Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QA57_LEIMA

TriTrypDb:

LmjF.25.0380 , LMJLV39_250009400 , LMJSD75_250009400

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QA57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QA57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	263	265	PF00675	0.419
CLV_NRD_NRD_1	408	410	PF00675	0.582
CLV_NRD_NRD_1	434	436	PF00675	0.492
CLV_NRD_NRD_1	449	451	PF00675	0.447
CLV_NRD_NRD_1	494	496	PF00675	0.524
CLV_NRD_NRD_1	624	626	PF00675	0.551
CLV_NRD_NRD_1	662	664	PF00675	0.576
CLV_PCSK_KEX2_1	408	410	PF00082	0.499
CLV_PCSK_KEX2_1	434	436	PF00082	0.415
CLV_PCSK_KEX2_1	494	496	PF00082	0.549
CLV_PCSK_KEX2_1	508	510	PF00082	0.419
CLV_PCSK_KEX2_1	662	664	PF00082	0.516
CLV_PCSK_KEX2_1	795	797	PF00082	0.424
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.460
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.430
CLV_PCSK_SKI1_1	264	268	PF00082	0.551
CLV_PCSK_SKI1_1	334	338	PF00082	0.464
CLV_PCSK_SKI1_1	350	354	PF00082	0.405
CLV_PCSK_SKI1_1	381	385	PF00082	0.531
CLV_PCSK_SKI1_1	400	404	PF00082	0.534
CLV_PCSK_SKI1_1	408	412	PF00082	0.408
CLV_PCSK_SKI1_1	468	472	PF00082	0.424
CLV_PCSK_SKI1_1	487	491	PF00082	0.340
CLV_PCSK_SKI1_1	504	508	PF00082	0.358
CLV_PCSK_SKI1_1	617	621	PF00082	0.456
CLV_PCSK_SKI1_1	640	644	PF00082	0.493
CLV_PCSK_SKI1_1	735	739	PF00082	0.641
DEG_APCC_KENBOX_2	420	424	PF00400	0.475
DEG_SPOP_SBC_1	100	104	PF00917	0.572
DEG_SPOP_SBC_1	111	115	PF00917	0.528
DEG_SPOP_SBC_1	559	563	PF00917	0.589
DEG_SPOP_SBC_1	678	682	PF00917	0.676
DOC_CKS1_1	809	814	PF01111	0.595
DOC_CYCLIN_RxL_1	262	270	PF00134	0.436
DOC_CYCLIN_yClb3_PxF_3	116	122	PF00134	0.580
DOC_MAPK_gen_1	637	645	PF00069	0.485
DOC_MAPK_MEF2A_6	462	471	PF00069	0.428
DOC_PP2B_LxvP_1	276	279	PF13499	0.558
DOC_USP7_MATH_1	111	115	PF00917	0.597
DOC_USP7_MATH_1	130	134	PF00917	0.785
DOC_USP7_MATH_1	14	18	PF00917	0.735
DOC_USP7_MATH_1	195	199	PF00917	0.599
DOC_USP7_MATH_1	542	546	PF00917	0.645
DOC_USP7_MATH_1	558	562	PF00917	0.561
DOC_USP7_MATH_1	581	585	PF00917	0.661
DOC_USP7_MATH_1	710	714	PF00917	0.654
DOC_USP7_MATH_1	722	726	PF00917	0.669
DOC_USP7_MATH_1	80	84	PF00917	0.507
DOC_USP7_MATH_1	813	817	PF00917	0.563
DOC_USP7_MATH_1	99	103	PF00917	0.582
DOC_USP7_UBL2_3	504	508	PF12436	0.465
DOC_USP7_UBL2_3	791	795	PF12436	0.428
DOC_WW_Pin1_4	101	106	PF00397	0.664
DOC_WW_Pin1_4	107	112	PF00397	0.705
DOC_WW_Pin1_4	151	156	PF00397	0.600
DOC_WW_Pin1_4	198	203	PF00397	0.698
DOC_WW_Pin1_4	281	286	PF00397	0.600
DOC_WW_Pin1_4	579	584	PF00397	0.732
DOC_WW_Pin1_4	585	590	PF00397	0.692
DOC_WW_Pin1_4	730	735	PF00397	0.633
DOC_WW_Pin1_4	808	813	PF00397	0.522
LIG_14-3-3_CanoR_1	206	210	PF00244	0.507
LIG_14-3-3_CanoR_1	365	371	PF00244	0.690
LIG_14-3-3_CanoR_1	372	379	PF00244	0.599
LIG_14-3-3_CanoR_1	640	646	PF00244	0.501
LIG_14-3-3_CanoR_1	67	76	PF00244	0.482
LIG_14-3-3_CanoR_1	735	744	PF00244	0.616
LIG_14-3-3_CanoR_1	765	770	PF00244	0.519
LIG_14-3-3_CanoR_1	796	802	PF00244	0.498
LIG_14-3-3_CanoR_1	823	828	PF00244	0.564
LIG_Actin_WH2_2	412	429	PF00022	0.510
LIG_Actin_WH2_2	453	470	PF00022	0.419
LIG_Actin_WH2_2	626	642	PF00022	0.500
LIG_Actin_WH2_2	772	788	PF00022	0.415
LIG_APCC_ABBA_1	599	604	PF00400	0.386
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	587	591	PF00533	0.539
LIG_DLG_GKlike_1	823	830	PF00625	0.470
LIG_EVH1_2	118	122	PF00568	0.584
LIG_FHA_1	169	175	PF00498	0.645
LIG_FHA_1	271	277	PF00498	0.621
LIG_FHA_1	281	287	PF00498	0.590
LIG_FHA_1	32	38	PF00498	0.645
LIG_FHA_1	393	399	PF00498	0.500
LIG_FHA_1	552	558	PF00498	0.589
LIG_FHA_1	573	579	PF00498	0.632
LIG_FHA_1	595	601	PF00498	0.566
LIG_FHA_1	60	66	PF00498	0.541
LIG_FHA_1	652	658	PF00498	0.532
LIG_FHA_1	70	76	PF00498	0.563
LIG_FHA_1	724	730	PF00498	0.686
LIG_FHA_1	775	781	PF00498	0.507
LIG_FHA_1	847	853	PF00498	0.491
LIG_FHA_1	87	93	PF00498	0.436
LIG_FHA_2	23	29	PF00498	0.693
LIG_FHA_2	233	239	PF00498	0.549
LIG_FHA_2	340	346	PF00498	0.392
LIG_FHA_2	372	378	PF00498	0.584
LIG_FHA_2	41	47	PF00498	0.379
LIG_FHA_2	481	487	PF00498	0.449
LIG_FHA_2	736	742	PF00498	0.624
LIG_FHA_2	766	772	PF00498	0.520
LIG_FHA_2	776	782	PF00498	0.442
LIG_FHA_2	80	86	PF00498	0.455
LIG_Integrin_RGD_1	530	532	PF01839	0.547
LIG_LIR_Gen_1	750	757	PF02991	0.529
LIG_LIR_Gen_1	85	95	PF02991	0.554
LIG_LIR_LC3C_4	726	731	PF02991	0.569
LIG_LIR_Nem_3	584	590	PF02991	0.727
LIG_LIR_Nem_3	750	755	PF02991	0.540
LIG_LIR_Nem_3	85	91	PF02991	0.552
LIG_NRBOX	347	353	PF00104	0.484
LIG_NRBOX	826	832	PF00104	0.526
LIG_NRP_CendR_1	850	853	PF00754	0.516
LIG_Pex14_2	688	692	PF04695	0.570
LIG_RPA_C_Fungi	490	502	PF08784	0.335
LIG_SH2_CRK	587	591	PF00017	0.539
LIG_SH2_CRK	88	92	PF00017	0.555
LIG_SH2_NCK_1	318	322	PF00017	0.416
LIG_SH2_NCK_1	587	591	PF00017	0.539
LIG_SH2_STAP1	33	37	PF00017	0.643
LIG_SH2_STAP1	88	92	PF00017	0.531
LIG_SH2_STAT3	433	436	PF00017	0.509
LIG_SH2_STAT5	33	36	PF00017	0.616
LIG_SH2_STAT5	88	91	PF00017	0.414
LIG_SH3_3	113	119	PF00018	0.753
LIG_SH3_3	282	288	PF00018	0.544
LIG_SH3_3	35	41	PF00018	0.573
LIG_SH3_3	575	581	PF00018	0.585
LIG_SH3_3	583	589	PF00018	0.545
LIG_SH3_3	728	734	PF00018	0.555
LIG_SH3_3	806	812	PF00018	0.547
LIG_SUMO_SIM_par_1	488	493	PF11976	0.470
LIG_SUMO_SIM_par_1	725	733	PF11976	0.562
LIG_TRAF2_1	768	771	PF00917	0.518
LIG_TRAF2_2	734	739	PF00917	0.594
LIG_TYR_ITIM	585	590	PF00017	0.540
LIG_UBA3_1	632	637	PF00899	0.633
MOD_CDK_SPK_2	730	735	PF00069	0.603
MOD_CK1_1	110	116	PF00069	0.650
MOD_CK1_1	154	160	PF00069	0.512
MOD_CK1_1	198	204	PF00069	0.692
MOD_CK1_1	234	240	PF00069	0.494
MOD_CK1_1	328	334	PF00069	0.423
MOD_CK1_1	561	567	PF00069	0.616
MOD_CK1_1	6	12	PF00069	0.683
MOD_CK1_1	651	657	PF00069	0.554
MOD_CK1_1	79	85	PF00069	0.481
MOD_CK2_1	232	238	PF00069	0.494
MOD_CK2_1	339	345	PF00069	0.444
MOD_CK2_1	351	357	PF00069	0.561
MOD_CK2_1	371	377	PF00069	0.627
MOD_CK2_1	40	46	PF00069	0.430
MOD_CK2_1	437	443	PF00069	0.498
MOD_CK2_1	446	452	PF00069	0.519
MOD_CK2_1	480	486	PF00069	0.449
MOD_CK2_1	563	569	PF00069	0.653
MOD_CK2_1	700	706	PF00069	0.633
MOD_CK2_1	735	741	PF00069	0.589
MOD_CK2_1	747	753	PF00069	0.550
MOD_CK2_1	765	771	PF00069	0.423
MOD_CK2_1	775	781	PF00069	0.447
MOD_CK2_1	79	85	PF00069	0.454
MOD_CK2_1	90	96	PF00069	0.413
MOD_GlcNHglycan	133	136	PF01048	0.590
MOD_GlcNHglycan	16	19	PF01048	0.554
MOD_GlcNHglycan	314	317	PF01048	0.514
MOD_GlcNHglycan	428	431	PF01048	0.494
MOD_GlcNHglycan	666	669	PF01048	0.677
MOD_GlcNHglycan	688	691	PF01048	0.649
MOD_GlcNHglycan	694	698	PF01048	0.642
MOD_GlcNHglycan	706	709	PF01048	0.626
MOD_GlcNHglycan	78	81	PF01048	0.554
MOD_GlcNHglycan	82	85	PF01048	0.567
MOD_GlcNHglycan	9	12	PF01048	0.639
MOD_GlcNHglycan	92	95	PF01048	0.649
MOD_GSK3_1	107	114	PF00069	0.695
MOD_GSK3_1	14	21	PF00069	0.667
MOD_GSK3_1	147	154	PF00069	0.735
MOD_GSK3_1	179	186	PF00069	0.688
MOD_GSK3_1	196	203	PF00069	0.754
MOD_GSK3_1	205	212	PF00069	0.597
MOD_GSK3_1	230	237	PF00069	0.492
MOD_GSK3_1	270	277	PF00069	0.556
MOD_GSK3_1	280	287	PF00069	0.612
MOD_GSK3_1	3	10	PF00069	0.692
MOD_GSK3_1	325	332	PF00069	0.416
MOD_GSK3_1	392	399	PF00069	0.501
MOD_GSK3_1	532	539	PF00069	0.632
MOD_GSK3_1	558	565	PF00069	0.610
MOD_GSK3_1	581	588	PF00069	0.587
MOD_GSK3_1	680	687	PF00069	0.604
MOD_GSK3_1	688	695	PF00069	0.580
MOD_GSK3_1	700	707	PF00069	0.600
MOD_GSK3_1	75	82	PF00069	0.707
MOD_GSK3_1	86	93	PF00069	0.508
MOD_N-GLC_1	271	276	PF02516	0.538
MOD_N-GLC_1	437	442	PF02516	0.426
MOD_N-GLC_1	542	547	PF02516	0.599
MOD_N-GLC_1	796	801	PF02516	0.525
MOD_NEK2_1	121	126	PF00069	0.553
MOD_NEK2_1	231	236	PF00069	0.473
MOD_NEK2_1	239	244	PF00069	0.467
MOD_NEK2_1	271	276	PF00069	0.596
MOD_NEK2_1	351	356	PF00069	0.566
MOD_NEK2_1	426	431	PF00069	0.404
MOD_NEK2_1	490	495	PF00069	0.563
MOD_NEK2_1	524	529	PF00069	0.402
MOD_NEK2_1	688	693	PF00069	0.595
MOD_NEK2_1	75	80	PF00069	0.586
MOD_NEK2_1	831	836	PF00069	0.481
MOD_PIKK_1	121	127	PF00454	0.534
MOD_PIKK_1	239	245	PF00454	0.507
MOD_PIKK_1	525	531	PF00454	0.610
MOD_PIKK_1	643	649	PF00454	0.456
MOD_PIKK_1	67	73	PF00454	0.448
MOD_PIKK_1	680	686	PF00454	0.650
MOD_PKA_2	165	171	PF00069	0.580
MOD_PKA_2	205	211	PF00069	0.502
MOD_PKA_2	301	307	PF00069	0.563
MOD_PKA_2	371	377	PF00069	0.627
MOD_PKA_2	396	402	PF00069	0.457
MOD_PKA_2	532	538	PF00069	0.496
MOD_PKA_2	684	690	PF00069	0.708
MOD_PKA_2	764	770	PF00069	0.523
MOD_PKA_2	86	92	PF00069	0.455
MOD_PKB_1	310	318	PF00069	0.492
MOD_Plk_1	271	277	PF00069	0.474
MOD_Plk_1	462	468	PF00069	0.340
MOD_Plk_1	569	575	PF00069	0.526
MOD_Plk_1	651	657	PF00069	0.502
MOD_Plk_1	796	802	PF00069	0.527
MOD_Plk_2-3	716	722	PF00069	0.626
MOD_Plk_4	33	39	PF00069	0.621
MOD_Plk_4	775	781	PF00069	0.611
MOD_ProDKin_1	101	107	PF00069	0.669
MOD_ProDKin_1	112	118	PF00069	0.706
MOD_ProDKin_1	151	157	PF00069	0.600
MOD_ProDKin_1	198	204	PF00069	0.699
MOD_ProDKin_1	281	287	PF00069	0.590
MOD_ProDKin_1	579	585	PF00069	0.731
MOD_ProDKin_1	730	736	PF00069	0.629
MOD_ProDKin_1	808	814	PF00069	0.527
MOD_SUMO_for_1	410	413	PF00179	0.527
MOD_SUMO_for_1	790	793	PF00179	0.466
MOD_SUMO_for_1	837	840	PF00179	0.481
MOD_SUMO_rev_2	422	429	PF00179	0.465
MOD_SUMO_rev_2	604	613	PF00179	0.475
TRG_DiLeu_BaEn_1	628	633	PF01217	0.539
TRG_DiLeu_BaEn_1	652	657	PF01217	0.504
TRG_DiLeu_BaEn_1	758	763	PF01217	0.440
TRG_DiLeu_BaEn_4	213	219	PF01217	0.456
TRG_DiLeu_BaEn_4	452	458	PF01217	0.423
TRG_DiLeu_BaEn_4	771	777	PF01217	0.519
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.482
TRG_DiLeu_LyEn_5	652	657	PF01217	0.504
TRG_ENDOCYTIC_2	587	590	PF00928	0.540
TRG_ENDOCYTIC_2	88	91	PF00928	0.556
TRG_ER_diArg_1	218	221	PF00400	0.496
TRG_ER_diArg_1	433	435	PF00400	0.458
TRG_ER_diArg_1	466	469	PF00400	0.437
TRG_ER_diArg_1	494	497	PF00400	0.406
TRG_ER_diArg_1	662	664	PF00400	0.566
TRG_NES_CRM1_1	259	270	PF08389	0.344
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y9	Leptomonas seymouri	46%	95%
A0A1X0P4S6	Trypanosomatidae	22%	100%
A0A3S7WYS7	Leishmania donovani	90%	100%
A4H4A4	Leishmania braziliensis	64%	99%
A4I181	Leishmania infantum	90%	100%
E9AXB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5B7N4	Trypanosoma cruzi	22%	100%