK3_1	209	216	PF00069	0.631
MOD_GSK3_1	265	272	PF00069	0.705
MOD_GSK3_1	321	328	PF00069	0.686
MOD_GSK3_1	380	387	PF00069	0.640
MOD_GSK3_1	489	496	PF00069	0.597
MOD_GSK3_1	533	540	PF00069	0.436
MOD_GSK3_1	589	596	PF00069	0.493
MOD_GSK3_1	63	70	PF00069	0.487
MOD_GSK3_1	665	672	PF00069	0.770
MOD_GSK3_1	700	707	PF00069	0.699
MOD_GSK3_1	745	752	PF00069	0.479
MOD_GSK3_1	772	779	PF00069	0.815
MOD_GSK3_1	800	807	PF00069	0.389
MOD_GSK3_1	846	853	PF00069	0.389
MOD_GSK3_1	93	100	PF00069	0.499
MOD_LATS_1	318	324	PF00433	0.485
MOD_N-GLC_1	262	267	PF02516	0.705
MOD_NEK2_1	114	119	PF00069	0.464
MOD_NEK2_1	142	147	PF00069	0.772
MOD_NEK2_1	211	216	PF00069	0.553
MOD_NEK2_1	248	253	PF00069	0.496
MOD_NEK2_1	282	287	PF00069	0.433
MOD_NEK2_1	29	34	PF00069	0.458
MOD_NEK2_1	386	391	PF00069	0.571
MOD_NEK2_1	533	538	PF00069	0.436
MOD_NEK2_1	55	60	PF00069	0.481
MOD_NEK2_1	63	68	PF00069	0.481
MOD_NEK2_1	684	689	PF00069	0.519
MOD_NEK2_1	800	805	PF00069	0.389
MOD_NEK2_1	93	98	PF00069	0.500
MOD_NEK2_2	542	547	PF00069	0.460
MOD_NEK2_2	804	809	PF00069	0.411
MOD_PIKK_1	253	259	PF00454	0.707
MOD_PIKK_1	265	271	PF00454	0.715
MOD_PIKK_1	540	546	PF00454	0.450
MOD_PIKK_1	93	99	PF00454	0.500
MOD_PK_1	112	118	PF00069	0.468
MOD_PK_1	745	751	PF00069	0.531
MOD_PKA_1	298	304	PF00069	0.488
MOD_PKA_1	4	10	PF00069	0.503
MOD_PKA_2	132	138	PF00069	0.571
MOD_PKA_2	265	271	PF00069	0.662
MOD_PKA_2	275	281	PF00069	0.612
MOD_PKA_2	319	325	PF00069	0.492
MOD_PKA_2	393	399	PF00069	0.767
MOD_PKA_2	4	10	PF00069	0.503
MOD_PKA_2	654	660	PF00069	0.601
MOD_PKA_2	776	782	PF00069	0.769
MOD_PKA_2	800	806	PF00069	0.389
MOD_PKB_1	159	167	PF00069	0.589
MOD_PKB_1	2	10	PF00069	0.505
MOD_PKB_1	279	287	PF00069	0.575
MOD_PKB_1	296	304	PF00069	0.447
MOD_PKB_1	360	368	PF00069	0.692
MOD_Plk_1	13	19	PF00069	0.481
MOD_Plk_1	142	148	PF00069	0.798
MOD_Plk_1	45	51	PF00069	0.485
MOD_Plk_1	533	539	PF00069	0.387
MOD_Plk_1	684	690	PF00069	0.511
MOD_Plk_1	717	723	PF00069	0.457
MOD_Plk_1	750	756	PF00069	0.559
MOD_Plk_4	14	20	PF00069	0.478
MOD_Plk_4	325	331	PF00069	0.619
MOD_Plk_4	516	522	PF00069	0.700
MOD_Plk_4	589	595	PF00069	0.479
MOD_Plk_4	685	691	PF00069	0.537
MOD_Plk_4	70	76	PF00069	0.488
MOD_Plk_4	745	751	PF00069	0.461
MOD_ProDKin_1	168	174	PF00069	0.738
MOD_ProDKin_1	213	219	PF00069	0.530
MOD_ProDKin_1	250	256	PF00069	0.596
MOD_ProDKin_1	322	328	PF00069	0.680
MOD_ProDKin_1	436	442	PF00069	0.490
MOD_ProDKin_1	524	530	PF00069	0.507
MOD_ProDKin_1	76	82	PF00069	0.506
MOD_SUMO_rev_2	718	727	PF00179	0.559
MOD_SUMO_rev_2	849	857	PF00179	0.410
TRG_DiLeu_BaEn_1	686	691	PF01217	0.504
TRG_DiLeu_BaEn_3	722	728	PF01217	0.460
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.473
TRG_DiLeu_BaLyEn_6	739	744	PF01217	0.451
TRG_ENDOCYTIC_2	127	130	PF00928	0.681
TRG_ENDOCYTIC_2	287	290	PF00928	0.553
TRG_ENDOCYTIC_2	351	354	PF00928	0.628
TRG_ENDOCYTIC_2	368	371	PF00928	0.485
TRG_ENDOCYTIC_2	721	724	PF00928	0.457
TRG_ENDOCYTIC_2	799	802	PF00928	0.411
TRG_ER_diArg_1	1	4	PF00400	0.511
TRG_ER_diArg_1	106	108	PF00400	0.482
TRG_ER_diArg_1	279	282	PF00400	0.632
TRG_ER_diArg_1	293	296	PF00400	0.635
TRG_ER_diArg_1	304	306	PF00400	0.522
TRG_ER_diArg_1	38	41	PF00400	0.483
TRG_ER_diArg_1	49	51	PF00400	0.482
TRG_ER_diArg_1	500	503	PF00400	0.698
TRG_NES_CRM1_1	598	613	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	850	854	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW5	Leptomonas seymouri	47%	100%
A0A3Q8IC76	Leishmania donovani	91%	100%
A4H4A7	Leishmania braziliensis	67%	100%
A4I178	Leishmania infantum	91%	100%
E9AXB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%